Published in Mol Biol Cell on August 01, 1994
Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors. Mol Biol Cell (1995) 2.06
In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. EMBO J (1995) 1.66
Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28. Mol Cell Biol (1996) 1.64
Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev (1998) 1.62
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol (1997) 1.31
Biochemical and biological analysis of Mek1 phosphorylation site mutants. Mol Biol Cell (1995) 1.28
T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. EMBO J (2001) 1.26
Phosphorylation of the RNA polymerase II largest subunit during Xenopus laevis oocyte maturation. Mol Cell Biol (1997) 1.16
Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK. EMBO J (1995) 1.14
Dephosphorylation of threonine 169 of Cdc28 is not required for exit from mitosis but may be necessary for start in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.02
Cyclins and cell cycle control in cancer and disease. Genes Cancer (2012) 0.90
MAT1-modulated CAK activity regulates cell cycle G(1) exit. Mol Cell Biol (2001) 0.89
Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. J Biol Chem (2010) 0.83
Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation. Mol Cell Biol (2008) 0.82
Activation of protein kinase C alters p34(cdc2) phosphorylation state and kinase activity in early sea urchin embryos by abolishing intracellular Ca2+ transients. Biochem J (2000) 0.76
Universal control mechanism regulating onset of M-phase. Nature (1990) 19.11
Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J Morphol (1972) 11.75
Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell (1991) 9.96
Cyclin synthesis drives the early embryonic cell cycle. Nature (1989) 9.73
Mammalian G1 cyclins. Cell (1993) 9.04
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell (1989) 8.19
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol (1991) 7.18
Cyclin activation of p34cdc2. Cell (1990) 6.87
Animal cell cycles and their control. Annu Rev Biochem (1992) 6.60
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell (1991) 6.32
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell (1991) 6.25
Control of the yeast cell cycle by the Cdc28 protein kinase. Curr Opin Cell Biol (1993) 5.88
Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J (1993) 5.80
Regulation of p34cdc2 protein kinase during mitosis. Cell (1989) 5.33
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell (1991) 4.88
Cyclin is a component of maturation-promoting factor from Xenopus. Cell (1990) 4.70
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature (1991) 4.54
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell (1989) 4.43
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature (1991) 4.36
Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell (1991) 4.33
The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle. EMBO J (1990) 4.25
Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J (1991) 4.24
The roles of Drosophila cyclins A and B in mitotic control. Cell (1990) 4.22
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J (1992) 4.21
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Mol Biol Cell (1992) 4.17
Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. EMBO J (1991) 4.04
Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell (1992) 3.95
p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase. EMBO J (1989) 3.70
Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae. Nature (1992) 3.68
S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature (1992) 3.56
p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. EMBO J (1991) 3.55
Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem Sci (1993) 3.48
Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc Natl Acad Sci U S A (1992) 3.38
Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J (1993) 3.30
p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc Natl Acad Sci U S A (1992) 3.20
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. EMBO J (1993) 3.03
The role of p34 kinases in the G1 to S-phase transition. Annu Rev Cell Biol (1992) 3.02
CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. EMBO J (1993) 2.96
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol (1993) 2.83
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1. EMBO J (1991) 2.71
Activation of human cyclin-dependent kinases in vitro. Mol Biol Cell (1992) 2.68
Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2. Proc Natl Acad Sci U S A (1991) 2.60
Braking the cycle. Cell (1993) 2.34
Two distinct mechanisms for negative regulation of the Wee1 protein kinase. EMBO J (1993) 2.21
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro. Mol Biol Cell (1993) 2.11
The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs. EMBO J (1993) 2.10
Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes. EMBO J (1992) 2.07
On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis. J Cell Biol (1991) 2.06
p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes. EMBO J (1990) 1.96
Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase. EMBO J (1992) 1.77
A proliferation of cyclins. Trends Cell Biol (1992) 1.61
Cyclin B in Xenopus oocytes: implications for the mechanism of pre-MPF activation. EMBO J (1991) 1.54
Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins. EMBO J (1994) 1.50
Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle. Proc Natl Acad Sci U S A (1992) 1.45
Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. EMBO J (1992) 1.41
The induction of oocyte maturation: transmembrane signaling events and regulation of the cell cycle. Development (1989) 1.39
Cell cycle. Dams and sluices. Nature (1993) 1.36
Cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation. Trends Cell Biol (1993) 1.31
cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells. J Cell Biol (1992) 1.27
Xenopus oocyte maturation does not require new cyclin synthesis. J Cell Biol (1991) 1.26
Intracellular localisation and expression of mammalian CDC2 protein during myogenic differentiation. Differentiation (1989) 1.20
The croonian lecture, 1976. Egg cytoplasm and gene control in development. Proc R Soc Lond B Biol Sci (1977) 1.02
Transcript levels and translational control of hsp70 synthesis in Xenopus oocytes. Genes Dev (1987) 0.99
Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene (1993) 0.92
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
The composite genome of the legume symbiont Sinorhizobium meliloti. Science (2001) 9.11
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell (1997) 8.23
Silent ischemia as a central problem: regional brain activation compared in silent and painful myocardial ischemia. Ann Intern Med (1996) 6.11
Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr (1980) 4.94
Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group. Ann Intern Med (1995) 3.93
In-vivo measurement of activated microglia in dementia. Lancet (2001) 3.51
Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. J Cell Sci (2000) 3.50
Evidence for striatal dopamine release during a video game. Nature (1998) 3.28
Validity and repeatability of the IUATLD (1984) Bronchial Symptoms Questionnaire: an international comparison. Eur Respir J (1989) 3.12
Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci U S A (2000) 3.09
Positron emission tomography for in-vivo measurement of regional blood flow, oxygen utilisation, and blood volume in patients with breast carcinoma. Lancet (1984) 3.05
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. EMBO J (1993) 3.03
CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. EMBO J (1993) 2.96
Cowpox: reservoir hosts and geographic range. Epidemiol Infect (1999) 2.93
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain (2000) 2.84
Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid. Proc Natl Acad Sci U S A (2001) 2.59
Diffuse-adhering Escherichia coli (DAEC) as a putative cause of diarrhea in Mayan children in Mexico. J Infect Dis (1991) 2.52
Genomic evidence for a complete sexual cycle in Candida albicans. Proc Natl Acad Sci U S A (2001) 2.52
Central nervous pathways mediating angina pectoris. Lancet (1994) 2.38
Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci U S A (2000) 2.32
Glucose utilization in vivo by human pulmonary neoplasms. Cancer (1987) 2.29
Physical performance of a positron tomograph for brain imaging with retractable septa. Phys Med Biol (1992) 2.27
Synergy between medical informatics and bioinformatics: facilitating genomic medicine for future health care. J Biomed Inform (2004) 2.25
Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry (1992) 2.21
Transmission dynamics of a zoonotic pathogen within and between wildlife host species. Proc Biol Sci (1999) 2.11
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J Biol Chem (1999) 2.09
The relative effects of fast neutrons and x rays on tumour and normal tissue in the rat. II. Fractionation: recovery and reoxygenation. Br J Radiol (1968) 2.09
Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain (1981) 2.08
BVD virus genotype 2 detected in British cattle. Vet Rec (2002) 2.05
Measurement of gastric emptying using the scintillation camera and 129Cs. Br J Radiol (1970) 1.92
Prevalence of small inversions in yeast gene order evolution. Proc Natl Acad Sci U S A (2000) 1.90
Azotobacter vinelandii NIFL is a flavoprotein that modulates transcriptional activation of nitrogen-fixation genes via a redox-sensitive switch. Proc Natl Acad Sci U S A (1996) 1.89
The in vitro inhibition of growth of intracellular Listeria monocytogenes by lymphocyte products. Cell Immunol (1973) 1.87
Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography. J Neurol Neurosurg Psychiatry (1986) 1.84
Spectral analysis of dynamic PET studies. J Cereb Blood Flow Metab (1993) 1.84
Oxygen-15 brain scanning for detection of cerebral involvement in systemic lupus erythematosus. Lancet (1978) 1.75
Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24. Nucleic Acids Res (1992) 1.74
Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metab (1983) 1.73
Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion. Lancet (1984) 1.70
Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection. Br J Cancer (1989) 1.68
Spectral analysis of respiratory noise in horses with upper airway disorders. Equine Vet J (2003) 1.65
Leaf photosynthetic traits scale with hydraulic conductivity and wood density in Panamanian forest canopy trees. Oecologia (2004) 1.64
Assessment of regional ventilation by continuous inhalation of radioactive krypton-81m. Br Med J (1975) 1.62
Supersensitivity and gastric emptying after vagotomy. Gut (1970) 1.58
Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction. Brain (1983) 1.58
Emergency asthma inhalers in school. Arch Dis Child (2003) 1.56
Mechanism and kinetics of iron release from ferritin by dihydroflavins and dihydroflavin analogues. Biochemistry (1978) 1.55
Benzodiazepine receptor quantification in vivo in humans using [11C]flumazenil and PET: application of the steady-state principle. J Cereb Blood Flow Metab (1995) 1.54
Gastric emptying of solid meals after truncal vagotomy and pyloroplasty in human subjects. Gut (1972) 1.52
The DNA region around the c-myc gene and its amplification in human tumour cell lines. Oncogene (1994) 1.50
High-affinity RNA ligands to Escherichia coli ribosomes and ribosomal protein S1: comparison of natural and unnatural binding sites. Biochemistry (1995) 1.50
Treatment outcomes for methadone clients receiving lump-sum payments at initiation of disability benefits. Psychiatr Serv (1996) 1.49
Congenital rubella syndrome: ophthalmic manifestations and associated systemic disorders. Br J Ophthalmol (1993) 1.48
Tracheo-innominate artery fistula after percutaneous tracheostomy: three case reports and a clinical review. Br J Anaesth (2005) 1.48
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195. Neurology (2000) 1.47
Effect of long-term beta2-agonist dosing on human cardiac beta-adrenoceptor expression in vivo: comparison with changes in lung and mononuclear leukocyte beta-receptors. J Nucl Cardiol (1998) 1.45
Dipyridamole-induced increased glucose uptake in patients with single-vessel coronary artery disease assessed with PET. J Nucl Cardiol (2001) 1.45
Impact of complementary parathyroid scintigraphy and ultrasonography on the surgical management of hyperparathyroidism. Surgery (1996) 1.43
Diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumour based on the detection of t(11;22) using fluorescence in situ hybridisation. Br J Cancer (1993) 1.42
Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Arch Gen Psychiatry (1998) 1.42
Enhanced myocardial 18F-2-fluoro-2-deoxyglucose uptake after orthotopic heart transplantation assessed by positron emission tomography. J Am Coll Cardiol (1997) 1.42
Detection of thirty-second cognitive activations in single subjects with positron emission tomography: a new low-dose H2(15)O regional cerebral blood flow three-dimensional imaging technique. J Cereb Blood Flow Metab (1993) 1.41
The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease. Arch Neurol (1990) 1.39
Dipyridamole vasodilator response after human orthotopic heart transplantation: quantification by oxygen-15-labeled water and positron emission tomography. J Am Coll Cardiol (1992) 1.38
Antiretroviral adherence and use of alternative therapies among older HIV-infected adults. J Natl Med Assoc (2001) 1.37
[11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis. Neurology (1999) 1.36
Fluorine-18 deoxyglucose uptake in sarcoidosis measured with positron emission tomography. Eur J Nucl Med (1994) 1.36
The effect of cowpox virus infection on fecundity in bank voles and wood mice. Proc Biol Sci (1997) 1.35
Measurements of blood flow and exchanging water space in breast tumors using positron emission tomography: a rapid and noninvasive dynamic method. Cancer Res (1992) 1.33
Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans. J Bacteriol (2001) 1.32
Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals. Eur J Nucl Med (1998) 1.31
The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man. Br J Radiol (1976) 1.30
Separation and characterization of a subset of human T8+ cells which function as antigen-presenting and contrasuppressor cells. Immunology (1985) 1.28
A method for measuring the absolute sensitivity of positron emission tomographic scanners. Eur J Nucl Med (1991) 1.27
In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. Brain (2001) 1.26
Parametric image reconstruction using spectral analysis of PET projection data. Phys Med Biol (1998) 1.26
Microfabricated silicon microneedles for nonviral cutaneous gene delivery. Br J Dermatol (2004) 1.25
Two cases of 5q deletions in patients with familial adenomatous polyposis: possible link with Caroli's disease. J Med Genet (1993) 1.23
Hyperpnoea during and immediately after exercise in man: evidence of motor cortical involvement. J Physiol (1995) 1.23
Transcriptional activation of the nitrogenase promoter in vitro: adenosine nucleotides are required for inhibition of NIFA activity by NIFL. J Bacteriol (1995) 1.23
Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 2. Results in normal subjects and brain tumour and stroke patients. J Cereb Blood Flow Metab (1983) 1.22
Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker and defines a novel gene family conserved in plants. J Immunol (1999) 1.21
The effects of L-DOPA on regional cerebral blood flow and oxygen metabolism in patients with Parkinson's disease. Brain (1985) 1.20
Studies on regional cerebral oxygen utilisation and cognitive function in multiple sclerosis. J Neurol Neurosurg Psychiatry (1984) 1.16
Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography. Circulation (1991) 1.15
Quantitative measurement of regional extravascular lung density using positron emission and transmission tomography. J Comput Assist Tomogr (1981) 1.15
The intracranial complications of rhinosinusitis: can they be prevented? Laryngoscope (2002) 1.14
Combination of dynamic and integral methods for generating reproducible functional CBF images. J Cereb Blood Flow Metab (1990) 1.14
Is buscopan effective in meat bolus obstruction? Clin Otolaryngol (2005) 1.14
Accessory human cytomegalovirus glycoprotein US9 in the unique short component of the viral genome promotes cell-to-cell transmission of virus in polarized epithelial cells. J Virol (1996) 1.13
Cerebral haemodynamics in occlusive carotid-artery disease. Lancet (1985) 1.13
Delivery of therapeutic aerosols to intubated babies. Arch Dis Child (1992) 1.12
The human collagen X gene. Complete primary translated sequence and chromosomal localization. Biochem J (1991) 1.12
Changes in central opioid receptor binding in relation to inflammation and pain in patients with rheumatoid arthritis. Br J Rheumatol (1994) 1.12
Comparison of sensitivity of immunofluorescent microscopy to that of a combination of immunofluorescent microscopy and immunomagnetic separation for detection of Cryptosporidium parvum oocysts in adult bovine feces. Appl Environ Microbiol (1999) 1.12
Complement factor H or a related protein is a marker for transitional cell cancer of the bladder. Clin Cancer Res (1998) 1.11
Alterations of regional cerebral blood flow and oxygen metabolism in Parkinson's disease. Neurology (1985) 1.10
Observations on salpingitis, peritonitis and salpingoperitonitis in a layer breeder flock. Vet Rec (2005) 1.09