Published in Lancet on August 11, 2001
Brain Inflammation in Major Depressive Disorder Background | NCT01851356
Role of microglia in central nervous system infections. Clin Microbiol Rev (2004) 2.69
Role of microglia in neurotrauma. Neurotherapeutics (2010) 2.53
Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacol Ther (2008) 2.47
Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers. Eur J Nucl Med Mol Imaging (2008) 2.41
Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med (2012) 2.36
The use of PET in Alzheimer disease. Nat Rev Neurol (2010) 2.13
The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol (2006) 2.10
Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci U S A (2011) 2.03
Methamphetamine causes microglial activation in the brains of human abusers. J Neurosci (2008) 1.96
APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain. Biol Psychiatry (2013) 1.95
Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol (2007) 1.90
Glial cells in (patho)physiology. J Neurochem (2012) 1.89
Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology (2009) 1.70
Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin. Nat Med (2015) 1.61
In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease. Brain (2013) 1.57
IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice. J Immunol (2010) 1.55
The significance of neuroinflammation in understanding Alzheimer's disease. J Neural Transm (Vienna) (2006) 1.55
How do immune cells support and shape the brain in health, disease, and aging? J Neurosci (2013) 1.51
Current and future uses of neuroimaging for cognitively impaired patients. Lancet Neurol (2008) 1.49
[11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Mol Imaging Biol (2009) 1.43
Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.43
Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer's disease in vivo? Eur J Nucl Med Mol Imaging (2004) 1.42
Biomarkers of Alzheimer's disease. Neurobiol Dis (2008) 1.37
Microglia and inflammation in Alzheimer's disease. CNS Neurol Disord Drug Targets (2010) 1.37
Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET. J Nucl Med (2008) 1.32
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. Am J Pathol (2011) 1.32
Molecular imaging of microglia/macrophages in the brain. Glia (2012) 1.29
TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflammation (2012) 1.29
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. J Neurosci (2008) 1.29
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout. Nat Commun (2014) 1.29
Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death Dis (2011) 1.27
NADPH oxidase as a therapeutic target in Alzheimer's disease. BMC Neurosci (2008) 1.27
NOX activity is increased in mild cognitive impairment. Antioxid Redox Signal (2010) 1.22
Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine. Brain (2009) 1.20
Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease. Mol Neurodegener (2011) 1.20
Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. Brain Res Brain Res Rev (2005) 1.19
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci (2011) 1.19
Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab (2012) 1.19
Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors. J Neuroinflammation (2004) 1.17
Microglia function in Alzheimer's disease. Front Pharmacol (2012) 1.17
Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory. Neuroscience (2009) 1.16
Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice. Am J Pathol (2005) 1.15
PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS. J Clin Invest (2004) 1.15
Interactions between APP secretases and inflammatory mediators. J Neuroinflammation (2008) 1.14
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch Neurol (2009) 1.14
The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders. J Neuropathol Exp Neurol (2008) 1.12
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging. Exp Neurol (2007) 1.12
Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease. Neuropharmacology (2014) 1.12
Imaging microglial activation during neuroinflammation and Alzheimer's disease. J Neuroimmune Pharmacol (2008) 1.11
Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies. J Cereb Blood Flow Metab (2012) 1.10
Progranulin mutations as risk factors for Alzheimer disease. JAMA Neurol (2013) 1.06
The changing phenotype of microglia from homeostasis to disease. Transl Neurodegener (2012) 1.06
Molecular mechanisms of cognitive dysfunction following traumatic brain injury. Front Aging Neurosci (2013) 1.05
Positron emission tomography in patients suffering from HIV-1 infection. Eur J Nucl Med Mol Imaging (2009) 1.04
Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease. PLoS One (2013) 1.04
Anti-inflammatory impact of minocycline in a mouse model of tauopathy. Front Psychiatry (2010) 1.03
Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease. Neuroimage Clin (2013) 1.02
Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease. Alzheimers Res Ther (2012) 1.02
Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain (2016) 1.01
Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy. Neuroscience (2014) 1.01
Altered microglial copper homeostasis in a mouse model of Alzheimer's disease. J Neurochem (2010) 1.01
In vivo imaging of cerebral "peripheral benzodiazepine binding sites" in patients with hepatic encephalopathy. Gut (2005) 1.01
The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. J Neurosci (2010) 1.00
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiol Aging (2008) 1.00
Fas ligand-mediated apoptosis in degenerative disorders of the brain. J Clin Immunol (2003) 0.99
Brain imaging in the study of Alzheimer's disease. Neuroimage (2011) 0.97
Maintaining brain health by monitoring inflammatory processes: a mechanism to promote successful aging. Aging Dis (2011) 0.97
NOX activity in brain aging: exacerbation by high fat diet. Free Radic Biol Med (2010) 0.97
Positron emission tomography imaging of neuroinflammation. J Child Neurol (2009) 0.97
The methodology of TSPO imaging with positron emission tomography. Biochem Soc Trans (2015) 0.96
Imaging of microglia in patients with neurodegenerative disorders. Front Pharmacol (2012) 0.96
MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. J Neurosci Methods (2012) 0.96
The role of inflammasome in Alzheimer's disease. Ageing Res Rev (2014) 0.95
Resolution of inflammation is altered in Alzheimer's disease. Alzheimers Dement (2014) 0.95
In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease. Eur J Nucl Med Mol Imaging (2010) 0.95
Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks. Brain Behav Immun (2011) 0.95
Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state. Glia (2011) 0.94
Positron emission tomography and single-photon emission computed tomography in central nervous system drug development. NeuroRx (2005) 0.94
Inflammation and Alzheimer's disease. Lancet (2001) 0.94
(11)C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease. Neurobiol Aging (2016) 0.94
Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better? Curr Neurovasc Res (2005) 0.93
Microglial cell dysregulation in brain aging and neurodegeneration. Front Aging Neurosci (2015) 0.92
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis. Neurobiol Dis (2007) 0.92
Basal forebrain atrophy is a presymptomatic marker for Alzheimer's disease. Alzheimers Dement (2008) 0.92
In vivo dynamics of innate immune sentinels in the CNS. Intravital (2012) 0.92
Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation. Eur J Nucl Med Mol Imaging (2009) 0.92
Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases. Front Cell Neurosci (2014) 0.91
Ocular changes in TgF344-AD rat model of Alzheimer's disease. Invest Ophthalmol Vis Sci (2014) 0.91
Microglial activation and progressive brain changes in schizophrenia. Br J Pharmacol (2016) 0.90
Chronic apocynin treatment attenuates beta amyloid plaque size and microglial number in hAPP(751)(SL) mice. PLoS One (2011) 0.90
Inflammation and aging: can endocannabinoids help? Biomed Pharmacother (2008) 0.89
Protein clearance mechanisms of alpha-synuclein and amyloid-Beta in lewy body disorders. Int J Alzheimers Dis (2012) 0.89
Microglial control of neuronal activity. Front Cell Neurosci (2013) 0.89
Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models. Int J Nanomedicine (2012) 0.89
Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies. Int Psychogeriatr (2008) 0.89
Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J Neuroinflammation (2005) 0.89
Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators Inflamm (2015) 0.89
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen. Proc Natl Acad Sci U S A (1980) 10.22
The composite genome of the legume symbiont Sinorhizobium meliloti. Science (2001) 9.11
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell (1997) 8.23
Second consensus statement on the diagnosis of multiple system atrophy. Neurology (2008) 7.27
Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet (1993) 6.53
A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. N Engl J Med (2000) 6.21
Silent ischemia as a central problem: regional brain activation compared in silent and painful myocardial ischemia. Ann Intern Med (1996) 6.11
Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. Euro Surveill (2012) 4.96
Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr (1980) 4.94
Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. Cereb Cortex (1993) 4.79
Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study. Brain (1996) 4.61
Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology (2006) 4.06
Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group. Ann Intern Med (1995) 3.93
Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. J Cell Sci (2000) 3.50
Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study. Neurology (2009) 3.49
Evidence for striatal dopamine release during a video game. Nature (1998) 3.28
Elevating clinical licensing examinations to professional testing standards. N Y State Dent J (1998) 3.20
Validity and repeatability of the IUATLD (1984) Bronchial Symptoms Questionnaire: an international comparison. Eur Respir J (1989) 3.12
Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci U S A (2000) 3.09
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Nat Genet (2002) 3.07
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nat Neurosci (1999) 3.06
Positron emission tomography for in-vivo measurement of regional blood flow, oxygen utilisation, and blood volume in patients with breast carcinoma. Lancet (1984) 3.05
The role of radiotracer imaging in Parkinson disease. Neurology (2005) 3.02
Cowpox: reservoir hosts and geographic range. Epidemiol Infect (1999) 2.93
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology (2007) 2.86
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain (2000) 2.84
The Huntington's disease candidate region exhibits many different haplotypes. Nat Genet (1992) 2.84
The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. Ann Neurol (1991) 2.84
Positron emission tomography studies on the dopaminergic system and striatal opioid binding in the olivopontocerebellar atrophy variant of multiple system atrophy. Ann Neurol (1995) 2.76
Motor sequence learning: a study with positron emission tomography. J Neurosci (1994) 2.71
Comparison of methods for analysis of clinical [11C]raclopride studies. J Cereb Blood Flow Metab (1996) 2.66
Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid. Proc Natl Acad Sci U S A (2001) 2.59
Diffuse-adhering Escherichia coli (DAEC) as a putative cause of diarrhea in Mayan children in Mexico. J Infect Dis (1991) 2.52
Genomic evidence for a complete sexual cycle in Candida albicans. Proc Natl Acad Sci U S A (2001) 2.52
Central nervous pathways mediating angina pectoris. Lancet (1994) 2.38
Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci U S A (2000) 2.32
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol Dis (2004) 2.29
Glucose utilization in vivo by human pulmonary neoplasms. Cancer (1987) 2.29
Anatomy of motor learning. I. Frontal cortex and attention to action. J Neurophysiol (1997) 2.29
Physical performance of a positron tomograph for brain imaging with retractable septa. Phys Med Biol (1992) 2.27
Synergy between medical informatics and bioinformatics: facilitating genomic medicine for future health care. J Biomed Inform (2004) 2.25
Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch Gen Psychiatry (2000) 2.25
Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET. J Neurol Neurosurg Psychiatry (1998) 2.24
Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry (1992) 2.21
Evidence for glutamate excitotoxicity in Huntington's disease with proton magnetic resonance spectroscopy. Lancet (1994) 2.17
Evidence for lateral premotor and parietal overactivity in Parkinson's disease during sequential and bimanual movements. A PET study. Brain (1997) 2.15
Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry (2008) 2.12
Transmission dynamics of a zoonotic pathogen within and between wildlife host species. Proc Biol Sci (1999) 2.11
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J Biol Chem (1999) 2.09
The relative effects of fast neutrons and x rays on tumour and normal tissue in the rat. II. Fractionation: recovery and reoxygenation. Br J Radiol (1968) 2.09
Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain (1981) 2.08
BVD virus genotype 2 detected in British cattle. Vet Rec (2002) 2.05
Artifacts due to stimulus correlated motion in functional imaging of the brain. Magn Reson Med (1994) 1.99
Anatomy of motor learning. II. Subcortical structures and learning by trial and error. J Neurophysiol (1997) 1.97
Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans. J Cogn Neurosci (2000) 1.94
Measurement of gastric emptying using the scintillation camera and 129Cs. Br J Radiol (1970) 1.92
Relation between cerebral activity and force in the motor areas of the human brain. J Neurophysiol (1995) 1.91
Changes in relative biological effectiveness with depth of the Clatterbridge neutron therapy beam. Br J Radiol (1988) 1.91
Prevalence of small inversions in yeast gene order evolution. Proc Natl Acad Sci U S A (2000) 1.90
Azotobacter vinelandii NIFL is a flavoprotein that modulates transcriptional activation of nitrogen-fixation genes via a redox-sensitive switch. Proc Natl Acad Sci U S A (1996) 1.89
Microglial activation correlates with severity in Huntington disease: a clinical and PET study. Neurology (2006) 1.88
An [18F]dopa-PET and clinical study of the rate of progression in Parkinson's disease. Brain (1996) 1.87
The in vitro inhibition of growth of intracellular Listeria monocytogenes by lymphocyte products. Cell Immunol (1973) 1.87
Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study. Ann Neurol (1992) 1.86
The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann Neurol (1999) 1.85
Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography. J Neurol Neurosurg Psychiatry (1986) 1.84
Spectral analysis of dynamic PET studies. J Cereb Blood Flow Metab (1993) 1.84
Long duration asymmetrical postural tremor is likely to predict development of Parkinson's disease and not essential tremor: clinical follow up study of 13 cases. J Neurol Neurosurg Psychiatry (2005) 1.83
Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation. Neurology (2005) 1.77
Oxygen-15 brain scanning for detection of cerebral involvement in systemic lupus erythematosus. Lancet (1978) 1.75
Self-initiated versus externally triggered movements. II. The effect of movement predictability on regional cerebral blood flow. Brain (2000) 1.75
Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24. Nucleic Acids Res (1992) 1.74
Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metab (1983) 1.73
The effect of ethanol on alcohol-responsive essential tremor: a positron emission tomography study. Ann Neurol (1996) 1.70
Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology (2009) 1.70
Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion. Lancet (1984) 1.70
Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection. Br J Cancer (1989) 1.68
Balancing justice and autonomy in clinical research with healthy volunteers. Clin Pharmacol Ther (2007) 1.68
Experimental increase in accommodative potential after neodymium: yttrium-aluminum-garnet laser photodisruption of paired cadaver lenses. Ophthalmology (2001) 1.64
Leaf photosynthetic traits scale with hydraulic conductivity and wood density in Panamanian forest canopy trees. Oecologia (2004) 1.64
Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41. Antimicrob Agents Chemother (2005) 1.63
Assessment of regional ventilation by continuous inhalation of radioactive krypton-81m. Br Med J (1975) 1.62
Familial history of stroke and stroke risk. The Family Heart Study. Stroke (1997) 1.61
Tremor in Parkinson's disease and serotonergic dysfunction: an 11C-WAY 100635 PET study. Neurology (2003) 1.61
A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections. Ann Neurol (1993) 1.58
Supersensitivity and gastric emptying after vagotomy. Gut (1970) 1.58
Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction. Brain (1983) 1.58