Published in Mol Cell Biochem on January 31, 1995
A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur J Biochem (1974) 6.65
Phosphoenolpyruvate:carbohydrate phosphotransferase system of bacteria. Microbiol Rev (1985) 5.90
Complexes of sequential metabolic enzymes. Annu Rev Biochem (1987) 4.99
Metabolic control analysis: a survey of its theoretical and experimental development. Biochem J (1992) 4.14
MOlecular democracy: who shares the controls? Biochem Soc Trans (1979) 3.60
Mathematical analysis of multienzyme systems. II. Steady state and transient control. Biosystems (1975) 2.92
Quantification of the contribution of various steps to the control of mitochondrial respiration. J Biol Chem (1982) 2.92
Metabolic control and its analysis. Additional relationships between elasticities and control coefficients. Eur J Biochem (1985) 2.65
Metabolic control theory: a structural approach. J Theor Biol (1988) 2.63
Physiological significance of metabolic channelling. J Theor Biol (1991) 2.12
Metabolic regulation and mathematical models. Prog Biophys Mol Biol (1977) 2.06
Characterization of rate-controlling steps in vivo by use of an adjustable expression vector. Proc Natl Acad Sci U S A (1985) 1.69
Control of the flux in the arginine pathway of Neurospora crassa. Modulations of enzyme activity and concentration. Biochem J (1981) 1.35
Biophysical chemistry of metabolic reaction sequences in concentrated enzyme solution and in the cell. Annu Rev Biophys Biophys Chem (1987) 1.31
Metabolic control analysis of moiety-conserved cycles. Eur J Biochem (1986) 1.31
Kinetics of metabolic pathways. A system in vitro to study the control of flux. Biochem J (1986) 1.27
Excess capacity of H(+)-ATPase and inverse respiratory control in Escherichia coli. EMBO J (1993) 1.20
Enzyme-enzyme interactions and control analysis. 1. The case of non-additivity: monomer-oligomer associations. Eur J Biochem (1990) 1.17
Retarded diffusion of ADP in cardiomyocytes: possible role of mitochondrial outer membrane and creatine kinase in cellular regulation of oxidative phosphorylation. Biochim Biophys Acta (1993) 1.15
Role of creatine phosphokinase in cellular function and metabolism. Can J Physiol Pharmacol (1978) 1.09
Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. II. Complex systems. Math Biosci (1989) 1.07
Enzyme-enzyme interactions and their metabolic role. FEBS Lett (1990) 1.04
Enzyme-enzyme interactions and control analysis. 2. The case of non-independence: heterologous associations. Eur J Biochem (1990) 1.02
Metabolic channelling and control of the flux. FEBS Lett (1993) 0.98
Control analysis of metabolic networks. 1. Homogeneous functions and the summation theorems for control coefficients. Eur J Biochem (1988) 0.94
The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. Eur J Biochem (1993) 0.93
The definitions of metabolic control analysis revisited. Biosystems (1992) 0.92
Metabolic control analysis. The effects of high enzyme concentrations. Eur J Biochem (1990) 0.92
Substrate channeling in glycolysis: a phantom phenomenon. Proc Natl Acad Sci U S A (1991) 0.90
The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria. FEBS Lett (1987) 0.89
Getting to the inside of cells using metabolic control analysis. Biophys Chem (1994) 0.85
Influence of the mitochondrial outer membrane and the binding of creatine kinase to the mitochondrial inner membrane on the compartmentation of adenine nucleotides in the intermembrane space of rat heart mitochondria. Biochim Biophys Acta (1993) 0.84
The role of adenylate kinase in dynamic compartmentation of adenine nucleotides in the mitochondrial intermembrane space. FEBS Lett (1992) 0.83
Control of the metabolic flux in a system with high enzyme concentrations and moiety-conserved cycles. The sum of the flux control coefficients can drop significantly below unity. Eur J Biochem (1992) 0.83
'Channelled' pathways can be more sensitive to specific regulatory signals. FEBS Lett (1993) 0.81
Metabolite channelling in aerobic energy metabolism. J Theor Biol (1992) 0.81
How do external parameters control fluxes and concentrations of metabolites? An additional relationship in the theory of metabolic control. FEBS Lett (1988) 0.79
Re-evaluation of the glycerol-3-phosphate dehydrogenase/L-lactate dehydrogenase enzyme system. Evidence against the direct transfer of NADH between active sites. Biochem J (1991) 0.77
Cellular infrastructure and metabolic organization. Curr Top Cell Regul (1992) 0.76
[Control of molecular transformations in polyenzyme systems: quantitative theory of the regulation of metabolism]. Mol Biol (Mosk) (1989) 0.75
Kinetics and thermodynamics of metabolite transfer between enzymes. Biophys Chem (1990) 0.75
Substrate channeling among glycolytic enzymes: fact or fiction. J Theor Biol (1991) 0.75
Redistribution of the flux-control coefficients in mitochondrial oxidative phosphorylations in the course of brain edema. Biochim Biophys Acta (1988) 0.75
Tryptophan synthetase of E. coli: a multifunctional, multicomponent enzyme; a commentary on 'A Second Reaction Catalyzed by the Tryptophan Synthetase of Escherichia coli'. Biochim Biophys Acta (1989) 0.75
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat Biotechnol (2001) 4.66
Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry. Eur J Biochem (2000) 3.33
Quantification of the contribution of various steps to the control of mitochondrial respiration. J Biol Chem (1982) 2.92
The danger of metabolic pathways with turbo design. Trends Biochem Sci (1998) 2.66
Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res (1997) 2.35
Quantification of information transfer via cellular signal transduction pathways. FEBS Lett (1997) 2.33
Why cytoplasmic signalling proteins should be recruited to cell membranes. Trends Cell Biol (2000) 2.03
Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose. Am J Physiol (1998) 1.99
An alternative PII protein in the regulation of glutamine synthetase in Escherichia coli. Mol Microbiol (1996) 1.97
Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway. FEBS Lett (2001) 1.91
How enzymes can capture and transmit free energy from an oscillating electric field. Proc Natl Acad Sci U S A (1986) 1.78
Modern theories of metabolic control and their applications (review). Biosci Rep (1984) 1.75
GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition. J Mol Biol (1998) 1.75
A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units. Biochim Biophys Acta (1984) 1.74
Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes. J Biol Chem (1997) 1.59
The use of lac-type promoters in control analysis. Eur J Biochem (1993) 1.56
The macroworld versus the microworld of biochemical regulation and control. Trends Biochem Sci (1995) 1.54
Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry (1993) 1.53
Acetaldehyde mediates the synchronization of sustained glycolytic oscillations in populations of yeast cells. Eur J Biochem (1996) 1.50
Structure and partitioning of bacterial DNA: determined by a balance of compaction and expansion forces? FEMS Microbiol Lett (1995) 1.48
Understanding glucose transport by the bacterial phosphoenolpyruvate:glycose phosphotransferase system on the basis of kinetic measurements in vitro. J Biol Chem (2000) 1.46
Sustained oscillations in free-energy state and hexose phosphates in yeast. Yeast (1996) 1.45
FnrP and NNR of Paracoccus denitrificans are both members of the FNR family of transcriptional activators but have distinct roles in respiratory adaptation in response to oxygen limitation. Mol Microbiol (1997) 1.44
Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data. Biochem J (2001) 1.44
The signal transduction function for oxidative phosphorylation is at least second order in ADP. J Biol Chem (1996) 1.43
Mutational analysis of the nor gene cluster which encodes nitric-oxide reductase from Paracoccus denitrificans. Eur J Biochem (1996) 1.39
Nitrite and nitric oxide reduction in Paracoccus denitrificans is under the control of NNR, a regulatory protein that belongs to the FNR family of transcriptional activators. FEBS Lett (1995) 1.37
Quantifying heterogeneity: flow cytometry of bacterial cultures. Antonie Van Leeuwenhoek (1992) 1.37
Can free energy be transduced from electric noise? Proc Natl Acad Sci U S A (1987) 1.36
Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells. J Biol Chem (2001) 1.35
What controls glycolysis in bloodstream form Trypanosoma brucei? J Biol Chem (1999) 1.35
The two opposing activities of adenylyl transferase reside in distinct homologous domains, with intramolecular signal transduction. EMBO J (1997) 1.35
Control theory of regulatory cascades. J Theor Biol (1991) 1.34
Compartmentation protects trypanosomes from the dangerous design of glycolysis. Proc Natl Acad Sci U S A (2000) 1.34
The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli. Mol Microbiol (1993) 1.32
Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations. Biophys J (2000) 1.29
How yeast cells synchronize their glycolytic oscillations: a perturbation analytic treatment. Biophys J (2000) 1.29
Magainin 2 amide and analogues. Antimicrobial activity, membrane depolarization and susceptibility to proteolysis. FEBS Lett (1989) 1.28
Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res (2000) 1.28
The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study. Eur J Biochem (2001) 1.28
Nitric oxide is a signal for NNR-mediated transcription activation in Paracoccus denitrificans. J Bacteriol (1999) 1.26
DNA supercoiling depends on the phosphorylation potential in Escherichia coli. Mol Microbiol (1996) 1.25
Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism? Med Hypotheses (1998) 1.24
Mathematical models of purine metabolism in man. Math Biosci (1998) 1.23
How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control. Eur J Biochem (1984) 1.22
Autoamplification of a two-component regulatory system results in "learning" behavior. J Bacteriol (2001) 1.21
The puzzle of the Krebs citric acid cycle: assembling the pieces of chemically feasible reactions, and opportunism in the design of metabolic pathways during evolution. J Mol Evol (1996) 1.21
An additional PII in Escherichia coli: a new regulatory protein in the glutamine synthetase cascade. FEMS Microbiol Lett (1995) 1.20
Excess capacity of H(+)-ATPase and inverse respiratory control in Escherichia coli. EMBO J (1993) 1.20
Around the growth phase transition S. cerevisiae's make-up favours sustained oscillations of intracellular metabolites. FEBS Lett (1993) 1.19
Intracellular glucose concentration in derepressed yeast cells consuming glucose is high enough to reduce the glucose transport rate by 50%. J Bacteriol (1998) 1.18
A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. Am J Physiol Cell Physiol (2000) 1.18
Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett (1999) 1.18
Control of glycolytic dynamics by hexose transport in Saccharomyces cerevisiae. Biophys J (2001) 1.16
Bacteriorhodopsin in liposomes. II. Experimental evidence in support of a theoretical model. Biochim Biophys Acta (1979) 1.16
Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells. Eur J Biochem (1992) 1.15
Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress. FEBS Lett (2000) 1.13
Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure? Atherosclerosis (2000) 1.12
Thermodynamic efficiency of microbial growth is low but optimal for maximal growth rate. Proc Natl Acad Sci U S A (1983) 1.12
The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate. Eur J Biochem (1994) 1.11
Thermodynamics of growth. Non-equilibrium thermodynamics of bacterial growth. The phenomenological and the mosaic approach. Biochim Biophys Acta (1982) 1.09
Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. II. Complex systems. Math Biosci (1989) 1.07
Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment. Br J Cancer (2004) 1.07
Yeast cells with a specific cellular make-up and an environment that removes acetaldehyde are prone to sustained glycolytic oscillations. FEBS Lett (1994) 1.06
How did glycogen structure evolve to satisfy the requirement for rapid mobilization of glucose? A problem of physical constraints in structure building. J Mol Evol (1997) 1.06
Implications of macromolecular crowding for signal transduction and metabolite channeling. Proc Natl Acad Sci U S A (1998) 1.06
Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells. Pancreas (2001) 1.05
Comparative characterization of the fermentation pathway of Saccharomyces cerevisiae using biochemical systems theory and metabolic control analysis: model definition and nomenclature. Math Biosci (1995) 1.05
Energy buffering of DNA structure fails when Escherichia coli runs out of substrate. J Bacteriol (1995) 1.04
Analysis of abnormalities in purine metabolism leading to gout and to neurological dysfunctions in man. Biochem J (1998) 1.04
Electric potentiation, cooperativity, and synergism of magainin peptides in protein-free liposomes. Biochemistry (1993) 1.02
Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. I. Unbranched pathways. Math Biosci (1989) 1.02
The Escherichia coli signal transducers PII (GlnB) and GlnK form heterotrimers in vivo: fine tuning the nitrogen signal cascade. Proc Natl Acad Sci U S A (2000) 1.02
Control analysis of glycolytic oscillations. Biophys Chem (1996) 1.01
The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts. FEBS J (2007) 1.01
Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei. Proc Natl Acad Sci U S A (1999) 1.00
Branched-chain alpha-keto acid catabolism via the gene products of the bkd operon in Enterococcus faecalis: a new, secreted metabolite serving as a temporary redox sink. J Bacteriol (2000) 1.00
Control of frequency and amplitudes is shared by all enzymes in three models for yeast glycolytic oscillations. Biochim Biophys Acta (1996) 1.00
Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans. J Bioenerg Biomembr (1995) 1.00
Mosaic protonic coupling hypothesis for free energy transduction. FEBS Lett (1984) 0.99
Physical constraints in the synthesis of glycogen that influence its structural homogeneity: a two-dimensional approach. Biophys J (1998) 0.99
Metabolic channelling and control of the flux. FEBS Lett (1993) 0.98
Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein. Mol Microbiol (1999) 0.97
Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes. Biotechnol Bioeng (1998) 0.97
Metabolic control by pump slippage and proton leakage in 'delocalized' and more localized chemiosmotic energy-coupling schemes. Biochem Soc Trans (1983) 0.96
Structure identifiability in metabolic pathways: parameter estimation in models based on the power-law formalism. Biochem J (1994) 0.95
Control by enzymes, coenzymes and conserved moieties. A generalisation of the connectivity theorem of metabolic control analysis. Eur J Biochem (1994) 0.94
Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. Mol Biochem Parasitol (2000) 0.94
Redox interactions in cytochrome c oxidase: from the "neoclassical" toward "modern" models. Biophys J (1992) 0.94
The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. Eur J Biochem (1993) 0.93
Glucose and the ATP paradox in yeast. Biochem J (2000) 0.93
Dynamic regulation of yeast glycolytic oscillations by mitochondrial functions. J Cell Sci (1991) 0.92
A critical appraisal of evidence for localized energy coupling. Kinetic studies on liposomes containing bacteriorhodopsin and ATP synthase. Biochem J (1985) 0.92
Bacteriorhodopsin in liposomes. I. A description using irreversible thermodynamics. Biochim Biophys Acta (1979) 0.92
Variation of efficiency with free-energy dissipation in models of biological energy transduction. Biophys Chem (1987) 0.92
Control of mitochondrial respiration. Biochem Soc Trans (1983) 0.91
Signal transduction in bacteria: phospho-neural network(s) in Escherichia coli? FEMS Microbiol Rev (1995) 0.91
Mosaic nonequilibrium thermodynamics describes biological energy transduction. Proc Natl Acad Sci U S A (1981) 0.91
Channelling can decrease pool size. Eur J Biochem (1992) 0.91