Published in N Engl J Med on March 02, 1995
Platform Exercise Training | NCT01239823
What is an Important Change in the Short Physical Performance Battery (SPPB)? | NCT01649193
Exercise Trial for Alzheimer's Disease (EXTRA) | NCT01311492
Reliability and Validity of the Elderly Mobility Scale, French Version | NCT03008135
Treating Frailty in Lung Transplant Candidates (PREHAB) (PREHAB) | NCT03457545
Exercise Program Among Lung Cancer Dyads (PEP-LC) | NCT03649737
Adverse events associated with testosterone administration. N Engl J Med (2010) 10.94
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc (2011) 5.96
Video capture of the circumstances of falls in elderly people residing in long-term care: an observational study. Lancet (2012) 5.20
Chronic musculoskeletal pain and the occurrence of falls in an older population. JAMA (2009) 4.18
Sarcopenia and osteopenia among 70-80-year-old home-dwelling Finnish women: prevalence and association with functional performance. Osteoporos Int (2012) 3.48
Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev (2009) 3.40
Effects of home-based diet and exercise on functional outcomes among older, overweight long-term cancer survivors: RENEW: a randomized controlled trial. JAMA (2009) 3.37
Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA (2014) 3.36
Association between lower digit symbol substitution test score and slower gait and greater risk of mortality and of developing incident disability in well-functioning older adults. J Am Geriatr Soc (2008) 3.21
Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial. JAMA (2015) 3.20
Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging And Body Composition Study. J Am Geriatr Soc (2009) 3.12
Prognostic significance of potential frailty criteria. J Am Geriatr Soc (2008) 2.69
The MOBILIZE Boston Study: design and methods of a prospective cohort study of novel risk factors for falls in an older population. BMC Geriatr (2008) 2.42
Associations of borderline and low normal ankle-brachial index values with functional decline at 5-year follow-up: the WALCS (Walking and Leg Circulation Study). J Am Coll Cardiol (2009) 2.37
Unobtrusive and ubiquitous in-home monitoring: a methodology for continuous assessment of gait velocity in elders. IEEE Trans Biomed Eng (2009) 2.30
Gait variability and the risk of incident mobility disability in community-dwelling older adults. J Gerontol A Biol Sci Med Sci (2007) 2.30
Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons. Ann Intern Med (2012) 2.27
The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci (2011) 2.26
Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review. BMC Geriatr (2011) 2.21
Physical function and self-rated health status as predictors of mortality: results from longitudinal analysis in the ilSIRENTE study. BMC Geriatr (2008) 2.08
Six-minute walk is a better outcome measure than treadmill walking tests in therapeutic trials of patients with peripheral artery disease. Circulation (2014) 2.03
Hand-grip strength cut points to screen older persons at risk for mobility limitation. J Am Geriatr Soc (2010) 2.01
Serum micronutrient concentrations and decline in physical function among older persons. JAMA (2008) 1.96
Effect of a home-based exercise program on functional recovery following rehabilitation after hip fracture: a randomized clinical trial. JAMA (2014) 1.93
Racial variation in the relationship of anemia with mortality and mobility disability among older adults. Blood (2007) 1.92
Lower extremity ischemia, calf skeletal muscle characteristics, and functional impairment in peripheral arterial disease. J Am Geriatr Soc (2007) 1.92
Mobility and aging: new directions for public health action. Am J Public Health (2012) 1.92
Subclinical hypothyroidism and functional mobility in older adults. Arch Intern Med (2009) 1.91
Midlife physical activity and mobility in older age: The InCHIANTI study. Am J Prev Med (2006) 1.91
Age-associated declines in complex walking task performance: the Walking InCHIANTI toolkit. J Am Geriatr Soc (2007) 1.86
Predictive value of the Short Physical Performance Battery following hospitalization in older patients. J Gerontol A Biol Sci Med Sci (2010) 1.85
Use of the Short Physical Performance Battery Score to predict loss of ability to walk 400 meters: analysis from the InCHIANTI study. J Gerontol A Biol Sci Med Sci (2009) 1.83
Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med (2013) 1.83
Functional outcomes for clinical trials in frail older persons: time to be moving. J Gerontol A Biol Sci Med Sci (2008) 1.83
Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol (2013) 1.82
Prognostic value of functional performance for mortality in patients with peripheral artery disease. J Am Coll Cardiol (2008) 1.82
Health outcome priorities among competing cardiovascular, fall injury, and medication-related symptom outcomes. J Am Geriatr Soc (2008) 1.79
The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle (2011) 1.77
Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women. Eur J Epidemiol (2006) 1.76
Effects of six versus three times per week hemodialysis on physical performance, health, and functioning: Frequent Hemodialysis Network (FHN) randomized trials. Clin J Am Soc Nephrol (2012) 1.75
Lifestyle interventions and independence for elders study: recruitment and baseline characteristics. J Gerontol A Biol Sci Med Sci (2013) 1.75
Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY) (2011) 1.74
Use of accelerometry to measure physical activity in older adults at risk for mobility disability. J Aging Phys Act (2008) 1.73
Characteristics associated with fear of falling and activity restriction in community-living older persons. J Am Geriatr Soc (2002) 1.72
German health interview and examination survey for adults (DEGS) - design, objectives and implementation of the first data collection wave. BMC Public Health (2012) 1.72
Outcomes of decompression surgery for lumbar spinal stenosis in elderly diabetic patients. Eur Spine J (2003) 1.72
Subtle neurological abnormalities as risk factors for cognitive and functional decline, cerebrovascular events, and mortality in older community-dwelling adults. Arch Intern Med (2008) 1.71
A novel interdisciplinary analgesic program reduces pain and improves function in older adults after orthopedic surgery. J Am Geriatr Soc (2008) 1.71
Frailty among community-dwelling elderly people in France: the three-city study. J Gerontol A Biol Sci Med Sci (2008) 1.70
Measures of frailty in population-based studies: an overview. BMC Geriatr (2013) 1.69
Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop. J Allergy Clin Immunol (2011) 1.69
Prevalence and impact of pain among older adults in the United States: findings from the 2011 National Health and Aging Trends Study. Pain (2013) 1.67
Baseline functional performance predicts the rate of mobility loss in persons with peripheral arterial disease. J Am Coll Cardiol (2007) 1.67
Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study. Ann Neurol (2011) 1.66
Performance measures predict onset of activity of daily living difficulty in community-dwelling older adults. J Am Geriatr Soc (2010) 1.64
Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study. J Clin Endocrinol Metab (2010) 1.62
Cross-country differences in the association between diabetes and disability. J Diabetes Metab Disord (2014) 1.62
Assessment of function and disability in longitudinal studies. J Am Geriatr Soc (2010) 1.61
Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking? Thorax (2011) 1.60
Activity restriction induced by fear of falling and objective and subjective measures of physical function: a prospective cohort study. J Am Geriatr Soc (2008) 1.60
Frailty and sarcopenia: definitions and outcome parameters. Osteoporos Int (2012) 1.58
Drug Burden Index and physical function in older Australian men. Br J Clin Pharmacol (2009) 1.58
COPD as a systemic disease: impact on physical functional limitations. Am J Med (2008) 1.57
Percutaneous interspinous spacer versus open decompression: a 2-year follow-up of clinical outcome and quality of life. Eur Spine J (2013) 1.56
Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries. J Natl Cancer Inst (2009) 1.56
Persistent mobility disability after neurotoxic chemotherapy. Phys Ther (2010) 1.55
Physical activity as a preventative factor for frailty: the health, aging, and body composition study. J Gerontol A Biol Sci Med Sci (2009) 1.55
Socioeconomic status, race and COPD health outcomes. J Epidemiol Community Health (2009) 1.54
Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation. Am J Respir Crit Care Med (2015) 1.53
Lower urinary tract symptoms increase the risk of falls in older men. BJU Int (2009) 1.53
The impact of chronic low back pain on older adults: a comparative study of patients and controls. Pain (2007) 1.52
The association of menopause status with physical function: the Study of Women's Health Across the Nation. Menopause (2012) 1.52
The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study. Int J Obes (Lond) (2009) 1.52
The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. BMJ (2015) 1.49
Hormone therapy and physical function change among older women in the Women's Health Initiative: a randomized controlled trial. Menopause (2010) 1.48
Lifetime occupation and physical function: a prospective cohort study on persons aged 80 years and older living in a community. Occup Environ Med (2006) 1.47
The relationship of physical performance with HIV disease and mortality. AIDS (2014) 1.46
Differences in brain structure and function in older adults with self-reported disabling and nondisabling chronic low back pain. Pain Med (2010) 1.46
Validation and comparison of two frailty indexes: The MOBILIZE Boston Study. J Am Geriatr Soc (2009) 1.46
Prevalence and significance of unrecognized lower extremity peripheral arterial disease in general medicine practice*. J Gen Intern Med (2001) 1.45
Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD. Prim Care Respir J (2012) 1.45
Circulating vascular cell adhesion molecule-1 is associated with cerebral blood flow dysregulation, mobility impairment, and falls in older adults. Hypertension (2015) 1.45
Life and living in advanced age: a cohort study in New Zealand--e Puāwaitanga o Nga Tapuwae Kia Ora Tonu, LiLACS NZ: study protocol. BMC Geriatr (2012) 1.45
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults. J Gerontol A Biol Sci Med Sci (2012) 1.44
Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro Oncol (2012) 1.44
Functional impairment in older liver transplantation candidates: From the functional assessment in liver transplantation study. Liver Transpl (2015) 1.43
Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation. J Gerontol A Biol Sci Med Sci (2011) 1.43
Lower extremity muscle mass predicts functional performance in mobility-limited elders. J Nutr Health Aging (2008) 1.43
Aerobic exercise and vascular cognitive impairment: A randomized controlled trial. Neurology (2016) 1.42
Lateral balance factors predict future falls in community-living older adults. Arch Phys Med Rehabil (2008) 1.41
Correlates of 1-year incidence of urinary incontinence in older Latino adults enrolled in a community-based physical activity trial. J Am Geriatr Soc (2014) 1.41
Linking C-reactive protein to late-life disability in the National Health and Nutrition Examination Survey (NHANES) 1999-2002. J Gerontol A Biol Sci Med Sci (2006) 1.40
Risk factors for falls in older disabled women with diabetes: the women's health and aging study. J Gerontol A Biol Sci Med Sci (2005) 1.40
Properties of the 'timed up and go' test: more than meets the eye. Gerontology (2010) 1.40
Factors that modify the association between knee pain and mobility limitation in older women: the Women's Health and Aging Study. Ann Rheum Dis (2000) 1.39
A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev (2007) 1.39
Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study. J Transl Med (2016) 1.38
Evaluating Physical Outcomes in Acute Respiratory Distress Syndrome Survivors: Validity, Responsiveness, and Minimal Important Difference of 4-Meter Gait Speed Test. Crit Care Med (2016) 1.37
Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia. J Cachexia Sarcopenia Muscle (2012) 1.37
A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol (1994) 30.72
Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci (2000) 15.54
Hybridization of synthetic oligodeoxyribonucleotides to phi chi 174 DNA: the effect of single base pair mismatch. Nucleic Acids Res (1979) 14.12
Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology (2007) 12.42
The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA. Nucleic Acids Res (1981) 9.56
Simultaneous analysis of multiple polymorphic loci using amplified sequence polymorphisms (ASPs). Genomics (1988) 8.29
Calcium-channel blockade and incidence of cancer in aged populations. Lancet (1996) 8.04
Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA (2008) 7.84
Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides. Proc Natl Acad Sci U S A (1983) 7.52
Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. Proc Natl Acad Sci U S A (1981) 7.24
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med (1999) 6.92
Directed deletion of a yeast transfer RNA intervening sequence. Science (1980) 6.67
Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep (1995) 6.42
Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol (1994) 6.08
Allele-specific enzymatic amplification of beta-globin genomic DNA for diagnosis of sickle cell anemia. Proc Natl Acad Sci U S A (1989) 5.30
The rat serum albumin gene: analysis of cloned sequences. Proc Natl Acad Sci U S A (1979) 5.17
A set of synthetic oligodeoxyribonucleotide primers for DNA sequencing in the plasmid vector pBR322. Gene (1981) 5.06
A revised CES-D measure of depressive symptoms and a DSM-based measure of major depressive episodes in the elderly. Int Psychogeriatr (1999) 5.05
Measures of cognitive functioning in the AHEAD Study. J Gerontol B Psychol Sci Soc Sci (1997) 4.97
Do calcium channel blockers increase the risk of cancer? Am J Hypertens (1996) 4.75
National estimates of the quantity and cost of informal caregiving for the elderly with dementia. J Gen Intern Med (2001) 4.69
Synthesis and use of synthetic oligonucleotides. Annu Rev Biochem (1984) 4.53
alpha 1-antitrypsin deficiency detection by direct analysis of the mutation in the gene. Nature (1983) 4.38
Chronically depressed mood and cancer risk in older persons. J Natl Cancer Inst (1998) 4.27
Asset and Health Dynamics Among the Oldest Old: an overview of the AHEAD Study. J Gerontol B Psychol Sci Soc Sci (1997) 4.15
Depressive symptoms and physical decline in community-dwelling older persons. JAMA (1998) 4.05
Measuring higher level physical function in well-functioning older adults: expanding familiar approaches in the Health ABC study. J Gerontol A Biol Sci Med Sci (2001) 4.01
Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology (2003) 3.99
Oligonucleotide directed mutagenesis of the human beta-globin gene: a general method for producing specific point mutations in cloned DNA. Nucleic Acids Res (1981) 3.87
Maintaining mobility in late life. I. Demographic characteristics and chronic conditions. Am J Epidemiol (1993) 3.74
Predictors of functional recovery one year following hospital discharge for hip fracture: a prospective study. J Gerontol (1990) 3.65
Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor. Nature (1985) 3.59
Complete repair of transposition of the great arteries with pulmonary stenosis. A review and report of a case corrected by using a new surgical technique. Circulation (1969) 3.58
Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program Follow-up Study. Circulation (1987) 3.49
Established populations for epidemiologic studies of the elderly: study design and methodology. Aging (Milano) (1993) 3.47
Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci (2000) 3.45
Exploring the effect of depression on physical disability: longitudinal evidence from the established populations for epidemiologic studies of the elderly. Am J Public Health (1999) 3.17
Maintaining mobility in late life. II. Smoking, alcohol consumption, physical activity, and body mass index. Am J Epidemiol (1993) 3.05
Dissociation kinetics of 19 base paired oligonucleotide-DNA duplexes containing different single mismatched base pairs. Nucleic Acids Res (1987) 3.05
Disability as a public health outcome in the aging population. Annu Rev Public Health (1996) 3.02
Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB. Neurology (2010) 2.92
Smoking and mortality among older men and women in three communities. N Engl J Med (1991) 2.86
Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization. J Gerontol A Biol Sci Med Sci (2000) 2.81
Prenatal diagnosis of beta-thalassemia. Detection of a single nucleotide mutation in DNA. N Engl J Med (1983) 2.78
Anglo-American contrasts in general practice. Br Med J (1976) 2.76
Specificity of the nick-closing activity of bacteriophage T4 DNA ligase. Gene (1989) 2.73
Serum albumin level and physical disability as predictors of mortality in older persons. JAMA (1994) 2.66
Oligonucleotide probes for the screening of recombinant DNA libraries. Methods Enzymol (1987) 2.58
Estrogen use and all-cause mortality. Preliminary results from the Lipid Research Clinics Program Follow-Up Study. JAMA (1983) 2.57
Prevalence of antibody to HIV-1 among entrants to US correctional facilities. JAMA (1991) 2.51
Low cholesterol concentrations and severe depressive symptoms in elderly people. BMJ (1994) 2.51
Variations in the reporting of menstrual histories. Am J Epidemiol (1979) 2.48
Survival experience of aged hip fracture patients. Am J Public Health (1989) 2.46
Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition. Hypertension (2001) 2.46
HDL cholesterol predicts coronary heart disease mortality in older persons. JAMA (1995) 2.46
Diet and risk of non-Hodgkin lymphoma in older women. JAMA (1996) 2.46
Persistent, consistent, widespread, and robust? Another look at recent trends in old-age disability. J Gerontol B Psychol Sci Soc Sci (2001) 2.45
Patient-proxy response comparability on measures of patient health and functional status. J Clin Epidemiol (1988) 2.42
The impact of insomnia on cognitive functioning in older adults. J Am Geriatr Soc (2001) 2.36
Health status of older male prisoners: a comprehensive survey. Am J Public Health (1992) 2.34
Hand-grip strength predicts incident disability in non-disabled older men. Age Ageing (1999) 2.34
Cognitive impairment and risk of stroke in the older population. J Am Geriatr Soc (1996) 2.32
Incidence and remission of insomnia among elderly adults: an epidemiologic study of 6,800 persons over three years. Sleep (1999) 2.32
Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation (2001) 2.29
Is self-rated health comparable across cultures and genders? J Gerontol B Psychol Sci Soc Sci (1998) 2.28
Risk factors for falling in home-dwelling older women with stroke: the Women's Health and Aging Study. Stroke (2003) 2.28
Changes in driving patterns and worsening depressive symptoms among older adults. J Gerontol B Psychol Sci Soc Sci (2001) 2.24
Urinary incontinence in elderly women: findings from the Health, Aging, and Body Composition Study. Obstet Gynecol (2004) 2.24
Biotin-labeled oligonucleotides: enzymatic synthesis and use as hybridization probes. DNA (1984) 2.23
Transfusion-associated graft-versus-host disease in immunocompetent patients: report of a fatal case associated with transfusion of blood from a second-degree relative, and a survey of predisposing factors. Transfusion (1993) 2.22
Predictors of maintaining cognitive function in older adults: the Health ABC study. Neurology (2009) 2.21
Tissue-culture assay of antibodies to heat-liable Escherichia coli enterotoxins. N Engl J Med (1974) 2.20
Isolation of a cDNA clone for the murine transplantation antigen H-2Kb. Proc Natl Acad Sci U S A (1982) 2.20
The ligation amplification reaction (LAR)--amplification of specific DNA sequences using sequential rounds of template-dependent ligation. Genomics (1989) 2.19
Morbidity and disability in older persons in the years prior to death. Am J Public Health (1991) 2.13
The renal effects of nonsteroidal anti-inflammatory drugs in older people: findings from the Established Populations for Epidemiologic Studies of the Elderly. J Am Geriatr Soc (1999) 2.12
Self-reported adverse drug reactions and related resource use. A study of community-dwelling persons 65 years of age and older. Ann Intern Med (1992) 2.12
Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging (Milano) (2000) 2.09
Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax (2005) 2.08
Symptoms of depression among community-dwelling elderly African-American and white older adults. Psychol Med (1998) 2.01
Disability, physical activity, and muscle strength in older women: the Women's Health and Aging Study. Arch Phys Med Rehabil (1999) 1.99
Meta-analysis of genome-wide association studies for personality. Mol Psychiatry (2010) 1.96
Foot pain and disability in older persons: an epidemiologic survey. J Am Geriatr Soc (1995) 1.95
Progressive versus catastrophic disability: a longitudinal view of the disablement process. J Gerontol A Biol Sci Med Sci (1996) 1.95
Epidemiology of disability in the oldest old: methodologic issues and preliminary findings. Milbank Mem Fund Q Health Soc (1985) 1.94
Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A (1983) 1.92
A model of lifetime osteoporosis impact. Arch Intern Med (1991) 1.91