Published in J Cell Sci on September 01, 1994
The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim Biophys Acta (2010) 3.33
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13
Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities. Sci Signal (2008) 2.97
Progress in matrix metalloproteinase research. Mol Aspects Med (2008) 2.51
Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis. J Clin Invest (1998) 2.02
In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1. J Clin Invest (1998) 1.95
The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter. Oncogene (2000) 1.77
Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases. J Clin Invest (1997) 1.67
Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states. Am J Pathol (1998) 1.60
Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. J Clin Invest (1997) 1.49
Human trophoblast function during the implantation process. Reprod Biol Endocrinol (2005) 1.34
Expression of matrix metalloproteinases and their inhibitors in human brain tumors. Clin Exp Metastasis (1999) 1.29
The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis. Breast Cancer Res (2006) 1.25
Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal. J Neurosci (2005) 1.25
Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice. Am J Respir Cell Mol Biol (2005) 1.17
Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer. Br J Cancer (2006) 1.16
Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis. Am J Pathol (2005) 1.14
Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros. J Clin Invest (1999) 1.14
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP. Biochem J (2003) 1.13
Tissue inhibitor of metalloproteinases-3 is a component of Bruch's membrane of the eye. Am J Pathol (1997) 1.10
Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes. Am J Pathol (1997) 1.10
Tissue inhibitor of metalloproteinases-1 signalling pathway leading to erythroid cell survival. Biochem J (2003) 1.07
Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas. Br J Cancer (2001) 1.03
Regulation of TIMP-2, MT1-MMP, and MMP-2 expression during C2C12 differentiation. Muscle Nerve (2005) 1.00
Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo. PLoS One (2010) 0.99
Matrix metalloproteinase biology applied to vitreoretinal disorders. Br J Ophthalmol (2000) 0.98
Gefitinib ('Iressa', ZD1839) inhibits the growth response of bladder tumour cell lines to epidermal growth factor and induces TIMP2. Br J Cancer (2004) 0.96
Activation of gelatinase-tissue-inhibitors-of-metalloproteinase complexes by matrilysin. Biochem J (1998) 0.96
Tissue inhibitor of metalloproteinases-2 is expressed in the interstitial matrix in adult mouse organs and during embryonic development. Mol Biol Cell (1997) 0.96
Up-regulation of MMP-8 and MMP-9 activity in the BALB/c mouse spinal cord correlates with the severity of experimental autoimmune encephalomyelitis. Clin Exp Immunol (2002) 0.94
Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase. Br J Cancer (2004) 0.93
Blood flow interplays with elastin: collagen and MMP: TIMP ratios to maintain healthy vascular structure and function. Vasc Health Risk Manag (2010) 0.93
Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression is regulated by multiple neural differentiation signals. J Neurochem (2006) 0.91
The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer. Thorax (1999) 0.90
The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor. J Biol Chem (2010) 0.89
Proteinase inhibitors reduce basement membrane degradation by human breast cancer cell lines. Br J Cancer (1997) 0.88
Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics. Arthritis Res (2002) 0.87
Regulation of collagen turnover in human skin fibroblasts exposed to a gadolinium-based contrast agent. Invest Radiol (2009) 0.86
siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type I. J Invest Dermatol (2013) 0.85
An immunohistochemical study of TIMP-3 expression in oesophageal squamous cell carcinoma. Br J Cancer (2004) 0.85
Tissue inhibitor of metalloproteinase-1 promotes NIH3T3 fibroblast proliferation by activating p-Akt and cell cycle progression. Mol Cells (2011) 0.84
Collagenolytic activity is suppressed in organ-cultured human skin exposed to a gadolinium-based MRI contrast agent. Invest Radiol (2010) 0.84
The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos. Dev Genes Evol (2003) 0.83
Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells. BMC Cancer (2010) 0.82
Role of tissue inhibitor of metalloproteinases-1 in the development of autoimmune lymphoproliferation. Haematologica (2010) 0.82
Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats. Dev Neurobiol (2010) 0.81
Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin. Target Oncol (2013) 0.80
Ovarian expression, localization, and function of tissue inhibitor of metalloproteinase 3 (TIMP3) during the periovulatory period of the human menstrual cycle. Biol Reprod (2013) 0.80
Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses. Hypertens Res (2012) 0.80
DNA ploidy analysis and expression of MMP-9, TIMP-2, and E-cadherin in gastric carcinoma. World J Gastroenterol (2005) 0.80
Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2). Matrix Biol (2011) 0.79
TIMPs: versatile extracellular regulators in cancer. Nat Rev Cancer (2016) 0.79
Relationships between serum HER2 ECD, TIMP-1 and clinical outcomes in Taiwanese breast cancer. World J Surg Oncol (2012) 0.79
Immunolocalization of matrix metalloproteinases and their inhibitors in clinical specimens of bone metastasis from breast carcinoma. Clin Exp Metastasis (2000) 0.78
Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells. Oncotarget (2015) 0.78
TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis. PLoS One (2015) 0.78
Fetal hypoxia and programming of matrix metalloproteinases. Drug Discov Today (2011) 0.77
Expression of tissue inhibitors of metalloproteinases (TIMPs) in hepatocellular carcinoma. Korean J Intern Med (2000) 0.77
Temporal and spatial expression of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and -2) in the bovine corpus luteum. Reprod Biol Endocrinol (2003) 0.76
Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells. Biochem J (2001) 0.76
Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro. BMC Physiol (2012) 0.76
Increase of MT1-MMP, TIMP-2 and Ki-67 proteins in the odontogenic region of the rat incisor post-shortening procedure. J Mol Histol (2010) 0.75
Association of TIMP-2-418G/C and TIMP-2-303G/A with gastric cancer: a meta-analysis. Onco Targets Ther (2016) 0.75
Mitral tissue inhibitor of metalloproteinase 2 is associated with mitral valve surgery outcome. PLoS One (2014) 0.75
An Evaluation of the Stemness, Paracrine, and Tumorigenic Characteristics of Highly Expanded, Minimally Passaged Adipose-Derived Stem Cells. PLoS One (2016) 0.75
No correlation between TIMP2 -418 G>C polymorphism and increased risk of cancer: evidence from a meta-analysis. PLoS One (2014) 0.75
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature (1994) 9.31
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science (1992) 6.40
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. EMBO J (1993) 3.03
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J (1991) 2.86
Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells (1997) 2.72
A short timescale for terrestrial planet formation from Hf-W chronometry of meteorites. Nature (2002) 2.54
Improved results of atherosclerotic arch aneurysm operations with a refined technique. J Thorac Cardiovasc Surg (2001) 2.53
Lung nodule enhancement at CT: multicenter study. Radiology (2000) 2.32
Structural studies of two ovalbumin glycopeptides in relation to the endo-beta-N-acetylglucosaminidase specificity. J Biol Chem (1975) 2.23
The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem (1995) 2.22
Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum. FEBS Lett (1992) 2.21
Purification and characterization of normal and mutant forms of T4 endonuclease V. J Biol Chem (1982) 2.14
In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins. Antimicrob Agents Chemother (1991) 2.08
Surveillance of viral gastroenteritis in Japan: pediatric cases and outbreak incidents. J Infect Dis (2000) 2.04
Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. J Biol Chem (1995) 2.01
A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts. J Biol Chem (1989) 1.92
Chemotherapeutic efficacy of a newly synthesized benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex infection induced in mice. Antimicrob Agents Chemother (1992) 1.89
The substrate specificities of endo-beta-N-acetylglucosaminidases CII and H. Biochem Biophys Res Commun (1977) 1.87
Laparoscopic repair of a paraduodenal hernia. Surg Endosc (1998) 1.84
Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. J Biol Chem (1992) 1.82
Total arch replacement using aortic arch branched grafts with the aid of antegrade selective cerebral perfusion. Ann Thorac Surg (2000) 1.82
A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: induction and maintenance therapy. Am J Transplant (2009) 1.81
Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives. Chem Pharm Bull (Tokyo) (1993) 1.80
New electrophysiologic features and catheter ablation of atrioventricular and atriofascicular accessory pathways: evidence of decremental conduction and the anatomic structure of the Mahaim pathway. J Cardiovasc Electrophysiol (1998) 1.72
Role of biologic glue repair of proximal aortic dissection in the development of early and midterm redissection of the aortic root. Ann Thorac Surg (2001) 1.70
Characteristics of polarographic catalytic waves observed with bovine-serum albumin: kinetic or diffusion control. Proc Natl Acad Sci U S A (1973) 1.65
Analysis of oligosaccharides by gel filtration. Methods Enzymol (1982) 1.64
A new liquid material for embolization of arteriovenous malformations. AJNR Am J Neuroradiol (1990) 1.64
Nasal reconstruction based on aesthetic subunits in Orientals. Plast Reconstr Surg (2000) 1.60
TIMP-2 promotes activation of progelatinase A by membrane-type 1 matrix metalloproteinase immobilized on agarose beads. J Biol Chem (1998) 1.59
Life-threatening hyperkalaemia caused by angiotensin-converting enzyme-inhibitor and diuretics. Diabet Med (1997) 1.58
p53, but not c-Ki-ras, mutation and down-regulation of p21WAF1/CIP1 and cyclin D1 are associated with malignant transformation in gastric hyperplastic polyps. Am J Clin Pathol (2001) 1.58
Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties. J Biol Chem (1995) 1.54
Sclerotherapy plus ligation versus ligation for the treatment of esophageal varices: a prospective randomized study. Gastrointest Endosc (1999) 1.53
A case of cluster headache associated with mitochondrial DNA deletions. Muscle Nerve (1997) 1.53
The prognosis of surgery for cervical compression myelopathy. An analysis of the factors involved. J Bone Joint Surg Br (1989) 1.53
Myelopathy hand. New clinical signs of cervical cord damage. J Bone Joint Surg Br (1987) 1.53
Lung nodules: dual-kilovolt peak analysis with CT--multicenter study. Radiology (2000) 1.49
The structures of the galactose-containing sugar chains of ovalbumin. J Biol Chem (1978) 1.47
Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2. Cancer Res (1996) 1.45
Gender effects on age-related changes in brain structure. AJNR Am J Neuroradiol (2000) 1.44
Pathogenesis of retinoic acid-induced abnormal pad patterns on mouse volar skin. Teratology (2000) 1.43
Evaluation of diffusivity in the anterior lobe of the pituitary gland: 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation. AJNR Am J Neuroradiol (2013) 1.43
GC/MS analysis of urinary excretion of 9alpha,11beta-PGF2 in acute and exercise-induced asthma in children. Clin Exp Allergy (1998) 1.42
Experimental study on the effect of antegrade cerebral perfusion on brains with old cerebral infarction. J Thorac Cardiovasc Surg (2001) 1.41
Activated protein C resistance and Japanese NIDDM patients with coronary heart disease. Diabetes Care (1997) 1.40
Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion. J Cell Sci (1993) 1.36
Induction and stimulation of 92-kDa gelatinase/type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor alpha. Biochem Biophys Res Commun (1990) 1.36
Characteristics of polarographic catalytic waves observed with bovine-serum albumin: effects of type of buffers, pH, ionic strength, calcium, and tetraalkyl salts. Proc Natl Acad Sci U S A (1974) 1.36
Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1. Biochem Biophys Res Commun (1991) 1.32
Cerebellar hemorrhage after supratentorial craniotomy--report of three cases. Neurol Med Chir (Tokyo) (1990) 1.31
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res (1997) 1.31
Prognostic significance of intramural metastasis in patients with esophageal carcinoma. Cancer (1990) 1.31
Thoracic myelopathy secondary to ossification of the spinal ligament. J Neurosurg (1987) 1.29
Structure of the carbohydrate moieties of bovine rhodopsin. J Biol Chem (1979) 1.29
Fractionation of L-fucose-containing oligosaccharides on immobilized Aleuria aurantia lectin. J Biol Chem (1985) 1.26
Structures of the carbohydrate moiety of ovalbumin glycopeptide III and the difference in specificity of endo-beta-N-acetylglucosaminidases CII and H. J Biol Chem (1977) 1.25
Cell cycle regulation of the p34cdc2/p33cdk2-activating kinase p40MO15. J Cell Sci (1994) 1.25
Causes of neurologic deterioration following surgical treatment of cervical myelopathy. Spine (Phila Pa 1976) (1986) 1.24
MDM2 and MDMX bind and stabilize the p53-related protein p73. Curr Biol (1999) 1.24
Perfusion imaging of brain tumors using arterial spin-labeling: correlation with histopathologic vascular density. AJNR Am J Neuroradiol (2008) 1.24
Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2). Biochem Biophys Res Commun (1990) 1.23
Structural study of the carbohydrate moiety of bovine pancreatic ribonuclease B. J Biochem (1980) 1.23
IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line. Immunology (1991) 1.23
Endometrial cysts: diagnosis with MR imaging. Radiology (1991) 1.22
The asparagine-linked sugar chains of subcomponent C1q of the first component of human complement. J Biol Chem (1978) 1.22
Elevation of cyclic guanosine 3',5'-monophosphate levels in dog thyroid slices caused by acetylcholine and sodium fluoride. J Biol Chem (1972) 1.22
Comparative study of the oligosaccharides released from baby hamster kidney cells and their polyoma transformant by hydrazinolysis. J Biol Chem (1984) 1.21
Laparoscopic repair of a diaphragmatic hernia through the foramen of morgagni. Surg Endosc (1997) 1.20
Effect of diltiazem on electrical and mechanical activity of isolated cardiac ventricular muscle of guinea pig. Jpn J Pharmacol (1975) 1.19
Enzymatic basis for the structural changes of asparagine-linked sugar chains of membrane glycoproteins of baby hamster kidney cells induced by polyoma transformation. J Biol Chem (1985) 1.19
Urinary oligosaccharides of mannosidosis. J Biol Chem (1980) 1.18
Efficacy and safety of preoperative percutaneous transhepatic portal embolization with absolute ethanol: a clinical study. Surgery (1997) 1.18
Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. J Exp Med (2000) 1.17
Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells. J Clin Invest (1990) 1.16
Kinetics in parasite abundance in susceptible and resistant mice infected with an avirulent strain of Toxoplasma gondii by using quantitative competitive PCR. J Parasitol (1997) 1.16
A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies. Clin Chim Acta (1993) 1.16
Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer. Ann Oncol (2004) 1.15
Prospective clinical study of endoscopic ultrasound-guided choledochoduodenostomy with direct metallic stent placement using a forward-viewing echoendoscope. Endoscopy (2013) 1.15
Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting. Am J Cardiol (1989) 1.14
Changes of relaxation times (T1, T2) and apparent diffusion coefficient after permanent middle cerebral artery occlusion in the rat: temporal evolution, regional extent, and comparison with histology. Magn Reson Med (1995) 1.13
Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys. Arzneimittelforschung (1997) 1.13
Vascular endothelial growth factor is induced by long-term high glucose concentration and up-regulated by acute glucose deprivation in cultured bovine retinal pigmented epithelial cells. Biochem Biophys Res Commun (1996) 1.13
Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. J Neurochem (1984) 1.12
Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm. Mol Biol Cell (1992) 1.12
p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. Biochem Biophys Res Commun (2000) 1.11
Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases. Eur J Biochem (1998) 1.11
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas. Cancer Res (1999) 1.11
Manipulation of selective cell adhesion and growth by surface charges of electrically polarized hydroxyapatite. J Biomed Mater Res (2001) 1.10
Type II alveolar epithelial cells in lung express receptor for advanced glycation end products (RAGE) gene. Biochem Biophys Res Commun (1997) 1.10
MDM2 and MDMX can interact differently with ARF and members of the p53 family. FEBS Lett (2001) 1.10
Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease. AJNR Am J Neuroradiol (2009) 1.09
Extended total arch replacement for acute type a aortic dissection: experience with seventy patients. J Thorac Cardiovasc Surg (2000) 1.09
Carbohydrate binding properties of complex-type oligosaccharides on immobilized Datura stramonium lectin. J Biol Chem (1987) 1.09
Myelopathy hand characterized by muscle wasting. A different type of myelopathy hand in patients with cervical spondylosis. Spine (Phila Pa 1976) (1988) 1.09
Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy. Life Sci (1999) 1.08
Structures of the asparagine-linked sugar chains of human chorionic gonadotropin. J Biochem (1979) 1.07