Published in Biochemistry on February 07, 1995
Role of Y94 in proton and hydride transfers catalyzed by thymidylate synthase. Biochemistry (2007) 1.26
Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. Protein Sci (2001) 1.21
Temperature dependence of the kinetic isotope effects in thymidylate synthase. A theoretical study. J Am Chem Soc (2011) 1.21
QM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthase. Biochemistry (2013) 0.95
The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195. Biochemistry (2008) 0.92
Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc (2013) 0.89
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J Med Chem (2015) 0.82
Significance of mutations on the structural perturbation of thymidylate synthase: implications for their involvement in subunit exchange. Protein Sci (2007) 0.81
Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu. Protein Sci (1997) 0.80
Backbone and ILV methyl resonance assignments of E. coli thymidylate synthase bound to cofactor and a nucleotide analogue. Biomol NMR Assign (2013) 0.78
Chemical shift imprint of intersubunit communication in a symmetric homodimer. Proc Natl Acad Sci U S A (2016) 0.78
Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: calorimetric and crystallographic analysis of the K48Q mutant. Int J Biochem Cell Biol (2008) 0.77
Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity. J Am Chem Soc (2015) 0.77
Widespread Perturbation of Function, Structure, and Dynamics by a Conservative Single-Atom Substitution in Thymidylate Synthase. Biochemistry (2016) 0.77
HPV16-E7 expression causes fluorodeoxyuridine-mediated radiosensitization in SW620 human colon cancer cells. Neoplasia (1999) 0.75
Preserved hydride transfer mechanism in evolutionarily divergent thymidylate synthases. Curr Top Biochem Res (2016) 0.75
Structural conservation among three homologous introns of bacteriophage T4 and the group I introns of eukaryotes. Proc Natl Acad Sci U S A (1988) 2.45
Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product. Proc Natl Acad Sci U S A (1983) 2.43
Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level. Cell (1985) 1.68
Regulation of p53 expression by thymidylate synthase. Proc Natl Acad Sci U S A (1999) 1.37
Genetic delineation of functional components of the group I intron in the phage T4 td gene. Cold Spring Harb Symp Quant Biol (1987) 1.31
Characterization of the restriction site of a prokaryotic intron-encoded endonuclease. Proc Natl Acad Sci U S A (1990) 1.17
Genetic system for analyzing Escherichia coli thymidylate synthase. J Bacteriol (1984) 1.14
Processing of phage T4 td-encoded RNA is analogous to the eukaryotic group I splicing pathway. Proc Natl Acad Sci U S A (1986) 1.09
Two domains for splicing in the intron of the phage T4 thymidylate synthase (td) gene established by nondirected mutagenesis. Cell (1987) 0.98
Variable occurrence of the nrdB intron in the T-even phages suggests intron mobility. Science (1987) 0.97
RNA splicing and in vivo expression of the intron-containing td gene of bacteriophage T4. Gene (1986) 0.89
Purification and substrate specificity of a T4 phage intron-encoded endonuclease. Nucleic Acids Res (1991) 0.88
Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu. Protein Sci (1997) 0.80
Catalytically active cross-species heterodimers of thymidylate synthase. Biochemistry (1993) 0.77
Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase. Biochemistry (1998) 0.75