Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 7875526)

Published in Gen Pharmacol on October 01, 1994

Authors

F E Parkinson1, K A Rudolphi, B B Fredholm

Author Affiliations

1: Department of Pharmacology and Therapeutics, Faculty of Medicine University of Manitoba, Winnipeg, Canada.

Articles by these authors

(truncated to the top 100)

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A (2001) 2.73

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol (1998) 2.43

Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci (1997) 2.23

How does adenosine inhibit transmitter release? Trends Pharmacol Sci (1988) 2.20

A modification of a protein-binding method for rapid quantification of cAMP in cell-culture supernatants and body fluid. Anal Biochem (1990) 2.11

Effects of adenosine on adrenergic neurotransmission; prejunctional inhibition and postjunctional enhancement. Naunyn Schmiedebergs Arch Pharmacol (1976) 2.09

The birth and postnatal development of purinergic signalling. Acta Physiol (Oxf) (2010) 2.06

Modulation of neurotransmission by purine nucleotides and nucleosides. Biochem Pharmacol (1980) 1.81

Distribution, biochemistry and function of striatal adenosine A2A receptors. Prog Neurobiol (1999) 1.76

Diabetes-induced hyperfiltration in adenosine A(1)-receptor deficient mice lacking the tubuloglomerular feedback mechanism. Acta Physiol (Oxf) (2007) 1.71

Xanthine derivatives as adenosine receptor antagonists. Eur J Pharmacol (1982) 1.62

On the mechanism of relaxation of tracheal muscle by theophylline and other cyclic nucleotide phosphodiesterase inhibitors. Acta Pharmacol Toxicol (Copenh) (1979) 1.58

Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors. Acta Physiol (Oxf) (2013) 1.42

Adenosine and brain ischemia. Cerebrovasc Brain Metab Rev (1992) 1.40

Inhibition of sodium-linked glucose reabsorption normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A₁-receptor deficient mice. Acta Physiol (Oxf) (2013) 1.40

Adenosine-dopamine interactions in the brain. Neuroscience (1992) 1.39

Adenosine signaling and function in glial cells. Cell Death Differ (2009) 1.39

The release of adenosine and inosine from canine subcutaneous adipose tissue by nerve stimulation and noradrenaline. J Physiol (1981) 1.39

Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes. Proc Natl Acad Sci U S A (1991) 1.39

Neuroprotective role of adenosine in cerebral ischaemia. Trends Pharmacol Sci (1992) 1.38

Adenosine receptors. Med Biol (1982) 1.37

Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol (1999) 1.35

Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre. Neurosci Lett (1982) 1.34

Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors. Proc Natl Acad Sci U S A (2000) 1.30

Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons. Neuroscience (1998) 1.29

Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neurosci Lett (1985) 1.29

Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2. Mol Pharmacol (2000) 1.29

Neuropeptide Y receptor in pig spleen: binding characteristics, reduction of cyclic AMP formation and calcium antagonist inhibition of vasoconstriction. Eur J Pharmacol (1988) 1.28

Adenosine A(2A) receptors are colocalized with and activate g(olf) in rat striatum. Mol Pharmacol (2000) 1.27

Extracellular levels of adenosine and its metabolites in the striatum of awake rats: inhibition of uptake and metabolism. Acta Physiol Scand (1991) 1.27

Effect of theophylline and other drugs on rabbit renal cyclic nucleotide phosphodiesterase, 5'-nucleotidase and adenosine deaminase. Biochem Pharmacol (1978) 1.27

Adenosine receptor ligands: differences with acute versus chronic treatment. Trends Pharmacol Sci (1996) 1.25

Isomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin. Biochim Biophys Acta (1976) 1.25

Pharmacology of adenosine A2A receptors. Trends Pharmacol Sci (1996) 1.23

Inhibitory effect of adenosine on adrenergic neuroeffector transmission in the rabbit heart. Acta Physiol Scand (1979) 1.23

ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line. J Biol Chem (1992) 1.23

Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion. Neurochem Int (1993) 1.21

Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors? Pediatr Res (1984) 1.21

Adenosine A1 receptors inhibit adenylate cyclase activity and neurotransmitter release and hyperpolarize pyramidal neurons in rat hippocampus. J Pharmacol Exp Ther (1989) 1.20

Antagonistic effects of theophylline and adenosine on adrenergic neuroeffector transmission in the rabbit kidney. Circ Res (1978) 1.19

Adenosine receptors mediating cyclic AMP production in the rat hippocampus. J Neurochem (1982) 1.19

Caffeine--an atypical drug of dependence. Drug Alcohol Depend (1998) 1.19

On the mechanism of action of theophylline and caffeine. Acta Med Scand (1985) 1.18

Evidence for functionally important adenosine A2a receptors in the rat hippocampus. Brain Res (1994) 1.17

A novel 8-phenyl-substituted xanthine derivative is a selective antagonist at adenosine A1-receptors in vivo. Acta Physiol Scand (1985) 1.16

Neuropeptide Y is a potent inhibitor of cyclic AMP accumulation in feline cerebral blood vessels. Acta Physiol Scand (1985) 1.15

Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience (1997) 1.14

Localization of adenosine receptor messenger RNAs in the rat eye. Exp Eye Res (1997) 1.13

Distribution of adenosine receptors in the postmortem human brain: an extended autoradiographic study. Synapse (1997) 1.09

Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience (2002) 1.09

Adenosine receptors mediating inhibitory electrophysiological responses in rat hippocampus are different from receptors mediating cyclic AMP accumulation. Naunyn Schmiedebergs Arch Pharmacol (1984) 1.08

Adenosine actions and adenosine receptors after 1 week treatment with caffeine. Acta Physiol Scand (1982) 1.07

Reciprocal interactions between adenosine A2A and dopamine D2 receptors in Chinese hamster ovary cells co-transfected with the two receptors. Biochem Pharmacol (1999) 1.07

Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices. Neurochem Int (1995) 1.06

Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors. Acta Physiol (Oxf) (2007) 1.05

Stimulation of adenosine A1 receptors and bradykinin receptors, which act via different G proteins, synergistically raises inositol 1,4,5-trisphosphate and intracellular free calcium in DDT1 MF-2 smooth muscle cells. Proc Natl Acad Sci U S A (1992) 1.05

Theophylline actions on adenosine receptors. Eur J Respir Dis Suppl (1980) 1.05

Adenosine, adenosine A 2A antagonists, and Parkinson's disease. Parkinsonism Relat Disord (2009) 1.04

Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage. Acta Physiol Scand (1985) 1.02

Characterization of adenosine receptors in isolated cerebral arteries of cat. Br J Pharmacol (1983) 1.02

Cyclic AMP independent inhibition by papaverine of histamine release induced by compound 48/80. Biochem Pharmacol (1976) 1.02

Alkylxanthines elevate hippocampal excitability. Evidence for a role of endogenous adenosine. Naunyn Schmiedebergs Arch Pharmacol (1981) 1.02

The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions. J Neurosci (1999) 1.02

Characterization of adenosine A1 receptors in intact DDT1 MF-2 smooth muscle cells. Mol Pharmacol (1990) 1.02

Cardiovascular effects of adenosine. Clin Physiol (1986) 1.01

Release of endogenous and radioactive purines from the rabbit retina. Brain Res (1986) 1.00

A1 and A2A adenosine receptors and A1 mRNA in mouse brain: effect of long-term caffeine treatment. Brain Res (1997) 1.00

Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors. Naunyn Schmiedebergs Arch Pharmacol (1996) 1.00

Activation of dopamine D2 receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms. Neuroscience (1999) 1.00

Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration. J Neurosci (1995) 0.99

Effects of adenosine A1 and A2 receptor activation on electrically evoked dopamine and acetylcholine release from rat striatal slices. J Pharmacol Exp Ther (1993) 0.99

Effect of long term caffeine treatment on A1 and A2 adenosine receptor binding and on mRNA levels in rat brain. Naunyn Schmiedebergs Arch Pharmacol (1993) 0.99

Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. Kidney Int (2006) 0.98

Long-term caffeine treatment leads to a decreased susceptibility to NMDA-induced clonic seizures in mice without changes in adenosine A1 receptor number. Brain Res (1993) 0.98

Adenosine and neuropeptide Y enhance alpha 1-adrenoceptor-induced accumulation of inositol phosphates and attenuate forskolin-induced accumulation of cyclic AMP in rat vas deferens. Neurosci Lett (1987) 0.98

Levels of adenosine and adenine nucleotides in slices of rat hippocampus. Brain Res (1984) 0.98

Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A3 receptors. Neuroscience (2002) 0.97

Release of nucleosides and nucleotides from the rabbit heart by sympathetic nerve stimulation. Acta Physiol Scand (1982) 0.97

Dopamine-adenosine interactions in the striatum and the globus pallidus: inhibition of striatopallidal neurons through either D2 or A2A receptors enhances D1 receptor-mediated effects on c-fos expression. J Neurosci (1997) 0.97

Local regulation of lipolysis in adipose tissue by fatty acids, prostaglandins and adenosine. Med Biol (1978) 0.97

Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens. Neuroscience (1997) 0.96

Role of adenosine in hypoxic ventilatory depression. J Appl Physiol (1985) (1989) 0.96

Opposite changes in adenosine A1 and A2A receptor mRNA in the rat following sleep deprivation. Neuroreport (2001) 0.96

Oxidative tissue damage following regional intestinal ischemia and reperfusion in the cat. Res Exp Med (Berl) (1984) 0.96

Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. Brain Res (2000) 0.95

CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes. J Neuroimmunol (2010) 0.95

Dopamine D1 receptor-mediated facilitation of GABAergic neurotransmission in the rat strioentopenduncular pathway and its modulation by adenosine A1 receptor-mediated mechanisms. Eur J Neurosci (1996) 0.95

Adenosine A1 receptor-mediated modulation of dopamine D1 receptors in stably cotransfected fibroblast cells. J Biol Chem (1998) 0.95

Metabolic effects of prolonged sympathetic nerve stimulation in canine subcutaneous adipose tissue. Acta Physiol Scand (1970) 0.95

Microdialysis of intercellular adenosine concentration in subcutaneous tissue in humans. Am J Physiol (1989) 0.95

Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors. J Neurosci (2000) 0.94

Effect of some phosphodiesterase inhibitors on central dopamine mechanisms. Eur J Pharmacol (1976) 0.94

Role of adenosine in adipose tissue circulation. Acta Physiol Scand (1981) 0.94

The effect of long term caffeine treatment on hypoxic-ischemic brain damage in the neonate. Pediatr Res (1995) 0.94

Evidence that a novel 8-phenyl-substituted xanthine derivative is a cardioselective adenosine receptor antagonist in vivo. J Cardiovasc Pharmacol (1987) 0.94

Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment. Neurosci Lett (1989) 0.93

The binding of the adenosine A2 receptor selective agonist [3H]CGS 21680 to rat cortex differs from its binding to rat striatum. Eur J Pharmacol (1993) 0.93

On the mechanism by which theophylline inhibits histamine release from rat mast cells. Acta Physiol Scand (1982) 0.93

Expression of protein kinase C isoforms in smooth muscle cells in various states of differentiation. FEBS Lett (1994) 0.93

Inhibition of [3H] glutamate release from rat hippocampal slices by L-phenylisopropyladenosine. Acta Physiol Scand (1985) 0.93