PubRank

F Grosveld

Author PubWeight™ 274.15‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 1995 4.80
2 Progress towards construction of a total restriction fragment map of a human chromosome. Nucleic Acids Res 1987 4.68
3 The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein. Genes Dev 1988 4.61
4 Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns. Cell 1986 4.58
5 Transcription complex stability and chromatin dynamics in vivo. Nature 1995 4.51
6 DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells. Cell 1984 4.42
7 A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature 1989 4.17
8 Detailed analysis of the site 3 region of the human beta-globin dominant control region. EMBO J 1990 4.05
9 Development of hematopoietic stem cell activity in the mouse embryo. Immunity 1994 3.91
10 Role of PML in cell growth and the retinoic acid pathway. Science 1998 3.82
11 The beta-globin dominant control region: hypersensitive site 2. EMBO J 1990 3.75
12 The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner. Cell 1989 3.72
13 Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression. EMBO J 1990 3.72
14 Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell 2001 3.64
15 Unexpected relationships between four large deletions in the human beta-globin gene cluster. Cell 1983 3.57
16 Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene. Nucleic Acids Res 1989 3.56
17 The human beta-globin gene contains a downstream developmental specific enhancer. Nucleic Acids Res 1987 3.54
18 The 5'HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites. EMBO J 1991 3.28
19 The transcription factor GATA6 is essential for early extraembryonic development. Development 1999 3.19
20 Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell 1997 3.17
21 The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription. EMBO J 1988 3.16
22 Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice. Genes Dev 1992 3.10
23 Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J 1995 2.93
24 Importance of globin gene order for correct developmental expression. Genes Dev 1991 2.85
25 The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene 1995 2.80
26 Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell 1996 2.77
27 The role of EKLF in human beta-globin gene competition. Genes Dev 1996 2.72
28 Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes. Genes Dev 1993 2.65
29 Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. EMBO J 1990 2.56
30 The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J 1988 2.54
31 Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet 2000 2.53
32 Inefficient processing impairs release of RNA from the site of transcription. EMBO J 1999 2.50
33 DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression. Nucleic Acids Res 1990 2.40
34 Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J 2001 2.34
35 Human gamma-globin genes silenced independently of other genes in the beta-globin locus. Nature 1991 2.23
36 Sequence of an HLA-DR alpha-chain cDNA clone and intron-exon organization of the corresponding gene. Nature 1982 2.18
37 The POU factor Oct-6 and Schwann cell differentiation. Science 1996 2.17
38 A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region. EMBO J 1996 2.12
39 Transcriptional regulation of multigene loci: multilevel control. Trends Genet 1993 2.12
40 Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation. Nature 1984 2.12
41 The structure of a human neurofilament gene (NF-L): a unique exon-intron organization in the intermediate filament gene family. Biochim Biophys Acta 1987 2.10
42 A transgenic mouse model of sickle cell disorder. Nature 1990 2.05
43 Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J Comp Neurol 2001 2.02
44 A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin. Nature 1992 2.01
45 Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Genes Dev 1999 1.98
46 The effect of distance on long-range chromatin interactions. Mol Cell 1997 1.90
47 Functional analysis of CLIP-115 and its binding to microtubules. J Cell Sci 2000 1.89
48 Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes. Proc Natl Acad Sci U S A 1983 1.85
49 Embryonic expression and cloning of the murine GATA-3 gene. Development 1994 1.84
50 Hypersensitive site 4 of the human beta globin locus control region. Nucleic Acids Res 1991 1.81
51 Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers. EMBO J 1993 1.77
52 Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J 2000 1.77
53 Chromatin interaction mechanism of transcriptional control in vivo. EMBO J 1998 1.72
54 Structure of the murine Thy-1 gene. EMBO J 1985 1.69
55 Tissue-specific control elements of the Thy-1 gene. EMBO J 1990 1.69
56 Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev 2000 1.64
57 High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes. Genes Dev 1989 1.63
58 Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression. EMBO J 1987 1.56
59 Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region. EMBO J 1998 1.56
60 beta-globin dominant control region interacts differently with distal and proximal promoter elements. Genes Dev 1990 1.54
61 Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. Eur J Immunol 1999 1.52
62 GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development 1997 1.50
63 Locus control regions, chromatin activation and transcription. Curr Opin Cell Biol 1998 1.49
64 Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo. Genes Dev 1998 1.48
65 The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region. EMBO J 1993 1.46
66 An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells. Nature 2000 1.45
67 Developmental regulation of DNA replication timing at the human beta globin locus. EMBO J 2001 1.45
68 The two zinc finger-like domains of GATA-1 have different DNA binding specificities. EMBO J 1993 1.41
69 Increased MHC H-2K gene transcription in cultured mouse embryo cells after adenovirus infection. Nature 1985 1.41
70 In vivo transposition of Minos, a Drosophila mobile element, in mammalian tissues. Proc Natl Acad Sci U S A 2001 1.40
71 Efficient 3'-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction. Nucleic Acids Res 1998 1.38
72 Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene. Proc Natl Acad Sci U S A 1995 1.36
73 GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei. J Neurosci 1999 1.35
74 Chromatin domains as potential units of eukaryotic gene function. Curr Opin Genet Dev 1994 1.34
75 LCR/MEL: a versatile system for high-level expression of heterologous proteins in erythroid cells. Nucleic Acids Res 1992 1.34
76 The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development. Development 2001 1.34
77 The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954. Gene Ther 1997 1.33
78 The structure of a thirty-six kilobase region of the human chromosome including the fibroblast interferon gene IFN-beta. Nucleic Acids Res 1981 1.33
79 An in vitro globin gene switching model based on differentiated embryonic stem cells. Genes Dev 1990 1.30
80 Chromosomal localization of the human Thy-1 gene. Proc Natl Acad Sci U S A 1985 1.30
81 Nuclear protein factors and erythroid transcription of the human A gamma-globin gene. Nucleic Acids Res 1989 1.28
82 Cloning and developmental expression of the murine neurofilament gene family. Brain Res 1986 1.28
83 CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies. Neuron 1997 1.28
84 Baculovirus infection of nondividing mammalian cells: mechanisms of entry and nuclear transport of capsids. J Virol 2001 1.26
85 The maintenance of methylation-free islands in transgenic mice. Nucleic Acids Res 1986 1.26
86 Differential expression of human globin genes introduced in K562 cells. EMBO J 1985 1.25
87 Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells. J Biol Chem 1988 1.24
88 Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO J 1996 1.23
89 Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice. Nucleic Acids Res 1994 1.23
90 Regulated expression of an introduced MHC H-2K bm1 gene in murine embryonal carcinoma cells. Nature 1984 1.22
91 Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and deltabeta-thalassemia affects beta- but not gamma-globin gene expression. EMBO J 1999 1.21
92 Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. Science 1982 1.20
93 Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice. Arterioscler Thromb Vasc Biol 2000 1.20
94 Position effects and genetic disease. Trends Genet 1996 1.19
95 Characterisation of transcriptionally active and inactive chromatin domains in neurons. J Cell Sci 2000 1.19
96 The gene for MRC OX-2 membrane glycoprotein is localized on human chromosome 3. Immunogenetics 1987 1.18
97 Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Cell 1987 1.17
98 A membrane cofactor protein transgenic mouse model for the study of discordant xenograft rejection. Genes Cells 1996 1.16
99 Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus. Mol Cell Biol 1999 1.16
100 Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein. Nature 1992 1.15
101 Differential regulation of a Thy-1 gene in transgenic mice. Proc Natl Acad Sci U S A 1987 1.14
102 The stem cell antigen CD34 functions as a regulator of hemopoietic cell adhesion. Proc Natl Acad Sci U S A 1995 1.14
103 Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo. J Immunol 2001 1.14
104 Regulated expression of K+ channel genes in electrically silent mammalian cells by linkage to beta-globin gene-activation elements. Receptors Channels 1993 1.14
105 Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice. J Immunol 2001 1.13
106 Complex lymphoid and epithelial thymic tumours in Thy1-myc transgenic mice. Nature 1989 1.13
107 The human beta-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene. Development 1996 1.09
108 The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery. Genes Funct 1997 1.09
109 Activation of the beta globin locus by transcription factors and chromatin modifiers. EMBO J 2000 1.08
110 Temporal and spatial control of murine GATA-3 transcription by promoter-proximal regulatory elements. Dev Biol 1997 1.08
111 Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene. Genes Cells 2001 1.08
112 Sequence and structure of the mouse gene coding for the largest neurofilament subunit. Gene 1988 1.07
113 Role of the duplicated CCAAT box region in gamma-globin gene regulation and hereditary persistence of fetal haemoglobin. EMBO J 1996 1.06
114 Early arrest in B cell development in transgenic mice that express the E41K Bruton's tyrosine kinase mutant under the control of the CD19 promoter region. J Immunol 1999 1.05
115 Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase. EMBO J 1998 1.01
116 The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients. Hum Mol Genet 1997 1.01
117 A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration. EMBO J 2000 1.01
118 The functional domains of the murine Thy-1 gene promoter. Mol Cell Biol 1991 0.99
119 Gain adaptation and phase dynamics of compensatory eye movements in mice. Genes Funct 1997 0.99
120 Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse. J Exp Med 2001 0.97
121 The effect of class II gene transfection on the tumourigenicity of the H-2K-negative mouse leukaemia cell line K36.16. Immunology 1991 0.97
122 Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse. Mech Dev 1998 0.97
123 The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4. Development 1999 0.96
124 Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expression. Mech Dev 2001 0.96
125 Microinjection of cre recombinase RNA induces site-specific recombination of a transgene in mouse oocytes. Nucleic Acids Res 1998 0.94
126 Evaluation of beta-globin gene therapy constructs in single copy transgenic mice. Nucleic Acids Res 1997 0.94
127 Cloning of a cDNA encoding the smallest neurofilament protein from the rat. Biochim Biophys Acta 1985 0.93
128 Transcriptional unit of the murine Thy-1 gene: different distribution of transcription initiation sites in brain. Mol Cell Biol 1988 0.93
129 Regulated high-level human beta-globin gene expression in erythroid cells following recombinant adeno-associated virus-mediated gene transfer. Gene Ther 1995 0.92
130 The transcription factor GATA6 is essential for early extraembryonic development. Development 1999 0.91
131 The mode of anchorage to the cell surface determines both the function and the membrane location of Thy-1 glycoprotein. J Cell Sci 1994 0.91
132 Gp96/GRP94 is a putative high density lipoprotein-binding protein in liver. Biochim Biophys Acta 1999 0.89
133 The chicken beta/epsilon-globin enhancer directs autonomously regulated, high-level expression of the chicken epsilon-globin gene in transgenic mice. Proc Natl Acad Sci U S A 1994 0.88
134 Partial rescue of GATA-3 by yeast artificial chromosome transgenes. Dev Biol 1998 0.88
135 Differences in human cell lines to support stable replication of Epstein-Barr virus-based vectors. Biochim Biophys Acta 1990 0.88
136 The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domains. J Biol Chem 1998 0.84
137 A novel in vivo transcription assay demonstrates the presence of globin-inducing trans-acting factors in uninduced murine erythroleukemia cells. Mol Cell Biol 1988 0.83
138 T cell independent Thy-1 allo-antibody response with the use of transgenic mice. J Immunol 1986 0.83
139 Transcriptional activation by hypersensitive site three of the human beta-globin locus control region in murine erythroleukemia cells. Biochim Biophys Acta 1994 0.83
140 TBP binding and the rate of transcription initiation from the human beta-globin gene. Nucleic Acids Res 1995 0.83
141 Enhancer sequences located 3' of the mouse immunoglobulin lambda locus specify high-level expression of an immunoglobulin lambda gene in B cells of transgenic mice. New Biol 1990 0.82
142 Erythroid overexpression of C/EBPgamma in transgenic mice affects gamma-globin expression and fetal liver erythropoiesis. EMBO J 2000 0.82
143 Specific detection of neuronal cell bodies: in situ hybridization with a biotin-labeled neurofilament cDNA probe. J Histochem Cytochem 1986 0.82
144 The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region. Genomics 1998 0.82
145 Anti-Thy-1 antibody responses evoked by Thy-1 antigen expressed in transfected mouse mastocytoma cells and rat fibroblast. Immunology 1985 0.82
146 HLA-DR genotyping by restriction fragment length polymorphism analyses. Immunogenetics 1985 0.82
147 Structure and expression of the human globin genes and murine histocompatibility antigen genes. Cold Spring Harb Symp Quant Biol 1983 0.82
148 The role of the -50 region of the human gamma-globin gene in switching. EMBO J 2001 0.81
149 Expression of adult and tadpole specific globin genes from Xenopus laevis in transgenic mice. Nucleic Acids Res 1991 0.81
150 Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in neurons of the developing and adult CNS. Genomics 1996 0.81
151 Beta-globin gene promoter generates 5' truncated transcripts in the embryonic/fetal erythroid environment. Nucleic Acids Res 1986 0.81
152 Expression of Thy-1 in the nervous system of the rat and mouse. Immunol Ser 1989 0.80
153 Methylation and gamma-globin expression. Prog Clin Biol Res 1985 0.79
154 Correction of the X-linked immunodeficiency phenotype by transgenic expression of human Bruton tyrosine kinase under the control of the class II major histocompatibility complex Ea locus control region. Proc Natl Acad Sci U S A 1997 0.79
155 Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Cell 1988 0.77
156 A multi-domain protein for beta1 integrin-targeted DNA delivery. Gene Ther 2000 0.77
157 Efficient joining of large DNA fragments for transgenesis. Nucleic Acids Res 1992 0.77
158 Nucleotide changes in the gamma-globin promoter and the (AT)xNy(AT)z polymorphic sequence of beta LCRHS-2 region associated with altered levels of HbF. Eur J Hum Genet 1999 0.77
159 Functional analysis of the human neurofilament light chain gene promoter. Nucleic Acids Res 1993 0.76
160 LCR-mediated, long-term tissue-specific gene expression within replicating episomal plasmid and cosmid vectors. Gene Ther 2002 0.76
161 The beta-globin dominant control region. Prog Clin Biol Res 1989 0.76
162 The X-linked immunodeficiency defect in the mouse is corrected by expression of human Bruton's tyrosine kinase from a yeast artificial chromosome transgene. Eur J Immunol 1997 0.76
163 The human neurofilament gene (NEFL) is located on the short arm of chromosome 8. Cytogenet Cell Genet 1987 0.75
164 Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice. Nucleic Acids Res 1993 0.75
165 The regulation of the human gamma- and beta -globin domain. Prog Clin Biol Res 1989 0.75
166 Regulation of the CRABP-I gene during mouse embryogenesis. Mech Dev 1997 0.75
167 Relative roles of hCD46 and hCD55 in the regulation of hyperacute rejection. Transplant Proc 2000 0.75
168 Human CD46 rather than CD55 is a key element in protection against complement activation in vitro. Transplant Proc 2000 0.75
169 DNA sequences required for regulated expression of beta-globin genes in murine erythroleukaemia cells. Philos Trans R Soc Lond B Biol Sci 1984 0.75
170 Neurocristopathy resembling neurofibromatosis type 1 in an NGF-SV40 transgenic line. Genes Cells 1996 0.75
171 Regulated expression of the erythroid-specific-promoter of the human PBG-D gene during erythroid differentiation. Prog Clin Biol Res 1989 0.75
172 Murine MHC class II locus control region drives expression of human beta-glucocerebrosidase in antigen presenting cells of transgenic mice. Gene Ther 1999 0.75
173 The human beta-globin genes. Oxf Surv Eukaryot Genes 1985 0.75
174 The structure and expression of the haemoglobin genes. Adv Exp Med Biol 1982 0.75