Published in Genes Dev on September 15, 1998
The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev (2004) 4.04
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res (1999) 3.68
Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci U S A (2005) 1.96
Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol (2001) 1.93
Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. Nucleic Acids Res (2000) 1.85
Advances in the understanding of haemoglobin switching. Br J Haematol (2010) 1.74
Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev (2000) 1.64
Hemoglobin induction in mouse macrophages. Proc Natl Acad Sci U S A (1999) 1.64
Role of NF-Y in in vivo regulation of the gamma-globin gene. Mol Cell Biol (2001) 1.51
Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain. Proc Natl Acad Sci U S A (2002) 1.51
Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. Mol Cell Biol (2008) 1.42
Transcription factor networks in erythroid cell and megakaryocyte development. Blood (2011) 1.29
Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice. Mol Cell Biol (2006) 1.26
Stage-specific repression by the EKLF transcriptional activator. Mol Cell Biol (2004) 1.21
Antagonistic regulation of beta-globin gene expression by helix-loop-helix proteins USF and TFII-I. Mol Cell Biol (2006) 1.18
Unanticipated repression function linked to erythroid Krüppel-like factor. Mol Cell Biol (2001) 1.14
Erythroid Kruppel-like factor is recruited to the CACCC box in the beta-globin promoter but not to the CACCC box in the gamma-globin promoter: the role of the neighboring promoter elements. Proc Natl Acad Sci U S A (2000) 1.14
Activation of the beta globin locus by transcription factors and chromatin modifiers. EMBO J (2000) 1.08
The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cells. Proc Natl Acad Sci U S A (1999) 1.06
Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals. BMC Biol (2008) 1.03
HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells. EMBO J (2003) 0.99
Structural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin. Mol Cell Biol (1999) 0.98
Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol (2007) 0.95
Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity. Mol Cell Biol (2004) 0.94
Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives. Eur J Haematol (2009) 0.93
Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor. Mol Cell Biol (2009) 0.89
Beta-globin locus control region HS2 and HS3 interact structurally and functionally. Nucleic Acids Res (2003) 0.86
Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes. Hum Mol Genet (2003) 0.82
Subclass-specific nuclear localization of a novel CD4 silencer binding factor. J Exp Med (1999) 0.80
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. Science (1991) 15.97
Transcriptional activation by tetracyclines in mammalian cells. Science (1995) 13.90
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell (1987) 12.30
Transcriptional activation by recruitment. Nature (1997) 10.44
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell (1997) 5.78
A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol Cell Biol (1993) 5.70
Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J Biol Chem (1996) 5.52
Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (1995) 4.97
A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science (1997) 4.93
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature (1995) 4.80
The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein. Genes Dev (1988) 4.61
Transcription complex stability and chromatin dynamics in vivo. Nature (1995) 4.51
A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature (1989) 4.17
The beta-globin dominant control region: hypersensitive site 2. EMBO J (1990) 3.75
Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A (1996) 3.57
OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts. Nucleic Acids Res (1987) 3.56
Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell (1991) 3.46
Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol (1995) 3.39
Synergy between adjacent zinc fingers in sequence-specific DNA recognition. Proc Natl Acad Sci U S A (1997) 3.32
In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence. Nature (1994) 3.31
Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J (1994) 3.27
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell (1997) 3.17
Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice. Genes Dev (1992) 3.10
Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol Cell Biol (1992) 3.10
Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins. Proc Natl Acad Sci U S A (1993) 3.09
Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res (1992) 2.89
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell (1996) 2.77
The role of EKLF in human beta-globin gene competition. Genes Dev (1996) 2.72
Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J (1989) 2.70
Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J (1992) 2.65
Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence. Nucleic Acids Res (1989) 2.47
Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol Cell Biol (1995) 2.41
DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression. Nucleic Acids Res (1990) 2.40
Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol Cell Biol (1996) 2.31
Determination of the base recognition positions of zinc fingers from sequence analysis. EMBO J (1992) 2.31
An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Mol Cell Biol (1994) 2.26
Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor. J Biol Chem (1994) 2.22
Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol (1996) 2.17
Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc Natl Acad Sci U S A (1991) 2.16
A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region. EMBO J (1996) 2.12
Ultra-sensitive FISH using peroxidase-mediated deposition of biotin- or fluorochrome tyramides. Hum Mol Genet (1995) 2.07
Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proc Natl Acad Sci U S A (1996) 1.99
A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA. Nucleic Acids Res (1993) 1.93
The effect of distance on long-range chromatin interactions. Mol Cell (1997) 1.90
Ligand-inducible and liver-specific target gene expression in transgenic mice. Nat Biotechnol (1997) 1.88
In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region. Proc Natl Acad Sci U S A (1992) 1.87
Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature (1992) 1.84
Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition. J Biol Chem (1997) 1.48
The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region. EMBO J (1993) 1.46
LCR/MEL: a versatile system for high-level expression of heterologous proteins in erythroid cells. Nucleic Acids Res (1992) 1.34
Position effects and genetic disease. Trends Genet (1996) 1.19
Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines. Methods Mol Biol (1991) 1.14
beta-Thalassaemia. Baillieres Clin Haematol (1993) 1.12
The human beta-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene. Development (1996) 1.09
The regulation of human globin gene expression. Baillieres Clin Haematol (1993) 1.06
Structural and functional analyses of DNA bending induced by Sp1 family transcription factors. J Mol Biol (1997) 0.88
Transcriptional activation by hypersensitive site three of the human beta-globin locus control region in murine erythroleukemia cells. Biochim Biophys Acta (1994) 0.83
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature (1995) 4.80
Progress towards construction of a total restriction fragment map of a human chromosome. Nucleic Acids Res (1987) 4.68
The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein. Genes Dev (1988) 4.61
Transcription complex stability and chromatin dynamics in vivo. Nature (1995) 4.51
DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells. Cell (1984) 4.42
Intergenic transcription and transinduction of the human beta-globin locus. Genes Dev (1997) 4.30
A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature (1989) 4.17
Detailed analysis of the site 3 region of the human beta-globin dominant control region. EMBO J (1990) 4.05
Development of hematopoietic stem cell activity in the mouse embryo. Immunity (1994) 3.91
Role of PML in cell growth and the retinoic acid pathway. Science (1998) 3.82
The beta-globin dominant control region: hypersensitive site 2. EMBO J (1990) 3.75
The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner. Cell (1989) 3.72
Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression. EMBO J (1990) 3.72
Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell (2001) 3.64
Unexpected relationships between four large deletions in the human beta-globin gene cluster. Cell (1983) 3.57
Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene. Nucleic Acids Res (1989) 3.56
The human beta-globin gene contains a downstream developmental specific enhancer. Nucleic Acids Res (1987) 3.54
The transcription factor GATA6 is essential for early extraembryonic development. Development (1999) 3.19
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell (1997) 3.17
The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription. EMBO J (1988) 3.16
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol Cell Biol (1992) 3.12
Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice. Genes Dev (1992) 3.10
Applications of pectinases in the commercial sector: a review. Bioresour Technol (2001) 2.91
Importance of globin gene order for correct developmental expression. Genes Dev (1991) 2.85
Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J (1993) 2.83
The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene (1995) 2.80
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell (1996) 2.77
The role of EKLF in human beta-globin gene competition. Genes Dev (1996) 2.72
Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes. Genes Dev (1993) 2.65
Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. EMBO J (1990) 2.56
The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J (1988) 2.54
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet (2000) 2.53
Inefficient processing impairs release of RNA from the site of transcription. EMBO J (1999) 2.50
Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Hum Mol Genet (2001) 2.46
DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression. Nucleic Acids Res (1990) 2.40
Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J (2001) 2.34
Human gamma-globin genes silenced independently of other genes in the beta-globin locus. Nature (1991) 2.23
Sequence of an HLA-DR alpha-chain cDNA clone and intron-exon organization of the corresponding gene. Nature (1982) 2.18
The POU factor Oct-6 and Schwann cell differentiation. Science (1996) 2.17
A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region. EMBO J (1996) 2.12
Transcriptional regulation of multigene loci: multilevel control. Trends Genet (1993) 2.12
Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation. Nature (1984) 2.12
The structure of a human neurofilament gene (NF-L): a unique exon-intron organization in the intermediate filament gene family. Biochim Biophys Acta (1987) 2.10
A transgenic mouse model of sickle cell disorder. Nature (1990) 2.05
Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J Comp Neurol (2001) 2.02
A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin. Nature (1992) 2.01
Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Genes Dev (1999) 1.98
The effect of distance on long-range chromatin interactions. Mol Cell (1997) 1.90
Functional analysis of CLIP-115 and its binding to microtubules. J Cell Sci (2000) 1.89
Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes. Proc Natl Acad Sci U S A (1983) 1.85
Embryonic expression and cloning of the murine GATA-3 gene. Development (1994) 1.84
Hypersensitive site 4 of the human beta globin locus control region. Nucleic Acids Res (1991) 1.81
Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers. EMBO J (1993) 1.77
Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J (2000) 1.77
Chromatin interaction mechanism of transcriptional control in vivo. EMBO J (1998) 1.72
Structure of the murine Thy-1 gene. EMBO J (1985) 1.69
Tissue-specific control elements of the Thy-1 gene. EMBO J (1990) 1.69
Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev (2000) 1.64
High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes. Genes Dev (1989) 1.63
Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression. EMBO J (1987) 1.56
beta-globin dominant control region interacts differently with distal and proximal promoter elements. Genes Dev (1990) 1.54
Microbial alkaline pectinases and their industrial applications: a review. Appl Microbiol Biotechnol (2002) 1.53
Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. Eur J Immunol (1999) 1.52
GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development (1997) 1.50
Locus control regions, chromatin activation and transcription. Curr Opin Cell Biol (1998) 1.49
The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region. EMBO J (1993) 1.46
An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells. Nature (2000) 1.45
Developmental regulation of DNA replication timing at the human beta globin locus. EMBO J (2001) 1.45
The two zinc finger-like domains of GATA-1 have different DNA binding specificities. EMBO J (1993) 1.41
Increased MHC H-2K gene transcription in cultured mouse embryo cells after adenovirus infection. Nature (1985) 1.41
In vivo transposition of Minos, a Drosophila mobile element, in mammalian tissues. Proc Natl Acad Sci U S A (2001) 1.40
Efficient 3'-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction. Nucleic Acids Res (1998) 1.38
Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells. Genes Dev (1995) 1.37
Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene. Proc Natl Acad Sci U S A (1995) 1.36
GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei. J Neurosci (1999) 1.35
Chromatin domains as potential units of eukaryotic gene function. Curr Opin Genet Dev (1994) 1.34
LCR/MEL: a versatile system for high-level expression of heterologous proteins in erythroid cells. Nucleic Acids Res (1992) 1.34
The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development. Development (2001) 1.34
The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954. Gene Ther (1997) 1.33
The structure of a thirty-six kilobase region of the human chromosome including the fibroblast interferon gene IFN-beta. Nucleic Acids Res (1981) 1.33
An in vitro globin gene switching model based on differentiated embryonic stem cells. Genes Dev (1990) 1.30
Chromosomal localization of the human Thy-1 gene. Proc Natl Acad Sci U S A (1985) 1.30
Impaired ossification in mice lacking the transcription factor Sp3. Mech Dev (2001) 1.29
Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the beta-globin locus control region. Domain opening and synergism between HS2 and HS3. J Biol Chem (1996) 1.29