p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

PubWeight™: 1.82‹?› | Rank: Top 3%

🔗 View Article (PMID 7890669)

Published in J Biol Chem on March 10, 1995

Authors

D M Milne1, L E Campbell, D G Campbell, D W Meek

Author Affiliations

1: Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, United Kingdom.

Articles citing this

DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78

DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev (1997) 5.76

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72

Molecular interaction map of the mammalian cell cycle control and DNA repair systems. Mol Biol Cell (1999) 3.41

Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev (2006) 3.30

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J (1999) 2.64

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci U S A (1996) 2.58

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J (1999) 2.50

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol (1997) 2.41

MEKK1/JNK signaling stabilizes and activates p53. Proc Natl Acad Sci U S A (1998) 2.27

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation. Proc Natl Acad Sci U S A (1998) 2.11

3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Mol Cell Biol (1996) 1.63

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol (2001) 1.54

The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol Cell Biol (1999) 1.47

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proc Natl Acad Sci U S A (1996) 1.44

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress. Neoplasia (2000) 1.36

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Mol Cell Biol (1997) 1.34

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal (2010) 1.34

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol (1997) 1.31

Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol (2000) 1.29

Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells. J Virol (1998) 1.28

Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Proc Natl Acad Sci U S A (1998) 1.20

Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochem Pharmacol (2008) 1.13

The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1. J Virol (2003) 1.11

Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Mol Med (1997) 1.08

p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle. Mol Cell Biol (1997) 1.07

Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. Cell Death Dis (2013) 1.03

Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma. PLoS One (2012) 1.02

A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system. Proc Natl Acad Sci U S A (1998) 0.96

Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. Toxicol Appl Pharmacol (2011) 0.93

Linking JNK Activity to the DNA Damage Response. Genes Cancer (2013) 0.89

Primate Torpor: Regulation of Stress-activated Protein Kinases During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus. Genomics Proteomics Bioinformatics (2015) 0.86

Activation of the Jun N-terminal kinase pathway by friend spleen focus-forming virus and its role in the growth and survival of friend virus-induced erythroleukemia cells. J Virol (2005) 0.86

Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53. Mol Cell Biol (2003) 0.85

c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer. Mol Cell Biol (2009) 0.84

Destabilization of the outer and inner mitochondrial membranes by core and linker histones. PLoS One (2012) 0.82

Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression. Inflamm Res (2011) 0.80

Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-α and Nitrite, an Intermediate of Nitric Oxide, in a Cellular Model of Inflammation. Open Biochem J (2011) 0.80

Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1ε. PLoS One (2011) 0.80

Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis. Brain Res (2012) 0.80

p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo. Gene Regul Syst Bio (2015) 0.79

Casein kinase 2 inhibits the renaturation of complementary DNA strands mediated by p53 protein. Biochem J (1996) 0.79

Growth inhibition by the muscarinic M(3) acetylcholine receptor: evidence for p21(Cip1/Waf1) involvement in G(1) arrest. Biochem J (2002) 0.79

Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis. FEBS Lett (2009) 0.78

Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells. Apoptosis (2014) 0.77

Regulation of p53 by protein kinase C during multi-stage carcinogenesis. J Cancer Res Clin Oncol (1997) 0.77

Effects of heavy metals on mitogen-activated protein kinase pathways. Environ Health Prev Med (2002) 0.75

Eiger-induced cell death relies on Rac1-dependent endocytosis. Cell Death Dis (2016) 0.75

Apoptosis resistance in tumor cells. Cytotechnology (1998) 0.75

Articles by these authors

Regulation of the specific DNA binding function of p53. Cell (1992) 6.16

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J (1992) 4.97

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett (1992) 3.07

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J (1999) 3.00

Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem J (1998) 2.65

Rat brain Thy-1 glycoprotein. The amino acid sequence, disulphide bonds and an unusual hydrophobic region. Biochem J (1981) 2.63

Specific volumes of lipids in fully hydrated bilayer dispersions. Biochim Biophys Acta (1988) 2.60

Pigmentary dispersion and glaucoma. A new theory. Arch Ophthalmol (1979) 2.46

Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein. Curr Biol (2001) 2.09

Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J Exp Med (1995) 2.05

Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor. Eur J Biochem (1987) 1.91

Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. Eur J Biochem (1989) 1.88

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur J Biochem (1988) 1.87

Modern goniosynechialysis for the treatment of synechial angle-closure glaucoma. Ophthalmology (1984) 1.83

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase. Eur J Biochem (1993) 1.83

Isolation and sequence analysis of a cDNA clone encoding a type-1 protein phosphatase catalytic subunit: homology with protein phosphatase 2A. FEBS Lett (1987) 1.72

Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme. Oncogene (1992) 1.60

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy (2011) 1.59

Carbon monoxide poisoning in the home: recognition and treatment. BMJ (1990) 1.54

The corneal endothelium and the spectrum of essential iris atrophy. Am J Ophthalmol (1978) 1.53

Activation of the cryptic DNA binding function of mutant forms of p53. Nucleic Acids Res (1993) 1.49

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene (1997) 1.46

Structural similarities between Thy-1 antigen from rat brain and immunoglobulin. Nature (1979) 1.42

MAP kinase kinase from rabbit skeletal muscle. A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone-dependent signal transduction. FEBS Lett (1992) 1.41

Analysis of structural similarities between brain Thy-1 antigen and immunoglobulin domains. Evidence for an evolutionary relationship and a hypothesis for its functional significance. Biochem J (1981) 1.38

IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene (2000) 1.36

Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. Biochim Biophys Acta (1992) 1.35

Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo. EMBO J (2001) 1.35

Isolation and sequence analysis of a cDNA clone encoding the entire catalytic subunit of a type-2A protein phosphatase. FEBS Lett (1987) 1.35

Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases. J Biol Chem (1994) 1.33

Molecular weights of the Thy-1 glycoproteins from rat thymus and brain in the presence and absence of deoxycholate. Biochem J (1978) 1.33

Postoperative suprachoroidal hemorrhage following filtration procedures. Arch Ophthalmol (1986) 1.31

The molecular mechanism by which adrenalin inhibits glycogen synthesis. Eur J Biochem (1991) 1.30

Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase. J Biol Chem (1986) 1.24

The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. FEBS Lett (1995) 1.24

Ghost cells as a cause of glaucoma. Am J Ophthalmol (1976) 1.24

Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin. Eur J Biochem (1987) 1.24

Dynamic changes in circulating and antigen-responsive T-cell subpopulations post-Mycobacterium bovis infection in cattle. Immunology (1996) 1.22

Catalytic activity of protein kinase CK1 delta (casein kinase 1delta) is essential for its normal subcellular localization. Exp Cell Res (2001) 1.21

Molecular cloning and primary structure of a protein phosphatase 2C isoform. FEBS Lett (1992) 1.21

Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. FEBS Lett (1994) 1.20

O- and N-glycosylation of the Leishmania mexicana-secreted acid phosphatase. Characterization of a new class of phosphoserine-linked glycans. J Biol Chem (1994) 1.17

Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations. Br J Dermatol (2011) 1.17

Nucleotide sequence of the rpoA-rplQ DNA of Escherichia coli: a second regulatory binding site for protein S4? Nucleic Acids Res (1984) 1.17

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. FEBS Lett (1999) 1.16

Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur J Biochem (1993) 1.14

Patient-perceived outcome measures following unicompartmental knee arthroplasty with mini-incision. Int Orthop (2004) 1.14

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover. Biochem J (2001) 1.14

Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains. FEBS Lett (2000) 1.14

The essential iris atrophies. Am J Ophthalmol (1978) 1.13

Characteristics of a cell surface antigen defined by an anti-human osteogenic sarcoma monoclonal antibody. Eur J Cancer Clin Oncol (1983) 1.12

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53. Nucleic Acids Res (1992) 1.12

Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase. FEBS Lett (1988) 1.10

Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9. Eur J Biochem (1994) 1.10

The interaction of fructose 2,6-bisphosphate with an allosteric site of rat liver fructose 1,6-bisphosphatase. FEBS Lett (1983) 1.08

Nitrate loss in subsurface drainage as affected by nitrogen fertilizer rate. J Environ Qual (2001) 1.07

Identification of the phosphorylation sites in elongation factor-2 from rabbit reticulocytes. FEBS Lett (1991) 1.05

The protein phosphatases involved in cellular regulation. Primary structure of inhibitor-2 from rabbit skeletal muscle. Eur J Biochem (1986) 1.04

Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. EMBO J (1985) 1.04

Posterior capsule rupture after a paint-pellet injury. J Cataract Refract Surg (2000) 1.03

Identification of protein phosphatase 2A as the major tyrosine hydroxylase phosphatase in adrenal medulla and corpus striatum: evidence from the effects of okadaic acid. FEBS Lett (1989) 1.01

Evaluation of nitrate nitrogen fluxes from a tile-drained watershed in central Iowa. J Environ Qual (2003) 1.00

The phosphorylation of stathmin by MAP kinase. Mol Cell Biochem (1993) 0.99

Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase. Eur J Biochem (1988) 0.99

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation. Nucleic Acids Res (1996) 0.99

The heredity and treatment of angle-closure glaucoma secondary to iris and ciliary body cysts. Ophthalmology (1984) 0.98

The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage. Oncogene (2012) 0.97

The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells. FEBS Lett (1994) 0.97

Iris nodules in essential iris atrophy. Arch Ophthalmol (1976) 0.97

Murine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate. Oncogene (1996) 0.96

Hemolytic ghost cell glaucoma. Further studies. Arch Ophthalmol (1979) 0.95

Ghost cell glaucoma following trauma. Ophthalmology (1981) 0.95

The Environmental Rating Scale (ERS): a measure of the quality of the residential environment for adults with autism. Res Dev Disabil (1999) 0.94

Identification of three in vivo phosphorylation sites on the glycogen-binding subunit of protein phosphatase 1 from rabbit skeletal muscle, and their response to adrenaline. FEBS Lett (1990) 0.93

Multisite phosphorylation of the glycogen-binding subunit of protein phosphatase-1G by cyclic AMP-dependent protein kinase and glycogen synthase kinase-3. FEBS Lett (1989) 0.92

Excretion of oestrogens, pregnanediol and chorionic gonadotrophin in patients with hydatidiform mole. J Obstet Gynaecol Br Commonw (1970) 0.92

Amino acid sequence at the site on protein phosphatase inhibitor-2, phosphorylated by glycogen synthase kinase-3. Biochim Biophys Acta (1984) 0.92

Partial structure and hormonal regulation of rabbit liver inhibitor-1; distribution of inhibitor-1 and inhibitor-2 in rabbit and rat tissues. Biochim Biophys Acta (1989) 0.92

Controlled trial of intensive care for very low birth weight infants. Pediatrics (1971) 0.91

Hormone levels in threatened abortion. J Obstet Gynaecol Br Commonw (1970) 0.90

The automated analysis of urinary oestrogens during pregnancy. Clin Chim Acta (1971) 0.90

The formation of tri-iodothyronine and reverse tri-iodothyronine from thyroxine in isolated rat renal tubules. Clin Sci Mol Med Suppl (1978) 0.90

Direct evidence for autogenous regulation of the Escherichia coli genes rpoBC in vivo. Mol Gen Genet (1986) 0.90

Interplay between insulin and nutrients in the regulation of translation factors. Biochem Soc Trans (2001) 0.90

Cloning and expression of cystolic phospholipase A2 (cPLA2) and a naturally occurring variant. Phosphorylation of Ser505 of recombinant cPLA2 by p42 mitogen-activated protein kinase results in an increase in specific activity. Eur J Biochem (1996) 0.89

Pathophysiology of pigment dispersion syndrome and pigmentary glaucoma. Curr Opin Ophthalmol (1995) 0.89

A myofibrillar protein phosphatase from rabbit skeletal muscle contains the beta isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin. Eur J Biochem (1992) 0.89

Ongoing postdivorce conflict and child disturbance. J Abnorm Child Psychol (1987) 0.88

Primary structure analysis proves that protein phosphatases 2C1 and 2C2 are isozymes. Biochim Biophys Acta (1987) 0.88

Modifications of p53 protein and accumulation of p21 and gadd45 mRNA in TGF-beta 1 growth inhibited cells. Cell Signal (1997) 0.88

The Unispacer knee implant: early clinical results. J Bone Joint Surg Br (2008) 0.87

Arthrofibrosis following total knee replacement; does therapeutic warfarin make a difference? Knee (2005) 0.87

Dissection of the protein kinase cascades involved in insulin and nerve growth factor action. Biochem Soc Trans (1992) 0.87

Effects of phosphorylation on the kinetic properties of rat liver fructose-1,6-bisphosphatase. Biochem J (1984) 0.87