Summary of the National Toxicology Program benzidine dye initiative.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 1567082)

Published in Environ Health Perspect on June 01, 1994

Authors

D L Morgan1, J K Dunnick, T Goehl, M P Jokinen, H B Matthews, E Zeiger, J H Mennear

Author Affiliations

1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

Articles cited by this

The carcinogenic action of benzidine. Cancer (1950) 6.25

Ha-ras oncogenes are activated by somatic alterations in human urinary tract tumours. Nature (1984) 1.99

Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol (1979) 1.47

Frequency of molecular alterations affecting ras protooncogenes in human urinary tract tumors. Proc Natl Acad Sci U S A (1985) 1.43

Arylamine-DNA adducts in vitro and in vivo: their role in bacterial mutagenesis and urinary bladder carcinogenesis. Environ Health Perspect (1983) 1.18

Tests for chemical carcinogens. Report on the activity of derivatives of aromatic amines, nitrosamines, quinolines, nitroalkanes, amides, epoxides, aziridines, and purine antimetabolites. J Natl Cancer Inst (1968) 1.17

Enzymatic reduction of prontosil and other azo dyes. J Pharmacol Exp Ther (1957) 1.17

Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen (1987) 1.07

Benzidine revisited: a review of the literature and problems associated with the use of benzidine and its congeners. Clin Toxicol (1975) 1.04

Metabolic reduction of benzidine azo dyes to benzidine in the rhesus monkey. J Natl Cancer Inst (1975) 0.99

Covalent binding of benzidine and N-acetylbenzidine to DNA at the C-8 atom of deoxyguanosine in vivo and in vitro. Cancer Res (1982) 0.98

Metabolism of benzidine and benzidine-congener based dyes by human, monkey and rat intestinal bacteria. Biochem Biophys Res Commun (1982) 0.98

Design of animal carcinogenicity studies for goodness-of-fit of multistage models. Fundam Appl Toxicol (1984) 0.95

Metabolic activation of carcinogenic aromatic amines by dog bladder and kidney prostaglandin H synthase. Cancer Res (1984) 0.91

Chemical monitoring of urine from workers potentially exposed to benzidine-derived azo dyes. Toxicol Lett (1980) 0.91

Transplantation characteristics, morphologic features, and interpretation of preputial gland neoplasia in the Fischer 344 rat. Environ Health Perspect (1988) 0.89

Metabolism of the human carcinogen, benzidine, in the isolated perfused rat liver. Drug Metab Dispos (1983) 0.88

Enzymic deacetylation of carcinogenic arylacetamides by tissue microsomes of the dog and other species. J Toxicol Environ Health (1976) 0.87

Analysis of a method for testing azo dyes for mutagenic activity in Salmonella typhimurium in the presence of flavin mononucleotide and hamster liver S9. Mutat Res (1982) 0.87

Metabolism of benzidine to N-hydroxy-N,N'-diacetylbenzidine and subsequent nucleic acid binding and mutagenicity. Cancer Res (1979) 0.86

The biotransformation of benzidine. II. Studies in mouse and man. Arch Environ Health (1961) 0.86

Metabolism of bisazobiphenyl dyes derived from benzidine, 3,3'-dimethylbenzidine or 3,3'-dimethoxybenzidine to carcinogenic aromatic amines in the dog and rat. Toxicol Appl Pharmacol (1980) 0.86

Arachidonic acid-dependent peroxidative activation of carcinogenic arylamines by extrahepatic human tissue microsomes. Cancer Res (1989) 0.85

Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ Mutagen (1984) 0.84

Morphology of hyperplastic and neoplastic lesions in the clitoral and preputial gland of the F344 rat. Vet Pathol (1981) 0.83

Mutagenicity of benzidine and benzidine-congener dyes and selected monoazo dyes in a modified Salmonella assay. Mutat Res (1984) 0.82

Thirteen-week subchronic toxicity studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 dyes. Toxicol Appl Pharmacol (1980) 0.79

Binding of benzidine, N-acetylbenzidine, N, N'-diacetylbenzidine and Direct Blue 6 to rat liver DNA. Environ Health Perspect (1983) 0.78

Hepatic N-oxidation, acetyl-transfer and DNA-binding of the acetylated metabolites of the carcinogen, benzidine. Carcinogenesis (1985) 0.78

Role of N-glucuronidation in benzidine-induced bladder cancer in dog. Carcinogenesis (1992) 0.77

Carcinogenicity study of 3,3'-dimethylbenzidine dihydrochloride in BALB/c mice. Food Chem Toxicol (1989) 0.77

Thirteen-week toxicity studies of 3,3'-dimethoxybenzidene and C.I. Direct Blue 15 in the Fischer 344 rat. Toxicology (1989) 0.77

ras gene activation in rat tumors induced by benzidine congeners and derived dyes. Cancer Res (1990) 0.77

Disposition of the aromatic amine, benzidine, in the rat: characterization of mutagenic urinary and biliary metabolites. Toxicol Appl Pharmacol (1984) 0.77

Metabolism, distribution, and excretion of the carcinogenic aromatic amine, 3,3'-dimethoxybenzidine in the rat. Formation of mutagenic urinary and biliary metabolites. Drug Metab Dispos (1983) 0.77

Carcinogen-DNA adduct formation as a predictor of metabolic activation pathways and reactive intermediates in benzidine carcinogenesis. Adv Exp Med Biol (1986) 0.76

ON SOME REGULAR RELATIONSHIPS BETWEEN CARCINOGENICITY OF AMINODIPHENYL DERIVATIVES AND THE STRUCTURE OF SUBSTANCE. Acta Unio Int Contra Cancrum (1963) 0.76

Mutagenicity of some benzidine congeners and their N-acetylated and N,N'-diacetylated derivatives in different strains of Salmonella typhimurium. Environ Mutagen (1984) 0.76

Transplantation studies of preputial gland and epithelial skin neoplasms derived from benzidine-based dye carcinogenicity assays in Fischer 344 male rats. Toxicol Pathol (1989) 0.76

Articles by these authors

(truncated to the top 100)

Light and stomatal function: blue light stimulates swelling of guard cell protoplasts. Science (1977) 4.70

The Ames Salmonella/microsome mutagenicity assay. Mutat Res (2000) 3.51

Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science (1987) 3.36

Red light stimulates an electrogenic proton pump in Vicia guard cell protoplasts. Proc Natl Acad Sci U S A (1988) 3.22

Kinetic properties of the blue-light response of stomata. Proc Natl Acad Sci U S A (1985) 3.09

HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat Res (2003) 2.90

Chlorophyll a Fluorescence Transients in Mesophyll and Guard Cells : MODULATION OF GUARD CELL PHOTOPHOSPHORYLATION BY CO(2). Plant Physiol (1982) 2.79

Cyclic and Noncyclic Photophosphorylation in Isolated Guard Cell Chloroplasts from Vicia faba L. Plant Physiol (1985) 2.70

Herpes simplex encephalitis: vidarabine therapy and diagnostic problems. N Engl J Med (1981) 2.56

Isolation of Guard Cell Protoplasts from Mechanically Prepared Epidermis of Vicia faba Leaves. Plant Physiol (1989) 2.49

Red Light-Dependent CO(2) Uptake and Oxygen Evolution in Guard Cell Protoplasts of Vicia faba L.: Evidence for Photosynthetic CO(2) Fixation. Plant Physiol (1987) 2.12

Photosynthetic Carbon Fixation in Guard Cell Protoplasts of Vicia faba L. : Evidence from Radiolabel Experiments. Plant Physiol (1988) 2.12

Correlation of bacteria lipid composition with antibiotic resistance. J Bacteriol (1970) 1.82

Light quality and osmoregulation in vicia guard cells : evidence for involvement of three metabolic pathways. Plant Physiol (1988) 1.79

The HUman MicroNucleus Project--An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutat Res (1999) 1.60

The carbonate environment in bone mineral: a resolution-enhanced Fourier Transform Infrared Spectroscopy Study. Calcif Tissue Int (1989) 1.59

Regenerative hyperplasia is not required for liver tumor induction in female B6C3F1 mice exposed to trihalomethanes. Toxicol Appl Pharmacol (1998) 1.59

Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen (1986) 1.55

Statistical analysis of the Ames Salmonella/microsome test. Proc Natl Acad Sci U S A (1981) 1.53

Stomatal responses to light and leaf-air water vapor pressure difference show similar kinetics in sugarcane and soybean. Plant Physiol (1986) 1.49

Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns. Carcinogenesis (2007) 1.48

Vanadate inhibits blue light-stimulated swelling of vicia guard cell protoplasts. Plant Physiol (1992) 1.45

Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice. Carcinogenesis (2001) 1.44

The carcinogenic activity of commercial grade toluene diisocyanate in rats and mice in relation to the metabolism of the 2,4- and 2,6-TDI isomers. Toxicol Ind Health (1990) 1.43

Chromosome 11 loss from thymic lymphomas induced in heterozygous Trp53 mice by phenolphthalein. Toxicol Sci (2001) 1.39

Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP. Environ Health Perspect (1982) 1.39

Comparative results of 327 chemical carcinogenicity studies. Environ Health Perspect (1987) 1.39

Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program. Mutat Res (1989) 1.37

Clinical trials with exogenous interferon: summary of a meeting. J Infect Dis (1979) 1.36

HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ Mol Mutagen (2001) 1.27

Toxicology and carcinogenesis studies of dietary titanium dioxide-coated mica in male and female Fischer 344 rats. J Toxicol Environ Health (1990) 1.26

Close correspondence between the action spectra for the blue light responses of the guard cell and coleoptile chloroplasts, and the spectra for blue light-dependent stomatal opening and coleoptile phototropism. Proc Natl Acad Sci U S A (1996) 1.25

Reversal of blue light-stimulated stomatal opening by green light. Plant Cell Physiol (2000) 1.20

Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen (1983) 1.20

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies. Environ Mol Mutagen (2012) 1.19

Enhanced Photosynthesis and Stomatal Conductance of Pima Cotton (Gossypium barbadense L.) Bred for Increased Yield. Plant Physiol (1991) 1.19

A putative role of the xanthophyll, zeaxanthin, in blue light photoreception of corn coleoptiles. Science (1994) 1.19

The metabolism and disposition of tris(1,3-dichloro-2-propyl) phosphate (Fyrol FR-2) in the rat. Toxicol Appl Pharmacol (1981) 1.19

Blue light-induced, intrinsic vacuolar fluorescence in onion guard cells. J Cell Sci (1979) 1.19

Gas exchange in paphiopedilum: lack of chloroplasts in guard cells correlates with low stomatal conductance. Plant Physiol (1983) 1.17

A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat. Drug Metab Dispos (1977) 1.17

Carcinogenicity of mutagens: predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity. Cancer Res (1987) 1.17

Longevity of guard cell chloroplasts in falling leaves: implication for stomatal function and cellular aging. Science (1982) 1.17

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Mol Mutagen (2014) 1.15

Metabolic energy for stomatal opening. Roles of photophosphorylation and oxidative phosphorylation. Planta (1984) 1.15

Blue light-modulation of chlorophyll a fluorescence transients in guard cell chloroplasts. Plant Physiol (1991) 1.12

Stomata from npq1, a zeaxanthin-less Arabidopsis mutant, lack a specific response to blue light. Plant Cell Physiol (1999) 1.12

Genetic variability for stomatal conductance in Pima cotton and its relation to improvements of heat adaptation. Proc Natl Acad Sci U S A (1994) 1.10

Pharmacokinetics of PCBs. Annu Rev Pharmacol Toxicol (1984) 1.09

The distribution and excretion of 2,4,5,2',5'-pentachlorobiphenyl in the rat. Drug Metab Dispos (1975) 1.09

Distribution and excretion of 2,2',4,4',5,5'-hexabromobiphenyl in rats and man: pharmacokinetic model predictions. Toxicol Appl Pharmacol (1980) 1.08

Sensory transduction and electrical signaling in guard cells. Plant Physiol (1989) 1.07

Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen (1987) 1.07

Metabolism of 4-chlorobiphenyl and 4,4'-dichlorobiphenyl in the rat: qualitative and quantitative aspects. J Agric Food Chem (1977) 1.06

Evaluations of a patient isolator system. I. Evaluations of subsystems and procedures for sterilization and concurrent sanitation. Arch Environ Health (1965) 1.04

Rotenone, an anticarcinogen, inhibits cellular proliferation but not peroxisome proliferation in mouse liver. Cancer Lett (1995) 1.03

Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen:carcinogen pair--2,6- and 2,4-diaminotoluene. Toxicol Appl Pharmacol (1991) 1.01

Genetic toxicology: current status of methods of carcinogen identification. Environ Health Perspect (1993) 1.00

Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): consensus of a National Toxicology Program Pathology Working Group. Toxicol Pathol (1997) 0.99

Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories. Environ Mutagen (1985) 0.99

Effects of the hepatic S9 fraction from aroclor-1254-treated rats on the mutagenicity of benzo[alpha]pyrene and 2-aminoanthracene in the Salmonella/microsome assay. Mutat Res (1979) 0.99

Microsomal rat liver UDP glucuronyltransferase: effects of piperonyl butoxide and other factors on enzyme activity. Arch Biochem Biophys (1971) 0.99

Genetic effects of PR toxin in eukaryotic microorganisms. Environ Mutagen (1979) 0.98

Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat. Toxicol Appl Pharmacol (1980) 0.98

Fast Fluorescence Quenching from Isolated Guard Cell Chloroplasts of Vicia faba Is Induced by Blue Light and Not by Red Light. Plant Physiol (1992) 0.98

Animal models in atherosclerosis research. Exp Mol Pathol (1985) 0.98

Allyl isothiocyanate: comparative disposition in rats and mice. Toxicol Appl Pharmacol (1984) 0.97

Stomata from growth-chamber-grown Vicia faba have an enhanced sensitivity to CO2. Plant Cell Environ (1996) 0.96

Antagonism of analgesics by amine-depleting agents. J Pharm Pharmacol (1965) 0.95

Hormone action at the membrane level. 3. Epinephrine interaction with the rat liver plasma membrane. Biochim Biophys Acta (1971) 0.95

Stomatal Responses to CO(2) in Paphiopedilum and Phragmipedium: Role of the Guard Cell Chloroplast. Plant Physiol (1985) 0.94

Activity of human carcinogens in the Salmonella and rodent bone-marrow cytogenetics tests. Mutat Res (1990) 0.94

Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model. Drug Metab Dispos (1985) 0.94

Metabolism, disposition, and mutagenicity of 2,6-diaminotoluene, a mutagenic noncarcinogen. Drug Metab Dispos (1990) 0.93

Distribution and fate of synthetic lipid vesicles in the mouse: a combined radionuclide and spin label study. Proc Natl Acad Sci U S A (1974) 0.93

Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls. Toxicol Appl Pharmacol (1997) 0.92

Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent. Carcinogenesis (2001) 0.91

Sensory transduction of blue light in guard cells. Trends Plant Sci (2000) 0.91

Regulation of ADPGlucose Synthesis in Guard Cells of Commelina communis. Plant Physiol (1983) 0.91

In vivo distribution of vesicles loaded with radiopharmaceuticals: a study of different routes of administration. J Nucl Med (1975) 0.91

Mutagenic activity of chemical carcinogens and related compounds in the intraperitoneal host-mediated assay. J Natl Cancer Inst (1979) 0.91

Metabolism and disposition of diethylene glycol in rat and dog. Drug Metab Dispos (1992) 0.91

Metabolism and disposition of luminol in the rat. Xenobiotica (2000) 0.90

Relationship of hepatocarcinogenicity and hepatocellular proliferation induced by mutagenic noncarcinogens vs carcinogens. II. 1- vs 2-nitropropane. Toxicol Appl Pharmacol (1991) 0.90

In vitro estrogenicity of the catechol metabolites of selected polychlorinated biphenyls. Toxicol Appl Pharmacol (1999) 0.90

Phthalate ester testing in the National Toxicology Program's environmental mutagenesis test development program. Environ Health Perspect (1982) 0.90

Hematologic toxicity of AZT and ddC administered as single agents and in combination to rats and mice. Fundam Appl Toxicol (1991) 0.89

Pharmacokinetics of halogenated hydrocarbons. Ann N Y Acad Sci (1979) 0.89

Evaluations of a patient isolator system. 3. Microbial contamination of the isolator interior. Arch Environ Health (1965) 0.89

2,3,7,8-Tetrachlorodibenzofuran tissue distribution and excretion in guinea pig. Toxicol Appl Pharmacol (1981) 0.89

Effects of 1,1-dichloro-2,2-bis[p-chlorophenyl]ethylene (DDE) on lactation in rats. J Toxicol Environ Health (1986) 0.89

Naturally occurring schwannoma in a Fischer 344 rat. Vet Pathol (1988) 0.89

Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing. Mutat Res (2006) 0.89

Glutathione metabolism by gamma-glutamyltranspeptidase leads to lipid peroxidation: characterization of the system and relevance to hepatocarcinogenesis. Carcinogenesis (1993) 0.88

Distribution and excretion of 2,4,5,2',4',5'-hexabromobiphenyl, the major component of Firemaster BP-6. J Toxicol Environ Health (1977) 0.88

Biochemical responses of rat and mouse lung to inhaled nickel compounds. Toxicology (1989) 0.88

Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ Mol Mutagen (1989) 0.88

Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escherichia coli. Environ Mutagen (1985) 0.88

Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chem Res Toxicol (1995) 0.87

Relationship between the time of sustained ethyl acrylate forestomach hyperplasia and carcinogenicity. Environ Health Perspect (1993) 0.87