Published in Antimicrob Agents Chemother on July 01, 1994
Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob Agents Chemother (1995) 5.64
Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother (2001) 5.23
Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria. Antimicrob Agents Chemother (2000) 3.22
DNA topoisomerase targets of the fluoroquinolones: a strategy for avoiding bacterial resistance. Proc Natl Acad Sci U S A (1997) 2.99
A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother (2000) 2.91
In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM. Antimicrob Agents Chemother (1999) 2.90
Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1999) 2.11
Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1997) 2.06
Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1995) 1.84
MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane-damaging agents dependent upon the AlgU stress response sigma factor. Antimicrob Agents Chemother (2008) 1.17
Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. Antimicrob Agents Chemother (2008) 1.15
Role of mutations in DNA gyrase genes in ciprofloxacin resistance of Pseudomonas aeruginosa susceptible or resistant to imipenem. Antimicrob Agents Chemother (1995) 1.13
Pharmacodynamics of levofloxacin against Pseudomonas aeruginosa with reduced susceptibility due to different efflux pumps: do elevated MICs always predict reduced in vivo efficacy? Antimicrob Agents Chemother (2006) 0.93
Cloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IV. Antimicrob Agents Chemother (1999) 0.91
Overexpression of MexCD-OprJ reduces Pseudomonas aeruginosa virulence by increasing its susceptibility to complement-mediated killing. Antimicrob Agents Chemother (2014) 0.86
In vivo oral efficacy of levofloxacin for treatment of systemic Pseudomonas aeruginosa infections in a murine model of septicemia. Antimicrob Agents Chemother (1996) 0.86
In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents. Antimicrob Agents Chemother (1983) 21.48
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob Agents Chemother (1990) 11.71
Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes. Antimicrob Agents Chemother (1984) 6.81
Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli. Antimicrob Agents Chemother (1986) 6.03
Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1987) 4.96
Cross-resistance to nalidixic acid, trimethoprim, and chloramphenicol associated with alterations in outer membrane proteins of Klebsiella, Enterobacter, and Serratia. J Infect Dis (1985) 4.52
New norfloxacin resistance gene in Pseudomonas aeruginosa PAO. Antimicrob Agents Chemother (1990) 3.71
In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother (1988) 3.52
Some properties of subunits of DNA gyrase from Pseudomonas aeruginosa PAO1 and its nalidixic acid-resistant mutant. J Bacteriol (1987) 3.04
Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1990) 2.17
Characterization of mechanisms of quinolone resistance in Pseudomonas aeruginosa strains isolated in vitro and in vivo during experimental endocarditis. Antimicrob Agents Chemother (1989) 2.05
Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1992) 1.69
Broad-host-range gyrase A gene probe. Antimicrob Agents Chemother (1990) 1.38
Plasmid-mediated gentamicin resistance of Pseudomonas aeruginosa and its lack of expression in Escherichia coli. Antimicrob Agents Chemother (1982) 1.38
In vitro activity of OPC-17116. Antimicrob Agents Chemother (1992) 1.26
Cloning and characterization of a DNA fragment that complements the nfxB mutation in Pseudomonas aeruginosa PAO. FEMS Microbiol Lett (1991) 1.26
The in-vitro activity of Bay y 3118, a new chlorofluoroquinolone. J Antimicrob Chemother (1993) 1.17
Lipopolysaccharide alterations responsible for combined quinolone and beta-lactam resistance in Pseudomonas aeruginosa. Chemotherapy (1992) 0.89
In vitro antibacterial activity of AM-715, a new nalidixic acid analog. Antimicrob Agents Chemother (1980) 26.28
In vitro and in vivo activity of DL-8280, a new oxazine derivative. Antimicrob Agents Chemother (1982) 21.31
Comparative activities of AM-715 and pipemidic and nalidixic acids against experimentally induced systemic and urinary tract infections. Antimicrob Agents Chemother (1981) 8.59
Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection (1984) 7.53
In vitro and in vivo antibacterial activity of T-1220, a new semisynthetic penicillin. Antimicrob Agents Chemother (1977) 7.35
Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia. Antimicrob Agents Chemother (1982) 7.11
Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1991) 7.10
Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli. Antimicrob Agents Chemother (1986) 6.03
Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12. Antimicrob Agents Chemother (1986) 6.00
The purification and properties of penicillin beta-lactamases mediated by transmissible R factors in Escherichia coli. J Biochem (1969) 5.35
Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1987) 4.96
In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin. Antimicrob Agents Chemother (1979) 4.49
In vitro activity of AT-4140 against clinical bacterial isolates. Antimicrob Agents Chemother (1989) 4.38
Purification and properties of a new beta-lactamase from Pseudomonas cepacia. Antimicrob Agents Chemother (1980) 4.09
In vitro and in vivo activity of NY-198, a new difluorinated quinolone. Antimicrob Agents Chemother (1987) 3.84
In vitro and in vivo antibacterial activity of AT-2266. Antimicrob Agents Chemother (1983) 3.80
New norfloxacin resistance gene in Pseudomonas aeruginosa PAO. Antimicrob Agents Chemother (1990) 3.71
Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli. Antimicrob Agents Chemother (1986) 3.69
Antibacterial activity of apalcillin (PC-904) against gram-negative bacilli, especially ampicillin-, carbenicillin-, and gentamicin-resistant clinical isolates. Antimicrob Agents Chemother (1978) 3.65
Biochemical properties of beta-lactamase produced by Flavobacterium odoratum. Antimicrob Agents Chemother (1985) 3.62
Properties of novel beta-lactamase produced by Bacteroides fragilis. Antimicrob Agents Chemother (1983) 3.59
In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother (1988) 3.52
Induction of beta-lactamase by various beta-lactam antibiotics in Enterobacter cloacae. Antimicrob Agents Chemother (1980) 3.48
Plasmid-mediated penicillin beta-lactamases in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1976) 3.40
Variant of penicillinase mediated by an R factor in Escherichia coli. J Bacteriol (1970) 3.33
In vitro and in vivo antibacterial activities of CS-807, a new oral cephalosporin. Antimicrob Agents Chemother (1987) 3.12
Determination of the ID50 values of antibacterial agents in agar. J Antibiot (Tokyo) (1978) 3.08
Purification and properties of an inducible cephalosporinase from Pseudomonas maltophilia GN12873. Antimicrob Agents Chemother (1984) 3.07
Drug resistance of enteric bacteria. XIV. Comparison of beta-lactamases in gram-negative rod bacteria resistant to alpha-aminobenzylpenicillin. Jpn J Microbiol (1968) 3.04
Some properties of subunits of DNA gyrase from Pseudomonas aeruginosa PAO1 and its nalidixic acid-resistant mutant. J Bacteriol (1987) 3.04
In vitro and in vivo antibacterial activity of AB206, a new naphthyridine derivative. Antimicrob Agents Chemother (1980) 2.98
Activity of beta-lactamase produced by Bacteroides fragilis against newly introduced cephalosporins. Antimicrob Agents Chemother (1980) 2.76
Beta-lactamase stability and antibacterial activity of cefmenoxime (SCE-1365), a novel cephalosporin. Antimicrob Agents Chemother (1981) 2.72
Biochemical properties of a penicillin beta-lactamase mediated by R factor from Bordetella bronchiseptica. Antimicrob Agents Chemother (1975) 2.70
Comparative studies of penicillin-binding proteins in Pseudomonas aeruginosa and Escherichia coli. Eur J Biochem (1979) 2.58
Phosphorylative inactivation of aminoglycosidic antibiotics by Escherichia coli carrying R factor. Science (1967) 2.55
Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains. Antimicrob Agents Chemother (1980) 2.53
Biochemical properties of a cephalosporin beta-lactamase from Pseudomonas aeruginosa. Jpn J Microbiol (1973) 2.50
In vitro activity of AT-4140 against quinolone- and methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (1990) 2.43
Purification and some properties of a cephalosporinase from Proteus vulgaris. Antimicrob Agents Chemother (1981) 2.42
Purification and properties of a cephalosporinase from Enterobacter cloacae. Antimicrob Agents Chemother (1980) 2.37
Norfloxacin resistance in a clinical isolate of Escherichia coli. Antimicrob Agents Chemother (1987) 2.33
Detection of carbapenemase-producing Acinetobacter baumannii in a hospital. J Clin Microbiol (2000) 2.29
Purification and properties of chromosomally mediated beta-lactamase from Citrobacter freundii GN7391. J Gen Microbiol (1980) 2.28
Properties of a new penicillinase type produced by Bacteroides fragilis. Antimicrob Agents Chemother (1982) 2.27
In vitro antibacterial activity of DR-3355, the S-(-)-isomer of ofloxacin. Chemotherapy (1990) 2.19
Letter: Two beta-lactamase inhibitors produced by a streptomyces. J Antibiot (Tokyo) (1973) 2.16
Drug resistance to staphylococci. 3. Resistance to some macrolide antibiotics and inducible system. Jpn J Microbiol (1966) 2.13
In vitro activity of T-3761, a new fluoroquinolone. Antimicrob Agents Chemother (1992) 2.10
Biochemical properties of beta-lactamase produced by Legionella gormanii. Antimicrob Agents Chemother (1986) 2.10
In vitro and in vivo antibacterial activities of ME1207, a new oral cephalosporin. Antimicrob Agents Chemother (1988) 2.08
In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I. Antimicrob Agents Chemother (1990) 2.05
In vitro antibacterial activity of AM-1155, a novel 6-fluoro-8-methoxy quinolone. Antimicrob Agents Chemother (1994) 1.96
Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother (1988) 1.93
Comparison of penicillinases produced by R factors isolated from ampicillin-resistant gram-negative bacteria. Jpn J Microbiol (1970) 1.92
Purification and properties of cephalosporinase in Escherichia coli. Antimicrob Agents Chemother (1980) 1.90
Antibacterial activities of SM-1652 compared with those of other broad-spectrum cephalosporins. Antimicrob Agents Chemother (1982) 1.88
In vitro and in vivo antibacterial activity of T-1982, a new semisynthetic cephamycin antibiotic. Antimicrob Agents Chemother (1982) 1.87
Cloning and expression in Enterobacteriaceae of the extended-spectrum beta-lactamase gene from a Pseudomonas aeruginosa plasmid. FEMS Microbiol Lett (1994) 1.83
Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase. J Infect Chemother (2001) 1.75
Penicillinases of Klebsiella pneumoniae and their phylogenetic relationship to penicillinases mediated by R factors. J Bacteriol (1973) 1.74
Demonstration of R factors from Pseudomonas aeruginosa. Antimicrob Agents Chemother (1974) 1.73
nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1995) 1.73
Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1992) 1.69
Cephalosporinase interactions and antimicrobial activity of BMY-28142, ceftazidime and cefotaxime. J Antibiot (Tokyo) (1988) 1.69
Mapping of the gene specifying aminoglycoside 3'-phosphotransferase II on the Pseudomonas aeruginosa chromosome. J Bacteriol (1983) 1.68
In-vitro and in-vivo antibacterial activity of imipenem against clinical isolates of bacteria. J Antimicrob Chemother (1983) 1.63
R factor-mediated aminoglycoside antibiotic resistance in Pseudomonas aeruginosa: a new aminoglycoside 6'-N-acetyltransferase. Antimicrob Agents Chemother (1975) 1.61
Insertion of a carbapenemase gene cassette into an integron of a Pseudomonas aeruginosa plasmid. J Antimicrob Chemother (1996) 1.61
A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant. Appl Microbiol Biotechnol (2002) 1.58
New antipseudomonal penicillin, PC-904: affinity to penicillin-binding proteins and inhibition of the enzyme cross-linking peptidoglycan. Antimicrob Agents Chemother (1978) 1.55
Distribution of R factors among Shigella strains isolated in Japan (II). Jpn J Microbiol (1973) 1.55
Acetylation of amikacin, a new semisynthetic antibiotic, by Pseudomonas aeruginosa carrying an R factor. Antimicrob Agents Chemother (1975) 1.52
Role of permeability in the activities of beta-lactams against gram-negative bacteria which produce a group 3 beta-lactamase. Antimicrob Agents Chemother (1999) 1.52
Purification and biochemical properties of beta-lactamase produced by Proteus rettgeri. Antimicrob Agents Chemother (1980) 1.52
Enzymatic inactivation of gentamicin C components by cell-free extract from Pseudomonas aeruginosa. J Antibiot (Tokyo) (1971) 1.52
Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus. Antimicrob Agents Chemother (1991) 1.51
The R factors. J Infect Dis (1969) 1.51
Imipenem and cephem resistant Pseudomonas aeruginosa carrying plasmids coding for class B beta-lactamase. J Antimicrob Chemother (1996) 1.50
Transmissible drug-ressistance factor R with special reference to replication. Gunma J Med Sci (1965) 1.50
Drug resistance of enteric bacteria. IX. Distribution of R factors in gram-negative bacteria from clinical sources. J Bacteriol (1967) 1.47
Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains. Antimicrob Agents Chemother (1980) 1.45
Drug resistance of staphylococci. IX. Inducible resistance to macrolide antibiotics in Staphylococcus aureus. Jpn J Microbiol (1968) 1.43
Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus. Antimicrob Agents Chemother (1991) 1.42
Sequences of homologous beta-lactamases from clinical isolates of Serratia marcescens with different substrate specificities. Antimicrob Agents Chemother (1998) 1.40
Beta-lactamase formation and resistance of Proteus morganii to various penicillins and cephalosporins. Jpn J Microbiol (1974) 1.39
Plasmid-mediated gentamicin resistance of Pseudomonas aeruginosa and its lack of expression in Escherichia coli. Antimicrob Agents Chemother (1982) 1.38