Published in Am J Pathol on December 01, 1994
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science (1987) 8.29
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science (1990) 4.71
Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol (1994) 3.19
Normal and abnormal biology of the beta-amyloid precursor protein. Annu Rev Neurosci (1994) 2.81
Prion protein is necessary for normal synaptic function. Nature (1994) 2.69
Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia. Ann Neurol (1979) 2.50
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A (1989) 2.48
Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci (1993) 2.12
The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition. Ann Neurol (1989) 2.07
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc Natl Acad Sci U S A (1990) 1.66
Inherited prion disease with 144 base pair gene insertion. 2. Clinical and pathological features. Brain (1992) 1.66
Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J Neurosci (1993) 1.54
beta-Amyloid precursor protein mRNA is increased in inclusion-body myositis muscle. Neuroreport (1993) 1.19
Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels. Science (1994) 1.14
Paired helical filament tau in Alzheimer's disease. The kinase connection. Am J Pathol (1994) 1.12
Prion diseases and neurodegeneration. Annu Rev Neurosci (1994) 1.11
New advances in inclusion-body myositis. Curr Opin Rheumatol (1993) 1.00
A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred. Brain Res (1993) 0.97
Beta PP participates in PrP-amyloid plaques of Gerstmann-Sträussler-Scheinker disease, Indiana kindred. J Neuropathol Exp Neurol (1993) 0.95
Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cells. J Neurosci Res (1992) 0.95
Prion protein is strongly immunolocalized at the postsynaptic domain of human normal neuromuscular junctions. Neurosci Lett (1993) 0.93
Abnormal accumulation of prion protein mRNA in muscle fibers of patients with sporadic inclusion-body myositis and hereditary inclusion-body myopathy. Am J Pathol (1994) 0.90
Strong immunoreactivity of beta-amyloid precursor protein, including the beta-amyloid protein sequence, at human neuromuscular junctions. Neurosci Lett (1992) 0.87
Creutzfeldt-Jakob disease and cerebral amyloid angiopathy. Acta Neuropathol (1994) 0.84
Amyloid fibril formation in the rough endoplasmic reticulum of plasma cells from a patient with localized A lambda amyloidosis. Lab Invest (1991) 0.83
Dorothy Russell Memorial Lecture. The molecular pathology of Alzheimer's disease: are we any closer to understanding the neurodegenerative process? Neuropathol Appl Neurobiol (1994) 0.82
Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol (2001) 4.80
Mitochondrial abnormalities in Alzheimer's disease. J Neurosci (2001) 4.39
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Copernicus revisited: amyloid beta in Alzheimer's disease. Neurobiol Aging (2001) 3.48
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci U S A (1997) 3.47
The family health worker. Am J Public Health Nations Health (1968) 3.34
Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci (1997) 3.08
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc Natl Acad Sci U S A (1987) 2.97
RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci (1999) 2.86
Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc Natl Acad Sci U S A (1985) 2.86
4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem (1997) 2.80
Oxidative damage in Alzheimer's. Nature (1996) 2.55
Radical AGEing in Alzheimer's disease. Trends Neurosci (1995) 2.32
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol (1999) 2.31
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol (2000) 2.11
The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition. Ann Neurol (1989) 2.07
Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases. Proc Natl Acad Sci U S A (1988) 2.04
Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci U S A (1994) 1.91
Prepregnancy body mass index and pregnancy weight gain: associations with preterm delivery. The NMIHS Collaborative Study Group. Obstet Gynecol (2000) 1.91
Oxidative stress in Alzheimer's disease. Biochim Biophys Acta (2000) 1.84
Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nat Med (1995) 1.69
Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem (2001) 1.68
Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers. Annu Rev Nutr (1992) 1.68
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem (1998) 1.68
Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem (2001) 1.64
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am J Pathol (1994) 1.62
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. J Neurochem (2000) 1.60
Causes of oxidative stress in Alzheimer disease. Cell Mol Life Sci (2007) 1.59
Filaments of Lewy bodies contain insoluble cytoskeletal elements. Am J Pathol (1992) 1.55
Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J Neurosci (1993) 1.54
Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways. J Neurochem (2005) 1.53
Association of apolipoprotein E with murine amyloid A protein amyloid. Lab Invest (1995) 1.52
Activation of NADPH oxidase in Alzheimer's disease brains. Biochem Biophys Res Commun (2000) 1.51
Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles. J Neuropathol Exp Neurol (1988) 1.49
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mech Ageing Dev (2001) 1.47
Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol (2000) 1.42
Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. Am J Pathol (1990) 1.41
Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci U S A (1991) 1.41
Phosphorylation of neurofilaments is altered in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol (1988) 1.40
The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Am J Pathol (1990) 1.40
Oxidative stress signaling in Alzheimer's disease. Curr Alzheimer Res (2008) 1.38
Postradiotherapy prostate biopsies: what do they really mean? Results for 498 patients. Int J Radiat Oncol Biol Phys (2000) 1.37
Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neural Transm (Vienna) (1998) 1.35
Redox-active iron mediates amyloid-beta toxicity. Free Radic Biol Med (2001) 1.35
Forearm glucose uptake during the oral glucose tolerance test in normal subjects. Diabetes (1973) 1.34
Amyloid precursor protein in senile plaques of Alzheimer disease. Lancet (1988) 1.33
Hirano body filaments contain actin and actin-associated proteins. J Neuropathol Exp Neurol (1987) 1.32
Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome. J Neuropathol Exp Neurol (2000) 1.31
Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Am J Pathol (1998) 1.29
Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. J Histochem Cytochem (1998) 1.27
Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Res (1998) 1.26
Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles. Proc Natl Acad Sci U S A (1991) 1.26
Hibernation, a model of neuroprotection. Am J Pathol (2001) 1.24
Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol Disord Drug Targets (2007) 1.24
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc. J Biol Chem (2000) 1.24
Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. J Neurochem (1995) 1.20
Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease. Antioxid Redox Signal (2000) 1.17
Alz 50 recognizes abnormal filaments in Alzheimer's disease and progressive supranuclear palsy. Ann Neurol (1988) 1.17
Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp Neurol (1998) 1.17
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. J Neurochem (2000) 1.16
Monitoring kinetic and frequency-domain properties of eyelid responses in mice with magnetic distance measurement technique. J Neurophysiol (2002) 1.15
Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes. Eur J Cell Biol (1988) 1.15
Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine. Free Radic Biol Med (2001) 1.14
Hirano bodies contain tau protein. Brain Res (1987) 1.14
A primate model for human cerebral malaria: Plasmodium coatneyi-infected rhesus monkeys. Am J Trop Med Hyg (1992) 1.14
Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res (1993) 1.13
Ubiquitin is present on the cytokeratin intermediate filaments and Mallory bodies of hepatocytes. Lab Invest (1988) 1.12
The glucose transporter of the human brain and blood-brain barrier. Ann Neurol (1988) 1.12
Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease. Acta Neuropathol (1995) 1.12
Neurofilament proteins in neurodegenerative diseases. Cell Mol Life Sci (2004) 1.12
Learning invariant object recognition in the visual system with continuous transformations. Biol Cybern (2005) 1.10
Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease. Brain Res (1996) 1.10
Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology. J Nutr Health Aging (2006) 1.09
Homocysteine and folate in healthy east London Bangladeshis. Lancet (1998) 1.09
Oxidative RNA damage and neurodegeneration. Curr Med Chem (2007) 1.08
Abnormal localization of iron regulatory protein in Alzheimer's disease. Brain Res (1998) 1.08
Sequestration of iron by Lewy bodies in Parkinson's disease. Acta Neuropathol (2000) 1.07
Selective presence of ubiquitin in intracellular inclusions. Am J Pathol (1989) 1.07
Antibodies to neurofibrillary tangles of Alzheimer's disease raised from human and animal neurofilament fractions. Lab Invest (1983) 1.07
Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease. Ann N Y Acad Sci (1994) 1.07
The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience (1999) 1.06
Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease. J Neurochem (1995) 1.06
Apoptosis and Alzheimer's disease. Science (1998) 1.06
Effect of polyamines on the metabolism of [16-14C]estradiol by rat-liver microsomes. Biochim Biophys Acta (1967) 1.06
Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain. Neuroreport (1993) 1.05
Neuronal binucleation in Alzheimer disease hippocampus. Neuropathol Appl Neurobiol (2007) 1.05
Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome. Ann N Y Acad Sci (1999) 1.05
Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease. Arch Biochem Biophys (1999) 1.04
Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal aged and Alzheimer's disease brains. Acta Neuropathol (1993) 1.04
Paramyosin and actin in schistosomal teguments. Nature (1988) 1.04
Sexually transmitted infections among UK street-based sex workers. Sex Transm Infect (2007) 1.03
Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J Cell Mol Med (2006) 1.03
Filaments of Pick's bodies contain altered cytoskeletal elements. Am J Pathol (1987) 1.03
Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein. J Neurochem (2001) 1.02
Abortive apoptosis in Alzheimer's disease. Acta Neuropathol (2001) 1.02
Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysis. Neurobiol Dis (2013) 1.02
Immunocytochemical localization of the erythroid glucose transporter: abundance in tissues with barrier functions. J Neurosci (1990) 1.01
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. Biochem Biophys Res Commun (1989) 1.01
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. J Neurochem (2001) 1.01
Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease. J Histochem Cytochem (1991) 1.01