Published in Cell on August 26, 1994
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A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J Cell Biol (1996) 1.55
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Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol. Mol Cancer (2010) 1.50
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Loss of matrix adhesion triggers rapid transformation-selective apoptosis in fibroblasts. J Cell Biol (1997) 1.38
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Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction. BMC Cancer (2006) 1.35
DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective. EMBO J (1995) 1.33
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Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs. J Clin Invest (2000) 1.22
p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study. Br J Cancer (1997) 1.21
Inhibition of apoptosis in human tumour cells by the tumour-associated serpin, SCC antigen-1. Br J Cancer (2000) 1.20
Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression. J Cell Biol (1995) 1.20
Mutant adenovirus type 9 E4 ORF1 genes define three protein regions required for transformation of CREF cells. J Virol (1997) 1.20
The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Mol Cell Biol (1997) 1.15
Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1. Mol Cell Biol (1996) 1.13
BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc Natl Acad Sci U S A (1996) 1.13
The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage. Proc Natl Acad Sci U S A (1995) 1.12
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Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia (2002) 1.11
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Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci U S A (1997) 1.10
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Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light. Br J Cancer (1999) 1.01
Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer. Br J Cancer (1999) 1.01
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Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells. World J Gastroenterol (2008) 0.99
Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis. Mol Pathol (1997) 0.97
Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes. J Clin Invest (1998) 0.96
A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol Cell Biol (2000) 0.96
Induction of apoptosis by TPA and VP-16 is through translocation of TR3. World J Gastroenterol (2002) 0.95
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Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX. Br J Cancer (1996) 0.94
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Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Int J Cancer (2013) 0.94
In vitro analysis of ovarian cancer response to cisplatin, carboplatin, and paclitaxel identifies common pathways that are also associated with overall patient survival. Br J Cancer (2012) 0.93
Impression cytology following mitomycin C therapy for ocular surface squamous neoplasia. Br J Ophthalmol (2001) 0.93
Melatonin and doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines. World J Gastroenterol (2010) 0.93
Antitumor activity and prolonged expression from a TRAIL-expressing adenoviral vector. Neoplasia (2002) 0.91
Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines. Br J Cancer (1998) 0.90
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p53 and cancer therapy: a double-edged sword. J Clin Invest (1999) 0.90
Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence. Neoplasia (2001) 0.89
Directing DNA methylation to inhibit gene expression. Cell Mol Neurobiol (2006) 0.89
Anti-Cripto Mab inhibit tumour growth and overcome MDR in a human leukaemia MDR cell line by inhibition of Akt and activation of JNK/SAPK and bad death pathways. Br J Cancer (2007) 0.89
Hormonal regulation of physiological cell turnover and apoptosis. Cell Tissue Res (2000) 0.89
Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. PLoS One (2009) 0.89
Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells. Oncotarget (2012) 0.88
Nuclear accumulation of p53 correlates significantly with clinical features and inversely with the expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in pancreatic cancer. Br J Cancer (1997) 0.88
Noninvasive molecular imaging of apoptosis in a mouse model of anthracycline-induced cardiotoxicity. Circ Cardiovasc Imaging (2015) 0.88
Regulation of apoptosis-related genes by nitric oxide in cancer. Nitric Oxide (2008) 0.87
Relevance of proliferative and pro-apoptotic factors in non-small-cell lung cancer for patient survival. Br J Cancer (2000) 0.87
Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells. Acta Pharmacol Sin (2011) 0.86
Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion. Oncotarget (2015) 0.86
Pro-apoptotic activity of imidazole derivatives mediated by up-regulation of Bax and activation of CAD in Ehrlich Ascites Tumor cells. Invest New Drugs (2007) 0.86
A potent lead induces apoptosis in pancreatic cancer cells. PLoS One (2012) 0.85
Similarity of apoptosis induction by 2-chlorodeoxyadenosine and cisplatin in human mononuclear blood cells. Br J Cancer (1997) 0.84
Skeletal muscle phenotypically converts and selectively inhibits metastatic cells in mice. PLoS One (2010) 0.84
Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells. J Cancer Res Clin Oncol (2003) 0.84
ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells. Biochim Biophys Acta (2010) 0.84
Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32. J Clin Invest (1996) 0.83