Published in Proc Natl Acad Sci U S A on July 01, 1993
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med (1997) 6.53
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. J Exp Med (1994) 3.02
Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect Immun (2001) 2.94
Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J Exp Med (1995) 2.80
Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev (1996) 2.77
Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med (1999) 2.05
A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun (1995) 1.99
Interleukin 12 at the site of disease in tuberculosis. J Clin Invest (1994) 1.98
Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis. J Exp Med (1995) 1.74
Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J Clin Invest (1995) 1.71
Interleukin-12 is required for control of the growth of attenuated aromatic-compound-dependent salmonellae in BALB/c mice: role of gamma interferon and macrophage activation. Infect Immun (1998) 1.69
Effect of interleukin 12 neutralization on host resistance and gamma interferon production in mouse typhoid. Infect Immun (1996) 1.66
Interleukin-12 in infectious diseases. Clin Microbiol Rev (1997) 1.63
A primer on cytokines: sources, receptors, effects, and inducers. Clin Microbiol Rev (1997) 1.57
Effects of protein calorie malnutrition on tuberculosis in mice. Proc Natl Acad Sci U S A (1996) 1.39
Macrophage migration inhibitory factor release by macrophages after ingestion of Plasmodium chabaudi-infected erythrocytes: possible role in the pathogenesis of malarial anemia. Infect Immun (2000) 1.37
Interleukin-12 regulation of host defenses against Coccidioides immitis. Infect Immun (1996) 1.27
Therapy with a combination of low doses of interleukin 12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection. Infect Immun (1999) 1.19
Natural killer cell receptors specific for major histocompatibility complex class I molecules. Proc Natl Acad Sci U S A (1995) 1.16
Mechanism of entry determines the ability of Toxoplasma gondii to inhibit macrophage proinflammatory cytokine production. Infect Immun (2002) 1.08
Etiology of sarcoidosis: does infection play a role? Yale J Biol Med (2012) 1.08
Interleukin-12-stimulated natural killer cells can activate human macrophages to inhibit growth of Mycobacterium avium. Infect Immun (1995) 1.06
Regulation of cytokine production by soluble CD23: costimulation of interferon gamma secretion and triggering of tumor necrosis factor alpha release. J Exp Med (1994) 1.06
Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections. Biomaterials (2009) 1.05
Interleukin-12 and tumor necrosis factor alpha mediate innate production of gamma interferon by group B Streptococcus-treated splenocytes of severe combined immunodeficiency mice. Infect Immun (1996) 1.03
Cardiac myosin and the TH1/TH2 paradigm in autoimmune myocarditis. Am J Pathol (2001) 1.02
Interleukin-12 is critical for induction of nitric oxide-mediated immunosuppression following vaccination of mice with attenuated Salmonella typhimurium. Infect Immun (1997) 1.01
Role of interleukin 12 in experimental neonatal sepsis caused by group B streptococci. Infect Immun (1997) 0.98
CD2 regulates responsiveness of activated T cells to interleukin 12. J Exp Med (1995) 0.97
Performance characteristics of putative tests for subclinical chorioamnionitis. Infect Dis Obstet Gynecol (2001) 0.96
Interferon gamma-independent rejection of interleukin 12-transduced carcinoma cells requires CD4+ T cells and Granulocyte/Macrophage colony-stimulating factor. J Exp Med (1998) 0.92
Administration of killed bacteria together with listeriolysin O induces protective immunity against Listeria monocytogenes in mice. Immunology (1998) 0.90
IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression. Immunology (1995) 0.88
Transient control of interleukin-4-producing natural killer T cells in the livers of Listeria monocytogenes-infected mice by interleukin-12. Infect Immun (1997) 0.88
Antigen-specific T-cell responses during primary and secondary Listeria monocytogenes infection. Infect Immun (1994) 0.87
Interleukin 12 exerts a differential effect on the maturation of neonatal and adult human CD45R0- CD4 T cells. J Clin Invest (1994) 0.85
Legionella pneumophila evades gamma interferon-mediated growth suppression through interleukin-10 induction in bone marrow-derived macrophages. Infect Immun (2005) 0.83
Inhibition of human interleukin-12 production by pentoxifylline. Immunology (1997) 0.83
Increased IL-12 release by monocytes in nephrotic patients. Clin Exp Immunol (1999) 0.83
Interleukin-12 up-regulates perforin- and Fas-mediated lymphokine-activated killer activity by intestinal intraepithelial lymphocytes. Clin Exp Immunol (2004) 0.80
Reduced interleukin-12, interleukin-18, and interferon-gamma production with prolonged rat hepatic allograft survival after donor-specific blood transfusion. Dig Dis Sci (2000) 0.78
Activation of mononuclear cells by interleukin-12: an in vivo study in chimpanzees. J Clin Immunol (1999) 0.75
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science (1993) 19.80
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med (1991) 16.81
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80
IL-4 directs the development of Th2-like helper effectors. J Immunol (1990) 7.20
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci U S A (1993) 6.87
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci U S A (1993) 6.33
Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med (1993) 5.75
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc Natl Acad Sci U S A (1992) 5.55
Induction of TH1 and TH2 responses: a key role for the 'natural' immune response? Immunol Today (1992) 4.63
Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli. Infect Immun (1991) 4.18
Natural immunity: a T-cell-independent pathway of macrophage activation, defined in the scid mouse. Immunol Rev (1991) 3.49
IL-12: initiation cytokine for cell-mediated immunity. Science (1993) 2.97
Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens. J Leukoc Biol (1991) 2.30
Interferon gamma inhibits interleukin 10 production by monocytes. J Exp Med (1993) 1.96