Published in Proc Natl Acad Sci U S A on February 15, 1994
Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain. Proc Natl Acad Sci U S A (1994) 2.34
14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol Cell Biol (1998) 2.07
A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. Mol Cell Biol (1995) 1.82
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol (1997) 1.76
Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro. Mol Cell Biol (1995) 1.60
Physical modulation of intracellular signaling processes by locational regulation. Biophys J (1997) 1.32
Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins. EMBO J (1995) 1.32
Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol Cell Biol (1995) 1.29
Biochemical and biological analysis of Mek1 phosphorylation site mutants. Mol Biol Cell (1995) 1.28
Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling. EMBO J (1998) 1.07
The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway. J Exp Med (1995) 1.05
Activation of (His)6-Raf-1 in vitro by partially purified plasma membranes from v-Ras-transformed and serum-stimulated fibroblasts. Proc Natl Acad Sci U S A (1994) 1.02
Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase. EMBO J (1995) 1.00
Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway. J Clin Invest (1998) 0.94
Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: single-molecule imaging analysis. J Biol Chem (2011) 0.88
Interconnected network motifs control podocyte morphology and kidney function. Sci Signal (2014) 0.87
Mitochondrial ATP production is necessary for activation of the extracellular-signal-regulated kinases during ischaemia/reperfusion in rat myocyte-derived H9c2 cells. Biochem J (2000) 0.87
Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells. J Exp Med (1995) 0.87
Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner. Stem Cells (2015) 0.78
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Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature (1988) 7.82
Raf-1 activates MAP kinase-kinase. Nature (1992) 7.05
Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science (1992) 6.80
cPLA2 is phosphorylated and activated by MAP kinase. Cell (1993) 6.61
Activation of the MAP kinase pathway by the protein kinase raf. Cell (1992) 5.95
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell (1992) 5.77
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature (1992) 5.69
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science (1992) 5.55
The periodic association of MAP2 with brain microtubules in vitro. J Cell Biol (1979) 4.97
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell (1989) 4.86
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases. Nature (1991) 4.35
Complex formation between RAS and RAF and other protein kinases. Proc Natl Acad Sci U S A (1993) 4.30
Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J Biol Chem (1991) 3.81
Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. Proc Natl Acad Sci U S A (1991) 3.57
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci U S A (1988) 3.52
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev (1992) 3.46
Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature (1985) 2.82
Separation and characterization of microtubule proteins from calf brain. Biochemistry (1977) 2.71
Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J Biol Chem (1993) 2.55
Purification of a hepatic S6 kinase from cycloheximide-treated Rats. J Biol Chem (1989) 2.44
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Raf-1: a kinase currently without a cause but not lacking in effects. Cell (1991) 1.68
Purification and characterization of the zeta isoform of protein kinase C from bovine kidney. J Biol Chem (1992) 1.66
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Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO J (1990) 1.55
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Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation. J Biol Chem (1990) 1.49
Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. Oncogene (1992) 1.48
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Mol Cell Biol (1993) 1.40
Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf. J Biol Chem (1990) 1.36
Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation. J Biol Chem (1991) 1.30
Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J Biol Chem (1993) 1.26
Insulin-activated protein kinases phosphorylate a pseudosubstrate synthetic peptide inhibitor of the p70 S6 kinase. J Biol Chem (1991) 1.23
Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains. Proc Natl Acad Sci U S A (1993) 1.17
Insulin activates the Raf-1 protein kinase. J Biol Chem (1990) 1.14
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15
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Phosphorylation of c-jun mediated by MAP kinases. Nature (1991) 8.07
Raf-1 activates MAP kinase-kinase. Nature (1992) 7.05
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature (1996) 6.75
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (1995) 6.20
Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem (1998) 5.99
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Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (1993) 5.23
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol (1998) 5.04
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science (1992) 5.00
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature (1995) 5.00
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88
Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature (2001) 4.82
Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem (1996) 4.49
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37
Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature (1991) 4.04
Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays (1996) 3.96
Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest (1996) 3.73
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res (1997) 3.55
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci U S A (1988) 3.52
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev (1992) 3.46
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem (1998) 3.29
Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int (2007) 3.23
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol (2000) 3.08
Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A (1992) 3.01
Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science (1991) 2.99
A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature (1998) 2.89
Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury. Kidney Int (2007) 2.86
Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem Sci (1994) 2.75
Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem (1997) 2.73
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol Cell Biol (2001) 2.72
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol (2000) 2.70
Identification of the major phosphorylation sites of the Raf-1 kinase. J Biol Chem (1993) 2.70
Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells. J Biol Chem (1999) 2.65
A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc Natl Acad Sci U S A (1996) 2.54
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J Biol Chem (1999) 2.49
The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc Natl Acad Sci U S A (1994) 2.46
Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J Biol Chem (1998) 2.46
Purification of a hepatic S6 kinase from cycloheximide-treated Rats. J Biol Chem (1989) 2.44
Multiple independent inputs are required for activation of the p70 S6 kinase. Mol Cell Biol (1995) 2.39
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol Cell Biol (1992) 2.34
Intracellular signalling: PDK1--a kinase at the hub of things. Curr Biol (1999) 2.31
Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature (1996) 2.29
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Mechanism of inhibition of Raf-1 by protein kinase A. Mol Cell Biol (1994) 2.18
MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci U S A (1999) 2.16
Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc Natl Acad Sci U S A (1995) 2.06
The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J Biol Chem (1996) 2.06
Sequence analysis of zein cDNAs obtained by an efficient mRNA cloning method. Nucleic Acids Res (1983) 2.05
A method for cloning full-length cDNA in plasmid vectors. Methods Enzymol (1987) 2.02
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol Cell Biol (1991) 2.00
Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A (2001) 1.98
Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res (2001) 1.87
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J (1993) 1.86
The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J Biol Chem (1994) 1.84
Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr Biol (2001) 1.82
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase. Proc Natl Acad Sci U S A (1990) 1.80
An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase. J Biol Chem (1992) 1.79
Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature (1995) 1.79
Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem (2001) 1.77
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol (1997) 1.76
Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J Biol Chem (1994) 1.74
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. Mol Med (1996) 1.71
Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II. Eur J Biochem (1991) 1.69
Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells. Oncogene (1993) 1.69
Identification of Nore1 as a potential Ras effector. J Biol Chem (1998) 1.69
Insulin regulation of protein biosynthesis in differentiated 3T3 adipocytes. Regulation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem (1985) 1.68
Expression of raf oncogenes activates the PEA1 transcription factor motif. Mol Cell Biol (1989) 1.66
A novel method for site-directed mutagenesis using PCR and uracil DNA glycosylase. PCR Methods Appl (1992) 1.65
Cell biology and molecular mechanisms of injury in ischemic acute renal failure. Curr Opin Nephrol Hypertens (2000) 1.64
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Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252. J Biol Chem (1999) 1.61
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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues. Mol Cell Biol (1994) 1.56
Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells. J Biol Chem (1988) 1.56
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