Ectopic expression of gamma interferon in the eyes of transgenic mice induces ocular pathology and MHC class II gene expression.

PubWeight™: 0.87‹?›

🔗 View Article (PMID 8112978)

Published in Invest Ophthalmol Vis Sci on February 01, 1994

Authors

C E Egwuagu1, J Sztein, C C Chan, W Reid, R Mahdi, R B Nussenblatt, A B Chepelinsky

Author Affiliations

1: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.

Articles by these authors

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84

International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol (1987) 5.13

Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. Am J Ophthalmol (2000) 4.70

Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol (1994) 4.07

Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology (1985) 3.83

Phenol injection of the sympathetic chain. Br J Surg (1970) 3.73

Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. Proc Natl Acad Sci U S A (1999) 3.66

Oncogenesis of the lens in transgenic mice. Science (1987) 3.40

Recoverin-associated retinopathy: a clinically and immunologically distinctive disease. Am J Ophthalmol (1998) 2.89

A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J Immunol (1988) 2.68

Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen. Am J Ophthalmol (1982) 2.61

T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J Immunol (1986) 2.55

Comparison of invasive and noninvasive tests for detecting Helicobacter pylori infection in bleeding peptic ulcers. Gastrointest Endosc (1999) 2.51

Distribution of enzymes forming polysaccharide from sucrose and the composition of extracellular polysaccharide synthesized by Streptococcus mutans. Appl Microbiol (1972) 2.47

Isolation of human T-lymphotropic virus type III from the tears of a patient with the acquired immunodeficiency syndrome. Lancet (1985) 2.45

Conjunctival lesions in adults. A clinical and histopathologic review. Cornea (1987) 2.43

An unusually high prevalence of ocular toxoplasmosis in southern Brazil. Am J Ophthalmol (1992) 2.41

Cyclosporin A therapy in the treatment of intraocular inflammatory disease resistant to systemic corticosteroids and cytotoxic agents. Am J Ophthalmol (1983) 2.30

A randomized, masked, cross-over trial of acetazolamide for cystoid macular edema in patients with uveitis. Ophthalmology (1996) 2.27

Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22

Treatment of cytomegalovirus retinitis with an intraocular sustained-release ganciclovir implant. A randomized controlled clinical trial. Arch Ophthalmol (1994) 2.15

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J Immunol (1990) 2.13

Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology (1984) 2.12

Increased survival of a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis who received sodium phosphonoformate (foscarnet). Am J Med (1993) 2.11

Intraocular lymphoma. Clinical and histopathologic diagnosis. Ophthalmology (1993) 2.10

Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. Retina (1981) 2.05

Infertility among human immunodeficiency virus-positive women: incidence and treatment dilemmas. Hum Reprod (1996) 2.01

Cystoid macular edema after phacoemulsification: relationship to blood-aqueous barrier damage and visual acuity. J Cataract Refract Surg (1999) 1.97

Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease. Histol Histopathol (1997) 1.90

Prospective regional study of planned home births. Home Birth Study Steering Group. BMJ (1996) 1.76

Cellular immune responsiveness of uveitis patients to retinal S-antigen. Am J Ophthalmol (1980) 1.75

Treatment of intraocular inflammatory disease with cyclosporin A. Lancet (1983) 1.74

Pathology of experimental autoimmune uveoretinitis in mice. J Autoimmun (1990) 1.71

Clinical biochemical and pathologic correlations in Bietti's crystalline dystrophy. Am J Ophthalmol (1994) 1.70

Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med (1999) 1.70

Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci (2000) 1.68

IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J Immunol (1997) 1.68

Primary intraocular lymphoma diagnosed by fine needle aspiration biopsy of a subretinal lesion. Retina (2001) 1.67

Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia. Proc Natl Acad Sci U S A (1985) 1.65

Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther (2001) 1.65

Studying promoters and terminators by gene fusion. Science (1983) 1.64

Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. J Comp Neurol (2001) 1.63

Respiratory symptoms of primary school children living in a petrochemical polluted area in Taiwan. Pediatr Pulmonol (1998) 1.61

Cystic adventitial disease of the popliteal artery. Br Med J (1967) 1.59

Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol (1989) 1.57

The role of apoptosis in the pathogenesis of Fuchs endothelial dystrophy of the cornea. Arch Ophthalmol (2001) 1.56

Cyclosporine: immunology, pharmacology and therapeutic uses. Surv Ophthalmol (1987) 1.55

Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530. Bioorg Med Chem Lett (1998) 1.54

Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice. J Immunol (1994) 1.53

Case report: portal vein thrombosis associated with hereditary protein C deficiency: a report of two cases. J Gastroenterol Hepatol (1999) 1.52

Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. Trans Am Ophthalmol Soc (1981) 1.52

Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene rearrangement. Arch Ophthalmol (1999) 1.52

Corneal endothelial deposits in children positive for human immunodeficiency virus receiving rifabutin prophylaxis for Mycobacterium avium complex bacteremia. Am J Ophthalmol (1999) 1.52

Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2. Mol Microbiol (1996) 1.49

Effectiveness of cyclosporin therapy for Behçet's disease. Arthritis Rheum (1985) 1.49

Adoptive transfer of experimental autoimmune uveoretinitis in rats. Immunopathogenic mechanisms and histologic features. Invest Ophthalmol Vis Sci (1985) 1.47

Utility of microdissection and polymerase chain reaction for the detection of immunoglobulin gene rearrangement and translocation in primary intraocular lymphoma. Ophthalmology (1998) 1.46

Medical education in mainland China. J Med Educ (1972) 1.45

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol (1997) 1.44

60Co contamination in recycled steel resulting in elevated civilian radiation doses: causes and challenges. Health Phys (1997) 1.44

32 cases of sympathetic ophthalmia. A retrospective study at the National Eye Institute, Bethesda, Md., from 1982 to 1992. Arch Ophthalmol (1995) 1.43

Evidence against a role for endotoxin in the hyperdynamic circulation of rats with prehepatic portal hypertension. J Hepatol (1999) 1.43

In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats. Am J Vet Res (2001) 1.43

Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals. Clin Exp Immunol (1997) 1.43

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol (2000) 1.43

Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. Am J Ophthalmol (1995) 1.43

Phakic patients with cystoid macular edema, retinal periphlebitis, and vitreous inflammation. Arch Ophthalmol (1998) 1.42

The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment. Invest Ophthalmol Vis Sci (1999) 1.42

Inhibition of prostacyclin by indomethacin ameliorates the splanchnic hyposensitivity to glypressin in haemorrhage-transfused common bile duct-ligated rats. Eur J Clin Invest (2001) 1.40

Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats. J Clin Invest (1981) 1.40

Ocular and central nervous system lymphoma: clinical features and diagnosis. Ocul Immunol Inflamm (2000) 1.39

Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. J Immunol (1996) 1.39

S-antigen uveitis in primates. A new model for human disease. Arch Ophthalmol (1981) 1.39

Discontinuation of anticytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis. JAMA (1999) 1.38

Tandem sequence repeats in transmembrane channel proteins. Trends Biochem Sci (1991) 1.37

Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype. Invest Ophthalmol Vis Sci (1995) 1.37

Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. J Biol Chem (2000) 1.35

Cellular immune responses of patients with uveitis to retinal antigens and their fragments. Am J Ophthalmol (1990) 1.35

Contribution of nitric oxide to the host parasite equilibrium in toxoplasmosis. J Immunol (1996) 1.34

Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev (2001) 1.34

Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Br J Pharmacol (1999) 1.34

Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine. Am J Ophthalmol (1986) 1.34

A follow-up study of Toxoplasma gondii infection in southern Brazil. Am J Ophthalmol (2001) 1.32

Association of interleukin 10 in the vitreous and cerebrospinal fluid and primary central nervous system lymphoma. Arch Ophthalmol (1997) 1.32

Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J Immunol (1998) 1.32

Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response. J Immunol (1997) 1.31

Inflammatory response in the early stages of wound healing after excimer laser keratectomy. Arch Ophthalmol (1998) 1.30

The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor. Bioorg Med Chem Lett (1999) 1.30

Renal histopathologic alterations in patients treated with cyclosporine for uveitis. N Engl J Med (1986) 1.29