Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice.

PubWeight™: 1.53‹?› | Rank: Top 4%

🔗 View Article (PMID 8283058)

Published in J Immunol on January 15, 1994

Authors

R R Caspi1, C C Chan, B G Grubbs, P B Silver, B Wiggert, C F Parsa, S Bahmanyar, A Billiau, H Heremans

Author Affiliations

1: National Eye Institute, Bethesda, MD 20892.

Articles citing this

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med (2008) 5.25

IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol (2009) 2.65

A look at autoimmunity and inflammation in the eye. J Clin Invest (2010) 2.30

Th1 and Th17 cells: adversaries and collaborators. Ann N Y Acad Sci (2010) 2.08

A rush to judgment on Th17. J Exp Med (2008) 2.07

Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest (2006) 2.02

Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med (1999) 1.70

Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol (2009) 1.57

Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype. Am J Pathol (2001) 1.52

The genetic and immunopathological processes underlying collagen-induced arthritis. Immunology (2001) 1.49

Autoimmunity in the immune privileged eye: pathogenic and regulatory T cells. Immunol Res (2008) 1.34

Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity. Arthritis Res (2002) 1.31

Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J Immunol (2008) 1.26

Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford) (2009) 1.26

Cytokines in autoimmune uveitis. J Interferon Cytokine Res (2011) 1.19

Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. Immunology (2011) 1.19

Understanding autoimmune uveitis through animal models. The Friedenwald Lecture. Invest Ophthalmol Vis Sci (2011) 1.11

Rodent models of experimental autoimmune uveitis. Methods Mol Biol (2012) 1.06

Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency. Invest Ophthalmol Vis Sci (2007) 1.06

Apoptotic cells induce dendritic cell-mediated suppression via interferon-gamma-induced IDO. Immunology (2007) 1.04

New perspectives on effector mechanisms in uveitis. Semin Immunopathol (2008) 1.02

Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest (1995) 1.01

Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid. Mol Vis (2011) 0.98

The tumour necrosis factor/TNF receptor superfamily: therapeutic targets in autoimmune diseases. Clin Exp Immunol (2011) 0.92

Updates on the risk markers and outcomes of severe juvenile idiopathic arthritis-associated uveitis. Int J Clin Rheumtol (2013) 0.87

Are cytokine gene polymorphisms associated with outcome in patients with idiopathic intermediate uveitis in the United Kingdom? Br J Ophthalmol (2005) 0.86

Mice lacking the IFN-gamma receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses. Immunogenetics (2005) 0.84

Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. Arthritis Res Ther (2015) 0.80

NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis. J Exp Med (2015) 0.79

Discrepant expression of cytokines in inflammation- and age-related cataract patients. PLoS One (2014) 0.78

Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis. J Immunol (2013) 0.78

Role of IFN-γ in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells. J Leukoc Biol (2011) 0.78

Targeting the complement system for the management of retinal inflammatory and degenerative diseases. Eur J Pharmacol (2016) 0.78

Culture promotes transfer of thyroid epithelial cell hyperplasia and proliferation by reducing regulatory T cell numbers. Cell Immunol (2013) 0.76

Upregulation of DR3 expression in CD4⁺ T cells promotes secretion of IL-17 in experimental autoimmune uveitis. Mol Vis (2011) 0.76

Influence of Interferon-γ Deficiency in Immune Tolerance Induced by Male Islet Transplantation. Immune Netw (2011) 0.75

Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget (2016) 0.75

Expression of MicroRNAs in the Eyes of Lewis Rats with Experimental Autoimmune Anterior Uveitis. Mediators Inflamm (2015) 0.75

Articles by these authors

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest (1999) 5.30

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med (1987) 4.58

Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology (1985) 3.83

Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. Proc Natl Acad Sci U S A (1999) 3.66

Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J Immunol (1997) 3.35

Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease. Science (1987) 3.07

Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc Natl Acad Sci U S A (1989) 3.03

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J Immunol (1988) 2.91

A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity. J Exp Med (1988) 2.90

Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature (1985) 2.87

Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor. Eur J Biochem (1985) 2.77

A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J Immunol (1988) 2.68

Comparison of invasive and noninvasive tests for detecting Helicobacter pylori infection in bleeding peptic ulcers. Gastrointest Endosc (1999) 2.51

Conjunctival lesions in adults. A clinical and histopathologic review. Cornea (1987) 2.43

Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors. Proc Natl Acad Sci U S A (1989) 2.37

Cyclosporin A therapy in the treatment of intraocular inflammatory disease resistant to systemic corticosteroids and cytotoxic agents. Am J Ophthalmol (1983) 2.30

Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice. J Exp Med (1990) 2.25

Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase. J Biol Chem (2000) 2.14

Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts. Eur J Immunol (1987) 2.13

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J Immunol (1990) 2.13

Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology (1984) 2.12

Intraocular lymphoma. Clinical and histopathologic diagnosis. Ophthalmology (1993) 2.10

Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice. J Immunol (1991) 2.08

Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. Retina (1981) 2.05

The mode of action of interferons in viral infections and their possible role in the control of hepatitis B. J Hepatol (1986) 1.93

Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide. J Immunol (1987) 1.91

Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease. Histol Histopathol (1997) 1.90

Human interferon: mass production in a newly established cell line, MG-63. Antimicrob Agents Chemother (1977) 1.79

Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo. J Virol (1968) 1.78

AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice. J Immunol (2001) 1.77

Pathology of experimental autoimmune uveoretinitis in mice. J Autoimmun (1990) 1.71

Clinical biochemical and pathologic correlations in Bietti's crystalline dystrophy. Am J Ophthalmol (1994) 1.70

Infection of human cell cultures with bovine visna virus. J Gen Virol (1978) 1.70

Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med (1999) 1.70

Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci (2000) 1.68

IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J Immunol (1997) 1.68

Protective effect of anti-interleukin (IL)-6 antibody against endotoxin, associated with paradoxically increased IL-6 levels. Eur J Immunol (1992) 1.68

Primary intraocular lymphoma diagnosed by fine needle aspiration biopsy of a subretinal lesion. Retina (2001) 1.67

Shared genetic factors may not explain the raised risk of comorbid inflammatory diseases in multiple sclerosis. Mult Scler (2012) 1.65

Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther (2001) 1.65

Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions. J Clin Invest (1999) 1.64

Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. J Comp Neurol (2001) 1.63

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am J Pathol (1994) 1.62

Respiratory symptoms of primary school children living in a petrochemical polluted area in Taiwan. Pediatr Pulmonol (1998) 1.61

Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol (1989) 1.57

Role of CD8 T cells in primary Chlamydia infection. Infect Immun (1995) 1.56

The role of apoptosis in the pathogenesis of Fuchs endothelial dystrophy of the cornea. Arch Ophthalmol (2001) 1.56

Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530. Bioorg Med Chem Lett (1998) 1.54

Mass production of human interferon in diploid cells stimulated by poly-I:C. J Gen Virol (1973) 1.53

Interferon treatment of NZB mice: accelerated progression of autoimmune disease. Infect Immun (1978) 1.53

Interferon induced in human leukocytes by mitogens: production, partial purification and characterization. Eur J Immunol (1980) 1.52

Case report: portal vein thrombosis associated with hereditary protein C deficiency: a report of two cases. J Gastroenterol Hepatol (1999) 1.52

Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. Trans Am Ophthalmol Soc (1981) 1.52

Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene rearrangement. Arch Ophthalmol (1999) 1.52

Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro. J Virol (1968) 1.52

Polyacetal carboxylic acids: a new group of antiviral polyanions. J Virol (1970) 1.51

Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2. Mol Microbiol (1996) 1.49

Effectiveness of cyclosporin therapy for Behçet's disease. Arthritis Rheum (1985) 1.49

Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia. J Exp Med (1990) 1.48

Severe cachexia in mice inoculated with interferon-gamma-producing tumor cells. Int J Cancer (1991) 1.47

Human T cell activation with phytohemagglutinin. The function of IL-6 as an accessory signal. J Immunol (1988) 1.46

Utility of microdissection and polymerase chain reaction for the detection of immunoglobulin gene rearrangement and translocation in primary intraocular lymphoma. Ophthalmology (1998) 1.46

Antiviral activity of chlorite-oxidized oxyamylose, a polyacetal carboxylic acid. J Virol (1970) 1.46

Medical education in mainland China. J Med Educ (1972) 1.45

Stimulation of fibroblast interferon production by a 22K protein from human leukocytes. J Gen Virol (1985) 1.45

Cooperation between bovine leukaemia virus transactivator protein and Ha-ras oncogene product in cellular transformation. EMBO J (1990) 1.44

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol (1997) 1.44

60Co contamination in recycled steel resulting in elevated civilian radiation doses: causes and challenges. Health Phys (1997) 1.44

Functional properties of interphotoreceptor retinoid-binding protein. Photochem Photobiol (1991) 1.44

Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals. Clin Exp Immunol (1997) 1.43

In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats. Am J Vet Res (2001) 1.43

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease. Proc Natl Acad Sci U S A (1988) 1.43

Evidence against a role for endotoxin in the hyperdynamic circulation of rats with prehepatic portal hypertension. J Hepatol (1999) 1.43

Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun (1997) 1.43

The role of interferon-beta 1 and the 26-kDa protein (interferon-beta 2) as mediators of the antiviral effect of interleukin 1 and tumor necrosis factor. J Immunol (1987) 1.42

The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment. Invest Ophthalmol Vis Sci (1999) 1.42

Interphotoreceptor retinoid-binding protein (IRBP). Molecular biology and physiological role in the visual cycle of rhodopsin. Mol Neurobiol (1993) 1.41

Maternal smoking during pregnancy and multiple sclerosis amongst offspring. Eur J Neurol (2008) 1.41

Isolation and characterization of monkey interphotoreceptor retinoid-binding protein, a unique extracellular matrix component of the retina. Biochemistry (1985) 1.40

Inhibition of prostacyclin by indomethacin ameliorates the splanchnic hyposensitivity to glypressin in haemorrhage-transfused common bile duct-ligated rats. Eur J Clin Invest (2001) 1.40

Ocular and central nervous system lymphoma: clinical features and diagnosis. Ocul Immunol Inflamm (2000) 1.39

Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. J Immunol (1996) 1.39