Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

PubWeight™: 5.74‹?› | Rank: Top 1%

🔗 View Article (PMC 43329)

Published in Proc Natl Acad Sci U S A on March 15, 1994

Authors

A Kallioniemi1, O P Kallioniemi, J Piper, M Tanner, T Stokke, L Chen, H S Smith, D Pinkel, J W Gray, F M Waldman

Author Affiliations

1: Department of Biomedical Sciences, University of Tampere, Finland.

Articles citing this

(truncated to the top 100)

Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci U S A (2002) 12.68

Mendelian Inheritance in Man and its online version, OMIM. Am J Hum Genet (2007) 9.61

Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35

Whole genome DNA copy number changes identified by high density oligonucleotide arrays. Hum Genomics (2004) 5.65

Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs). Genome Res (2007) 4.99

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A (2003) 4.79

Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer (2009) 4.66

DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies. Am J Pathol (1998) 4.61

Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Res (2006) 4.25

Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH. Genome Res (2003) 4.10

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J (1998) 3.12

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell (2010) 2.86

Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin-embedded tumor samples. Am J Pathol (1994) 2.86

CARAT: a novel method for allelic detection of DNA copy number changes using high density oligonucleotide arrays. BMC Bioinformatics (2006) 2.82

Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc Natl Acad Sci U S A (1998) 2.80

DNA copy number losses in human neoplasms. Am J Pathol (1999) 2.73

High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res (2005) 2.72

Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer. Proc Natl Acad Sci U S A (2001) 2.16

Molecular cytogenetic analysis of 11 new breast cancer cell lines. Br J Cancer (1999) 2.05

Mutational heterogeneity in human cancers: origin and consequences. Annu Rev Pathol (2010) 2.02

Comprehensive copy number profiles of breast cancer cell model genomes. Breast Cancer Res (2006) 2.02

Genetic alterations in hormone-refractory recurrent prostate carcinomas. Am J Pathol (1998) 1.97

The mutation rate and cancer. Genetics (1998) 1.88

Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays. J Biol Chem (2007) 1.88

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer. Proc Natl Acad Sci U S A (2001) 1.88

Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer. Am J Pathol (1995) 1.81

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br J Cancer (2001) 1.77

Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression. Proc Natl Acad Sci U S A (1997) 1.76

Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study. PLoS One (2008) 1.75

Comprehensive genome sequence analysis of a breast cancer amplicon. Genome Res (2001) 1.74

Evidence for a prostate cancer-susceptibility locus on chromosome 20. Am J Hum Genet (2000) 1.69

High-resolution analysis of gene copy number alterations in human prostate cancer using CGH on cDNA microarrays: impact of copy number on gene expression. Neoplasia (2004) 1.66

Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am J Pathol (1994) 1.62

Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61

Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation. J Clin Pathol (1998) 1.54

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data. Nucleic Acids Res (2008) 1.52

Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol (2003) 1.51

Lessons learned from the initial sequencing of the pig genome: comparative analysis of an 8 Mb region of pig chromosome 17. Genome Biol (2007) 1.45

Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation. Breast Cancer Res (2014) 1.44

Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer. Am J Pathol (1999) 1.42

Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. J Cell Biol (2005) 1.41

Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells. Cancer Res (2008) 1.37

Detection of chromosomal imbalances in transitional cell carcinoma of the bladder by comparative genomic hybridization. Am J Pathol (1995) 1.34

Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours. BMC Cancer (2005) 1.33

High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays. Am J Pathol (2002) 1.24

Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Cancer Res (2006) 1.24

Comparative genomic hybridization: an overview. Am J Pathol (1994) 1.23

Recurrent DNA copy number changes in 1q, 4q, 6q, 9p, 13q, 14q and 22q detected by comparative genomic hybridization in malignant mesothelioma. Br J Cancer (1997) 1.19

Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples. Nucleic Acids Res (2004) 1.18

The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. Nucleic Acids Res (1998) 1.15

The complex genetic landscape of familial breast cancer. Hum Genet (2013) 1.14

Correlation of microscopic phenotype with genotype in a formalin-fixed, paraffin-embedded testicular germ cell tumor with universal DNA amplification, comparative genomic hybridization, and interphase cytogenetics. Am J Pathol (1995) 1.13

DNA amplifications at 20q13 and MDM2 define distinct subsets of evolved breast and ovarian tumours. Br J Cancer (1996) 1.11

Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers. PLoS One (2012) 1.10

Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression. Am J Pathol (2012) 1.09

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. EMBO Mol Med (2010) 1.08

Interphase cytogenetics reveals a high incidence of aneuploidy and intra-tumour heterogeneity in breast cancer. Br J Cancer (1995) 1.06

Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer. Br J Cancer (2004) 1.06

Genetic variation in the chromosome 17q23 amplicon and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.05

Colorectal cancer genomics: evidence for multiple genotypes which influence survival. Br J Cancer (2001) 1.04

Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations. Br J Cancer (1995) 1.04

Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling. BMC Bioinformatics (2005) 1.04

A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17. J Proteome Res (2012) 1.03

The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis. BMC Cancer (2008) 1.02

Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q. Br J Cancer (1998) 1.02

Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2. Elife (2014) 1.01

Functional interaction of Aurora-A and PP2A during mitosis. Mol Biol Cell (2007) 1.01

Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization. Br J Cancer (1999) 1.01

Deciphering a subgroup of breast carcinomas with putative progression of grade during carcinogenesis revealed by comparative genomic hybridisation (CGH) and immunohistochemistry. Br J Cancer (2004) 1.00

The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism. Proc Natl Acad Sci U S A (1998) 1.00

Adenomyoepithelial tumours and myoepithelial carcinomas of the breast--a spectrum of monophasic and biphasic tumours dominated by immature myoepithelial cells. BMC Cancer (2005) 1.00

ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells. Oncogene (2010) 0.99

From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization. Am J Hum Genet (1998) 0.98

Molecular cytogenetic investigations of synchronous bilateral breast cancer. J Clin Pathol (2003) 0.98

The consequences of chromosomal aneuploidy on the transcriptome of cancer cells. Biochim Biophys Acta (2012) 0.97

The molecular basis of lung cancer: molecular abnormalities and therapeutic implications. Respir Res (2003) 0.97

DNA copy number changes in development and progression in leiomyosarcomas of soft tissues. Am J Pathol (1998) 0.97

Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer. Breast Cancer Res (2003) 0.95

The mutator phenotype in cancer: molecular mechanisms and targeting strategies. Curr Drug Targets (2010) 0.95

A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. J Biol Chem (2009) 0.95

Tissue microdissection and degenerate oligonucleotide primed-polymerase chain reaction (DOP-PCR) is an effective method to analyze genetic aberrations in invasive tumors. J Mol Diagn (2001) 0.94

Genetic characterisation of invasive breast cancer: a comparison of CGH and PCR based multiplex microsatellite analysis. J Clin Pathol (2001) 0.94

Detecting cancer gene networks characterized by recurrent genomic alterations in a population. PLoS One (2011) 0.94

Genetic aberrations in hypodiploid breast cancer: frequent loss of chromosome 4 and amplification of cyclin D1 oncogene. Am J Pathol (1998) 0.94

A novel method for gene expression mapping of metastatic competence in human bladder cancer. Neoplasia (2006) 0.93

Variation in RNA expression and genomic DNA content acquired during cell culture. Br J Cancer (2004) 0.92

Molecular characterization of a novel amplicon at 1q21-q22 frequently observed in human sarcomas. Br J Cancer (1998) 0.91

The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression. Genet Res Int (2011) 0.90

The role of BPTF in melanoma progression and in response to BRAF-targeted therapy. J Natl Cancer Inst (2015) 0.89

The biological role of actinin-4 (ACTN4) in malignant phenotypes of cancer. Cell Biosci (2015) 0.89

Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity. Br J Cancer (1996) 0.89

BORIS (CTCFL) is not expressed in most human breast cell lines and high grade breast carcinomas. PLoS One (2010) 0.88

Genomic interaction profiles in breast cancer reveal altered chromatin architecture. PLoS One (2013) 0.88

Assessment of palindromes as platforms for DNA amplification in breast cancer. Genome Res (2011) 0.88

Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk. PLoS One (2015) 0.88

Genomic instability and proliferative activity as risk factors for distant metastases in breast cancer. Br J Cancer (2008) 0.87

High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer. Br J Cancer (2007) 0.87

Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. J Pediatr Surg (2013) 0.87

Articles cited by this

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (1987) 49.88

Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (1992) 16.38

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell (1992) 7.06

Molecular themes in oncogenesis. Cell (1991) 6.73

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell (1992) 6.03

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc Natl Acad Sci U S A (1992) 3.25

BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers. Oncogene (1991) 2.89

Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum Genet (1993) 2.64

Oncogene amplification in tumor cells. Adv Cancer Res (1986) 2.44

Comparative genomic hybridization: a rapid new method for detecting and mapping DNA amplification in tumors. Semin Cancer Biol (1993) 2.09

Whole-arm t(1;16) and i(1q) as sole anomalies identify gain of 1q as a primary chromosomal abnormality in breast cancer. Genes Chromosomes Cancer (1992) 1.86

Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells. Cell (1990) 1.85

Chromosome 11q13 abnormalities in human cancer. Cancer Cells (1991) 1.74

Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer. Genes Chromosomes Cancer (1990) 1.67

Characterization of chromosomal anomalies in human breast cancer. A comparison of 30 paradiploid cases with few chromosome changes. Cancer Genet Cytogenet (1990) 1.45

SAS amplification in soft tissue sarcomas. Cancer Res (1992) 1.15

Sporadic amplification of the insulin-like growth factor 1 receptor gene in human breast tumors. Cancer Res (1992) 1.14

Cytogenetic study of breast cancer: clinicopathologic significance of homogeneously staining regions in 84 patients. Hum Pathol (1992) 1.12

Proto-oncogene amplification and homogeneously staining regions in human breast carcinomas. Genes Chromosomes Cancer (1990) 1.11

Incidence of double minutes, cytogenetic equivalents of gene amplification, in human carcinoma cells. Int J Cancer (1984) 1.07

Amplification of the proto-oncogenes int-2, c-erb B-2 and c-myc in human breast cancer. Clin Chim Acta (1989) 0.99

Articles by these authors

The sequence of the human genome. Science (2001) 101.55

A whole-genome assembly of Drosophila. Science (2000) 38.48

Gene-expression profiles in hereditary breast cancer. N Engl J Med (2001) 29.80

Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med (1998) 25.41

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet (1998) 21.52

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 16.91

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (1992) 16.38

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc Natl Acad Sci U S A (1986) 12.92

Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet (2001) 11.06

Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet (1998) 8.91

Effect of large-scale social marketing of insecticide-treated nets on child survival in rural Tanzania. Lancet (2001) 8.43

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science (1997) 8.05

The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90

In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet (1995) 6.60

PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet (1999) 6.18

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell (1999) 6.08

Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Lancet (1997) 5.59

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosomes Cancer (1994) 5.52

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49

Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science (1996) 5.06

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Nat Genet (2001) 4.96

NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90

Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo-controlled trial. Lancet (2001) 4.86

The Human Connectome Project: a data acquisition perspective. Neuroimage (2012) 4.64

Molecular cytogenetics of primary breast cancer by CGH. Genes Chromosomes Cancer (1998) 4.22

Impact on malaria morbidity of a programme supplying insecticide treated nets in children aged under 2 years in Tanzania: community cross sectional study. BMJ (2001) 4.14

Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene. Nat Genet (2000) 4.13

B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol (2001) 4.10

A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08

Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer. Cancer Res (1997) 4.02

Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization. Cancer Res (1995) 3.98

Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma. J Natl Cancer Inst (1995) 3.96

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89

African children with malaria in an area of intense Plasmodium falciparum transmission: features on admission to the hospital and risk factors for death. Am J Trop Med Hyg (1999) 3.87

Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data. Cancer Res (2000) 3.83

Tissue microarrays for rapid linking of molecular changes to clinical endpoints. Am J Pathol (2001) 3.83

A new mouse tumor model system (RIF-1) for comparison of end-point studies. J Natl Cancer Inst (1980) 3.75

Diagnostic accuracy and case management of clinical malaria in the primary health services of a rural area in south-eastern Tanzania. Trop Med Int Health (2001) 3.62

Absence of seasonal variation in malaria parasitaemia in an area of intense seasonal transmission. Acta Trop (1993) 3.59

Quantitative mRNA expression analysis from formalin-fixed, paraffin-embedded tissues using 5' nuclease quantitative reverse transcription-polymerase chain reaction. J Mol Diagn (2000) 3.59

Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature (1998) 3.54

Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science (1996) 3.54

Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44

Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays. Cancer Res (1999) 3.41

Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer (1979) 3.37

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37

Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Cancer Res (1997) 3.37

Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines. J Natl Cancer Inst (1977) 3.35

Liver transplantation in children from living related donors. Surgical techniques and results. Ann Surg (1991) 3.32

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30

Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution. Parasitology (2009) 3.27

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc Natl Acad Sci U S A (1992) 3.25

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res (1994) 3.18

The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell (1995) 3.17

Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci U S A (1983) 3.14

Population-based study of BRCA1 and BRCA2 mutations in 1035 unselected Finnish breast cancer patients. J Natl Cancer Inst (2000) 3.12

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J (1998) 3.12

The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing Schistosoma mansoni and hookworm co-infections in rural Côte d'Ivoire. Parasitology (2003) 3.11

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol (1997) 3.10

Aggressiveness of screen-detected breast cancers. Lancet (1995) 3.07

Drug dosage and remission duration in childhood lymphocytic leukemia. Cancer (1971) 3.04

An estimation of the entomological inoculation rate for Ifakara: a semi-urban area in a region of intense malaria transmission in Tanzania. Trop Med Int Health (2003) 2.94

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93

Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol (2013) 2.92

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc Natl Acad Sci U S A (1994) 2.91

Evidence for a prostate cancer susceptibility locus on the X chromosome. Nat Genet (1998) 2.90

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A (1999) 2.81

Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc Natl Acad Sci U S A (1998) 2.80

Tissue microarrays for gene amplification surveys in many different tumor types. Clin Cancer Res (1999) 2.79

Chromosome-specific alpha satellite DNA from human chromosome 1: hierarchical structure and genomic organization of a polymorphic domain spanning several hundred kilobase pairs of centromeric DNA. Genomics (1987) 2.77

Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol Biochem Parasitol (1997) 2.77

KINET: a social marketing programme of treated nets and net treatment for malaria control in Tanzania, with evaluation of child health and long-term survival. Trans R Soc Trop Med Hyg (1999) 2.73

Long-term (6 and 12 months) follow-up of two prospective, randomized, controlled phase III trials of photodynamic therapy with BF-200 ALA and methyl aminolaevulinate for the treatment of actinic keratosis. Br J Dermatol (2013) 2.70

Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer (2006) 2.67

Associations between gene expressions in breast cancer and patient survival. Hum Genet (2002) 2.67