Published in Neurology on March 01, 1994
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci U S A (2000) 4.83
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet (2011) 2.29
The neuropathology of genetic Parkinson's disease. Mov Disord (2012) 1.73
Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36. Am J Hum Genet (2001) 1.72
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.70
The genetics of Parkinson disease. J Geriatr Psychiatry Neurol (2010) 1.69
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol (2002) 1.54
How does parkin ligate ubiquitin to Parkinson's disease? EMBO Rep (2004) 1.54
Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway. Autophagy (2007) 1.50
Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27. Am J Hum Genet (1997) 1.43
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem (2009) 1.34
Genetic mouse models of parkinsonism: strengths and limitations. NeuroRx (2005) 1.22
Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects. Am J Hum Genet (2001) 1.13
The prion hypothesis in Parkinson's disease: Braak to the future. Acta Neuropathol Commun (2013) 1.11
Mitochondrial contribution to Parkinson's disease pathogenesis. Parkinsons Dis (2011) 1.10
Targets for neuroprotection in Parkinson's disease. Biochim Biophys Acta (2008) 1.08
A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease. Biochim Biophys Acta (2009) 1.02
α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. J Neurochem (2011) 0.96
The neurological mutant quaking(viable) is Parkin deficient. Mamm Genome (2004) 0.95
Role of the ubiquitin proteasome system in Parkinson's disease. BMC Biochem (2007) 0.91
Progress in the pathogenesis and genetics of Parkinson's disease. Philos Trans R Soc Lond B Biol Sci (2008) 0.91
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance. J Neurochem (2016) 0.91
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease. Parkinsonism Relat Disord (2009) 0.87
Genetically engineered mouse models of Parkinson's disease. Brain Res Bull (2011) 0.86
A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci (2016) 0.86
Parkin disease and the Lewy body conundrum. Mov Disord (2013) 0.84
Autosomal recessive juvenile parkinsonism maps to 6q25.2-q27 in four ethnic groups: detailed genetic mapping of the linked region. Am J Hum Genet (1998) 0.84
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system. Cell Mol Life Sci (2014) 0.82
Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism. BMC Neurol (2008) 0.80
Pathologic and therapeutic implications for the cell biology of parkin. Mol Cell Neurosci (2015) 0.78
Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. Curr Genomics (2014) 0.78
Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair. Biomed Res Int (2017) 0.76
Identifying the genetic components underlying the pathophysiology of movement disorders. Appl Clin Genet (2011) 0.75
Striatal Plasticity in L-DOPA- and Graft-Induced Dyskinesia; The Common Link? Front Cell Neurosci (2016) 0.75
The Monoamine Brainstem Reticular Formation as a Paradigm for Re-Defining Various Phenotypes of Parkinson's Disease Owing Genetic and Anatomical Specificity. Front Cell Neurosci (2017) 0.75
Mitochondrial matters in Parkinson disease: introduction. J Bioenerg Biomembr (2009) 0.75
Cerebellar Pathology in Childhood-Onset vs. Adult-Onset Essential Tremor. Neurosci Lett (2017) 0.75
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. Mol Cell (1998) 9.85
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet (2000) 8.33
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med (2009) 7.53
Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell (1998) 7.25
Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates. J Biol Chem (1968) 6.28
Purification and properties of bacterial chondroitinases and chondrosulfatases. J Biol Chem (1968) 5.66
Reactive oxygen intermediates mediate a systemic signal network in the establishment of plant immunity. Cell (1998) 5.46
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science (1998) 5.23
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene (2010) 4.81
Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation (1983) 4.70
Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ Res (1995) 4.55
Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat Genet (1994) 4.36
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27
Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY. Nat Genet (1997) 4.19
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (2001) 4.13
Amino acid sequence of the human fibronectin receptor. J Cell Biol (1987) 4.08
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell (2001) 3.49
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene. Nat Genet (1994) 3.39
IFNβ-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum. Neurology (2010) 3.34
The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Mol Cell (1998) 3.22
Artificial surfactant therapy in hyaline-membrane disease. Lancet (1980) 3.21
Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res (1986) 3.17
Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis. J Neurol Neurosurg Psychiatry (2007) 3.12
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology (2008) 2.85
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Nat Genet (2001) 2.79
A mutation in the human glucocerebrosidase gene in neuronopathic Gaucher's disease. N Engl J Med (1987) 2.77
Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin. EMBO J (1985) 2.69
Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin Cancer Res (2000) 2.61
cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. Proc Natl Acad Sci U S A (1986) 2.58
Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke (2001) 2.51
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J (2000) 2.48
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A (2001) 2.39
Pattern electrical stimulation of the human retina. Vision Res (1999) 2.35
The correlation between papillary thyroid carcinoma and lymphocytic infiltration in the thyroid gland. J Clin Endocrinol Metab (1995) 2.32
The inhomogeneous structure of water at ambient conditions. Proc Natl Acad Sci U S A (2009) 2.31
SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Hum Mol Genet (2001) 2.30
Hepatitis C virus particle detected by immunoelectron microscopic study. J Gen Virol (1994) 2.28
Arginine-glycine-aspartic acid adhesion receptors. Methods Enzymol (1987) 2.25
Rapid diagnosis of tuberculous meningitis by polymerase chain reaction (PCR). Neurology (1990) 2.21
Nucleotide sequence of the staphylocoagulase gene: its unique COOH-terminal 8 tandem repeats. J Biochem (1987) 2.21
Membrane hyperpolarization inhibits agonist-induced synthesis of inositol 1,4,5-trisphosphate in rabbit mesenteric artery. J Physiol (1992) 2.20
Frequency and stability of chromosomal integration of adenovirus vectors. J Virol (1999) 2.18
Administration of thyroxine in treated Graves' disease. Effects on the level of antibodies to thyroid-stimulating hormone receptors and on the risk of recurrence of hyperthyroidism. N Engl J Med (1991) 2.17
Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b. J Trauma (1998) 2.15
Suppression of the heterotrimeric G protein causes abnormal morphology, including dwarfism, in rice. Proc Natl Acad Sci U S A (1999) 2.15
Urinary excretion of podocytes in patients with diabetic nephropathy. Nephrol Dial Transplant (2000) 2.15
Subtotal corpectomy versus laminoplasty for multilevel cervical spondylotic myelopathy: a long-term follow-up study over 10 years. Spine (Phila Pa 1976) (2001) 2.14
New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology (2005) 2.14
Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett (1998) 2.14
Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res (2000) 2.14
The influence of p-nitrophenyl beta-d-xyloside on the synthesis of proteochondroitin sulfate by slices of embryonic chick cartilage. J Biochem (1973) 2.08
Clinical features of a new disease concept, IgG4-related thyroiditis. Scand J Rheumatol (2013) 2.05
Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses. Acta Neuropathol (1988) 2.01
Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families. Neurology (2008) 2.00
Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol Gen Genet (1996) 2.00
Phase-sensitive observation of a spin-orbital Mott state in Sr2IrO4. Science (2009) 1.97
A carbonic anhydrase from the nacreous layer in oyster pearls. Proc Natl Acad Sci U S A (1996) 1.97
Pulmonary artery disease in Takayasu's arteritis: angiographic findings. AJR Am J Roentgenol (1992) 1.96
New fluorogenic substrates for alpha-thrombin, factor Xa, kallikreins, and urokinase. J Biochem (1977) 1.96
Frequent presence of anti-GQ1b antibody in Fisher's syndrome. Neurology (1993) 1.96
Chromogenic substrates for horseshoe crab clotting enzyme. Its application for the assay of bacterial endotoxins. Haemostasis (1978) 1.96
Eyelid reconstruction using a hard palate mucoperiosteal graft combined with a V-Y subcutaneously pedicled flap. Br J Plast Surg (2001) 1.96
Impact of cerebral microcirculatory changes on cerebral blood flow during cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke (2000) 1.94
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. Nat Genet (2000) 1.92
Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol (1987) 1.92
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch. Nat Genet (1998) 1.91
Possible relationship of a 36-megadalton Salmonella enteritidis plasmid to virulence in mice. Infect Immun (1985) 1.91
Relation between blood pressure and outcome in intracerebral hemorrhage. Stroke (1995) 1.90
In vitro and in vivo comparison of the abilities of purine and pyrimidine 2',3'-dideoxynucleosides to inhibit duck hepadnavirus. Antimicrob Agents Chemother (1989) 1.90
Tremorgenic toxins from Aspergillus fumigatus Fres. Chem Pharm Bull (Tokyo) (1971) 1.88
A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1beta. Hum Mol Genet (1999) 1.87
Structural analysis of chick-embryo cartilage proteoglycan by selective degradation with chondroitin lyases (chondroitinases) and endo-beta-D-galactosidase (keratanase). Biochem J (1980) 1.86
Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion. J Biol Chem (1968) 1.86
A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J Clin Invest (2000) 1.85
Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. Am J Gastroenterol (1999) 1.83
Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology (2004) 1.82
Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis. Cancer Res (2000) 1.82
RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes. J Cell Biol (1999) 1.81
Cloning and sequence of the human RecA-like gene cDNA. Nucleic Acids Res (1993) 1.81
Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells. J Natl Cancer Inst (1997) 1.81
Vitronectin--a major cell attachment-promoting protein in fetal bovine serum. Exp Cell Res (1985) 1.81
DNA mutation analysis of Gaucher patients. Am J Med Genet (1992) 1.80
Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. J Virol (1991) 1.80
A novel antagonist, No. 7943, of the Na+/Ca2+ exchange current in guinea-pig cardiac ventricular cells. Br J Pharmacol (1996) 1.79
A single stage posterior approach and rigid fixation for preventing kyphosis in the treatment of spinal tuberculosis. Spine (Phila Pa 1976) (1994) 1.77
Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. Acta Neuropathol (1990) 1.76
The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Nucleic Acids Res (1996) 1.75
Protocadherins: a large family of cadherin-related molecules in central nervous system. EMBO J (1993) 1.72
A remote monitoring system for patients with implantable ventricular assist devices with a personal handy phone system. ASAIO J (1999) 1.70
Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury. Kidney Int (2006) 1.70
Structural study of phosphomannan of yeast-form cells of Candida albicans J-1012 strain with special reference to application of mild acetolysis. Arch Biochem Biophys (1989) 1.70
A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease? Hum Mol Genet (1999) 1.69
Early MRI and outcomes of untreated patients with mild or improving ischemic stroke. Neurology (2006) 1.68
FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus. Jpn J Exp Med (1975) 1.67