Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.

PubWeight™: 4.83‹?› | Rank: Top 1%

🔗 View Article (PMC 27228)

Published in Proc Natl Acad Sci U S A on November 21, 2000

Authors

Y Zhang1, J Gao, K K Chung, H Huang, V L Dawson, T M Dawson

Author Affiliations

1: Departments of Neurology, Neuroscience, and Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287-0005, USA.

Articles citing this

(truncated to the top 100)

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A (2003) 7.57

The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41

The continuing challenges of leprosy. Clin Microbiol Rev (2006) 4.09

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell (2011) 4.00

Genetic animal models of Parkinson's disease. Neuron (2010) 3.86

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 3.40

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17

The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Proc Natl Acad Sci U S A (2004) 3.16

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc Natl Acad Sci U S A (2010) 2.91

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci U S A (2007) 2.88

Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest (2006) 2.86

Septins: the fourth component of the cytoskeleton. Nat Rev Mol Cell Biol (2012) 2.77

Autoregulation of Parkin activity through its ubiquitin-like domain. EMBO J (2011) 2.75

Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Mol Cell Biol (2004) 2.70

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep (2012) 2.60

Concern Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proc Natl Acad Sci U S A (2003) 2.52

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat Genet (2009) 2.51

Structure of the human Parkin ligase domain in an autoinhibited state. EMBO J (2013) 2.38

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J (2012) 2.36

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat (2010) 2.29

Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet (2011) 2.29

Parkin-deficient mice are not a robust model of parkinsonism. Proc Natl Acad Sci U S A (2005) 2.27

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J Neurosci (2009) 2.11

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10

Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem (2005) 2.07

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain. EMBO Rep (2003) 2.01

Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci U S A (2004) 1.99

Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin. J Biol Chem (2009) 1.98

Ubiquitination in postsynaptic function and plasticity. Annu Rev Cell Dev Biol (2010) 1.94

Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration. Mol Neurobiol (2008) 1.93

The role of parkin in familial and sporadic Parkinson's disease. Mov Disord (2010) 1.90

The role of oxidative stress in Parkinson's disease. J Parkinsons Dis (2013) 1.86

Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications. JAMA Neurol (2013) 1.81

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc Natl Acad Sci U S A (2010) 1.81

Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx (2004) 1.77

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci (2003) 1.75

Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.73

Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Mol Biol Cell (2007) 1.69

Evolutionary and functional relationships within the DJ1 superfamily. BMC Evol Biol (2004) 1.67

Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. Am J Pathol (2003) 1.67

What causes cell death in Parkinson's disease? Ann Neurol (2008) 1.66

Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. J Biol Chem (2010) 1.65

The ring between ring fingers (RBR) protein family. Genome Biol (2007) 1.59

The septins. Genome Biol (2003) 1.58

Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells. J Virol (2009) 1.55

How does parkin ligate ubiquitin to Parkinson's disease? EMBO Rep (2004) 1.54

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol (2002) 1.54

Rare genetic mutations shed light on the pathogenesis of Parkinson disease. J Clin Invest (2003) 1.52

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease. Nat Commun (2013) 1.51

Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation. J Biol Chem (2013) 1.50

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) (2010) 1.50

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Mol Cell (2015) 1.49

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc Natl Acad Sci U S A (2005) 1.48

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. J Neurosci (2011) 1.45

Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J Biol Chem (2010) 1.45

CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Hum Mol Genet (2008) 1.43

Parkin mediates the degradation-independent ubiquitination of Hsp70. J Neurochem (2008) 1.42

The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet (2010) 1.41

Following Ariadne's thread: a new perspective on RBR ubiquitin ligases. BMC Biol (2012) 1.33

Conquering the complex world of human septins: implications for health and disease. Clin Genet (2010) 1.29

Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. J Biol Chem (2010) 1.29

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. PLoS Genet (2006) 1.23

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin. Mol Biol Cell (2003) 1.23

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase. Proc Natl Acad Sci U S A (2008) 1.23

Genetic mouse models of parkinsonism: strengths and limitations. NeuroRx (2005) 1.22

Genes associated with Parkinson syndrome. J Neurol (2008) 1.21

The ubiquitin-proteasome pathway and synaptic plasticity. Learn Mem (2010) 1.20

The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Mol Cell Biol (2002) 1.19

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity. Open Biol (2014) 1.19

The basis for selective E1-E2 interactions in the ISG15 conjugation system. J Biol Chem (2008) 1.17

After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy (2013) 1.17

Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene (2010) 1.17

Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. J Biol Chem (2014) 1.16

Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. Hum Mol Genet (2010) 1.15

Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. Prog Neurobiol (2011) 1.14

Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol Neurobiol (2010) 1.13

RBR E3 ubiquitin ligases: new structures, new insights, new questions. Biochem J (2014) 1.13

Parkin counteracts symptoms in a Drosophila model of Parkinson's disease. BMC Neurosci (2004) 1.12

Chasing genes in Alzheimer's and Parkinson's disease. Hum Genet (2004) 1.11

Identification and characterization of the ARIADNE gene family in Arabidopsis. A group of putative E3 ligases. Plant Physiol (2003) 1.11

Mitochondrial contribution to Parkinson's disease pathogenesis. Parkinsons Dis (2011) 1.10

MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity. Neurobiol Dis (2007) 1.09

The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Genes Dev (2015) 1.08

Targets for neuroprotection in Parkinson's disease. Biochim Biophys Acta (2008) 1.08

Disruption of protein quality control in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.07

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol Neurodegener (2009) 1.05

Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. Mamm Genome (2007) 1.04

Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination. PLoS One (2011) 1.03

A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease. Biochim Biophys Acta (2009) 1.02

Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity. BMC Neurosci (2005) 1.01

Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1. Proc Natl Acad Sci U S A (2003) 1.00

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection. Front Neurol (2013) 0.99

Mitochondrial dynamics and Parkinson's disease: focus on parkin. Antioxid Redox Signal (2011) 0.99

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila. PLoS Genet (2014) 0.99

Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination. Biochemistry (2011) 0.99

Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis. PLoS One (2012) 0.98

Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome. J Clin Invest (2012) 0.97

Articles cited by this

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science (1997) 28.30

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature (1998) 21.49

Alpha-synuclein in Lewy bodies. Nature (1997) 20.83

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet (1998) 12.92

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83

A Drosophila model of Parkinson's disease. Nature (2000) 7.82

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (1999) 7.60

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A (1999) 7.32

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem (2000) 6.92

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science (2000) 6.28

Parkinson's disease. First of two parts. N Engl J Med (1998) 5.90

Association between early-onset Parkinson's disease and mutations in the parkin gene. N Engl J Med (2000) 4.98

The ubiquitin pathway in Parkinson's disease. Nature (1998) 4.48

Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays (2000) 4.38

Parkinson's disease. Second of two parts. N Engl J Med (1998) 3.46

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. Hum Mol Genet (1999) 2.41

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q. Neurology (1998) 2.37

The septin CDCrel-1 binds syntaxin and inhibits exocytosis. Nat Neurosci (1999) 2.32

Septins: cytoskeletal polymers or signalling GTPases? Trends Cell Biol (1999) 2.31

Understanding cell death in Parkinson's disease. Ann Neurol (1998) 2.16

Prospects for new restorative and neuroprotective treatments in Parkinson's disease. Nature (1999) 2.07

Pathology and biology of the Lewy body. J Neuropathol Exp Neurol (1993) 1.99

Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis (2000) 1.97

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. Cell Death Differ (1998) 1.92

A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nat Genet (1998) 1.84

Modes of regulation of ubiquitin-mediated protein degradation. J Cell Physiol (2000) 1.82

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. J Biol Chem (1999) 1.64

Filaments of Lewy bodies contain insoluble cytoskeletal elements. Am J Pathol (1992) 1.55

Septins: a highly conserved family of membrane-associated GTPases with functions in cell division and beyond. J Membr Biol (1999) 1.48

Familial juvenile parkinsonism: clinical and pathologic study in a family. Neurology (1994) 1.46

A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor. Hum Mol Genet (1999) 1.43

Identification of septins in neurofibrillary tangles in Alzheimer's disease. Am J Pathol (1998) 1.34

A novel transactivation domain in parkin. Trends Biochem Sci (1999) 1.31

A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett (1999) 1.07

Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism. The European Consortium on Genetic Susceptibility in Parkinson's Disease and the French Parkinson's Disease Genetics Study Group. Lancet (1998) 1.06

New animal models for Parkinson's disease. Cell (2000) 1.05

Clinical and neuropathological aspects of autosomal recessive juvenile parkinsonism. J Neurol (1998) 1.03

Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene. Genomics (1998) 1.02

cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme. Cytogenet Cell Genet (1997) 0.93

A kindred with Parkinson's disease not showing genetic linkage to established loci. Neurology (2000) 0.87

Ubiquitin immunoreactivity of multiple polypeptides in rat brain synaptic membranes. Biochem Soc Trans (1992) 0.87

Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities. Neurosci Lett (1994) 0.87

The post-synaptic density: putative involvement in synapse stabilization via cadherins and covalent modification by ubiquitination. Biochem Soc Trans (1995) 0.84

Articles by these authors

All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B (1998) 54.00

CHARMM: the biomolecular simulation program. J Comput Chem (2009) 27.71

The protein information resource (PIR). Nucleic Acids Res (2000) 13.54

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (1999) 7.60

Functional arteries grown in vitro. Science (1999) 6.08

A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell (1981) 5.87

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A (1991) 5.70

DIAN: a novel algorithm for genome ontological classification. Genome Res (2001) 5.55

Targeted disruption of the neuronal nitric oxide synthase gene. Cell (1993) 5.02

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell (2001) 4.98

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med (1999) 4.88

iProClass: an integrated, comprehensive and annotated protein classification database. Nucleic Acids Res (2001) 4.33

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (2001) 4.13

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood (1992) 3.93

Deletion mapping of Sindbis virus DI RNAs derived from cDNAs defines the sequences essential for replication and packaging. Cell (1986) 3.89

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science (1994) 3.86

Evaluation of PCR-generated chimeras, mutations, and heteroduplexes with 16S rRNA gene-based cloning. Appl Environ Microbiol (2001) 3.76

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci U S A (2003) 3.53

Zebrafish comparative genomics and the origins of vertebrate chromosomes. Genome Res (2000) 3.50

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A (1996) 3.29

Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature (1995) 3.15

Crude-oil biodegradation via methanogenesis in subsurface petroleum reservoirs. Nature (2007) 3.06

Androgen receptor signaling in androgen-refractory prostate cancer. J Natl Cancer Inst (2001) 3.06

Membrane thinning caused by magainin 2. Biochemistry (1995) 3.03

Protein Information Resource: a community resource for expert annotation of protein data. Nucleic Acids Res (2001) 3.01

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem (1992) 2.97

Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol (2001) 2.91

A comparative map of the zebrafish genome. Genome Res (2000) 2.90

The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea (1998) 2.86

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol (2000) 2.85

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci (1998) 2.78

The prevalence of NIDDM and associated risk factors in native Canadians. Diabetes Care (1997) 2.68

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron (1991) 2.60

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry (2007) 2.53

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat Genet (1999) 2.53

The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res (2003) 2.48

A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol (1992) 2.47

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum Mol Genet (1998) 2.39

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Mol Cell Biol (1996) 2.26

Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase. Proc Natl Acad Sci U S A (2000) 2.18

Overlapping retrovirus U5 sequence elements are required for efficient integration and initiation of reverse transcription. J Virol (1991) 2.16

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci (1993) 2.16

Evaluation of a school-based HIV/AIDS peer-led prevention programme: the first intervention trial for children of migrant workers in China. Int J STD AIDS (2010) 2.13

Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc Natl Acad Sci U S A (1999) 2.13

Air pollution and daily mortality in residential areas of Beijing, China. Arch Environ Health (1994) 2.12

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci U S A (1996) 2.10

Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment. Neurology (2003) 2.04

Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development (1999) 2.00

Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology (2001) 2.00

Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis (2000) 1.97

PIR: a new resource for bioinformatics. Bioinformatics (2000) 1.97

Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol (1994) 1.95

A systems biology analysis of the Drosophila phagosome. Nature (2006) 1.95

The menisci of the knee joint. Anatomical and functional characteristics, and a rationale for clinical treatment. J Anat (1998) 1.91

Gene structure, intracellular localization, and functional roles of sterol carrier protein-2. Prog Lipid Res (2001) 1.91

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci U S A (1999) 1.88

The efficient intracellular sequestration of the insulin-regulatable glucose transporter (GLUT-4) is conferred by the NH2 terminus. J Cell Biol (1992) 1.86

Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects. J Pharm Sci (1977) 1.85

Nitric oxide synthase in models of focal ischemia. Stroke (1997) 1.85

Morphologic and mechanical characteristics of engineered bovine arteries. J Vasc Surg (2001) 1.84

Techniques for a structural analysis of dermatoscopic imagery. Comput Med Imaging Graph (1999) 1.84

Cochlear function in Prestin knockout mice. J Physiol (2004) 1.83

The return of research results to participants: pilot questionnaire of adolescents and parents of children with cancer. Pediatr Blood Cancer (2007) 1.83

Effects of the renin-angiotensin system on the current I(to) in epicardial and endocardial ventricular myocytes from the canine heart. Circ Res (2000) 1.81

Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle. J Biol Chem (1994) 1.79

Evolution of a knowledge base for a clinical decision support system encoded in the Arden Syntax. Proc AMIA Symp (1998) 1.78

Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science (1996) 1.76

Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain. J Neurosci (1993) 1.76

Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci U S A (1993) 1.75

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet (2001) 1.74

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J Neurosci (1996) 1.73

Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor. Proc Natl Acad Sci U S A (2001) 1.72

Nitric oxide in neurodegeneration. Prog Brain Res (1998) 1.69

Human infection with avian influenza A(H7N9) virus re-emerges in China in winter 2013. Euro Surveill (2013) 1.68

Genetic linkage mapping of zebrafish genes and ESTs. Genome Res (2000) 1.67

Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report. Am J Transplant (2006) 1.63

Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat Genet (1994) 1.63