PubRank

H N Ginsberg

Author PubWeight™ 87.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin Invest 1992 2.80
2 HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia. Nat Med 2001 2.14
3 Is hypertriglyceridemia a risk factor for atherosclerotic cardiovascular disease? A simple question with a complicated answer. Ann Intern Med 1997 2.04
4 Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo. J Clin Invest 1986 1.96
5 The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem 1997 1.87
6 Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B. J Biol Chem 1991 1.73
7 Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells. J Lipid Res 1993 1.68
8 HDL-subpopulation patterns in response to reductions in dietary total and saturated fat intakes in healthy subjects. Am J Clin Nutr 1999 1.54
9 Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse. Science 1983 1.44
10 Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein. J Biol Chem 1998 1.44
11 Reducing total dietary fat without reducing saturated fatty acids does not significantly lower total plasma cholesterol concentrations in normal males. Am J Clin Nutr 1992 1.42
12 Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk 1999 1.40
13 Lipoprotein metabolism during acute inhibition of hepatic triglyceride lipase in the cynomolgus monkey. J Clin Invest 1982 1.39
14 Increased plasma and renal clearance of an exchangeable pool of apolipoprotein A-I in subjects with low levels of high density lipoprotein cholesterol. J Clin Invest 1993 1.37
15 Regulation of the production and catabolism of plasma low density lipoproteins in hypertriglyceridemic subjects. Effect of weight loss. J Clin Invest 1985 1.23
16 Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne. N Engl J Med 1985 1.15
17 Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence. Proc Natl Acad Sci U S A 1998 1.11
18 Human plasma LDL cryopreserved with sucrose maintains in vivo kinetics indistinguishable from freshly isolated human LDL in cynomolgus monkeys. J Lipid Res 1994 1.10
19 Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity, and insulin resistance. J Biol Chem 2001 1.10
20 Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins. J Lipid Res 1988 1.09
21 Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein Cl. J Clin Invest 1996 1.09
22 Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production. J Lipid Res 1990 1.08
23 Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice. J Clin Invest 1994 1.08
24 Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes. Arterioscler Thromb Vasc Biol 2000 1.07
25 Direct measurement of apoprotein B specific activity in 125I-labeled lipoproteins. J Lipid Res 1978 1.07
26 Lipoprotein metabolism during acute inhibition of lipoprotein lipase in the cynomolgus monkey. J Clin Invest 1988 1.05
27 Dehydroepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbit. Arteriosclerosis 1989 0.99
28 Treatment of common lipoprotein disorders. Prog Cardiovasc Dis 1984 0.98
29 Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells. J Biol Chem 1993 0.98
30 Evidence that a rapidly turning over protein, normally degraded by proteasomes, regulates hsp72 gene transcription in HepG2 cells. J Biol Chem 1996 0.97
31 Heterogeneity of apolipoprotein A-I turnover in subjects with reduced concentrations of plasma high density lipoprotein cholesterol. Metabolism 1988 0.97
32 Evidence for non-equilibrating pools of apolipoprotein C-III in plasma lipoproteins. J Lipid Res 1985 0.96
33 Low rates of apoB secretion from HepG2 cells result from reduced delivery of newly synthesized triglyceride to a "secretion-coupled" pool. J Lipid Res 1996 0.96
34 Effect of a high carbohydrate diet on apoprotein-B catabolism in man. Metabolism 1981 0.96
35 Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study. Pediatrics 2001 0.96
36 Association of plasma lipoproteins with postheparin lipase activities. J Clin Invest 1986 0.95
37 Demonstration of a physical interaction between microsomal triglyceride transfer protein and apolipoprotein B during the assembly of ApoB-containing lipoproteins. J Biol Chem 1996 0.93
38 Co-translational interactions of apoprotein B with the ribosome and translocon during lipoprotein assembly or targeting to the proteasome. J Biol Chem 2001 0.93
39 Radiotracers for low density lipoprotein biodistribution studies in vivo: technetium-99m low density lipoprotein versus radioiodinated low density lipoprotein preparations. J Nucl Med 1988 0.92
40 Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells. J Biol Chem 1992 0.92
41 Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance. Diabetes Obes Metab 2001 0.92
42 Metabolism of apoprotein B in cynomolgus monkey: evidence for independent production of low-density lipoprotein apoprotein B. Am J Physiol 1983 0.90
43 Very low density lipoprotein metabolism in diabetes mellitus. Diabetes Metab Rev 1987 0.89
44 Effect of heparin-induced lipolysis on the distribution of apolipoprotein e among lipoprotein subclasses. Studies with patients deficient in hepatic triglyceride lipase and lipoprotein lipase. J Clin Invest 1985 0.88
45 Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apolipoprotein B lipoproteins from liver cells. J Biol Chem 2001 0.88
46 Kinetic analysis using specific radioactivity data. Methods Enzymol 1986 0.87
47 Apo E-mediated uptake and degradation of normal very low density lipoproteins by human monocyte/macrophages: a saturable pathway distinct from the LDL receptor. Biochem Biophys Res Commun 1985 0.87
48 Investigation of insulin resistance during diabetic ketoacidosis: role of counterregulatory substances and effect of insulin therapy. Metabolism 1977 0.86
49 Hypertriglyceridemia: new insights and new approaches to pharmacologic therapy. Am J Cardiol 2001 0.85
50 Hepatic synthesis of lipoproteins and apolipoproteins. Semin Liver Dis 1992 0.85
51 Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: evidence for reduced assembly and secretion of triglyceride-rich lipoproteins. Metabolism 1992 0.85
52 Exogenous VLDL stimulates apolipoprotein B secretion from HepG2 cells by both pre- and post-translational mechanisms. J Lipid Res 1994 0.84
53 LPL promoter -93T/G transition influences fasting and postprandial plasma triglycerides response in African-Americans and Hispanics. J Lipid Res 1998 0.84
54 Inhibition of translocation of nascent apolipoprotein B across the endoplasmic reticulum membrane is associated with selective inhibition of the synthesis of apolipoprotein B. J Biol Chem 2000 0.84
55 Abnormalities in lipoprotein metabolism in Gaucher type 1 disease. Metabolism 1988 0.84
56 Indium-111-labeled LDL: a potential agent for imaging atherosclerotic disease and lipoprotein biodistribution. J Nucl Med 1990 0.84
57 Investigation of insulin sensitivity in treated subjects with ketosis-prone diabetes mellitus. Diabetes 1977 0.84
58 Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB production, and decrease in particle affinity for the receptor. Results from a novel triple-tracer approach. J Lipid Res 1998 0.83
59 Lack of effect of dehydroepiandrosterone in obese men. Int J Obes 1990 0.83
60 The use of continuous insulin infusion for the peripartum management of pregnant diabetic women. Am J Obstet Gynecol 1978 0.83
61 Demonstration of biphasic effects of docosahexaenoic acid on apolipoprotein B secretion in HepG2 cells. Arterioscler Thromb Vasc Biol 1997 0.82
62 Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: role in dyslipidemia. J Lipid Res 1992 0.82
63 Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene. J Clin Invest 1997 0.82
64 Apoprotein B100, an inefficiently translocated secretory protein, is bound to the cytosolic chaperone, heat shock protein 70. J Biol Chem 1995 0.81
65 Predictors of postprandial triacylglycerol response in children: the Columbia University Biomarkers Study. Am J Clin Nutr 2000 0.81
66 ApoE genotype does not predict lipid response to changes in dietary saturated fatty acids in a heterogeneous normolipidemic population. The DELTA Research Group. Dietary Effects on Lipoproteins and Thrombogenic Activity. Arterioscler Thromb Vasc Biol 1997 0.80
67 Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester. J Biol Chem 1994 0.80
68 Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience. Diabetologia 2012 0.80
69 Altered high density lipoprotein metabolism in patients with myeloproliferative disorders and hypocholesterolemia. Metabolism 1986 0.80
70 Fenofibrate for the treatment of type IV and V hyperlipoproteinemias: a double-blind, placebo-controlled multicenter US study. Clin Ther 1989 0.80
71 A two-site model for ApoB degradation in HepG2 cells. J Biol Chem 1997 0.79
72 Effect of somatostatin-induced suppression of postprandial insulin response upon the hypertriglyceridemia associated with a high carbohydrate diet. J Clin Invest 1982 0.79
73 Apo E-containing lipoproteins in low or high density lipoprotein deficiency. Arteriosclerosis 1985 0.79
74 Direct determination of apolipoprotein C-III specific activity using immunoaffinity chromatography. Methods Enzymol 1986 0.79
75 Nonuniform radiolabeling of VLDL apolipoprotein B: implications for the analysis of studies of the kinetics of the metabolism of lipoproteins containing apolipoprotein B. J Lipid Res 1990 0.78
76 Low-density lipoprotein (LDL) distribution shown by 99mtechnetium-LDL imaging in patients with myeloproliferative diseases. Ann Intern Med 1989 0.78
77 Plasma lipoprotein distribution of apolipoprotein E in familial hypercholesterolemia. Arteriosclerosis 1987 0.78
78 Circulating lipoprotein profiles are modulated differently by lipoprotein lipase in obese humans. J Cardiovasc Risk 2000 0.78
79 In vitro metabolism of apolipoprotein E. Biochim Biophys Acta 1986 0.78
80 Direct measurement of apoprotein C-III specific activity in 125I-labeled very low density lipoproteins using immunoaffinity chromatography. J Lipid Res 1983 0.77
81 New insights into the regulation of lipoprotein metabolism: studies in procaryocytes, eukaryocytes, rodents, pigs, and people. Curr Opin Lipidol 1997 0.77
82 The amino-terminal domain of apolipoprotein B does not undergo retrograde translocation from the endoplasmic reticulum to the cytosol. Proteasomal degradation of nascent apolipoprotein B begins at the carboxyl terminus of the protein, while apolipoprotein B is still in its original translocon. J Biol Chem 2000 0.77
83 Zinc supplementation during pregnancy. JAMA 1995 0.75
84 Treatment of and screening for hyperlipidemia. N Engl J Med 1993 0.75
85 Syndrome X: what's old, what's new, what's etiologic? J Clin Invest 1993 0.75
86 Low HDL cholesterol: what are the prospects of increasing it? Ann Med 1995 0.75
87 Transient lipoprotein lipase deficiency with hyperchylomicronemia. Am J Med Sci 1983 0.75
88 Lipid metabolism: new approaches to old problems. Curr Opin Lipidol 1998 0.75
89 Potential false-positive red blood cell gastrointestinal bleeding study secondary to osseous metastasis. Clin Nucl Med 1991 0.75
90 Glucose does not stimulate apoprotein B secretion from HepG2 cells because of insufficient stimulation of triglyceride synthesis. J Lipid Res 1998 0.75
91 Cyclosporine, plasma lipids, and organ transplantation. Hepatology 1996 0.75
92 Variation in the human ApoB signal peptide modulates ApoB17 translocation. Biochem Biophys Res Commun 2001 0.75
93 Pneumoretroperitoneum secondary to hydrogen peroxide wound irrigations. AJR Am J Roentgenol 1987 0.75
94 Clinical syndrome and lipid metabolism in hereditary deficiency of apolipoproteins A-I and C-III, variant 1. Adv Exp Med Biol 1986 0.75
95 Protocol for efficient plasma sampling for low density lipoprotein turnover studies. J Lipid Res 1984 0.75
96 Isolation of apolipoprotein E-containing lipoproteins by immunoaffinity chromatography. Methods Enzymol 1986 0.75
97 Diagnosis of acute cholecystitis by cholescintigraphy: significance of pericholecystic hepatic uptake. AJR Am J Roentgenol 1989 0.75
98 Immunoaffinity isolation of apolipoprotein E-containing lipoproteins. Biochim Biophys Acta 1985 0.75
99 Unusual collateral venous blood flow following surgical repair of a thoracic aortic dissection. Clin Nucl Med 1991 0.75
100 Propranolol in the treatment of restless legs syndrome induced by imipramine withdrawal. Am J Psychiatry 1986 0.75
101 Pericholecystic hepatic activity in a postcholecystectomy patient. Clin Nucl Med 1989 0.75