Published in J Biol Chem on May 20, 1994
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci U S A (2001) 3.06
Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell (2007) 2.13
Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomembr (1997) 1.36
Nephrotoxicity testing in vitro--what we know and what we need to know. Environ Health Perspect (1998) 1.26
Modes of action of trichloroethylene for kidney tumorigenesis. Environ Health Perspect (2000) 1.21
The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. Carcinogenesis (2005) 1.07
Vacuolating cytotoxin in Helicobacter pylori water-soluble proteins upregulates chemokine expression in human eosinophils via Ca2+ influx, mitochondrial reactive oxygen intermediates, and NF-kappaB activation. Infect Immun (2007) 1.02
Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury. Am J Physiol Renal Physiol (2007) 1.00
Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light. Sci Rep (2014) 0.95
Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard. Pharmacol Ther (2013) 0.91
Protein kinase C mediates repair of mitochondrial and transport functions after toxicant-induced injury in renal cells. J Pharmacol Exp Ther (2003) 0.83
Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. Biochem Pharmacol (2008) 0.81
A role for c-myc in chemically induced renal-cell death. Mol Cell Biol (1997) 0.80
Catechin prevents the calcium oxalate monohydrate induced renal calcium crystallization in NRK-52E cells and the ethylene glycol induced renal stone formation in rat. BMC Complement Altern Med (2013) 0.78
Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine. Biol Reprod (2016) 0.75
In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. J Biol Chem (1983) 2.61
Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cells. J Biol Chem (1997) 2.16
Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. Blood (2001) 1.83
Loss of nuclear p53 protein in preneoplastic rat hepatocytes is accompanied by Mdm2 and Bcl-2 overexpression and by defective response to DNA damage in vivo. Hepatology (2000) 1.42
Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J Pharmacol Exp Ther (1997) 1.37
The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. DNA Cell Biol (1991) 1.35
Substrate specificity of rat liver glutathione S-transferase isoenzymes for a series of glutathione analogues, modified at the gamma-glutamyl moiety. Biochem J (1988) 1.20
Phenol sulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and vitro. 2,6-Dichloro-4-nitrophenol as selective inhibitor of sulphation. Biochem J (1977) 1.19
Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells. J Biol Chem (1999) 1.16
A rapid NAD+-linked assay for microsomal uridine diphosphate glucuronyltransferase of rat liver and some observations on substrate specificity of the enzyme. Biochem J (1975) 1.14
UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions. Biochem Pharmacol (1983) 1.14
The effect of phenobarbital on the submicrosomal distribution of uridine diphosphate glucuronyltransferase from rat liver. Biochem J (1970) 1.13
Rearrangements of the fibrin network and spatial distribution of fibrinolytic components during plasma clot lysis. Study with confocal microscopy. J Biol Chem (1996) 1.12
The heterogeneity of uridine diphosphate glucuronyltransferase from rat liver. Biochem J (1971) 1.09
Interaction of rat glutathione S-transferases 7-7 and 8-8 with gamma-glutamyl- or glycyl-modified glutathione analogues. Biochem J (1989) 1.08
Natural killer cells infiltrating colorectal cancer and MHC class I expression. Mol Immunol (2005) 1.08
Synthesis and nucleophilic reactivity of a series of glutathione analogues, modified at the gamma-glutamyl moiety. Biochem J (1988) 1.07
The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and gamma-glutamyl domains. Biochem J (1990) 1.06
p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion. Carcinogenesis (1997) 1.06
Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues. Carcinogenesis (1994) 1.05
UDP glucuronyltransferase and phenolsulfotransferase in vivo and in vitro. Conjugation of harmol and harmalol. Biochem Pharmacol (1974) 1.04
Processing of acetylated human low-density lipoprotein by parenchymal and non-parenchymal liver cells. Involvement of calmodulin? Biochem J (1982) 1.03
Generation of reactive metabolites of N-hydroxy-phenacetin by glucoronidation and sulfation. Biochem Pharmacol (1977) 1.02
Caspase-3 activity as a prognostic factor in colorectal carcinoma. Lab Invest (2001) 1.01
Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro. Cell Death Differ (1998) 1.00
Hepatic processing of the cholesteryl ester from low density lipoprotein in the rat. J Biol Chem (1986) 0.99
New developments in glucuronidation research: report of a workshop on "glucuronidation, its role in health and disease". Hepatology (1992) 0.99
The effect of Ca2+ and the trifluoperazine on the processing of human acetylated low density lipoprotein by non-parenchymal liver cells. FEBS Lett (1981) 0.99
The effect of a water-soluble tris-galactoside-terminated cholesterol derivative on the fate of low density lipoproteins and liposomes. J Biol Chem (1985) 0.98
UDP glucuronyltransferase and phenolsulfotransferase from rat liver in vivo and in vitro. Characterization of conjugation and biliary excretion of harmol in vivo and in the perfused liver. Biochem Pharmacol (1975) 0.96
Prolonged high intracellular free calcium concentrations induced by ATP are not immediately cytotoxic in isolated rat hepatocytes. Changes in biochemical parameters implicated in cell toxicity. Biochem J (1989) 0.94
Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors. Biochem Pharmacol (1999) 0.93
The oxidation of L- and D-cysteine to inorganic sulfate and taurine in the rat. Biochim Biophys Acta (1981) 0.93
Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. J Biol Chem (2000) 0.93
Isolated perfused rat liver technique. Methods Enzymol (1981) 0.92
In vivo catabolism of biologically modified LDL. Arteriosclerosis (1984) 0.92
A method for comparison of the properties of UDP glucuronyltransferase from rat liver, with a joint substrate. Anal Biochem (1975) 0.91
Inhibition of sulfate conjugation of N-hydroxy-2-acetylaminofluorene in isolated perfused rat liver and in the rat in vivo by pentachlorophenol and low sulfate. Cancer Res (1980) 0.91
Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines. Environ Health Perspect (1983) 0.91
F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells. Am J Physiol (1996) 0.90
Role of sulfation in the formation of DNA adducts from N-hydroxy-2-acetylaminofluorene in rat liver in vivo. Inhibition of N-acetylated aminofluorene adduct formation by pentachlorophenol. Carcinogenesis (1981) 0.90
Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes. Carcinogenesis (1994) 0.90
Visualization of the interaction of native and modified low density lipoproteins with isolated rat liver cells. Eur J Cell Biol (1985) 0.89
Formation and identification of glutathione conjugates from 2-nitrosofluorene and N-hydroxy-2-aminofluorene. Chem Biol Interact (1982) 0.89
Analytical study of microsomes and isolated subcellular membranes from rat liver. IX. Nicotinamide adenine dinucleotide glycohydrolase: a plasma membrane enzyme prominently found in Kupffer cells. J Cell Biol (1985) 0.89
In vivo uptake of polyisobutyl cyanoacrylate nanoparticles by rat liver Kupffer, endothelial, and parenchymal cells. J Pharm Sci (1984) 0.89
The availability of inorganic sulphate in blood for sulphate conjugation of drugs in rat liver in vivo. (35S)Sulphate incorporation into harmol sulphate. Biochem J (1978) 0.89
Alteration of urinary levels of the carcinogen, N-hydroxy-2-naphthylamine, and its N-glucuronide in the rat by control of urinary pH, inhibition of metabolic sulfation, and changes in biliary excretion. Chem Biol Interact (1981) 0.88
Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver. Br J Cancer (2000) 0.88
alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver. J Pharmacol Exp Ther (1986) 0.88
Stereoselective glutathione conjugation and amidase-catalyzed hydrolysis of alpha-bromoisovalerylurea enantiomers in isolated rat hepatocytes. J Pharmacol Exp Ther (1987) 0.87
Reaction of mutagenic phenacetin metabolites with glutathione and DNA. Possible implications for toxicity. Mol Pharmacol (1984) 0.87
Quantification and visualization of the transport of octreotide, a somatostatin analogue, across monolayers of cerebrovascular endothelial cells. Pharm Res (1994) 0.87
Morphogenesis of HHV8 in primary human dermal microvascular endothelium and primary effusion lymphomas. Ultrastruct Pathol (2001) 0.86
Role of NK cells in adoptive immunotherapy of metastatic colorectal cancer in a syngeneic rat model. Immunol Rev (2001) 0.86
Liquid chromatographic determination of diastereomeric glutathione conjugates and further derivatives of alpha-bromoisovalerylurea in rat bile and urine by electrochemically generated bromine. J Chromatogr (1988) 0.86
Inhibition of the oxidative metabolism of theophylline in isolated rat hepatocytes by the quinolone antibiotic enoxacin and its metabolite oxoenoxacin, but not by ofloxacin. Biochem Pharmacol (1988) 0.86
Glutathione conjugation of 4-hydroxy-trans-2,3-nonenal in the rat in vivo, the isolated perfused liver and erythrocytes. Toxicol Appl Pharmacol (1999) 0.86
Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan (L-phenylalanine mustard) in human colorectal cancer cells. Biochem Pharmacol (1999) 0.86
Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat: enhanced tumor glutathione depletion by infusion of BSO in the hepatic artery. Cancer Chemother Pharmacol (1999) 0.86
Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat. Hepatology (1999) 0.86
Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition. Arch Biochem Biophys (1996) 0.85
An evaluation of methods to decrease the availability of inorganic sulphate for sulphate conjugation in the rat in vivo. Biochem Pharmacol (1981) 0.85
Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells: studies on involvement of adenosine receptors and adenosine uptake. Biochem Pharmacol (2001) 0.85
Evaluation of nephrotoxicity in vitro using a suspension of highly purified porcine proximal tubular cells and characterization of the cells in primary culture. Exp Nephrol (1995) 0.85
Diffusion rates and transport pathways of fluorescein isothiocyanate (FITC)-labeled model compounds through buccal epithelium. Pharm Res (1994) 0.85
Stereoselective glutathione conjugation of the separate alpha-bromoisovalerylurea and alpha-bromoisovaleric acid enantiomers in the rat in vivo and in rat liver subcellular fractions. Biochem Pharmacol (1988) 0.84
alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. I. (Bio-) synthesis, analysis and identification of diastereomeric glutathione conjugates and mercapturates. J Pharmacol Exp Ther (1986) 0.84
Processing of cholesteryl ester from low-density lipoproteins in the rat. Hepatic metabolism and biliary secretion after uptake by different hepatic cell types. Biochem J (1989) 0.84
Stereoselectivity of rat liver glutathione transferase isoenzymes for alpha-bromoisovaleric acid and alpha-bromoisovalerylurea enantiomers. Biochem J (1988) 0.84
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene. Arch Toxicol (1991) 0.84
Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates. Biochem Pharmacol (1978) 0.84
In vivo and in vitro catabolism of native and biologically modified LDL. FEBS Lett (1984) 0.84
Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives. Eur J Cancer (2004) 0.83
Inhibition of sulfation of phenols in vivo by 2,6-dichloro-4-nitrophenol: selectivity of its action in relation to other conjugations in the rat in vivo. Med Biol (1979) 0.83
Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes. Toxicol Appl Pharmacol (1999) 0.83
Effects of N-trimethyl chitosan chloride, a novel absorption enhancer, on caco-2 intestinal epithelia and the ciliary beat frequency of chicken embryo trachea. Int J Pharm (1999) 0.83
Inhibition of rat liver glutathione S-transferase isoenzymes by peptides stabilized against degradation by gamma-glutamyl transpeptidase. J Biol Chem (1991) 0.83
Absorption, serum levels and urinary excretion of inorganic sulfate after oral administration of sodium sulfate in the conscious rat. Biochim Biophys Acta (1979) 0.83
Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes. Biochem J (1992) 0.83
Bilirubin and heterogeneity of microsomal uridine diphosphate glucuronyltransferase from rat liver. Biochim Biophys Acta (1972) 0.83
Formation of chemically reactive metabolites of phenacetin and acetaminophen. Adv Exp Med Biol (1981) 0.82
UDP glucuronyltransferase and phenolsulfotransferase from rat liver in vivo and in vitro. III. The effect of phenolphthalein and its sulfate and glucuronide conjugate on conjugation and biliary excretion of harmol. Biochem Pharmacol (1975) 0.82
Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium. J Biol Chem (1993) 0.82
Binding of the radioligand [35S]adenosine 5'-O-(2-thiodiphosphate) and intracellular calcium response in rat liver parenchymal cells. Biochem Pharmacol (1993) 0.82
Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. Princess Takamatsu Symp (1995) 0.82