PubRank

B H Iglewski

Author PubWeight™ 328.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 1998 19.92
2 Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci U S A 1994 11.44
3 Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 1993 10.85
4 Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol 1991 9.89
5 NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,. Proc Natl Acad Sci U S A 1975 9.15
6 A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 1995 7.66
7 Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J Bacteriol 1997 7.51
8 Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol 1997 6.74
9 Bacterial quorum sensing in pathogenic relationships. Infect Immun 2000 5.92
10 Isolation and characterization of Pseudomonas aeruginosa PAO mutant that produces altered elastase. J Bacteriol 1980 5.74
11 Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 1999 5.58
12 LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression. Infect Immun 1993 4.90
13 Transformation of Pseudomonas aeruginosa by electroporation. Nucleic Acids Res 1989 4.75
14 Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg Infect Dis 1999 4.75
15 Codon usage in Pseudomonas aeruginosa. Nucleic Acids Res 1988 4.58
16 Influence of iron on yields of extracellular products in Pseudomonas aeruginosa cultures. J Bacteriol 1979 4.43
17 Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J Bacteriol 1999 4.42
18 A more sensitive plate assay for detection of protease production by Pseudomanas aeruginosa. J Clin Microbiol 1979 4.30
19 Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect Immun 1996 4.08
20 Effect of iron on yields of exotoxin A in cultures of Pseudomonas aeruginosa PA-103. Infect Immun 1978 4.01
21 Toxin A-deficient mutants of Pseudomonas aeruginosa PA103: isolation and characterization. Infect Immun 1980 3.95
22 Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: an autoinduction regulatory hierarchy. J Bacteriol 1995 3.91
23 Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A. Proc Natl Acad Sci U S A 1978 3.84
24 Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene. J Bacteriol 1988 3.83
25 Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR. Mol Microbiol 1991 3.73
26 Structure-activity relationships of an exotoxin of Pseudomonas aeruginosa. Infect Immun 1977 3.63
27 Passive protection by antitoxin in experimental Pseudomonas aeruginosa burn infections. Infect Immun 1977 3.25
28 Interchangeability and specificity of components from the quorum-sensing regulatory systems of Vibrio fischeri and Pseudomonas aeruginosa. J Bacteriol 1994 3.24
29 The contribution of exoproducts to virulence of Pseudomonas aeruginosa. Can J Microbiol 1985 3.21
30 Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo. Infect Immun 1977 3.17
31 Vfr controls quorum sensing in Pseudomonas aeruginosa. J Bacteriol 1997 3.10
32 Toxin inhibitors of protein synthesis: production, purification, and assay of Pseudomonas aeruginosa toxin A. Methods Enzymol 1979 3.10
33 Incidence of exotoxin production by Pseudomonas species. Infect Immun 1977 3.08
34 Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S. Infect Immun 1984 3.01
35 Quorum-sensing genes in Pseudomonas aeruginosa biofilms: their role and expression patterns. Appl Environ Microbiol 2001 2.96
36 Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide. Mol Microbiol 1999 2.95
37 Functional analysis of the Pseudomonas aeruginosa autoinducer PAI. J Bacteriol 1996 2.78
38 Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats. Infect Immun 1982 2.76
39 Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infect Immun 1999 2.67
40 The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol 2000 2.62
41 The chain of command in Pseudomonas quorum sensing. Trends Microbiol 1997 2.56
42 Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 2000 2.52
43 Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect Immun 2000 2.40
44 Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. J Bacteriol 1991 2.39
45 IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. J Immunol 2001 2.32
46 Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa. J Infect Dis 1980 2.29
47 Expression in Escherichia coli and function of Pseudomonas aeruginosa outer membrane porin protein F. J Bacteriol 1986 2.15
48 RsaL, a novel repressor of virulence gene expression in Pseudomonas aeruginosa. J Bacteriol 1999 2.14
49 Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections. Infect Immun 1997 2.11
50 Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model. Infect Immun 1984 2.11
51 Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility. J Bacteriol 1999 2.09
52 Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection. Infect Immun 1983 2.06
53 Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S. J Biol Chem 1989 2.00
54 Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother 2001 1.96
55 Kinetics of toxA and regA mRNA accumulation in Pseudomonas aeruginosa. J Bacteriol 1988 1.96
56 Analysis of the Pseudomonas aeruginosa elastase (lasB) regulatory region. J Bacteriol 1996 1.95
57 lasA and lasB genes of Pseudomonas aeruginosa: analysis of transcription and gene product activity. Infect Immun 1994 1.91
58 Evidence for the role of toxin A in the pathogenesis of infection with Pseudomonas aeruginosa in humans. J Infect Dis 1980 1.90
59 Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice. Infect Immun 1979 1.86
60 Identification of a cytotoxin produced by Legionella pneumophila. Infect Immun 1980 1.83
61 Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa. Antibiot Chemother (1971) 1985 1.78
62 Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant. Infect Immun 1998 1.77
63 Toxins of Pseudomonas aeruginosa: new perspectives. Rev Infect Dis 1983 1.77
64 Isolation and characterization of the Legionella pneumophila outer membrane. J Bacteriol 1984 1.74
65 Differential regulation by iron of regA and toxA transcript accumulation in Pseudomonas aeruginosa. J Bacteriol 1989 1.73
66 Pseudomonas aeruginosa mutants altered in their sensitivity to the effect of iron on toxin A or elastase yields. J Bacteriol 1982 1.72
67 Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin. Infect Immun 1989 1.72
68 The role of exoenzyme S in infections with Pseudomonas aeruginosa. J Infect Dis 1985 1.68
69 Mechanism of action of Pseudomonas aeruginosa exotoxin A in experimental mouse infections: adenosine diphosphate ribosylation of elongation factor 2. Infect Immun 1978 1.66
70 Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. Eur J Clin Microbiol 1985 1.59
71 Temperature-dependent inactivating factor of Pseudomonas aeruginosa exotoxin A. Infect Immun 1976 1.58
72 Nucleotide sequence and expression in Escherichia coli of the Pseudomonas aeruginosa lasA gene. J Bacteriol 1988 1.55
73 Inhibition of Neisseria gonorrhoeae by a bacteriocin from Pseudomonas aeruginosa. Antimicrob Agents Chemother 1976 1.52
74 Comparative toxicities of diphtherial toxin and Pseudomonas aeruginosa exotoxin A: evidence for different cell receptors. J Gen Microbiol 1978 1.52
75 Multiple promoters control the regulation of the Pseudomonas aeruginosa regA gene. Mol Microbiol 1990 1.51
76 Isolation and characterization of a Pseudomonas aeruginosa mutant producing a nontoxic, immunologically crossreactive toxin A protein. Proc Natl Acad Sci U S A 1980 1.50
77 Cloning and characterization of elastase genes from Pseudomonas aeruginosa. J Bacteriol 1987 1.49
78 Purification and characterization of an extracellular protease of Legionella pneumophila. Infect Immun 1986 1.48
79 Identification of regB, a gene required for optimal exotoxin A yields in Pseudomonas aeruginosa. Mol Microbiol 1990 1.48
80 Gene expression in Pseudomonas aeruginosa: evidence of iron override effects on quorum sensing and biofilm-specific gene regulation. J Bacteriol 2001 1.47
81 Locus of the Pseudomonas aeruginosa toxin A gene. J Bacteriol 1983 1.42
82 Molecular studies of a positive regulator of toxin A synthesis in Pseudomonas aeruginosa. Antibiot Chemother (1971) 1987 1.38
83 Pathogenesis of corneal damage from pseudomonas exotoxin A. Invest Ophthalmol Vis Sci 1977 1.35
84 Conjugation-mediated genetic exchange in Legionella pneumophila. J Bacteriol 1985 1.33
85 Novel synthetic analogs of the Pseudomonas autoinducer. Bioorg Med Chem Lett 1999 1.31
86 Expression of the Pseudomonas aeruginosa toxA positive regulatory gene (regA) in Escherichia coli. J Bacteriol 1990 1.28
87 Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa. Infect Immun 2005 1.26
88 In vitro production of an extracellular protease by Legionella pneumophila. Infect Immun 1981 1.26
89 Structure, function, and regulation of Pseudomonas aeruginosa exotoxin A. Annu Rev Microbiol 1990 1.18
90 Synthesis of diphtheria toxin in E. coli cell-free lysate. Biochem Biophys Res Commun 1974 1.18
91 Effect of oxygen-dependent antimicrobial systems on Legionella pneumophila. Infect Immun 1983 1.18
92 The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes. J Infect Dis 1982 1.17
93 Binding of diphtheria toxin to phospholipids in liposomes. Proc Natl Acad Sci U S A 1980 1.16
94 Elastase assays. Methods Enzymol 1994 1.16
95 Production of elastase and other exoproducts by environmental isolates of Pseudomonas aeruginosa. J Clin Microbiol 1986 1.14
96 Outer membrane proteins from Legionella pneumophila serogroups and other Legionella species. Infect Immun 1986 1.14
97 Characterization of a gene that regulates toxin A synthesis in Pseudomonas aeruginosa. Nucleic Acids Res 1988 1.14
98 Effect of regB on expression from the P1 and P2 promoters of the Pseudomonas aeruginosa regAB operon. J Bacteriol 1991 1.13
99 Production of alkaline protease by Pseudomonas aeruginosa. J Clin Microbiol 1980 1.12
100 Inhibition of quorum sensing by a Pseudomonas aeruginosa dksA homologue. J Bacteriol 2001 1.09
101 Characterization of Pseudomonas aeruginosa mutants that are deficient in exotoxin A synthesis and are altered in expression of regA, a positive regulator of exotoxin A. Infect Immun 1994 1.06
102 Regions of toxin A involved in toxin A excretion in Pseudomonas aeruginosa. J Bacteriol 1989 1.03
103 Selective toxicity of diphtheria toxin for malignant cells. Proc Natl Acad Sci U S A 1974 1.02
104 Expression patterns of genes encoding elastase and controlling mucoidy: co-ordinate regulation of two virulence factors in Pseudomonas aeruginosa isolates from cystic fibrosis. Mol Microbiol 1990 1.01
105 Identification of functional epitopes of Pseudomonas aeruginosa exotoxin A using synthetic peptides and subclone products. Mol Immunol 1990 1.00
106 Cloning and expression of a common Legionella outer membrane antigen in Escherichia coli. Microb Pathog 1987 0.99
107 Comparison of two methods of genetic exchange in determination of the genetic locus of the structural gene for Pseudomonas aeruginosa elastase. J Bacteriol 1983 0.99
108 Production of exoenzyme S by clinical isolates of Pseudomonas aeruginosa. Infect Immun 1981 0.99
109 Effect of formalin toxoiding on Pseudomonas aeruginosa toxin A: biological, chemical, and immunochemical studies. Infect Immun 1981 0.96
110 Modulatory effect of iron on the pathogenesis of Pseudomonas aeruginosa mouse corneal infections. Infect Immun 1982 0.93
111 Preferential inhibition of growth and protein synthesis in Rous sarcoma virus transformed cells by diphtheria toxin. Virology 1975 0.93
112 Identification of the principal T lymphocyte-stimulating antigens of Pseudomonas aeruginosa. J Exp Med 1984 0.92
113 Assessment of elastase as a Pseudomonas aeruginosa virulence factor in experimental lung infection in mink. Vet Microbiol 1987 0.91
114 Quorum sensing, gene expression, and Pseudomonas biofilms. Methods Enzymol 1999 0.90
115 Suppression of cytotoxicity of diphtheria toxin by monoclonal antibodies against phosphatidylinositol phosphate. Biophys J 1982 0.90
116 Analysis of the structure-function relationship of Pseudomonas aeruginosa exotoxin A. Mol Microbiol 1990 0.89
117 Defective triggering of polymorphonuclear leukocyte oxidative metabolism by Legionella pneumophila toxin. J Infect Dis 1985 0.88
118 Age-related susceptibility of mice to ocular challenge with Pseudomonas aeruginosa exotoxin A. Infect Immun 1981 0.86
119 Antigenic relationships on the diphtheria toxin molecule: antitoxin versus antitoxoid. Infect Immun 1976 0.85
120 Isolation and characterization of toxin A excretion-deficient mutants of Pseudomonas aeruginosa PAO1. Infect Immun 1992 0.84
121 Determination of the amino acid change responsible for the nontoxic, cross-reactive exotoxin A protein (CRM 66) of Pseudomonas aeruginosa PAO-PR1. J Bacteriol 1988 0.82
122 Secretion of toxin A from Pseudomonas aeruginosa PAO1, PAK, and PA103 by Escherichia coli. Infect Immun 1990 0.82
123 The antigenicity of a pulmonary pathogen defined by monoclonal T cells. Adv Exp Med Biol 1987 0.81
124 Identification of RegA protein from Pseudomonas aeruginosa using anti-RegA antibody. Biochem Biophys Res Commun 1989 0.80
125 Structure-function analysis of exotoxin A proteins with mutations at histidine 426. Infect Immun 1992 0.80
126 Diphtheria toxin: evidence for presence of fragment B in corynebacteriophage. Biochem Biophys Res Commun 1972 0.79
127 Toxoids of Pseudomonas aeruginosa toxin A: production by chemical and genetic means. Rev Infect Dis 1984 0.79
128 Genetic mapping and characterization of Pseudomonas aeruginosa mutants that hyperproduce exoproteins. J Bacteriol 1985 0.78
129 Microscopic characterization of ocular damage produced by Pseudomonas aeruginosa toxin A. Infect Immun 1981 0.78
130 Immunological cross-reactivity in the absence of DNA homology between Pseudomonas toxin A and diphtheria toxin. Infect Immun 1982 0.78
131 Genetic approaches to study Pseudomonas aeruginosa protein antigens. Adv Exp Med Biol 1985 0.77
132 Experimental Pseudomonas exotoxin A mediated ocular damage in mouse pups: microscopic observations. Ophthalmic Res 1982 0.77
133 Effects of pseudomonas toxin A, diphtheria toxin, and cholera toxin on electrical characteristics of turtle bladder. Proc Natl Acad Sci U S A 1979 0.75