Published in J Biol Chem on June 10, 1994
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol (2004) 3.19
The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease. J Biol Chem (2008) 1.58
Mechanism of release and fate of excised oligonucleotides during nucleotide excision repair. J Biol Chem (2012) 1.09
The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity. J Biol Chem (2011) 1.01
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc Natl Acad Sci U S A (2015) 1.00
Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease. J Biol Chem (2008) 0.99
The anti-human immunodeficiency virus agent 3'-fluorothymidine induces DNA damage and apoptosis in human lymphoblastoid cells. Antimicrob Agents Chemother (1996) 0.95
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups. Mech Ageing Dev (2006) 0.94
DNA binding induces active site conformational change in the human TREX2 3'-exonuclease. Nucleic Acids Res (2009) 0.88
TREX1 acts in degrading damaged DNA from drug-treated tumor cells. DNA Repair (Amst) (2009) 0.88
Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. Protein Sci (2008) 0.82
The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers. J Biol Chem (2014) 0.77
Audio-computer interviewing to measure risk behaviour for HIV among injecting drug users: a quasi-randomised trial. Lancet (1999) 8.91
Randomized controlled trial of audio computer-assisted self-interviewing: utility and acceptability in longitudinal studies. HIVNET Vaccine Preparedness Study Protocol Team. Am J Epidemiol (2000) 7.77
High-resolution record of Northern Hemisphere climate extending into the last interglacial period. Nature (2004) 6.44
Practical aspects of preparing phage and plasmid DNA: growth, maintenance, and storage of bacteria and bacteriophage. Methods Enzymol (1987) 2.67
The Retention of the Wheat Vitamins in Flour and Bread, a Problem of National Importance. Can Med Assoc J (1941) 2.35
Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence from a cryptic gene. Cell (1980) 2.14
Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions. J Physiol (2005) 2.12
Does severity of ischemic coronary disease correlate with erectile function? Int J Impot Res (1997) 2.01
Neurological disease in an English city. Acta Neurol Scand (1966) 1.93
The role of retinal pigment epithelium in the involution of subretinal neovascularization. Invest Ophthalmol Vis Sci (1986) 1.90
Medical education and medical research. Lancet (1971) 1.62
The use of videotaped information in cancer genetic counselling: a randomized evaluation study. Br J Cancer (1998) 1.61
Pain in the face. Br Med J (1968) 1.60
Platelet stickiness in multiple sclerosis. Lancet (1965) 1.58
RNA-dependent RNA polymerase activity in influenza virions. Proc Natl Acad Sci U S A (1971) 1.56
Improvements to the differential display method for gene analysis. Biochem Biophys Res Commun (1994) 1.46
Depression. Br Med J (1967) 1.45
Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use. Pediatr Pulmonol (2005) 1.43
Alternative discriminating function for determining hormone dependency of breast cancer. Br Med J (1967) 1.42
Protein-sulfenic acid stabilization and function in enzyme catalysis and gene regulation. FASEB J (1993) 1.42
Mental after-effects of head injury. Proc R Soc Med (1966) 1.40
Addiction in a coworker. Getting past the denial. Am J Nurs (1990) 1.40
Comparison of high- and low-intensity exercise training early after acute myocardial infarction. Am J Cardiol (1988) 1.39
Clinical and microbiologic aspects of serious infections caused by Staphylococcus epidermidis. Scand J Infect Dis (1983) 1.39
Substance abuse among patients presenting at an inner-city psychiatric emergency room. Hosp Community Psychiatry (1993) 1.38
Factors Influencing the Mutation Rate in Neurospora. Science (1948) 1.36
Congenital hepatic fibrosis and nephronophthisis. A family study. Q J Med (1973) 1.36
Translesion DNA synthesis catalyzed by human pol eta and pol kappa across 1,N6-ethenodeoxyadenosine. J Biol Chem (2001) 1.34
Polyneuritis. Br Med J (1966) 1.33
Responses to the major acrolein-derived deoxyguanosine adduct in Escherichia coli. J Biol Chem (2000) 1.29
Characterization of a cDNA clone coding for a sea urchin histone H2A variant related to the H2A.F/Z histone protein in vertebrates. Nucleic Acids Res (1987) 1.29
Comparative in vitro activities of teichomycin and vancomycin alone and in combination with rifampin and aminoglycosides against staphylococci and enterococci. Antimicrob Agents Chemother (1984) 1.28
Pyrogen from mouse macrophages causes fever in mice. Proc Soc Exp Biol Med (1976) 1.25
Fifty years after Flexner. Lancet (1966) 1.24
Traumatic rupture of the ascending aorta and aortic valve following blunt chest trauma. J Thorac Cardiovasc Surg (1977) 1.23
Burst fractures of the fifth lumbar vertebra. A report of four cases. J Bone Joint Surg Am (1982) 1.19
High anti-cytomegalovirus (CMV) IgG antibody titer is associated with coronary artery disease and may predict post-coronary balloon angioplasty restenosis. Am J Cardiol (1998) 1.18
Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine. Clin Pediatr (Phila) (1983) 1.18
Mutations in the region encoding the central domain of helper component-proteinase (HC-Pro) eliminate potato virus X/potyviral synergism. Virology (1997) 1.17
An evaluation of laparoscopic versus open cholecystectomy. Med J Aust (1994) 1.16
Antioxidants: their role in pregnancy and miscarriage. Antioxid Redox Signal (2000) 1.16
Non-specific factors that may influence significance of urinary steroid excretion in breast cancer. Br Med J (1973) 1.10
Antibiotic susceptibility and synergy of clinical isolates of Listeria monocytogenes. Antimicrob Agents Chemother (1982) 1.10
The Effect of Nitrogen Mustard Pretreatment on the Ultra-Violet-Induced Morphological and Biochemical Mutation Rate. Proc Natl Acad Sci U S A (1949) 1.07
A model protocol to assess the risks of agricultural introductions. Nat Biotechnol (1997) 1.05
Temporal relation of the first heart sound to closure of the mitral valve. Circulation (1973) 1.04
Simulation and malingering after injuries to the brain and spinal cord. Lancet (1972) 1.04
Antibacterial correlates of urine drug levels of hexamethylenetetramine and formaldehyde. Invest Urol (1970) 1.03
Effects of a low-oestrogen oral contraceptive on urinary excretion of luteinizing hormone and ovarian steroids. Br Med J (1974) 1.03
Pathophysiological role of cytokines in congestive heart failure. Annu Rev Med (2001) 1.03
Retinal wound healing. Cellular activity at the vitreoretinal interface. Arch Ophthalmol (1986) 1.02
Endocrine activity in multiple sclerosis. Lancet (1967) 1.02
THE EFFECT OF NEW DRUGS ON THE RHYTHMIC FUNCTION OF THE HEART. Calif Med (1950) 1.02
Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med (1988) 1.01
Nucleus taenia of the amygdala of birds: anatomical and functional studies in ring doves (Streptopelia risoria) and European starlings (Sturnus vulgaris). Brain Behav Evol (1999) 1.01
Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (scup): cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450. Arch Biochem Biophys (1986) 1.01
Parameters of red blood cell aggregation as correlates of the inflammatory state. Am J Physiol Heart Circ Physiol (2001) 1.00
Diagnostic strategies in the management of acute upper gastrointestinal bleeding: patient and physician preferences. J Gen Intern Med (1993) 1.00
Comparison of immunofluorescence and enzyme immunoassay for detection of measles-specific immunoglobulin M antibody. J Clin Microbiol (1991) 1.00
Multiple sclerosis and vaccination. Br Med J (1967) 0.99
L-tryptophan in affective disorders: indoleamine changes and differential clinical effects. Psychopharmacologia (1974) 0.98
Morphologic observations on experimental subretinal neovascularization in the monkey. Invest Ophthalmol Vis Sci (1987) 0.98
Marriage, pregnancy and multiple sclerosis. Brain (1966) 0.97
Urinary tract infection after stroke. QJM (2009) 0.97
Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in human peripheral blood monocytes. Nature (1974) 0.96
Idiopathic ventricular fibrillation: inducibility and beneficial effects of class I antiarrhythmic agents. Circulation (1987) 0.96
Purification and analysis of streptococcal NADH peroxidase expressed in Escherichia coli. J Biol Chem (1993) 0.96
Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450. Biochem Pharmacol (1984) 0.96
Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells. J Exp Med (1977) 0.96
Distance education and caregiver support groups: comparison of traditional and telephone groups. J Head Trauma Rehabil (1999) 0.95
Spinal-fluid gamma-globulin and multiple sclerosis. Br Med J (1966) 0.95
The mammalian DNA polymerase delta--proliferating cell nuclear antigen--template-primer complex: molecular characterization by direct binding. Biochemistry (1996) 0.94
Acute experimental myocarditis due to Trypanosoma cruzi. Exercise-induced cardiac hypertrophy. Arch Pathol (1967) 0.94
Hyperreactio luteinalis associated with pregnancy: a case report and review of the literature. Am J Perinatol (1996) 0.93
The estimation of urinary aetiocholanolone using thin-layer chromatography. Clin Chim Acta (1966) 0.93
Discriminants and breast cancer. Lancet (1969) 0.91
Role of cytokines in heart failure. Am Heart J (1998) 0.91
Headache. Trans Ophthalmol Soc U K (1964) 0.91
A new sensitive method for detecting human endogenous (leukocyte) pyrogen. Inflammation (1978) 0.91
Endoglin is overexpressed after arterial injury and is required for transforming growth factor-beta-induced inhibition of smooth muscle cell migration. Arterioscler Thromb Vasc Biol (2000) 0.91
Treatment of cannabis dependence using escitalopram in combination with cognitive-behavior therapy: a double-blind placebo-controlled study. Am J Drug Alcohol Abuse (2014) 0.90
Post-ictal psychosis after right temporal lobectomy. J Neurol Neurosurg Psychiatry (1993) 0.90
[Hyaloid-retinal dysplasia (pseudoglioma) due to recessive autosomal heredity]. Ann Ocul (Paris) (1969) 0.89
Speech Disorders in Childhood. Br Med J (1950) 0.88
Antimicrobial activity of street heroin. J Infect Dis (1980) 0.88
Epidemiological aspects of multiple sclerosis. Proc R Soc Med (1968) 0.88
Anomalous origin of the left coronary artery from the pulmonary artery: report of an adult with ventricular fibrillation as the presenting symptom. Am Heart J (1992) 0.87
Treatment of Felty's syndrome with the haemopoietic growth factor granulocyte colony-stimulating factor (G-CSF). QJM (1998) 0.87
E-mentoring: does it have a place in medicine? Postgrad Med J (2005) 0.87
The FROC curve: a representation of the observer's performance for the method of free response. J Acoust Soc Am (1969) 0.87
Diagnostic applications of the platinum electrode catheter. Br Heart J (1967) 0.87
Occupational therapy with children with pervasive developmental disorders. Am J Occup Ther (1999) 0.87
Asymmetrical cognitive differences associated with hemiparkinsonism. Arch Clin Neuropsychol (1992) 0.87
Primary Lung Cancer in Childhood. Br Med J (1946) 0.87
Clearance of chylomicron remnants in normolipidaemic patients with coronary artery disease: case control study over three years. BMJ (1996) 0.87
Mechanisms of glucose intolerance in cystic fibrosis. Diabet Med (2009) 0.87
Cyclophosphamide in multiple sclerosis. Lancet (1969) 0.86
Preparation and characterization of monoclonal antibodies to pregnenolone 16-alpha-carbonitrile inducible rat liver cytochrome P-450. Biochem Pharmacol (1986) 0.85
Facial paralysis. Br Med J (1967) 0.84