PubRank

D Ganem

Author PubWeight™ 285.19‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The molecular biology of the hepatitis B viruses. Annu Rev Biochem 1987 12.32
2 Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 1996 12.11
3 Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol 1997 6.61
4 Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A 1996 6.00
5 Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription. Nature 1990 5.68
6 The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 1996 5.56
7 Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 1998 5.43
8 Genetic studies of the lac repressor. I. Correlation of mutational sites with specific amino acid residues: construction of a colinear gene-protein map. J Mol Biol 1977 5.14
9 Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J Virol 1999 4.57
10 The role of envelope proteins in hepatitis B virus assembly. Proc Natl Acad Sci U S A 1991 4.37
11 A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J Virol 1998 4.23
12 Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science 1986 4.12
13 Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus. J Virol 1984 3.91
14 Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant. Cell 1985 3.78
15 An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsidation. J Virol 1993 3.72
16 Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest 1997 3.71
17 Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol 1998 3.54
18 Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc Natl Acad Sci U S A 2000 3.45
19 Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region. J Virol 1984 3.30
20 Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA. J Virol 1991 3.26
21 Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting. Nature 1989 3.10
22 Site-specific RNA binding by a hepatitis B virus reverse transcriptase initiates two distinct reactions: RNA packaging and DNA synthesis. J Virol 1994 3.05
23 Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. Science 1986 3.01
24 Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer. J Virol 1994 2.98
25 Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide. Mol Cell Biol 1986 2.69
26 cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA. J Virol 1991 2.66
27 The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. J Virol 1996 2.65
28 A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. Science 1996 2.60
29 A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J Cell Biol 2001 2.54
30 5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles. J Virol 1987 2.54
31 The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid. J Virol 1987 2.49
32 Translational restarts: AUG reinitiation of a lac repressor fragment. Proc Natl Acad Sci U S A 1972 2.45
33 The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated herpesvirus. Virology 1997 2.44
34 Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses. Genes Dev 1990 2.43
35 Expression of the precore region of an avian hepatitis B virus is not required for viral replication. J Virol 1987 2.42
36 A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. J Clin Invest 2001 2.36
37 DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters. J Virol 2001 2.32
38 Genetic studies of the lac repressor. II. Fine structure deletion map of the lacI gene, and its correlation with the physical map. J Mol Biol 1977 2.31
39 Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase. J Virol 1990 2.22
40 Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J Virol 1989 2.21
41 Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol 2001 2.19
42 Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen. Mol Cell Biol 1987 2.18
43 Sequence-independent RNA cleavages generate the primers for plus strand DNA synthesis in hepatitis B viruses: implications for other reverse transcribing elements. EMBO J 1991 2.17
44 A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. J Virol 1999 2.16
45 Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs. Implications for potential therapy. J Clin Invest 1997 2.10
46 Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: implications for KS pathogenesis. J Virol 1999 2.07
47 Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum. Mol Cell Biol 1989 2.05
48 Replication of duck hepatitis B virus in two differentiated human hepatoma cell lines after transfection with cloned viral DNA. Virology 1988 2.03
49 Chlamydial rRNA operons: gene organization and identification of putative tandem promoters. J Bacteriol 1987 1.97
50 Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning. J Virol 1982 1.96
51 A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J 1994 1.96
52 Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses. J Virol 1996 1.93
53 Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology 2000 1.93
54 Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor. J Cell Biol 1988 1.91
55 Characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear RNA encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J Virol 1997 1.90
56 Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities. J Virol 2000 1.89
57 A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin. Proc Natl Acad Sci U S A 1985 1.89
58 gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family. J Biol Chem 1995 1.83
59 Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus. J Virol 1983 1.79
60 Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription. Proc Natl Acad Sci U S A 1993 1.77
61 A cell surface protein that binds avian hepatitis B virus particles. J Virol 1994 1.77
62 A system for studying the selective encapsidation of hepadnavirus RNA. J Virol 1989 1.69
63 Regulation of polyadenylation in human immunodeficiency virus (HIV): contributions of promoter proximity and upstream sequences. EMBO J 1992 1.68
64 The N-terminal (pre-S2) domain of a hepatitis B virus surface glycoprotein is translocated across membranes by downstream signal sequences. J Virol 1990 1.68
65 Persistent infection of humans with hepatitis B virus: mechanisms and consequences. Rev Infect Dis 1983 1.66
66 Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. AIDS 1997 1.65
67 Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template. J Virol 1996 1.64
68 Heat shock response of murine Chlamydia trachomatis. J Bacteriol 1990 1.62
69 Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J Exp Med 1999 1.61
70 A developmentally regulated chlamydial gene with apparent homology to eukaryotic histone H1. Proc Natl Acad Sci U S A 1992 1.60
71 The cloned genome of ground squirrel hepatitis virus is infectious in the animal. Proc Natl Acad Sci U S A 1984 1.60
72 The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women. JAMA 1997 1.59
73 Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A 1999 1.57
74 Mutational analysis of hepatitis B surface antigen particle assembly and secretion. J Virol 1991 1.56
75 Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus. J Virol 2001 1.56
76 Altered sequences changing the operator-binding properties of the Lac repressor: colinearity of the repressor protein with the i-gene map. Proc Natl Acad Sci U S A 1972 1.55
77 Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcoma. J Infect Dis 1996 1.53
78 Developmental regulation of the cysteine-rich outer-membrane proteins of murine Chlamydia trachomatis. J Gen Microbiol 1988 1.52
79 Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. J Virol 2001 1.51
80 Biological characterization of acute infection with ground squirrel hepatitis virus. J Virol 1982 1.51
81 A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle. J Cell Biol 1994 1.51
82 Chlamydial gene encoding a 70-kilodalton antigen in Escherichia coli: analysis of expression signals and identification of the gene product. J Bacteriol 1989 1.39
83 A polymerase chain reaction-based approach to cloning sigma factors from eubacteria and its application to the isolation of a sigma-70 homolog from Chlamydia trachomatis. J Bacteriol 1990 1.38
84 Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses. Mol Cell Biol 1993 1.38
85 Mechanism of translation of the hepadnaviral polymerase (P) gene. Proc Natl Acad Sci U S A 1990 1.37
86 Reinitiation of a lac repressor fragment at a codon other than AUG. Proc Natl Acad Sci U S A 1973 1.35
87 The pre-S domain of the large viral envelope protein determines host range in avian hepatitis B viruses. Proc Natl Acad Sci U S A 1995 1.35
88 Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma. J Infect Dis 1999 1.31
89 Analysis of the binding of a host cell surface glycoprotein to the preS protein of duck hepatitis B virus. Virology 1994 1.31
90 Cultivation and serological characterization of a human Theiler's-like cardiovirus associated with diarrheal disease. J Virol 2010 1.30
91 Epitope mapping of the PreS1 domain of the hepatitis B virus large surface protein. Virology 1990 1.29
92 Propagation of a segment of bacteriophage lamda-DNA in monkey cells after covalent linkage to a defective simian virus 40 genome. Cell 1976 1.24
93 Myristylation of a duck hepatitis B virus envelope protein is essential for infectivity but not for virus assembly. Virology 1991 1.24
94 Immunoreceptor tyrosine-based activation motif-dependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: effects on lytic viral replication. J Virol 2001 1.23
95 RNA sequences controlling the initiation and transfer of duck hepatitis B virus minus-strand DNA. J Virol 1995 1.20
96 In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNAs produce infectious virus in squirrels. J Virol 1987 1.20
97 The biology of Kaposi's sarcoma. Cancer Treat Res 2001 1.15
98 Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus. J Virol 1986 1.15
99 Isolation, propagation and characterization of replication requirements of reiteration mutants of Simian Virus 40. J Mol Biol 1976 1.15
100 Cloning and characterization of RNA polymerase core subunits of Chlamydia trachomatis by using the polymerase chain reaction. J Bacteriol 1990 1.14
101 Homologous recombination between hepadnaviral genomes following in vivo DNA transfection: implications for studies of viral infectivity. Virology 1987 1.11
102 gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activity. J Biol Chem 1998 1.10
103 Activation of N-myc2 gene expression by cis-acting elements of oncogenic hepadnaviral genomes: key role of enhancer II. Virology 1996 1.09
104 Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II. J Virol 1996 1.06
105 Hepatitis delta virus replication generates complexes of large hepatitis delta antigen and antigenomic RNA that affiliate with and alter nuclear domain 10. J Virol 2000 1.04
106 The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J Virol 1997 1.04
107 Construction and propagation of a defective simian virus 40 genome bearing an operator from bacteriophage lambda. Proc Natl Acad Sci U S A 1976 1.03
108 Upstream sequences and cap proximity in the regulation of polyadenylation in ground squirrel hepatitis virus. J Virol 1992 1.02
109 Revised gene-protein map for the lacI gene-lac repressor system. J Mol Biol 1977 1.01
110 Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SIV-positive and SIV-negative rhesus macaques. J Med Primatol 2004 1.00
111 On the control of late gene expression in Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). J Gen Virol 2000 0.99
112 Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. J Infect Dis 2001 0.98
113 Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts. Hepatology 1985 0.98
114 Absence of detectable human herpesvirus 8 in the semen of human immunodeficiency virus-infected men without Kaposi's sarcoma. J Infect Dis 1997 0.97
115 Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host. J Virol 1991 0.97
116 Homologous and heterologous complementation of HBV and WHV capsid and polymerase functions in RNA encapsidation. Virology 1996 0.97
117 Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II. J Virol 1996 0.96
118 Genome Structures of reiteration mutants of simian virus 40. Virology 1977 0.94
119 Antibodies to human herpesvirus 8 in women and infants born in Haiti and the USA. Lancet 1997 0.94
120 Phenotypic mixing between different hepadnavirus nucleocapsid proteins reveals C protein dimerization to be cis preferential. J Virol 1994 0.92
121 Human herpesvirus 8 glycoprotein K8.1: expression, post-translational modification and localization analyzed by monoclonal antibody. J Clin Virol 2000 0.92
122 A host factor that binds near the termini of hepatitis B virus pregenomic RNA. J Virol 1996 0.91
123 Expression and function of microRNAs in viruses great and small. Cold Spring Harb Symp Quant Biol 2006 0.87
124 Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients. Hepatology 1989 0.86
125 Activation of heterologous gene expression by the large isoform of hepatitis delta antigen. J Virol 1998 0.86
126 Deleterious effects of hepatitis delta virus replication on host cell proliferation. J Virol 2001 0.86
127 A block to the intracellular transport and assembly of hepatitis B surface antigen polypeptides in Xenopus oocytes. Virology 1988 0.85
128 Sequences in the preC region of duck hepatitis B virus affect pregenomic RNA accumulation. Virology 1995 0.84
129 Inhibition of duck hepatitis B virus replication by interferon-gamma. J Med Virol 1993 0.82
130 Persistent hepatitis B virus following interferon alfa therapy and liver transplantation. Gastroenterology 1991 0.81
131 Effects of mutations within and adjacent to the terminal repeats of hepatitis B virus pregenomic RNA on viral DNA synthesis. J Virol 1997 0.81
132 Cloning and characterization of the RNA polymerase alpha-subunit operon of Chlamydia trachomatis. J Bacteriol 1993 0.80
133 In vivo effects of mutations in woodchuck hepatitis virus enhancer II. J Virol 1998 0.78
134 Oncogenic viruses. Of marmots and men. Nature 1990 0.77
135 Growth of Chlamydia trachomatis in enucleated cells. Infect Immun 1990 0.77
136 Efficient hepatitis delta virus RNA replication in avian cells requires a permissive factor(s) from mammalian cells. J Virol 2001 0.75
137 Towards a rational therapy for hepatitis B. J Clin Invest 1998 0.75
138 The polyalbumin hypothesis: where is it in 1989? Gastroenterology 1989 0.75
139 Extrahepatic hepadnavirus DNA: what does it mean? Gastroenterology 1985 0.75
140 Mathematicians turn their attention to hepatitis C. Nat Med 1998 0.75
141 [Thoughts on endodontic disinfection: are there several methods]. Inf Dent 1976 0.75
142 Laboratory diagnosis of viral hepatitis. Geriatrics 1983 0.75