Published in Mol Cell Biol on May 01, 1986
The role of envelope proteins in hepatitis B virus assembly. Proc Natl Acad Sci U S A (1991) 4.37
Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences. J Virol (1987) 3.16
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94
Biochemical and immunological characterization of the duck hepatitis B virus envelope proteins. J Virol (1987) 2.50
The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid. J Virol (1987) 2.49
Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment. J Cell Biol (1992) 2.45
Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol (1988) 2.41
Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle. Proc Natl Acad Sci U S A (1986) 2.28
Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen. Mol Cell Biol (1987) 2.18
Expression of membrane-associated and secreted variants of gp160 of human immunodeficiency virus type 1 in vitro and in continuous cell lines. J Virol (1988) 2.16
Infection process of the hepatitis B virus depends on the presence of a defined sequence in the pre-S1 domain. J Virol (1999) 2.09
Novel transmembrane topology of the hepatitis B virus envelope proteins. EMBO J (1995) 2.05
Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum. Mol Cell Biol (1989) 2.05
Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci U S A (1996) 2.00
A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J (1994) 1.96
Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor. J Cell Biol (1988) 1.91
Mapping a region of the large envelope protein required for hepatitis B virion maturation. J Virol (1994) 1.73
Topogenic analysis of the human immunodeficiency virus type 1 envelope glycoprotein, gp160, in microsomal membranes. J Cell Biol (1988) 1.71
The N-terminal (pre-S2) domain of a hepatitis B virus surface glycoprotein is translocated across membranes by downstream signal sequences. J Virol (1990) 1.68
Role of the large hepatitis B virus envelope protein in infectivity of the hepatitis delta virion. J Virol (1993) 1.65
Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein. J Virol (1987) 1.64
Mutational analysis of hepatitis B surface antigen particle assembly and secretion. J Virol (1991) 1.56
Three envelope proteins of hepatitis B virus: large S, middle S, and major S proteins needed for the formation of Dane particles. J Virol (1991) 1.51
Production of infectious hepatitis delta virus in vitro and neutralization with antibodies directed against hepatitis B virus pre-S antigens. J Virol (1992) 1.45
Distinctive properties of the hepatitis B virus envelope proteins. J Virol (1988) 1.32
Formation of intracellular particles by hepatitis B virus large surface protein. J Virol (1997) 1.19
Topology of the large envelope protein of duck hepatitis B virus suggests a mechanism for membrane translocation during particle morphogenesis. J Virol (1997) 1.17
Hepatitis B virus subviral envelope particle morphogenesis and intracellular trafficking. J Virol (2007) 1.16
Mutations in the carboxyl-terminal domain of the small hepatitis B virus envelope protein impair the assembly of hepatitis delta virus particles. J Virol (1999) 1.12
Analysis of the cytosolic domains of the hepatitis B virus envelope proteins for their function in viral particle assembly and infectivity. J Virol (2006) 1.05
Apical sorting of hepatitis B surface antigen (HBsAg) is independent of N-glycosylation and glycosylphosphatidylinositol-anchored protein segregation. Proc Natl Acad Sci U S A (1997) 1.02
Hepatitis delta virus ribonucleoproteins shuttle between the nucleus and the cytoplasm. RNA (2002) 1.02
Deletions in the hepatitis B virus small envelope protein: effect on assembly and secretion of surface antigen particles. J Virol (1992) 1.01
Virus-neutralizing monoclonal antibody to a conserved epitope on the duck hepatitis B virus pre-S protein. J Virol (1990) 0.98
Dysregulated surface gene expression from disrupted hepatitis B virus genomes. J Virol (1993) 0.97
Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the hepatitis B surface antigen. Microb Cell Fact (2011) 0.96
Virus-like particles production in green plants. Methods (2006) 0.94
Presentation and immunogenicity of the hepatitis B surface antigen and a poliovirus neutralization antigen on mixed empty envelope particles. J Virol (1988) 0.91
Developmental regulation of hepatitis B surface antigen expression in two lines of hepatitis B virus transgenic mice. J Virol (1989) 0.91
The first transmembrane domain of the hepatitis B virus large envelope protein is crucial for infectivity. J Virol (2009) 0.90
Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells. Virol J (2007) 0.89
Intracellular traffic of newly synthesized proteins. Current understanding and future prospects. J Clin Invest (1989) 0.89
Distinct Viral Lineages from Fish and Amphibians Reveal the Complex Evolutionary History of Hepadnaviruses. J Virol (2016) 0.85
Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins. PLoS One (2012) 0.81
Nano-visualization of oriented-immobilized IgGs on immunosensors by high-speed atomic force microscopy. Sci Rep (2012) 0.79
Hepatitis B Virus Middle Protein Enhances IL-6 Production via p38 MAPK/NF-κB Pathways in an ER Stress-Dependent Manner. PLoS One (2016) 0.75
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. Eur J Biochem (1974) 113.22
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature (1979) 15.42
Intracellular protein topogenesis. Proc Natl Acad Sci U S A (1980) 13.40
Hepatitis B virus genes and their expression in E. coli. Nature (1979) 10.83
Mechanisms for the incorporation of proteins in membranes and organelles. J Cell Biol (1982) 9.67
Purification and properties of an endo-beta-N-acetylglucosaminidase from Streptomyces griseus. J Biol Chem (1974) 8.13
Preparation of microsomal membranes for cotranslational protein translocation. Methods Enzymol (1983) 6.94
Large surface proteins of hepatitis B virus containing the pre-s sequence. J Virol (1984) 6.90
Protein translocation across the endoplasmic reticulum. Cell (1984) 6.69
Cell-free translation of messenger RNA in a wheat germ system. Methods Enzymol (1983) 4.52
Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region. J Virol (1983) 3.24
The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence. Cell (1984) 3.14
Structural relationships between minor and major proteins of hepatitis B surface antigen. J Virol (1983) 3.09
cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. Proc Natl Acad Sci U S A (1983) 2.66
Isolation and characterization of the major protein and glycoprotein of hepatitis B surface antigen. J Biol Chem (1981) 2.60
NH2-terminal hydrophobic region of influenza virus neuraminidase provides the signal function in translocation. Proc Natl Acad Sci U S A (1984) 2.50
A hepatitis B surface antigen polypeptide (P31) with the receptor for polymerized human as well as chimpanzee albumins. Gastroenterology (1983) 2.49
Cloning and sequence analysis of a cDNA for rat transforming growth factor-alpha. Nature (1985) 2.41
Partial amino acid sequence of two major component polypeptides of hepatitis B surface antigen. Proc Natl Acad Sci U S A (1977) 2.34
Pathogenesis and management of lipoprotein disorders. N Engl J Med (1985) 2.31
Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence. Proc Natl Acad Sci U S A (1984) 2.15
Glycosylation of a membrane protein is restricted to the growing polypeptide chain but is not necessary for insertion as a transmembrane protein. Cell (1978) 2.11
Filamentous phage pre-coat is an integral membrane protein: analysis by a new method of membrane preparation. Cell (1982) 2.05
A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins. J Biol Chem (1982) 1.96
Intracellular transport and secretion of hepatitis B surface antigen in mammalian cells. J Virol (1984) 1.95
A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin. Proc Natl Acad Sci U S A (1985) 1.89
Nascent chicken ovalbumin contains the functional equivalent of a signal sequence. J Cell Biol (1978) 1.88
Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes. Proc Natl Acad Sci U S A (1984) 1.82
Electron microscopic studies of Dane particles in hepatocytes with special reference to intracellular development of Dane particles and their relation with HBeAg in serum. Hepatology (1982) 1.72
Electron microscopy and immunoelectronmicroscopy of cytoplasmic hepatitis B antigen in hepatocytes. Am J Pathol (1974) 1.70
Structure of hepatitis B surface antigen. Characterization of the lipid components and their association with the viral proteins. J Biol Chem (1982) 1.69
Transmembrane biogenesis of the vesicular stomatitis virus glycoprotein. J Cell Biol (1979) 1.66
Direct expression of hepatitis B surface antigen in monkey cells from an SV40 vector. DNA (1982) 1.62
Complete amino acid sequence of a membrane receptor for glycoproteins. Sequence of the chicken hepatic lectin. J Biol Chem (1981) 1.60
The mode of association of the enzyme complex sucrase.isomaltase with the intestinal brush border membrane. J Biol Chem (1979) 1.50
On the hydrophobic part of aminopeptidase and maltases which bind the enzyme to the intestinal brush border membrane. Biochim Biophys Acta (1976) 1.48
The virus of hepatitis, type B. (Second of two parts). N Engl J Med (1976) 1.01
Primary hepatocytes in monolayer culture: a model for studies on lipoprotein metabolism. Annu Rev Physiol (1984) 0.86
The molecular biology of the hepatitis B viruses. Annu Rev Biochem (1987) 12.32
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med (1996) 12.11
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol (1997) 6.61
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription. Nature (1990) 5.68
The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med (1996) 5.56
Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein. Proc Natl Acad Sci U S A (1977) 5.51
Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology (1998) 5.43
Mechanism of protein translocation across the endoplasmic reticulum membrane. Annu Rev Cell Biol (1986) 5.28
Genetic studies of the lac repressor. I. Correlation of mutational sites with specific amino acid residues: construction of a colinear gene-protein map. J Mol Biol (1977) 5.14
Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J Virol (1999) 4.57
Translocation of proteins across membranes: the signal hypothesis and beyond. Symp Soc Exp Biol (1979) 4.54
A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. J Biol Chem (1978) 4.43
The role of envelope proteins in hepatitis B virus assembly. Proc Natl Acad Sci U S A (1991) 4.37
A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J Virol (1998) 4.23
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc Natl Acad Sci U S A (1979) 4.22
Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proc Natl Acad Sci U S A (1977) 4.14
Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science (1986) 4.12
Chicken ovalbumin contains an internal signal sequence. Nature (1979) 4.06
Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus. J Virol (1984) 3.91
Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant. Cell (1985) 3.78
A transmembrane form of the prion protein in neurodegenerative disease. Science (1998) 3.76
An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsidation. J Virol (1993) 3.72
Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest (1997) 3.71
Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol (1998) 3.54
Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc Natl Acad Sci U S A (2000) 3.45
Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region. J Virol (1984) 3.30
Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA. J Virol (1991) 3.26
Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein. Proc Natl Acad Sci U S A (1978) 3.11
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting. Nature (1989) 3.10
Site-specific RNA binding by a hepatitis B virus reverse transcriptase initiates two distinct reactions: RNA packaging and DNA synthesis. J Virol (1994) 3.05
Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. Science (1986) 3.01
Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer. J Virol (1994) 2.98
Transmissible and genetic prion diseases share a common pathway of neurodegeneration. Nature (1999) 2.83
cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA. J Virol (1991) 2.66
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. J Virol (1996) 2.65
A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. Science (1996) 2.60
A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J Cell Biol (2001) 2.54
5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles. J Virol (1987) 2.54
The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid. J Virol (1987) 2.49
A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems. Cell (1983) 2.47
Translational restarts: AUG reinitiation of a lac repressor fragment. Proc Natl Acad Sci U S A (1972) 2.45
The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated herpesvirus. Virology (1997) 2.44
Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses. Genes Dev (1990) 2.43
Expression of the precore region of an avian hepatitis B virus is not required for viral replication. J Virol (1987) 2.42
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. J Clin Invest (2001) 2.36
Uncoupling translocation from translation: implications for transport of proteins across membranes. Science (1986) 2.32
DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters. J Virol (2001) 2.32
Genetic studies of the lac repressor. II. Fine structure deletion map of the lacI gene, and its correlation with the physical map. J Mol Biol (1977) 2.31
Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase. J Virol (1990) 2.22
Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J Virol (1989) 2.21
Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol (2001) 2.19
Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen. Mol Cell Biol (1987) 2.18
Sequence-independent RNA cleavages generate the primers for plus strand DNA synthesis in hepatitis B viruses: implications for other reverse transcribing elements. EMBO J (1991) 2.17
A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. J Virol (1999) 2.16
Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs. Implications for potential therapy. J Clin Invest (1997) 2.10
Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: implications for KS pathogenesis. J Virol (1999) 2.07
Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum. Mol Cell Biol (1989) 2.05
Replication of duck hepatitis B virus in two differentiated human hepatoma cell lines after transfection with cloned viral DNA. Virology (1988) 2.03
Chlamydial rRNA operons: gene organization and identification of putative tandem promoters. J Bacteriol (1987) 1.97
Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning. J Virol (1982) 1.96
A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J (1994) 1.96
Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cells. N Engl J Med (1991) 1.95
Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses. J Virol (1996) 1.93
Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology (2000) 1.93
Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor. J Cell Biol (1988) 1.91
Characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear RNA encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J Virol (1997) 1.90
Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities. J Virol (2000) 1.89
A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin. Proc Natl Acad Sci U S A (1985) 1.89
Nascent chicken ovalbumin contains the functional equivalent of a signal sequence. J Cell Biol (1978) 1.88
gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family. J Biol Chem (1995) 1.83
Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes. Proc Natl Acad Sci U S A (1984) 1.82
Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus. J Virol (1983) 1.79
Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription. Proc Natl Acad Sci U S A (1993) 1.77
A cell surface protein that binds avian hepatitis B virus particles. J Virol (1994) 1.77
A system for studying the selective encapsidation of hepadnavirus RNA. J Virol (1989) 1.69
Regulation of polyadenylation in human immunodeficiency virus (HIV): contributions of promoter proximity and upstream sequences. EMBO J (1992) 1.68
The N-terminal (pre-S2) domain of a hepatitis B virus surface glycoprotein is translocated across membranes by downstream signal sequences. J Virol (1990) 1.68
Persistent infection of humans with hepatitis B virus: mechanisms and consequences. Rev Infect Dis (1983) 1.66
Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. AIDS (1997) 1.65
Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template. J Virol (1996) 1.64
Heat shock response of murine Chlamydia trachomatis. J Bacteriol (1990) 1.62
Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J Exp Med (1999) 1.61
A developmentally regulated chlamydial gene with apparent homology to eukaryotic histone H1. Proc Natl Acad Sci U S A (1992) 1.60
The cloned genome of ground squirrel hepatitis virus is infectious in the animal. Proc Natl Acad Sci U S A (1984) 1.60
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A (1999) 1.57
Mutational analysis of hepatitis B surface antigen particle assembly and secretion. J Virol (1991) 1.56
Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus. J Virol (2001) 1.56
Altered sequences changing the operator-binding properties of the Lac repressor: colinearity of the repressor protein with the i-gene map. Proc Natl Acad Sci U S A (1972) 1.55
A former amino terminal signal sequence engineered to an internal location directs translocation of both flanking protein domains. J Cell Biol (1985) 1.54
Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcoma. J Infect Dis (1996) 1.53
Developmental regulation of the cysteine-rich outer-membrane proteins of murine Chlamydia trachomatis. J Gen Microbiol (1988) 1.52
Expression of receptors for cholecystokinin and other Ca2+-mobilizing hormones in Xenopus oocytes. Proc Natl Acad Sci U S A (1988) 1.52
Biological characterization of acute infection with ground squirrel hepatitis virus. J Virol (1982) 1.51
Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. J Virol (2001) 1.51
A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle. J Cell Biol (1994) 1.51