Published in J Mol Biol on December 20, 1993
Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. EMBO J (2001) 2.64
HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature (2013) 2.06
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc Natl Acad Sci U S A (2002) 1.75
Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization. J Virol (1996) 1.59
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. Antimicrob Agents Chemother (2000) 1.42
Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A. Proc Natl Acad Sci U S A (1995) 1.42
X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. Proc Natl Acad Sci U S A (1994) 1.37
The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins. RNA (1998) 1.25
Peptidyl-prolyl isomerases: a new twist to transcription. EMBO Rep (2002) 1.25
Roles of cyclophilins in cancers and other organ systems. World J Surg (2005) 1.14
Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae. Mol Biol Cell (1997) 0.92
Downregulation of cyclophilin A by siRNA diminishes non-small cell lung cancer cell growth and metastasis via the regulation of matrix metallopeptidase 9. BMC Cancer (2012) 0.88
Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Mol Cancer (2011) 0.87
Structure-based identification of small molecule compounds targeting cell cyclophilin A with anti-HIV-1 activity. Eur J Pharmacol (2007) 0.85
Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin). Acta Crystallogr D Biol Crystallogr (2011) 0.84
Actinobacteria cyclophilins: phylogenetic relationships and description of new class- and order-specific paralogues. J Mol Evol (2006) 0.83
Folding of barstar C40A/C82A/P27A and catalysis of the peptidyl-prolyl cis/trans isomerization by human cytosolic cyclophilin (Cyp18). Protein Sci (1999) 0.81
The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS One (2010) 0.79
Characterization of cyclophilin-encoding genes in Phytophthora. Mol Genet Genomics (2009) 0.79
A molecular dynamics study of Cyclophilin A free and in complex with the Ala-Pro dipeptide. Eur Biophys J (2007) 0.78
Characterization of folding cores in the cyclophilin A-cyclosporin A complex. Biophys J (2015) 0.77
High-resolution crystal structures of two crystal forms of human cyclophilin D in complex with PEG 400 molecules. Acta Crystallogr F Struct Biol Commun (2014) 0.76
Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma. PLoS One (2015) 0.76
Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin. ACS Chem Neurosci (2015) 0.75
Thermo-kinetic analysis space expansion for cyclophilin-ligand interactions - identification of a new nonpeptide inhibitor using Biacore™ T200. FEBS Open Bio (2017) 0.75
Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. MBio (2016) 0.75
Crystal structure of the cyclophilin-like domain from the parasitic nematode Brugia malayi. Protein Sci (1998) 0.75
Discovery of novel low-molecular-weight HIV-1 inhibitors interacting with cyclophilin A using in silico screening and biological evaluations. J Mol Model (2012) 0.75
The ribosome binding sites recognized by E. coli ribosomes have regions with signal character in both the leader and protein coding segments. Nucleic Acids Res (1980) 3.74
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med (2001) 3.69
A computer aided oligonucleotide analysis provides a model sequence for RNA polymerase-promoter recognition in E.coli. Nucleic Acids Res (1978) 3.01
Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy. Nature (1991) 1.90
Conformation and interactions of pectins. I. X-ray diffraction analyses of sodium pectate in neutral and acidified forms. J Mol Biol (1981) 1.59
Two structures of cyclophilin 40: folding and fidelity in the TPR domains. Structure (2001) 1.57
X-ray structure of a decameric cyclophilin-cyclosporin crystal complex. Nature (1993) 1.47
Three-dimensional structure of the "long" neurotoxin from cobra venom. Proc Natl Acad Sci U S A (1980) 1.44
The "sponge deformity" after tangential excision and grafting of burns. Plast Reconstr Surg (1989) 1.39
X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. Proc Natl Acad Sci U S A (1994) 1.37
Conformations and interactions of pectins. II. Models for junction zones in pectinic acid and calcium pectate gels. J Mol Biol (1981) 1.27
X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. J Mol Biol (2000) 1.26
Order-disorder transition for a bacterial polysaccharide in solution. A role for polysaccharide conformation in recognition between Xanthomonas pathogen and its plant host. J Mol Biol (1977) 1.23
Structural and mechanistic mapping of a unique fumarate reductase. Nat Struct Biol (1999) 1.21
The X-ray structure of a tetrapeptide bound to the active site of human cyclophilin A. FEBS Lett (1992) 1.04
Excision of burns of the face. Plast Reconstr Surg (1986) 1.04
Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate. J Mol Biol (1999) 1.04
Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc (1998) 1.01
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cell Mol Life Sci (2005) 1.01
Cyclosporin A-cyclophilin complex formation. A model based on X-ray and NMR data. FEBS Lett (1992) 0.99
Identification of the active site acid/base catalyst in a bacterial fumarate reductase: a kinetic and crystallographic study. Biochemistry (2000) 0.99
Kinetic and crystallographic analysis of the key active site acid/base arginine in a soluble fumarate reductase. Biochemistry (2001) 0.94
Complexes of aspartate aminotransferase with hydroxylamine derivatives: spectral studies in solution and in the crystalline state. Biochimie (1989) 0.94
The discovery of steroids and other novel FKBP inhibitors using a molecular docking program. J Mol Biol (1999) 0.92
Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical properties. J Antibiot (Tokyo) (1999) 0.90
Impairment, time out of school, and time off from work after burns. Plast Reconstr Surg (1987) 0.90
Structural and spectroscopic analysis of the F393H mutant of flavocytochrome P450 BM3. Biochemistry (2001) 0.89
Ligand discovery and virtual screening using the program LIDAEUS. Br J Pharmacol (2007) 0.89
Structures of cyclophilin-ligand complexes. Prog Biophys Mol Biol (1997) 0.89
Structure of octreotide, a somatostatin analogue. Acta Crystallogr D Biol Crystallogr (1995) 0.88
Upper abdominal wall defects: immediate or staged reconstruction? Plast Reconstr Surg (1990) 0.87
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A. J Mol Biol (1998) 0.86
Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans. J Biol Chem (1999) 0.85
Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors. J Med Chem (1998) 0.85
Cyclosporins. Structure-activity relationships. Ann N Y Acad Sci (1993) 0.85
An example of a protein ligand found by database mining: description of the docking method and its verification by a 2.3 A X-ray structure of a thrombin-ligand complex. J Mol Biol (1998) 0.85
The X-ray structure of (MeBm2t)1-cyclosporin complexed with cyclophilin A provides an explanation for its anomalously high immunosuppressive activity. Protein Eng (1994) 0.84
Conformational polymorphism of cyclosporin A. Structure (1994) 0.82
X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations. J Mol Biol (1999) 0.82
Crystallization and preliminary X-ray crystallographic study of interleukin-8. FEBS Lett (1990) 0.81
Crystallization and preliminary X-ray analysis of ocr, the product of gene 0.3 of bacteriophage T7. Acta Crystallogr D Biol Crystallogr (2001) 0.81
Topical growth factors and wound contraction in the rat: Part I. Literature review and definition of the rat model. Ann Plast Surg (1989) 0.81
The molecular replacement solution and X-ray refinement to 2.8 A of a decameric complex of human cyclophilin A with the immunosuppressive drug cyclosporin A. J Mol Biol (1994) 0.80
Chondritis of the burned ear: a preventable complication if ... Ann Plast Surg (1989) 0.80
Outcome and treatment of electrical injury with immediate median and ulnar nerve palsy at the wrist: a retrospective review and a survey of members of the American Burn Association. Ann Plast Surg (1990) 0.79
Development of a microporous tracheal prosthesis. Trans Am Soc Artif Intern Organs (1979) 0.79
Demonstration of a cell-specific isomerization of invertebrate neuropeptides. Neuroscience (1998) 0.79
Novel mechanism of inhibition of elastase by beta-lactams is defined by two inhibitor crystal complexes. J Biol Chem (1999) 0.78
2-Epimutalomycin and 28-epimutalomycin, two new polyether antibiotics from Streptomyces mutabilis. Derivatization of mutalomycin and the structure elucidation of two minor metabolites. J Antibiot (Tokyo) (1989) 0.78
Crystallization and preliminary X-ray analysis of flavocytochrome c(3), the fumarate reductase from Shewanella frigidimarina. J Struct Biol (1999) 0.78
Three-dimensional structure and actions of immunosuppressants and their immunophilins. FASEB J (1995) 0.78
Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A. J Mol Biol (1998) 0.77
Prediction of substrate-specific pockets in cyclosporin synthetase. FEBS Lett (1997) 0.77
A new conformation of the integrin-binding fragment of human VCAM-1 crystallizes in a highly hydrated packing arrangement. Acta Crystallogr D Biol Crystallogr (2001) 0.77
Conformational polymorphism in peptidic and nonpeptidic drug molecules. Biopolymers (1996) 0.77
Structures of redox enzymes. Curr Opin Biotechnol (2000) 0.76
A comparison of intramarginal and extramarginal excision of hypertrophic burn scars. Plast Reconstr Surg (1988) 0.76
Modeling conformational changes in cyclosporin A. Protein Sci (1995) 0.76
The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi. FEBS Lett (1998) 0.76
Comparison of different X-ray data-collection systems using the crystal structure of octreotide. Acta Crystallogr D Biol Crystallogr (1995) 0.76
Six polymorphic crystal forms of alpha-cobratoxin. Eur J Biochem (1981) 0.75
Purification, characterization and crystallization in two crystal forms of bovine cyclophilin 40. Acta Crystallogr D Biol Crystallogr (1999) 0.75
Crystallisation and preliminary X-ray diffraction studies of cyclophilin-tetrapeptide and cyclophilin-cyclosporin complexes. FEBS Lett (1990) 0.75
Noninvasive evaluation of late left ventricular function after aortic valve replacement. J Thorac Cardiovasc Surg (1980) 0.75
Immunophilin structure: a template for immunosuppressive drug design? Transplant Proc (1992) 0.75
Partial excision of residual burn lesions. J Burn Care Rehabil (1987) 0.75
The influence of angiography on experimental free flap survival. Ann Plast Surg (1982) 0.75
Occult breast carcinoma in patients undergoing reduction mammaplasty. Aesthetic Plast Surg (1989) 0.75
Purification of factor X by hydrophobic interaction chromatography. J Chromatogr B Biomed Sci Appl (2001) 0.75
Separation of human vitamin K-dependent coagulation proteins using hydrophobic interaction chromatography. J Chromatogr B Biomed Sci Appl (1999) 0.75
Conformational control of cyclosporin through substitution of the N-5 position. A new class of cyclosporin antagonists. Bioorg Med Chem (1997) 0.75
Orbital osteoma in Gardner's syndrome. Am J Ophthalmol (1986) 0.75
Elucidation of structure function relationships in the IL-8 family by X-ray crystallography. Adv Exp Med Biol (1993) 0.75
Centrally acting alpha 1-adrenoceptor agonists based on hexahydronaphth[2,3-b]-1,4-oxazines and octahydrobenzo[g]quinolines. J Med Chem (1992) 0.75
The nasolabial flap: a problem and its correction. Plast Reconstr Surg (1982) 0.75
A new semisynthetic ergot peptide alkaloid: DCN 203-922. Experientia (1987) 0.75