Published in Cell on February 11, 1994
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly. Proc Natl Acad Sci U S A (1996) 4.83
Cholesterol is required for surface transport of influenza virus hemagglutinin. J Cell Biol (1998) 4.35
Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. J Virol (1995) 3.95
Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A (1996) 3.83
Binding of small basic peptides to membranes containing acidic lipids: theoretical models and experimental results. Biophys J (1996) 2.89
Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling. Proc Natl Acad Sci U S A (1995) 2.30
S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J (1997) 2.19
Identification of an outer segment targeting signal in the COOH terminus of rhodopsin using transgenic Xenopus laevis. J Cell Biol (2000) 2.14
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A (2006) 2.13
Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. J Cell Biol (1998) 2.13
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest (2002) 2.07
A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. EMBO J (1998) 2.05
PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol (1995) 2.05
Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3. J Cell Biol (1997) 2.03
Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae. Mol Cell Biol (1995) 2.02
Labeling HIV-1 virions with two fluorescent proteins allows identification of virions that have productively entered the target cell. Virology (2006) 1.97
Palmitoylation regulates raft affinity for the majority of integral raft proteins. Proc Natl Acad Sci U S A (2010) 1.96
Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway. EMBO J (1995) 1.95
The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study. J Cell Biol (1997) 1.89
Functional roles for fatty acylated amino-terminal domains in subcellular localization. Mol Biol Cell (1999) 1.82
Cystin localizes to primary cilia via membrane microdomains and a targeting motif. J Am Soc Nephrol (2009) 1.79
Decreased c-Src expression enhances osteoblast differentiation and bone formation. J Cell Biol (2000) 1.77
Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A (2011) 1.76
Use of analogs and inhibitors to study the functional significance of protein palmitoylation. Methods (2006) 1.72
Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity. J Virol (1998) 1.72
Evidence for a second function of the MA sequence in the Rous sarcoma virus Gag protein. J Virol (1996) 1.70
CD20-mediated apoptosis: signalling through lipid rafts. Immunology (2002) 1.69
Lipid activation of protein kinases. J Lipid Res (2008) 1.68
The human and simian immunodeficiency virus envelope glycoprotein transmembrane subunits are palmitoylated. Proc Natl Acad Sci U S A (1995) 1.65
Induction of caveolae in the apical plasma membrane of Madin-Darby canine kidney cells. J Cell Biol (2000) 1.63
Fc epsilon RI-mediated association of 6-micron beads with RBL-2H3 mast cells results in exclusion of signaling proteins from the forming phagosome and abrogation of normal downstream signaling. J Cell Biol (1996) 1.60
Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association. Mol Biol Cell (1997) 1.59
Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge. Mol Biol Cell (2006) 1.58
2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro. J Lipid Res (2008) 1.58
Electrostatic binding of proteins to membranes. Theoretical predictions and experimental results with charybdotoxin and phospholipid vesicles. Biophys J (1997) 1.58
Use of a gene expression system based on potato virus X to rapidly identify and characterize a tomato Pto homolog that controls fenthion sensitivity. Plant Cell (1995) 1.54
Csk suppression of Src involves movement of Csk to sites of Src activity. Mol Cell Biol (1994) 1.50
A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proc Natl Acad Sci U S A (1995) 1.49
A myristoyl switch regulates membrane binding of HIV-1 Gag. Proc Natl Acad Sci U S A (2004) 1.48
Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol Cell Biol (1995) 1.44
A large region within the Rous sarcoma virus matrix protein is dispensable for budding and infectivity. J Virol (1996) 1.43
MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins. Genome Biol (2004) 1.42
The chemical toolbox for monitoring protein fatty acylation and prenylation. Nat Chem Biol (2010) 1.42
Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing. Mol Cell Biol (2007) 1.42
Support vector machines for predicting membrane protein types by using functional domain composition. Biophys J (2003) 1.37
Biological activity of human immunodeficiency virus type 1 Vif requires membrane targeting by C-terminal basic domains. J Virol (1995) 1.36
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation. Mol Cell Biol (2000) 1.34
Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines. J Virol (1995) 1.34
Myristoylation and membrane binding regulate c-Src stability and kinase activity. Mol Cell Biol (2010) 1.33
A palmitoylation switch mechanism regulates Rac1 function and membrane organization. EMBO J (2011) 1.31
Signaling defects in anti-tumor T cells. Immunol Rev (2008) 1.28
A rice membrane-bound calcium-dependent protein kinase is activated in response to low temperature. Plant Physiol (2001) 1.25
A single homogeneous form of ATP6 protein accumulates in petunia mitochondria despite the presence of differentially edited atp6 transcripts. Plant Cell (1994) 1.25
Rapid localization of Gag/GagPol complexes to detergent-resistant membrane during the assembly of human immunodeficiency virus type 1. J Virol (2003) 1.23
Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells. BMC Biochem (2002) 1.23
Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBO J (1997) 1.23
Outer surface lipoproteins of Borrelia burgdorferi activate vascular endothelium in vitro. Infect Immun (1996) 1.22
Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck). Mol Biol Cell (2000) 1.22
The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes. Proc Natl Acad Sci U S A (1996) 1.21
Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. J Virol (1995) 1.21
Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proc Natl Acad Sci U S A (1999) 1.18
Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chem Biol (2009) 1.18
Dual fatty acylation of p59(Fyn) is required for association with the T cell receptor zeta chain through phosphotyrosine-Src homology domain-2 interactions. J Cell Biol (1999) 1.16
Compartmentalization of phosphatidylinositol 4,5-bisphosphate signaling evidenced using targeted phosphatases. J Biol Chem (2008) 1.15
Plasma membrane localization of G alpha z requires two signals. Mol Biol Cell (1998) 1.14
Regulation of T-cell receptor signalling by membrane microdomains. Immunology (2004) 1.14
Caveolae act as membrane reserves which limit mechanosensitive I(Cl,swell) channel activation during swelling in the rat ventricular myocyte. PLoS One (2009) 1.12
Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly function. Mol Cell Biol (2006) 1.11
Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Proc Natl Acad Sci U S A (1995) 1.10
Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain. Mol Cell Biol (2009) 1.10
Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells. J Cell Biol (1996) 1.09
Pseudo-enzymatic S-acylation of a myristoylated yes protein tyrosine kinase peptide in vitro may reflect non-enzymatic S-acylation in vivo. Biochem J (1998) 1.08
Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase. Biochem J (2000) 1.08
Two-color photoactivatable probe for selective tracking of proteins and cells. J Biol Chem (2010) 1.08
Intrinsic signals in the unique domain target p56(lck) to the plasma membrane independently of CD4. J Cell Biol (1997) 1.07
Conditions for copackaging rous sarcoma virus and murine leukemia virus Gag proteins during retroviral budding. J Virol (1999) 1.07
Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain. J Cell Biol (2004) 1.05
SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion. Mol Cell Biol (2010) 1.04
Regulation of the Src family kinase Lck by Hsp90 and ubiquitination. Mol Cell Biol (2004) 1.04
Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins. Biochem J (1996) 1.04
Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation. Mol Carcinog (2008) 1.02
Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi. J Biol Chem (2008) 1.02
Trafficking of an acylated cytosolic protein: newly synthesized p56(lck) travels to the plasma membrane via the exocytic pathway. J Cell Biol (1999) 1.02
A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck. J Virol (1996) 1.01
Palmitoylation of the intracytoplasmic R peptide of the transmembrane envelope protein in Moloney murine leukemia virus. J Virol (1999) 1.01
Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes. Mol Cell Biol (2000) 1.01
LPS and Taxol activate Lyn kinase autophosphorylation in Lps(n), but not in Lpsd), macrophages. Mol Med (1995) 1.00
Functional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction. Mol Cell Biol (1999) 1.00
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol Cell Biol (1999) 1.00
Molecular recognition of the palmitoylation substrate Vac8 by its palmitoyltransferase Pfa3. J Biol Chem (2009) 1.00
A dynamically coupled allosteric network underlies binding cooperativity in Src kinase. Nat Commun (2015) 0.98
The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells. J Virol (1999) 0.97
Genetic deletion of CD36 enhances injury after acute neonatal stroke. Ann Neurol (2012) 0.97
Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein. Br J Haematol (2007) 0.97
Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proc Natl Acad Sci U S A (2014) 0.96
Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. EMBO J (1999) 0.95
Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization. J Cell Biol (1996) 0.94
Phosphorylation site dynamics of early T-cell receptor signaling. PLoS One (2014) 0.93