Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.

PubWeight™: 2.38‹?› | Rank: Top 2%

🔗 View Article (PMID 8332912)

Published in Science on July 23, 1993

Authors

C H Warden1, C C Hedrick, J H Qiao, L W Castellani, A J Lusis

Author Affiliations

1: Department of Medicine, University of California, Los Angeles 90024.

Articles citing this

Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04

A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci U S A (1997) 4.17

A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81

Molecular regulation of HDL metabolism and function: implications for novel therapies. J Clin Invest (2006) 3.76

Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A (1994) 3.24

Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation. Proc Natl Acad Sci U S A (1997) 2.59

Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest (1994) 1.93

Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. J Clin Invest (1998) 1.76

Genome-wide association studies in mice. Nat Rev Genet (2012) 1.75

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J Clin Invest (1995) 1.74

Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest (1994) 1.70

Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism. J Clin Invest (1997) 1.67

Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J Clin Invest (1994) 1.56

Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio. J Clin Invest (1997) 1.45

Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc Natl Acad Sci U S A (1996) 1.42

Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach. J Clin Invest (1995) 1.39

Combined statin and niacin therapy remodels the high-density lipoprotein proteome. Circulation (2008) 1.38

Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol. J Clin Invest (1994) 1.18

Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance. J Biol Chem (2007) 1.17

Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles. J Clin Invest (1997) 1.14

Anti-oxidant properties of high-density lipoprotein and atherosclerosis. Clin Exp Pharmacol Physiol (2010) 1.11

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci U S A (1996) 1.10

Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model. J Clin Invest (1996) 1.08

Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV. J Clin Invest (1997) 1.03

Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits. Arterioscler Thromb Vasc Biol (2012) 1.03

HDL in humans with cardiovascular disease exhibits a proteomic signature. Clin Chim Acta (2010) 0.99

Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter. J Exp Med (1995) 0.98

Human ApoA-II inhibits the hydrolysis of HDL triglyceride and the decrease of HDL size induced by hypertriglyceridemia and cholesteryl ester transfer protein in transgenic mice. J Clin Invest (1994) 0.94

Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease. J Clin Invest (1994) 0.91

Proteomics investigations of HDL: challenges and promise. Curr Vasc Pharmacol (2012) 0.89

Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor. Mol Cell Biol (1996) 0.89

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun (2015) 0.88

A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models. Biochim Biophys Acta (2011) 0.88

High yield expression and purification of recombinant human apolipoprotein A-II in Escherichia coli. J Lipid Res (2012) 0.88

A pro-atherogenic HDL profile in coronary heart disease patients: an iTRAQ labelling-based proteomic approach. PLoS One (2014) 0.88

Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J × TALLYHO/JngJ) F2 mice. BMC Genomics (2010) 0.87

Evidence for linkage of the apolipoprotein A-II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans. Proc Natl Acad Sci U S A (1993) 0.86

Increasing association mapping power and resolution in mouse genetic studies through the use of meta-analysis for structured populations. Genetics (2012) 0.86

Immunology of atherosclerosis: the promise of mouse models. Am J Pathol (1996) 0.85

Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice. PLoS Genet (2014) 0.85

ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis. J Lipid Res (2011) 0.84

Effect of weight loss on HDL-apoA-II kinetics in the metabolic syndrome. Clin Sci (Lond) (2009) 0.83

Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice. Int J Hypertens (2012) 0.81

Evaluating the association of common APOA2 variants with type 2 diabetes. BMC Med Genet (2009) 0.81

Two regulatory elements of similar structure and placed in tandem account for the repressive activity of the first intron of the human apolipoprotein A-II gene. Biochem J (1996) 0.81

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway. J Lipid Res (2015) 0.80

Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein. J Lipid Res (2012) 0.80

Apolipoprotein A-II: still second fiddle in high-density lipoprotein metabolism? Arterioscler Thromb Vasc Biol (2013) 0.78

A new mouse mutant for the LDL receptor identified using ENU mutagenesis. J Lipid Res (2008) 0.78

Phospholipids mediated conversion of HDLs generates specific apoA-II pre-beta mobility particles. J Lipid Res (2008) 0.77

Murine mentors: transgenic and knockout models of surgical disease. Ann Surg (1999) 0.76

APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism. Cholesterol (2013) 0.76

Polymorphisms of mouse apolipoprotein A-II alter its physical and functional nature. PLoS One (2014) 0.76

The proximal element of the human apolipoprotein A-II promoter increases the enhancer activity of the distal region. Biochem J (1996) 0.76

Mouse senile amyloid deposition is suppressed by adenovirus-mediated overexpression of amyloid-resistant apolipoprotein A-II. Am J Pathol (1999) 0.76

Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor alpha/thyroid receptor beta heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor beta and upstream stimulatory factor 2a. Biochem J (2003) 0.75

Expression and purification of recombinant human apolipoprotein A-II in Pichia pastoris. Assay Drug Dev Technol (2013) 0.75

Substitution of the carboxyl-terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice. J Clin Invest (1998) 0.75

Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease. Am J Physiol Heart Circ Physiol (2016) 0.75

Evaluating the association of APOA2 polymorphism with insulin resistance in adolescents. Meta Gene (2014) 0.75

Congenic mice demonstrate the presence of QTLs conferring obesity and hypercholesterolemia on chromosome 1 in the TALLYHO mouse. Mamm Genome (2017) 0.75

Articles by these authors

Human lipoprotein lipase complementary DNA sequence. Science (1987) 9.50

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A (1998) 5.21

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature (1998) 3.84

Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation (1995) 3.82

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins. Nature (1990) 3.11

Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature (1993) 2.83

Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arterioscler Thromb Vasc Biol (1999) 2.73

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc Natl Acad Sci U S A (1987) 2.67

The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscler Thromb Vasc Biol (1996) 2.56

Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res (2001) 2.55

Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice. Circulation (2000) 2.39

Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification. Arterioscler Thromb (1994) 2.31

Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism. Circ Res (2000) 2.28

The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. J Biol Chem (1987) 2.20

Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration. J Clin Invest (2001) 2.16

Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice. Circ Res (2001) 2.14

Identification of a zinc finger protein that binds to the sterol regulatory element. Science (1989) 2.13

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem (1998) 2.13

The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J Biol Chem (1987) 2.13

Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J Biol Chem (2000) 2.02

Increased atherosclerosis in myeloperoxidase-deficient mice. J Clin Invest (2001) 2.01

An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1). Blood (1980) 1.86

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proc Natl Acad Sci U S A (2001) 1.84

Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ Res (2000) 1.80

Genome-tagged mice (GTM): two sets of genome-wide congenic strains. Genomics (2001) 1.79

Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics (2000) 1.79

Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics (2001) 1.79

Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21. Genomics (1987) 1.79

Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. Arterioscler Thromb Vasc Biol (2001) 1.79

Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. J Clin Invest (1998) 1.76

HDL and the inflammatory response induced by LDL-derived oxidized phospholipids. Arterioscler Thromb Vasc Biol (2001) 1.74

Production of erythroid-potentiating activity by a human T-lymphoblast cell line. Proc Natl Acad Sci U S A (1980) 1.71

Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest (1994) 1.70

Complete cDNA and derived protein sequence of human apolipoprotein B-100. Nucleic Acids Res (1986) 1.68

Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism. J Clin Invest (1997) 1.67

Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice. J Biol Chem (1993) 1.66

Cloning and expression of apolipoprotein B, the major protein of low and very low density lipoproteins. Proc Natl Acad Sci U S A (1985) 1.65

Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol (1997) 1.65

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest (1997) 1.62

Minimally modified low density lipoprotein is biologically active in vivo in mice. J Clin Invest (1991) 1.57

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice. J Clin Invest (1993) 1.57

Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. J Biol Chem (1996) 1.57

Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL. J Clin Invest (1997) 1.57

Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model. J Clin Invest (1998) 1.56

Human apolipoprotein B: partial amino acid sequence. FEBS Lett (1984) 1.54

Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J Biol Chem (1996) 1.54

A polymorphism affecting apolipoprotein A-II translational efficiency determines high density lipoprotein size and composition. J Biol Chem (1990) 1.53

Influence of the apoA-II gene locus on HDL levels and fatty streak development in mice. Arterioscler Thromb (1993) 1.49

Identification of four chromosomal loci determining obesity in a multifactorial mouse model. J Clin Invest (1995) 1.49

Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene (2001) 1.49

Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2. Arterioscler Thromb Vasc Biol (1999) 1.46

Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio. J Clin Invest (1997) 1.45

Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem (1983) 1.44

Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit. Proc Natl Acad Sci U S A (1985) 1.43

Purification and characterization of a human T-lymphocyte-derived granulocyte-macrophage colony-stimulating factor. Blood (1981) 1.43

Tissue-specific expression and developmental regulation of the rat apolipoprotein B gene. Proc Natl Acad Sci U S A (1986) 1.39

Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach. J Clin Invest (1995) 1.39

Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A synthase and the chromosomal localization of the human gene. J Biol Chem (1986) 1.36

Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. Genomics (1992) 1.36

Tissue-specific expression, developmental regulation, and chromosomal mapping of the lecithin: cholesterol acyltransferase gene. Evidence for expression in brain and testes as well as liver. J Biol Chem (1989) 1.36

Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics (1993) 1.35

Association between serum amyloid A proteins and coronary artery disease: evidence from two distinct arteriosclerotic processes. Circulation (1997) 1.34

Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells. Diabetologia (2004) 1.32

Hepatocellular carcinoma in Txnip-deficient mice. Oncogene (2006) 1.31

RFLP for the human lipoprotein lipase (LPL) gene: HindIII. Nucleic Acids Res (1987) 1.31

Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci U S A (2001) 1.30

Genetic control of lipid transport in mice. I. Structural properties and polymorphisms of plasma lipoproteins. J Biol Chem (1983) 1.29

Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res (1996) 1.29

Amino-terminal amino acid sequence of murine colony-stimulating factor 1. Proc Natl Acad Sci U S A (1985) 1.27

Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance. Diabetes (2001) 1.27

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J Clin Invest (1994) 1.27

Genetic determination of cartilaginous metaplasia in mouse aorta. Arterioscler Thromb Vasc Biol (1995) 1.24

A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci. Mol Psychiatry (2008) 1.22

Linkage of genetic determinants for mouse beta-galactosidase electrophoresis and activity. Genetics (1977) 1.21

Genetic factors controlling structure and expression of apolipoproteins B and E in mice. J Biol Chem (1987) 1.21

A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11. Am J Hum Genet (1999) 1.20

Apolipoprotein B mRNA editing. Direct determination of the edited base and occurrence in non-apolipoprotein B-producing cell lines. J Biol Chem (1990) 1.20

Quantitative trait locus analysis of plasma lipoprotein levels in an autoimmune mouse model : interactions between lipoprotein metabolism, autoimmune disease, and atherogenesis. Arterioscler Thromb Vasc Biol (1999) 1.20

Ultrastructure of early lipid accumulation in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (1999) 1.19

Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci U S A (1987) 1.18

Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet. Circ Res (1999) 1.18

The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23. Am J Hum Genet (1986) 1.17

Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J). J Lipid Res (2000) 1.16

Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. Hypertension (2001) 1.16

A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. Proc Natl Acad Sci U S A (1996) 1.15

Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles. J Clin Invest (1997) 1.14