Published in Metabolism on January 01, 1977
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes (1997) 1.96
Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med (1997) 1.92
Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology (2008) 1.86
Alterations in myocardial cardiolipin content and composition occur at the very earliest stages of diabetes: a shotgun lipidomics study. Biochemistry (2007) 1.70
Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest (2000) 1.68
Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na(+)-glucose cotransporter inhibitor T-1095. Br J Pharmacol (2001) 1.61
Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice. Endocrinology (2008) 1.52
Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest (1995) 1.35
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. Proc Natl Acad Sci U S A (1998) 1.27
Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Natl Acad Sci U S A (1996) 1.19
Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure. Diabetologia (2010) 1.19
The effects of cortisol, corticotropin and thyroxine on the synthesis of glycerolipids and on the phosphatidate phosphohydrolase activity in rat liver. Biochem J (1978) 1.15
Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. PLoS Genet (2009) 1.15
Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice. Mol Med (1996) 1.10
Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PLoS Genet (2011) 1.10
Biology of obesity: lessons from animal models of obesity. J Biomed Biotechnol (2011) 1.05
Genetic and epigenetic control of metabolic health. Mol Metab (2013) 1.03
Acute and chronic animal models for the evaluation of anti-diabetic agents. Cardiovasc Diabetol (2012) 1.02
Laboratory animals as surrogate models of human obesity. Acta Pharmacol Sin (2012) 1.01
The pig as a model for the study of obesity and of control of food intake: a review. Yale J Biol Med (1979) 1.00
Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study. Mol Med (1997) 0.99
Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice. Biochem J (1985) 0.97
Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1. Physiol Genomics (2009) 0.96
Blood pressure in 15 inbred mouse strains and its lack of relation with obesity and insulin resistance in the progeny of an NZO/HILtJ x C3H/HeJ intercross. Mamm Genome (2004) 0.93
Gender-specific expression and mechanism of regulation of estrogen sulfotransferase in adipose tissues of the mouse. Endocrinology (2008) 0.93
Effect of age and weight on upper airway function in a mouse model. J Appl Physiol (1985) (2011) 0.92
Glucose metabolism in perfused skeletal muscle. Demonstration of insulin resistance in the obese Zucker rat. Biochem J (1979) 0.91
Antidiabetic effects of interleukin 1. Proc Natl Acad Sci U S A (1989) 0.90
OB protein binds specifically to the choroid plexus of mice and rats. Proc Natl Acad Sci U S A (1996) 0.89
Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in db/db Mice by Quantitative Proteomics. J Diabetes Res (2013) 0.89
Obesity genetics in mouse and human: back and forth, and back again. PeerJ (2015) 0.89
Needs for animal models of human diseases of the endocrine system. Am J Pathol (1980) 0.87
Pathophysiological differences between obese and non-obese spontaneously hypertensive rats. Br J Exp Pathol (1980) 0.87
Glucagon immunoreactivities and amino acid profile in plasma of duodenopancreatectomized patients. J Clin Invest (1979) 0.87
Macrophage contact dependent and independent TLR4 mechanisms induce β-cell dysfunction and apoptosis in a mouse model of type 2 diabetes. PLoS One (2014) 0.81
The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models. Mamm Genome (2014) 0.81
Phenotypic characterization of the KK/HlJ inbred mouse strain. Vet Pathol (2013) 0.80
Early pregnancy urinary biomarkers of fatty acid and carbohydrate metabolism in pregnancies complicated by gestational diabetes. Diabetes Res Clin Pract (2014) 0.80
Gastrointestinal endocrine cells in an animal model for human type 2 diabetes. Dig Dis Sci (1999) 0.80
Increased ATP inhibition of liver phosphofructokinase from genetically diabetic mice. Proc Natl Acad Sci U S A (1980) 0.80
An enzymatic defect in the obese (ob/ob) mouse: loss of thyroid-induced sodium- and potassium-dependent adenosinetriphosphatase. Proc Natl Acad Sci U S A (1978) 0.79
Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice. PLoS One (2013) 0.78
Glucose metabolism and recycling of radioactively labelled glucose in the Zucker genetically obese rat (fa/fa). Biochem J (1980) 0.78
Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice. Drug Des Devel Ther (2017) 0.77
Biochemical individuality reflected in chromatographic, electrophoretic and mass-spectrometric profiles. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 0.77
Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle. Nutr Metab (Lond) (2014) 0.77
Abnormal regulation of insulin secretion in the genetically obese (ob/ob) mouse. Biochem J (1986) 0.77
A major X-linked locus affects kidney function in mice. Mol Genet Genomics (2012) 0.75
Adeno-associated virus-mediated expression of myostatin propeptide improves the growth of skeletal muscle and attenuates hyperglycemia in db/db mice. Gene Ther (2016) 0.75
Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice. Inhal Toxicol (2016) 0.75
Adipocytes from New Zealand obese mice exhibit aberrant proinflammatory reactivity to the stress signal heat shock protein 60. J Diabetes Res (2014) 0.75
The search for a hormonal switch for obesity. Br Med J (Clin Res Ed) (1987) 0.75
The Cancer Drug Dasatinib Increases PGC-1α in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice. Endocrinology (2016) 0.75
Effects of ventromedial hypothalamic lesions on adipose tissue of weanling male rats. Diabetologia (1981) 0.75
Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science (1987) 6.36
Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia (1978) 5.21
Diabetes, a new mutation in the mouse. Science (1966) 3.80
Effects of parabiosis of obese with diabetes and normal mice. Diabetologia (1973) 3.16
The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia (1973) 2.83
Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective randomized trial. Ann Intern Med (1986) 2.53
Assessment of routine chest roentgenograms and the physical examination to confirm endotracheal tube position. Chest (1989) 2.38
Diabetes-obesity syndromes in mice. Diabetes (1982) 2.01
Diagnostic utility of fiberoptic bronchoscopy in patients with Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome. Am Rev Respir Dis (1983) 1.79
The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains. Biochem Genet (1972) 1.69
Alteration of islet cell populations in spontaneously diabetic mice. Diabetes (1978) 1.60
Studies with the mutation, diabetes, in the mouse. Diabetologia (1967) 1.60
Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol (1969) 1.56
Granulocyte-macrophage colony-stimulating factor: pleiotropic cytokine with potential clinical usefulness. Rev Infect Dis (1990) 1.53
Association between serum inhibitory and bactericidal concentrations and therapeutic outcome in bacterial endocarditis. Am J Med (1982) 1.42
The non-obese diabetic (NOD) mouse. Am J Pathol (1987) 1.40
Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney Int (1990) 1.36
Electrical properties of dog tracheal epithelial cells grown in monolayer culture. Am J Physiol (1984) 1.33
Rat tracheal epithelial cells produce granulocyte/macrophage colony-stimulating factor. Am J Respir Cell Mol Biol (1990) 1.32
Secondary syphilis with pulmonary involvement. West J Med (1983) 1.31
An outbreak of Pneumocystis carinii pneumonia in homosexual men. Ann Intern Med (1982) 1.27
Correlation between gallium lung scans and fiberoptic bronchoscopy in patients with suspected Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome. Am Rev Respir Dis (1984) 1.23
Myocardial ischemia and infarction related to recreational cocaine use. West J Med (1982) 1.22
Stability of parenteral solutions of sodium cephalothin, cephaloridine, potassium penicillin G (buffered) and vancomycin hydrochloride. Am J Hosp Pharm (1971) 1.21
NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes (1998) 1.19
The foreign body reaction: a chronic inflammatory response. J Biomed Mater Res (1974) 1.17
Temporal changes in pancreatic islet composition in C57BL/6J-db/db (diabetes) mice. Diabetologia (1983) 1.17
Hyperinsulinemia in pre-weaning diabetes (db) mice. Diabetologia (1974) 1.16
Antibody to the retrovirus associated with the acquired immunodeficiency syndrome (AIDS). Presence in presumably healthy San Franciscans who died unexpectedly. Arch Intern Med (1986) 1.15
Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in non-obese diabetic mice. Diabetologia (1991) 1.13
Hypoxanthine and adenosine in murine ovarian follicular fluid: concentrations and activity in maintaining oocyte meiotic arrest. Biol Reprod (1985) 1.13
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice. Diabetes (1982) 1.09
Obesity genes: beneficial effects in heterozygous mice. Science (1979) 1.08
Purification and properties of delta-aminolevulinate dehydratase from tissues of two strains of mice. J Biol Chem (1966) 1.05
Enzymatic studies of the hemopoietic defect in flexed mice. Genetics (1969) 1.05
Dietary-induced hypertrophic--hyperplastic obesity in mice. J Lipid Res (1974) 1.04
The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. III. Effect of H-2 haplotype and sex. Diabetes (1981) 1.03
Electrical properties of monolayers cultured from cells of human tracheal mucosa. J Appl Physiol (1985) (1985) 1.03
Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor. J Clin Invest (1989) 1.03
Determination of moxalactam in human body fluids by liquid chromatographic and microbiological methods. Antimicrob Agents Chemother (1981) 1.02
Correlation between serial pulmonary function tests and fiberoptic bronchoscopy in patients with Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome. Am Rev Respir Dis (1984) 1.00
Symposium IV: Diabetic syndrome in animals. Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers. Isr J Med Sci (1975) 0.99
Monomeric Re lipopolysaccharide from Escherichia coli is more active than the aggregated form in the Limulus amebocyte lysate assay and in inducing Egr-1 mRNA in murine peritoneal macrophages. J Biol Chem (1994) 0.99
Hypoxanthine is the principal inhibitor of murine oocyte maturation in a low molecular weight fraction of porcine follicular fluid. Proc Natl Acad Sci U S A (1985) 0.98
Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse. Endocrinology (1997) 0.95
Linkage analyses using biochemical variants in mice. II. Levulinate dehydratase and autosomal glucose 6-phosphate dehydrogenase. Biochem Genet (1969) 0.95
Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages. J Immunol (1988) 0.95
Thermogenesis in diabetes-obesity syndromes in mutant mice. Diabetologia (1982) 0.94
Androgenic and estrogenic metabolites in serum of mice fed dehydroepiandrosterone: relationship to antihyperglycemic effects. Metabolism (1987) 0.93
The effects of hypothalamics lesions in genetically diabetic mice. Diabetologia (1970) 0.93
Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice. Diabetes (1984) 0.93
A new mutation (db3J) at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization. Diabetologia (1980) 0.92
Glucose- and arginine-induced insulin and glucagon responses from the isolated perfused pancreas of the BB-Wistar diabetic rat. Evidence for selective impairment of glucose regulation. Acta Endocrinol (Copenh) (1983) 0.92
The scholarship of application. Acad Med (2000) 0.92
Influence of dietary carbohydrate on the induction of diabetes in C57BL/KsJ-db/db diabetes mice. J Nutr (1983) 0.92
Susceptibility to db gene and streptozotocin-induced diabetes in C57BL mice: control by gender-associated, MHC-unlinked traits. Immunogenetics (1987) 0.91
GAD65 is recognized by T-cells, but not by antibodies from NOD-mice. Autoimmunity (1994) 0.91
Glucose metabolism in perfused skeletal muscle. Demonstration of insulin resistance in the obese Zucker rat. Biochem J (1979) 0.91
Muscle in Lafora disease. Arch Neurol (1974) 0.90
Defective calcium handling and insulin release in islets from diabetic Chinese hamsters. Biochem J (1979) 0.90
Plasma corticosterone concentrations in diabetic (db) mice. Diabetologia (1977) 0.90
Effect of physical training on glucose tolerance and on glucose metabolism of skeletal muscle in anaesthetized normal rats. Diabetologia (1979) 0.90
Endocrine pancreatic cells of postnatal "diabetes" (db) mice in cell culture. In Vitro (1979) 0.90
PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. Am J Physiol (1993) 0.89
Improved system for floor cleaning in health care facilities. Appl Environ Microbiol (1984) 0.89
The enzymatic conversion of porphobilinogen to uroporphyrinogen catalyzed by extracts of hematopoietic mouse spleen. J Biol Chem (1967) 0.89
Linkage of genes controlling the rate of synthesis and structure of aminolevulinate dehydratase. Science (1971) 0.88
Differences in the development of the obese-hyperglycemic syndrome in obob and NZO mice. Diabetologia (1970) 0.87
Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db). Endocrinology (1984) 0.86
Metabolic and underlying causes of diabetes mellitus. Diabetes (1982) 0.84
Calcification of nontextured implantable blood pumps. Trans Am Soc Artif Intern Organs (1981) 0.84
Acetone metabolism in mice: increased activity in mice heterozygous for obesity genes. Proc Natl Acad Sci U S A (1980) 0.84
Maintenance of murine oocyte meiotic arrest: uptake and metabolism of hypoxanthine and adenosine by cumulus cell-enclosed and denuded oocytes. Dev Biol (1986) 0.84
Keratinocyte-derived T-cell growth factor: a T-cell growth factor functionally distinct from interleukin 2. Proc Natl Acad Sci U S A (1986) 0.83
Lessons from studies with genetic forms of diabetes in the mouse. Metabolism (1983) 0.83
Glucose utilization by the mouse brain: influence of age and diabetes. Brain Res (1984) 0.83
A multiplicity of protein antigens in subcellular fractions of rat insulinoma tissue are able to stimulate T cells obtained from non-obese diabetic mice. Diabetologia (1993) 0.83
Granulocyte-macrophage colony-stimulating factor induces transcriptional activation of Egr-1 in murine peritoneal macrophages. J Biol Chem (1991) 0.83
Enhancement of macrophage Fc-dependent phagocytosis by resident thymocytes: effect of a unique heat-stable lymphokine. J Immunol (1983) 0.83
Transfection of adherent murine peritoneal macrophages with a reporter gene using DEAE-dextran. J Immunol Methods (1991) 0.82
Macrophage colony-stimulating factor production by murine and human keratinocytes. Enhancement by bacterial lipopolysaccharide. J Immunol (1990) 0.82
Insulin receptor kinase defects as a possible cause of cellular insulin resistance. Diabete Metab (1987) 0.82
CCK-resistance in Zucker obese versus lean rats. Regul Pept (1997) 0.82
Ultrastructural and morphometric studies of delta cells in pancreatic islets from C57BL/Ks diabetes mice. Diabetologia (1979) 0.82
Cell culture of the endocrine pancreas of the mouse in chemically defined media. In Vitro (1974) 0.82
The optical activity of the disulfide bond in L-cystine and some derivatives of L-cystine. J Am Chem Soc (1968) 0.81
Insulin resistance in the heart: studies on isolated cardiocytes of genetically obese Zucker rats. Endocrinology (1985) 0.81
Characterization of a keratinocyte-derived T cell growth factor distinct from interleukin 2 and B cell stimulatory factor 1. J Immunol (1987) 0.81
Enhancement of macrophage immune and nonimmune receptor-mediated phagocytosis by a low molecular weight soluble factor from resident thymocytes. J Immunol (1984) 0.81
Insulin-induced translocation of GLUT 4 in skeletal muscle of insulin-resistant Zucker rats. Diabetologia (1994) 0.81
Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor. Am J Physiol (1989) 0.81
Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity. Am J Physiol (1992) 0.81
Pneumocystis carinii pneumonia in homosexual men. AJR Am J Roentgenol (1982) 0.81
Ion transport across cat and ferret tracheal epithelia. J Appl Physiol (1985) (1986) 0.81
Adsorption of low density lipoproteins onto selected biomedical polymers. J Biomed Mater Res (1987) 0.81
Blood-materials interactions: the minimum interfacial free energy and the optimum polar/apolar ratio hypotheses. J Biomed Mater Res (1982) 0.80
An adipogenic serum factor in genetically obese rodents. FEBS Lett (1983) 0.80
The foreign body reaction--an experimental protocol. J Biomed Mater Res (1974) 0.80