Published in Proc Natl Acad Sci U S A on July 15, 1993
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Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives. Antimicrob Agents Chemother (1997) 1.10
Cooperative inhibition of NF-kappa B and Tat-induced superactivation of human immunodeficiency virus type 1 long terminal repeat. Proc Natl Acad Sci U S A (1993) 0.98
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A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter. J Virol (1995) 0.94
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Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis. J Virol (1996) 0.93
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Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors. Virology (2011) 0.88
Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription. Antimicrob Agents Chemother (2004) 0.87
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Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. Antimicrob Agents Chemother (1999) 0.79
Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication. J Virol (2013) 0.79
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Inhibition of human immunodeficiency virus type 1 replication in acutely and chronically infected cells by EM2487, a novel substance produced by a Streptomyces species. Antimicrob Agents Chemother (1999) 0.78
Combinative interactions of a human immunodeficiency virus (HIV) Tat antagonist with HIV reverse transcriptase inhibitors and an HIV protease inhibitor. Antimicrob Agents Chemother (1994) 0.75
An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (1987) 19.23
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science (1989) 14.63
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The trans-activator gene of the human T cell lymphotropic virus type III is required for replication. Cell (1986) 10.76
Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell (1986) 10.71
Cellular uptake of the tat protein from human immunodeficiency virus. Cell (1988) 10.19
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product. Nature (1988) 10.15
Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations. Cell (1989) 9.66
Mechanism of activation of early viral transcription by the adenovirus E1A gene product. Cell (1981) 9.38
Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science (1991) 8.76
The trans-activator gene of HTLV-III is essential for virus replication. Nature (1986) 8.65
Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes. J Virol (1983) 8.31
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors. J Virol (1991) 7.01
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Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science (1985) 6.51
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature (1991) 6.30
Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. Gene (1988) 6.13
HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation. Cell (1989) 6.11
Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc Natl Acad Sci U S A (1991) 5.83
Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene. Proc Natl Acad Sci U S A (1985) 5.40
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro. Proc Natl Acad Sci U S A (1989) 5.03
A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev (1990) 4.96
The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation. Proc Natl Acad Sci U S A (1991) 4.66
Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat. Genes Dev (1989) 4.63
Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature (1990) 4.47
Fragments of the HIV-1 Tat protein specifically bind TAR RNA. Science (1990) 4.33
A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator. Mol Cell Biol (1988) 3.74
Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat. J Virol (1988) 3.69
Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro. J Exp Med (1989) 3.63
HIV-1 Tat protein trans-activates transcription in vitro. Cell (1990) 3.57
Site-directed mutagenesis of two trans-regulatory genes (tat-III,trs) of HIV-1. Science (1988) 3.36
Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion. Cell (1988) 3.25
A quantitative bioassay for HIV-1 based on trans-activation. Science (1988) 2.99
CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor. J Virol (1990) 2.96
A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. Science (1990) 2.91
HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. Genes Dev (1992) 2.85
Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1. Science (1989) 2.44
Sequence-specific interaction of Tat protein and Tat peptides with the transactivation-responsive sequence element of human immunodeficiency virus type 1 in vitro. Proc Natl Acad Sci U S A (1990) 2.32
Differences in cytopathogenicity and host cell range among infectious molecular clones of human immunodeficiency virus type 1 simultaneously isolated from an individual. J Virol (1988) 2.24
Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane. J Virol (1990) 2.21
HIV-1 TAT "activates" presynthesized RNA in the nucleus. Cell (1989) 1.89
New human gene encoding a positive modulator of HIV Tat-mediated transactivation. Nature (1992) 1.69
Inhibition of HIV replication in acute and chronic infections in vitro by a Tat antagonist. Science (1991) 1.55
A human T-cell line resistant to cytopathic effects of the human immunodeficiency virus (HIV). Virology (1987) 1.26
Titration of human immunodeficiency virus type 1 (HIV-1) and quantitative analysis of virus expression in vitro using liquid RNA-RNA hybridization. J Virol Methods (1990) 1.17
Tat transactivation of the human immunodeficiency virus type 1 promoter is influenced by basal promoter activity and the simian virus 40 origin of DNA replication. Proc Natl Acad Sci U S A (1991) 1.04
Rapid activation and subsequent down-regulation of the human immunodeficiency virus type 1 promoter in the presence of Tat: possible mechanisms contributing to latency. J Virol (1991) 0.97
Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335. Antimicrob Agents Chemother (1992) 0.96
Restoration of cell surface CD4 expression in human immunodeficiency virus type 1-infected cells by treatment with a Tat antagonist. J Virol (1992) 0.94
Characterization of recombinant HIV-1 Tat and its interaction with TAR RNA. Biochemistry (1992) 0.92
Primary cytotoxicity against the envelope glycoprotein of human immunodeficiency virus-1: evidence for antibody-dependent cellular cytotoxicity in vivo. J Infect Dis (1990) 0.81
Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol Cell Biol (1996) 3.50
Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse. EMBO J (1985) 3.25
Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids. Genes Dev (1990) 2.87
Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. J Clin Oncol (2002) 2.70
Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. Pediatrics (2001) 2.36
Deletions in immunoglobulin mu chains. EMBO J (1982) 2.35
Adenine nucleotide binding sites on beef heart F1-ATPase. Evidence for three exchangeable sites that are distinct from three noncatalytic sites. J Biol Chem (1982) 1.84
A high-resolution, fluorescence-based, semiautomated method for DNA fingerprinting. Genomics (1989) 1.75
A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer. J Med Chem (2009) 1.60
Monoclonal antibodies specific for murine IgM I. Characterization of antigenic determinants on the four constant domains of the mu heavy chain. Eur J Immunol (1984) 1.58
Human immunodeficiency virus type 1 DNA synthesis, integration, and efficient viral replication in growth-arrested T cells. J Virol (1993) 1.57
Inhibition of HIV replication in acute and chronic infections in vitro by a Tat antagonist. Science (1991) 1.55
Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc Natl Acad Sci U S A (1996) 1.42
Obstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kong. Int J Tuberc Lung Dis (2012) 1.41
Kidney and pancreas transplantation in the United States, 1997-2006: the HRSA Breakthrough Collaboratives and the 58 DSA Challenge. Am J Transplant (2008) 1.38
Role of a disulfide bond in the gamma subunit in activation of the ATPase of chloroplast coupling factor 1. J Biol Chem (1984) 1.33
Highly productive infection with pseudotyped human immunodeficiency virus type 1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes. J Virol (2001) 1.28
Hormonal modulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines. Cancer Res (1990) 1.23
vif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages, producing attenuated progeny virus. J Virol (1996) 1.22
Infection of macrophages with lymphotropic human immunodeficiency virus type 1 can be arrested after viral DNA synthesis. J Virol (1993) 1.19
Primary DNA sequence determines sites of maintenance and de novo methylation by mammalian DNA methyltransferases. Mol Cell Biol (1986) 1.19
In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo. Proc Natl Acad Sci U S A (2000) 1.18
Interference to human immunodeficiency virus type 1 infection in the absence of downmodulation of the principal virus receptor, CD4. J Virol (1996) 1.10
Stress and the mesocorticolimbic dopamine systems. Ann N Y Acad Sci (1988) 1.09
In vitro methylation of the 5'-flanking regions of the mouse beta-globin gene. J Biol Chem (1987) 1.08
The vanishing twin. Acta Genet Med Gemellol (Roma) (1982) 1.08
Unexplained menorrhagia and hematuria: a case report of Munchausen's syndrome by proxy. Pediatr Hematol Oncol (1993) 1.07
Detection of anti-HTLV-I Tax antibodies in HTLV-I enzyme-linked immunosorbent assay-negative individuals. Blood (1989) 1.05
DNA methylation: sequences flanking C-G pairs modulate the specificity of the human DNA methylase. Nucleic Acids Res (1985) 1.03
Detection of mouse mast cell-associated protease mRNA. Heparinase treatment greatly improves RT-PCR of tissues containing mast cell heparin. Am J Pathol (1995) 1.02
Induction of rapid and extensive beta-chemokine synthesis in macrophages by human immunodeficiency virus type 1 and gp120, independently of their coreceptor phenotype. J Virol (2001) 1.02
Relationship between traumatic events in childhood and chronic pain. Disabil Rehabil (1999) 1.02
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Laparoscopic procedures: a national survey for 1975. J Reprod Med (1977) 1.01
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Footshock and conditioned stress increase 3,4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra. Brain Res (1985) 0.97
Discovery and characterization of an HIV-1 Tat antagonist. Biochem Soc Trans (1992) 0.97
Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor. Int Arch Allergy Immunol (1995) 0.97
The 3'-terminal sequence of a wound tumor virus transcript can influence conformational and functional properties associated with the 5'-terminus. Virology (1989) 0.95
Human immunodeficiency virus type 1 (HIV-1) protein Vif inhibits the activity of HIV-1 protease in bacteria and in vitro. J Virol (1997) 0.94
Working memory impairment in early multiple sclerosis. Evidence from an event-related potential study of patients with clinically isolated myelopathy. Brain (1997) 0.93
Characterization of recombinant HIV-1 Tat and its interaction with TAR RNA. Biochemistry (1992) 0.92
Contribution of multiple rounds of viral entry and reverse transcription to expression of human immunodeficiency virus type 1. A quantitative kinetic study. J Biol Chem (1991) 0.92
A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells. Clin Cancer Res (2000) 0.92
Lack of evidence for covalently-bound carbohydrates in energy-transducing ATPases from mitochondria, bacteria, and chloroplasts. FEBS Lett (1979) 0.91
Modifying an underlying component of perceived arm length: adaptation of tactile location induced by spatial discordance. J Exp Psychol Hum Percept Perform (1984) 0.90
Postgraduate internship in gynecology and obstetrics for physician assistants: a 4-year experience. Obstet Gynecol (1990) 0.90
Distinct patterns of early response gene expression and proliferation in mouse mast cells stimulated by stem cell factor, interleukin-3, or IgE and antigen. Eur J Immunol (1993) 0.90
Redefinition of tropism of common macrophage-tropic human immunodeficiency virus type 1. AIDS Res Hum Retroviruses (1995) 0.88
Adenine nucleotide binding sites on beef heart F1-ATPase. Specificity of cooperative interactions between catalytic sites. J Biol Chem (1982) 0.88
Selective modification of an alpha subunit of chloroplast coupling factor 1. Biochemistry (1985) 0.86
Uniform detection of HIV-1 in alveolar macrophages of pediatric but not adult AIDS patients. J Leukoc Biol (1993) 0.86
The human immunodeficiency virus type 1 vif gene: the road from an accessory to an essential role in human immunodeficiency virus type 1 replication. Curr Top Microbiol Immunol (1995) 0.86
Is optimism heritable? A study of twins. Behav Res Ther (1993) 0.86
Inhibition of hepatitis-B-virus core promoter by p53: implications for carcinogenesis in hepatocytes. Int J Cancer (1996) 0.85
Prolonged infection of peripheral blood lymphocytes by Vif-negative HIV type 1 induces resistance to productive HIV type 1 infection through soluble factors. AIDS Res Hum Retroviruses (2000) 0.83
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem (2005) 0.83
Use of two-piece polyetheretherketone (PEEK) implants in orbitozygomatic reconstruction. Br J Oral Maxillofac Surg (2011) 0.83
Biochemical genetics of the mouse IgM system. Can J Biochem Cell Biol (1984) 0.82
Interaction of (2,3)-methylenepenams with penicillin-binding proteins. Antimicrob Agents Chemother (1987) 0.82
Delayed graft function has an equally bad impact on deceased donor renal graft survival in both standard criteria donors and expanded criteria donors. Transplant Proc (2009) 0.82
Synthesis and anti-HIV activity of isonucleosides. J Med Chem (1992) 0.82
Isolation and long-term culture of primary ocular human immunodeficiency virus type 1 isolates in primary astrocytes. J Neurovirol (1997) 0.82
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Laparoscopic procedures: The American Association of Gynecologic Laparoscopists' Membership Survey for 1975. J Reprod Med (1977) 0.81
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Human immunodeficiency virus type 1 can infect human retinal pigment epithelial cells in culture and alter the ability of the cells to phagocytose rod outer segment membranes. AIDS Res Hum Retroviruses (2000) 0.79
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Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. Eur J Pharmacol (1987) 0.78
2-benzazepines. 5. Synthesis of pyrimido[5,4-d][2]benzazepines and their evaluation as anxiolytic agents. J Med Chem (1983) 0.78
A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase. Bioorg Med Chem Lett (2001) 0.78
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Recovery of graft function early posttransplant determines long-term graft survival in deceased donor renal transplants. Transplant Proc (2009) 0.78
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The primary DNA sequence determines in vitro methylation by mammalian DNA methyltransferases. Prog Nucleic Acid Res Mol Biol (1986) 0.77
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