Published in Proc Natl Acad Sci U S A on September 15, 1993
Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid Redox Signal (2007) 1.69
Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons. J Cell Biol (1999) 1.60
A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory. Learn Mem (2005) 1.17
Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. Proc Natl Acad Sci U S A (1997) 1.09
The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines. Proc Natl Acad Sci U S A (2011) 1.07
Protein kinase C-dependent and independent signaling pathways regulate synaptic GluR1 and GluR4 AMPAR subunits during in vitro classical conditioning. Neuroscience (2008) 1.07
Oxidative stress and neurodegenerative disorders. Int J Mol Sci (2013) 1.04
Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C. J Physiol (1994) 1.02
Pin1 and PKMzeta sequentially control dendritic protein synthesis. Sci Signal (2010) 1.00
Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress. Front Aging Neurosci (2011) 0.94
Nonclassical mechanisms of progesterone action in the brain: I. Protein kinase C activation in the hypothalamus of female rats. Endocrinology (2008) 0.93
Nonclassical mechanisms of progesterone action in the brain: II. Role of calmodulin-dependent protein kinase II in progesterone-mediated signaling in the hypothalamus of female rats. Endocrinology (2008) 0.92
Cognitive kinases. Proc Natl Acad Sci U S A (1993) 0.90
Postsynaptic signal transduction models for long-term potentiation and depression. Front Comput Neurosci (2010) 0.84
Autonomously active protein kinase C in the maintenance phase of N-methyl-D-aspartate receptor-independent long term potentiation. J Biol Chem (1994) 0.80
Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity. J Exp Neurosci (2016) 0.77
Time course and involvement of protein kinase C-mediated phosphorylation of F1/GAP-43 in area CA3 after mossy fiber stimulation. Cell Mol Neurobiol (1997) 0.76
Dopamine agonist signalling in the hypothalamus of female rats is independent of calcium-dependent kinases. J Neuroendocrinol (2009) 0.76
HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites. PLoS One (2015) 0.76
Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint. J Lipid Res (2017) 0.76
Diacylglycerol Kinases in the Coordination of Synaptic Plasticity. Front Cell Dev Biol (2016) 0.75
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol (1983) 6.04
Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (1992) 5.46
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science (1992) 4.58
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science (1989) 4.48
The long and the short of long-term memory--a molecular framework. Nature (1986) 3.68
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J Biol Chem (1977) 3.02
An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature (1989) 2.83
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation. Nature (1992) 2.48
Potentiation of synaptic transmission in the hippocampus by phorbol esters. Nature (1986) 2.16
Persistent protein kinase activity underlying long-term potentiation. Nature (1988) 2.07
Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1976) 1.75
Domain structure and phosphorylation of protein kinase C. J Biol Chem (1987) 1.65
Translocation of protein kinase C activity may mediate hippocampal long-term potentiation. Science (1986) 1.61
Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP. J Biol Chem (1985) 1.61
Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid. Neuron (1991) 1.59
Autophosphorylation of rat brain Ca2+-activated and phospholipid-dependent protein kinase. J Biol Chem (1986) 1.41
A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation. J Biol Chem (1990) 1.40
Protein kinase C inhibitors eliminate hippocampal long-term potentiation. Brain Res (1987) 1.17
Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region. Proc Natl Acad Sci U S A (1992) 1.17
Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation. Nature (1987) 1.15
Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells. J Biol Chem (1989) 1.15
Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates. Biochem Biophys Res Commun (1992) 1.09
Rapid activation of hippocampal casein kinase II during long-term potentiation. Proc Natl Acad Sci U S A (1991) 1.08
Subtractive cDNA cloning of RC3, a rodent cortex-enriched mRNA encoding a novel 78 residue protein. J Neurosci Res (1990) 1.03
Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C. Biochemistry (1993) 1.03
Immunochemical characterization of rat brain protein kinase C. J Biol Chem (1986) 1.01
Inhibition of protein kinase C blocks two components of LTP persistence, leaving initial potentiation intact. J Neurosci (1990) 1.01
Protein kinase C substrates from bovine brain. Purification and characterization of neuromodulin, a neuron-specific calmodulin-binding protein. J Biol Chem (1989) 1.01
Persistent protein kinase activation in the maintenance phase of long-term potentiation. J Biol Chem (1991) 1.00
Phosphorylation of the presynaptic protein B-50 (GAP-43) is increased during electrically induced long-term potentiation. Neuron (1992) 0.98
Constitutive activity of membrane-inserted protein kinase C. Biochem Biophys Res Commun (1988) 0.93
Inhibitors of calmodulin and protein kinase C block different phases of hippocampal long-term potentiation. Brain Res (1988) 0.89
Activation of multifunctional Ca2+/calmodulin-dependent kinase in intact hippocampal slices. Neuron (1991) 0.89
Role of protein kinase C in phosphorylation of vinculin in adriamycin-resistant HL-60 leukemia cells. Cancer Res (1988) 0.88
Selective increase in phosphorylation of a 47-kDa protein (F1) directly related to long-term potentiation. Behav Neural Biol (1985) 0.86
Increased phosphorylation of a 17-kDa protein kinase C substrate (P17) in long-term potentiation. J Neurochem (1992) 0.82
Dioctanoylglycerol and phorbol diesters enhance phosphorylation of phosphoprotein B-50 in native synaptic plasma membranes. Biochem Biophys Res Commun (1986) 0.77
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron (1998) 4.92
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78
The MAPK cascade is required for mammalian associative learning. Nat Neurosci (1998) 4.61
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56
A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation. J Biol Chem (1997) 3.06
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet (1996) 2.78
Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning. J Neurosci (2000) 2.64
Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther (2001) 2.53
Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J Natl Cancer Inst (1999) 2.41
Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology (1996) 2.35
Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J Biol Chem (1996) 2.24
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res (2000) 2.21
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci (2001) 2.15
Further characterization of amyloid-enhancing factor. Lab Invest (1982) 2.12
A necessity for MAP kinase activation in mammalian spatial learning. Learn Mem (1999) 2.04
The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus. J Neurosci (1999) 1.94
Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Nat Rev Neurosci (2001) 1.92
Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein. Proc Natl Acad Sci U S A (1996) 1.86
Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts after balloon injury of rat carotid arteries. Circulation (2000) 1.84
Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science (2004) 1.83
The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK. J Neurochem (2000) 1.79
Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc Natl Acad Sci U S A (1998) 1.78
Arsenic trioxide, a therapeutic agent for APL. Oncogene (2001) 1.72
Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn Mem (2001) 1.62
Age-related changes in Arc transcription and DNA methylation within the hippocampus. Neurobiol Aging (2010) 1.61
Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation. Cell Mol Life Sci (2006) 1.59
Increased histone acetyltransferase and lysine acetyltransferase activity and biphasic activation of the ERK/RSK cascade in insular cortex during novel taste learning. J Neurosci (2001) 1.58
PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors. Proc Natl Acad Sci U S A (1994) 1.57
Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia. Genes Chromosomes Cancer (1996) 1.49
Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J Appl Physiol (1985) (1994) 1.48
B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J Immunol (1997) 1.46
Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation. J Neurosci (1998) 1.46
Is the short insulin tolerance test safe and reproducible? Diabet Med (1998) 1.41
Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem (2000) 1.39
Gene expression networks underlying retinoic acid-induced differentiation of acute promyelocytic leukemia cells. Blood (2000) 1.38
Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience (2004) 1.38
Sequencing of proteins from two-dimensional gels by using in situ digestion and transfer of peptides to polyvinylidene difluoride membranes: application to proteins associated with sensitization in Aplysia. Proc Natl Acad Sci U S A (1988) 1.36
A role for the beta isoform of protein kinase C in fear conditioning. J Neurosci (2000) 1.36
Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets. J Biol Chem (1986) 1.34
A role for superoxide in protein kinase C activation and induction of long-term potentiation. J Biol Chem (1998) 1.31
Persistent transgene product in retina, optic nerve and brain after intraocular injection of rAAV. Vision Res (1999) 1.30
Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia. Oncogene (1996) 1.28
ETA-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat. Am J Physiol (1995) 1.28
5-HT modulates protein synthesis and the expression of specific proteins during long-term facilitation in Aplysia sensory neurons. Neuron (1989) 1.28
Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain. Learn Mem (2000) 1.26
IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum. J Immunol (1996) 1.23
Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching. Proc Natl Acad Sci U S A (1988) 1.22
Kinetics of cytokine expression and regulation of host protection following infection with molecularly cloned Venezuelan equine encephalitis virus. Virology (1997) 1.22
Epidermal growth factor (EGF) stimulates inositol trisphosphate formation in cells which overexpress the EGF receptor. Biochem Biophys Res Commun (1987) 1.20
Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. Nucleic Acids Res (1997) 1.19
A biochemical blueprint for long-term memory. Learn Mem (1999) 1.18
CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J Exp Med (1994) 1.17
Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. Br J Pharmacol (1995) 1.16
Human T lymphocytes express a protein-tyrosine kinase homologous to p56LSTRA. Biochim Biophys Acta (1986) 1.15
Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes. Proc Natl Acad Sci U S A (1997) 1.14
Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin. J Biol Chem (1985) 1.13
A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2. Proc Natl Acad Sci U S A (1985) 1.13
Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha. Proc Natl Acad Sci U S A (1999) 1.10
Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation. J Biol Chem (1996) 1.10
Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates. Biochem Biophys Res Commun (1992) 1.09
MAPK regulation of gene expression in the central nervous system. Acta Neurobiol Exp (Wars) (2000) 1.09
nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase. J Neurochem (1993) 1.09
EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. Proc Natl Acad Sci U S A (1997) 1.08
N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2+ channel activity in area CA1 of hippocampus. Proc Natl Acad Sci U S A (1991) 1.08
IL-13-mediated worm expulsion is B7 independent and IFN-gamma sensitive. J Immunol (2000) 1.07
Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step. J Biol Chem (1986) 1.07
Subcortical sites mediating sympathetic responses from insular cortex in rats. Am J Physiol (1990) 1.06
Observation of a charged charmoniumlike structure in e+ e- → π+ π- J/ψ at sqrt[s] = 4.26 GeV. Phys Rev Lett (2013) 1.05
Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta. Exp Cell Res (2000) 1.04
Endothelin-1 stimulation of endothelial nitric oxide synthase in the pathogenesis of hepatopulmonary syndrome. Am J Physiol (1999) 1.04
Left cervical aortic arch with aneurysm and obstruction: three-dimensional computed tomographic angiography and magnetic resonance angiographic appearance. Int J Cardiovasc Imaging (2002) 1.03
Molecular cytogenetic characterization and clinical relevance of additional, complex and/or variant chromosome abnormalities in acute promyelocytic leukemia. Leukemia (2001) 1.03
Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C. Biochemistry (1993) 1.03
Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries. Cardiovasc Res (1999) 1.01
Acute promyelocytic leukemia: cellular and molecular basis of differentiation and apoptosis. Pharmacol Ther (1998) 1.00
Observation of electron-antineutrino disappearance at Daya Bay. Phys Rev Lett (2012) 1.00
Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage. Leukemia (2001) 1.00
Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. J Biol Chem (1999) 1.00
Persistent protein kinase activation in the maintenance phase of long-term potentiation. J Biol Chem (1991) 1.00
Mitochondria mediate tumor necrosis factor-alpha/NF-kappaB signaling in skeletal muscle myotubes. Antioxid Redox Signal (1999) 0.99
Comparison of pulmonary arterial flow phenomena in spiral and Lecompte models by computational fluid dynamics. J Thorac Cardiovasc Surg (2001) 0.98
Long-term sensitization training in Aplysia leads to an increase in calreticulin, a major presynaptic calcium-binding protein. Neuron (1992) 0.98
Visual impairment in a Taiwanese population: prevalence, causes, and socioeconomic factors. Ophthalmic Epidemiol (2001) 0.98
A biochemist's view of long-term potentiation. Learn Mem (1999) 0.98
Operable squamous esophageal cancer: current results from the East. World J Surg (1994) 0.98
Protein kinase inhibition by omega-3 fatty acids. J Biol Chem (2001) 0.97
Isolated infundibuloarterial inversion and fifth aortic arch in an infant: a newly recognized cardiovascular phenotypes with chromosome 22q11 deletion. Int J Cardiol (1999) 0.97
No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese. Cancer Lett (2000) 0.97
Regression of ductus arteriosus aneurysm in a neonate demonstrated by three-dimensional computed tomography. Int J Cardiol (1999) 0.96
MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes. Cancer Res (1997) 0.96
Effect of retinoic acid isomers on proliferation, differentiation and PML relocalization in the APL cell line NB4. Leukemia (1995) 0.96
Pharmacokinetics and efficacy of low-dose all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Leukemia (1996) 0.95
Gender-related decrease in Raven's progressive matrices scores in children prenatally exposed to polychlorinated biphenyls and related contaminants. Bull Environ Contam Toxicol (1995) 0.95
Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene. Proc Natl Acad Sci U S A (1999) 0.95