Published in Oncogene on May 01, 1993
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A (2004) 4.17
The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol (2000) 2.07
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J (1994) 2.04
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. EMBO J (2004) 1.94
The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol (1999) 1.67
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol (1996) 1.65
Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction. J Cell Biol (1994) 1.64
Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. Mol Cell Biol (2001) 1.58
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis. Adv Cancer Res (2008) 1.54
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. Mol Biol Cell (1996) 1.42
Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer. J Exp Clin Cancer Res (2016) 1.41
Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP). Protein Sci (1994) 1.29
STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J (1996) 1.28
RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma. Cancer Biol Ther (2011) 1.26
Hepatocyte growth factor/scatter factor-induced intracellular signalling. Int J Exp Pathol (2000) 1.22
Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder. Br J Cancer (2005) 1.19
Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells. Mol Cell Biol (2000) 1.19
MSP-RON signalling in cancer: pathogenesis and therapeutic potential. Nat Rev Cancer (2013) 1.17
Proteolytic cleavage and activation of pro-macrophage-stimulating protein by resident peritoneal macrophage membrane proteases. J Clin Invest (1996) 1.17
The envelope glycoprotein of friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk. J Virol (2001) 1.15
Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma. J Biol Chem (2009) 1.15
A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. Proc Natl Acad Sci U S A (1996) 1.14
Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol Cell Biol (1996) 1.13
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A (1995) 1.13
Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Mol Carcinog (2010) 1.12
The role of the c-Met pathway in lung cancer and the potential for targeted therapy. Ther Adv Med Oncol (2011) 1.11
Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. J Clin Invest (1997) 1.07
MET: a critical player in tumorigenesis and therapeutic target. Cold Spring Harb Perspect Biol (2013) 1.06
The murine stk gene product, a transmembrane protein tyrosine kinase, is a receptor for macrophage-stimulating protein. Proc Natl Acad Sci U S A (1995) 1.04
Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol (2005) 1.03
The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells. Oncogene (2008) 1.02
Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells. J Biol Chem (2008) 1.02
Ron receptor regulates Kupffer cell-dependent cytokine production and hepatocyte survival following endotoxin exposure in mice. Hepatology (2011) 1.02
Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy. Acta Pharmacol Sin (2010) 1.00
The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse. J Clin Invest (1999) 0.97
Immunohistochemical analysis of distribution of RON receptor tyrosine kinase in human digestive organs. Dig Dis Sci (2001) 0.92
The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells. Mol Cancer (2011) 0.92
An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells. Carcinogenesis (2010) 0.92
MLL-ENL cooperates with SCF to transform primary avian multipotent cells. EMBO J (2002) 0.91
Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironment. Clin Exp Metastasis (2012) 0.91
The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells. Pancreas (2010) 0.89
Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET. J Biol Chem (2011) 0.88
Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase. Mol Cancer (2010) 0.87
The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming. Cell Rep (2014) 0.87
SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene. Biochim Biophys Acta (2014) 0.86
The Ron receptor promotes prostate tumor growth in the TRAMP mouse model. Oncogene (2011) 0.86
HIV-1 Tat mediates degradation of RON receptor tyrosine kinase, a regulator of inflammation. J Immunol (2008) 0.85
Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer. Inflamm Bowel Dis (2014) 0.84
Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2. BMC Cancer (2004) 0.84
Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction. J Biomed Res (2013) 0.84
Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival. J Clin Invest (1997) 0.84
MicroRNA-375 Functions as a Tumor-Suppressor Gene in Gastric Cancer by Targeting Recepteur d'Origine Nantais. Int J Mol Sci (2016) 0.82
The Ron receptor tyrosine kinase is not required for adenoma formation in Apc(Min/+) mice. Mol Carcinog (2009) 0.81
The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies. Pancreas (2014) 0.80
Ron receptor tyrosine kinase signaling as a therapeutic target. Expert Opin Ther Targets (2012) 0.80
Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160. J Exp Clin Cancer Res (2008) 0.80
Isolation of Fully Human Antagonistic RON Antibodies Showing Efficient Block of Downstream Signaling and Cell Migration. Transl Oncol (2011) 0.80
Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. PLoS One (2012) 0.80
STK receptor tyrosine kinase regulates susceptibility to infection with Listeria monocytogenes. Infect Immun (2002) 0.79
A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. Oncogene (2015) 0.78
Ron tyrosine kinase receptor synergises with EGFR to confer adverse features in head and neck squamous cell carcinoma. Br J Cancer (2013) 0.77
Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice. Cancer Lett (2010) 0.77
Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment. Am J Cancer Res (2016) 0.77
Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer. Oncotarget (2015) 0.77
Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery. J Cancer Res Clin Oncol (2016) 0.76
The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease. Am J Cancer Res (2016) 0.75
Characterizing the Hot Spots Involved in RON-MSPβ Complex Formation Using In Silico Alanine Scanning Mutagenesis and Molecular Dynamics Simulation. Adv Pharm Bull (2017) 0.75
Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis. Oncol Rep (2017) 0.75
The RON receptor tyrosine kinase is a potential therapeutic target in Burkitt lymphoma. Cancer Biol Ther (2013) 0.75
Crosstalk between RON and androgen receptor signaling in the development of castration resistant prostate cancer. Oncotarget (2016) 0.75
A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene. Oncol Rep (2013) 0.75
Effects of PTCs on nonsense-mediated mRNA decay are dependent on PTC location. Oncol Lett (2017) 0.75
Prognostic significance of MST1R dysregulation in renal cell tumors. Am J Cancer Res (2016) 0.75
Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data. Front Immunol (2017) 0.75
Short-form Ron is a novel determinant of ovarian cancer initiation and progression. Genes Cancer (2016) 0.75
Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression. Chonnam Med J (2017) 0.75
A missing link between RON expression and oncological outcomes in resected left-sided pancreatic cancer. Oncol Lett (2017) 0.75
Organization and expression of eucaryotic split genes coding for proteins. Annu Rev Biochem (1981) 49.46
The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res (1980) 18.04
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A (1978) 14.82
Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature (1979) 9.30
Ovalbumin gene is split in chicken DNA. Nature (1977) 7.05
Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase. Proc Natl Acad Sci U S A (1981) 5.38
Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res (1982) 5.14
A new member of the immunoglobulin superfamily--CTLA-4. Nature (1987) 5.10
Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes. Nature (1991) 4.77
Plasmids for the cloning and expression of full-length double-stranded cDNAs under control of the SV40 early or late gene promoter. Nucleic Acids Res (1983) 4.33
Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). Development (1994) 3.71
Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J (1985) 3.60
Isolation by molecular cloning of a fragment in the split ovalbumin gene. Nature (1978) 3.40
Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J (1990) 2.97
hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer. Mol Cell Biol (1999) 2.93
The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation. EMBO J (1992) 2.86
The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site. Mol Cell Biol (2000) 2.75
Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts. Mol Cell Biol (1986) 2.74
Organization of coding and intervening sequences in the chicken ovalbumin split gene. Cell (1978) 2.61
DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome. Hum Genet (1985) 2.59
The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur J Immunol (2000) 2.58
An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature (1994) 2.57
A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity (1998) 2.56
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. Mol Cell Biol (2000) 2.56
Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. Nucleic Acids Res (1984) 2.52
The collagenase gene family in humans consists of at least four members. Biochem J (1988) 2.45
A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol (1998) 2.36
Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol (1995) 2.34
Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen. Am J Hum Genet (1988) 2.34
Close linkage of fragile X-mental retardation syndrome to haemophilia B and transmission through a normal male. Nature (1984) 2.28
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors. Proc Natl Acad Sci U S A (1986) 2.28
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol (1991) 2.26
Constitutional chromosomal breakage. Hum Genet (1976) 2.24
Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. Oncogene (1989) 2.20
Corrected splicing of a chicken ovalbumin gene transcript in mouse L cells. Proc Natl Acad Sci U S A (1980) 2.19
The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. Gene (1995) 2.19
Structure-function relationships in the collagenase family member transin. J Biol Chem (1988) 2.15
Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts. Nature (1988) 2.12
Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene. Gene (1995) 2.11
X-autosome translocations: cytogenetic characteristics and their consequences. Hum Genet (1982) 2.09
Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes. Nucleic Acids Res (1985) 2.08
TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. Oncogene (1999) 2.05
TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs. J Biol Chem (2001) 1.96
Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. Genomics (1995) 1.96
Genetic control of diabetes progression. Immunity (1997) 1.95
The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. Nat Genet (1997) 1.88
Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron (1992) 1.85
Identification of the ron gene product as the receptor for the human macrophage stimulating protein. Science (1994) 1.84
Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol (1997) 1.83
Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol (1992) 1.81
T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis. J Exp Med (1996) 1.80
Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2. Proc Natl Acad Sci U S A (1988) 1.79
A mouse model for hereditary thyroid dysgenesis and cleft palate. Nat Genet (1998) 1.74
A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. J Biol Chem (1998) 1.70
Human elastin gene: new evidence for localization to the long arm of chromosome 7. Am J Hum Genet (1991) 1.69
Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12. J Biol Chem (1998) 1.68
Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proc Natl Acad Sci U S A (1989) 1.68
The gene encoding L1, a neural adhesion molecule of the immunoglobulin family, is located on the X chromosome in mouse and man. Genomics (1990) 1.67
Synthetic donor and acceptor splice sites function in an RNA polymerase B (II) transcription unit. EMBO J (1984) 1.66
Human type VII collagen: cDNA cloning and chromosomal mapping of the gene. Proc Natl Acad Sci U S A (1991) 1.66
The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias. Oncogene (1989) 1.65
Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J (1991) 1.65
Cloning of two novel ABC transporters mapping on human chromosome 9. Genomics (1994) 1.63
The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14. Nature (1986) 1.61
No more than seven interruptions in the ovalbumin gene: comparison of genomic and double-stranded cDNA sequences. Nucleic Acids Res (1979) 1.60
A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human. Hum Mol Genet (1994) 1.60
The exon sequence TAGG can inhibit splicing. Nucleic Acids Res (1996) 1.60
BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Oncogene (1994) 1.59
Chromosome 15 anomalies and the Prader-Willi syndrome: cytogenetic analysis. Hum Genet (1984) 1.58
Structural anomalies of the X chromosome and inactivation center. Hum Genet (1981) 1.57
Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics (1995) 1.54
Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2. Genomics (1990) 1.49
Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics (1994) 1.44
Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. J Biol Chem (1999) 1.44
Isolation and characterization of a repetitive DNA sequence from Leishmania infantum: development of a visceral leishmaniasis polymerase chain reaction. Am J Trop Med Hyg (1993) 1.43
Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors. Receptors Channels (1994) 1.43
Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach. Mech Dev (1995) 1.42
Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA. Mol Cell Biol (1993) 1.41
The mouse neuronal cell surface protein F3: a phosphatidylinositol-anchored member of the immunoglobulin superfamily related to chicken contactin. J Cell Biol (1989) 1.40
Isolation of 37 single-copy DNA probes from human chromosome 6 and physical mapping of 11 probes by in situ hybridization. Genomics (1991) 1.40
Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor. Oncogene (1991) 1.40
Localization of the human NCAM gene to band q23 of chromosome 11: the third gene coding for a cell interaction molecule mapped to the distal portion of the long arm of chromosome 11. J Cell Biol (1986) 1.37
The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice. Nature (1986) 1.36
Prader-Willi syndrome and chromosome 15. A clinical discussion of 20 cases. Hum Genet (1983) 1.36
The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region. Hum Mol Genet (1999) 1.35
Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members. Biochemistry (1989) 1.35
Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet (1998) 1.34
Isolation of the human Xp21 glycerol kinase gene by positional cloning. Hum Mol Genet (1993) 1.34
Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. J Biol Chem (2000) 1.33
A role for branchpoints in splicing in vivo. Nature (1985) 1.32
Expression of metalloproteinase genes in human prostate cancer. J Cancer Res Clin Oncol (1991) 1.31
Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. Proc Natl Acad Sci U S A (1993) 1.30
Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours. Int J Cancer (1991) 1.29
Related fibroblast growth factor receptor genes exist in the human genome. Proc Natl Acad Sci U S A (1990) 1.29
Interstitial 22q11 microdeletion excluding the ADU breakpoint in a patient with DiGeorge syndrome. Hum Mol Genet (1995) 1.27
Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects. Hum Genet (1976) 1.26
Mapping of DNA markers close to the fragile site on the human X chromosome at Xq27.3. Nucleic Acids Res (1987) 1.26
The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6. Mamm Genome (1999) 1.26
Two members of an HNF1 homeoprotein family are expressed in human liver. Nucleic Acids Res (1991) 1.24