Augmented resting sympathetic activity in awake patients with obstructive sleep apnea.

PubWeight™: 2.24‹?› | Rank: Top 2%

🔗 View Article (PMID 8404098)

Published in Chest on June 01, 1993

Authors

J T Carlson1, J Hedner, M Elam, H Ejnell, J Sellgren, B G Wallin

Author Affiliations

1: Department of Pulmonary Medicine, Reström's Hospital, Goteborg, Sweden.

Associated clinical trials:

Intermittent Hypoxia 2: Cardiovascular and Metabolism (IH2) | NCT02058823

Articles citing this

Pathophysiology of sleep apnea. Physiol Rev (2010) 4.69

Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study. Am J Respir Crit Care Med (2009) 3.24

Brain structural changes in obstructive sleep apnea. Sleep (2008) 2.30

Increased mortality among sleepy snorers: a prospective population based study. Thorax (1998) 1.82

Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol (2003) 1.51

Sympathetic neural mechanisms in human cardiovascular health and disease. Mayo Clin Proc (2009) 1.36

Prevalence of type 2 diabetes in patients with obstructive sleep apnea in a multi-ethnic sample. J Clin Sleep Med (2009) 1.29

Impact of intermittent hypoxia on long-term facilitation of minute ventilation and heart rate variability in men and women: do sex differences exist? J Appl Physiol (1985) (2008) 1.26

"Syndrome Z": the interaction of sleep apnoea, vascular risk factors and heart disease. Thorax (1998) 1.22

Lack of association between impaired glucose tolerance and appetite regulating hormones in patients with obstructive sleep apnea. J Clin Sleep Med (2011) 1.14

Autonomic cardiovascular control in children with obstructive sleep apnea. Clin Auton Res (1999) 1.10

Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia. Respir Physiol Neurobiol (2010) 1.07

Firing probability and mean firing rates of human muscle vasoconstrictor neurones are elevated during chronic asphyxia. J Physiol (2010) 1.07

Sex differences in white matter alterations accompanying obstructive sleep apnea. Sleep (2012) 1.06

Sympatho-adrenal activation by chronic intermittent hypoxia. J Appl Physiol (1985) (2012) 1.06

Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia. J Physiol (2011) 1.05

Which aspects of breathing during sleep influence the overnight fall of blood pressure in a community population? Thorax (2000) 1.04

Pathophysiology of resistant hypertension: the role of sympathetic nervous system. Int J Hypertens (2011) 1.03

Single-unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover. J Physiol (2011) 1.03

Impaired vascular regulation in patients with obstructive sleep apnea: effects of continuous positive airway pressure treatment. Am J Respir Crit Care Med (2009) 1.01

Chronic intermittent hypoxia in humans during 28 nights results in blood pressure elevation and increased muscle sympathetic nerve activity. Am J Physiol Heart Circ Physiol (2010) 1.00

The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms. Diabetol Metab Syndr (2015) 1.00

Sympathetic and catecholaminergic alterations in sleep apnea with particular emphasis on children. Front Neurol (2012) 0.99

Obstructive sleep apnea and non-alcoholic Fatty liver disease: is the liver another target? Front Neurol (2012) 0.97

Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases. Antioxid Redox Signal (2009) 0.96

Increased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea. Sleep (2016) 0.96

Sleep staging based on autonomic signals: a multi-center validation study. J Clin Sleep Med (2011) 0.96

Autonomic cardiovascular tests in children with obstructive sleep apnea syndrome. Sleep (2010) 0.94

Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing. Antioxid Redox Signal (2011) 0.94

Effect of repetitive hypoxic apnoeas on baroreflex function in humans. J Physiol (2006) 0.93

The relative impact of obstructive sleep apnea and hypertension on the structural and functional changes of the thoracic aorta. Sleep (2010) 0.93

Effects of simulated obstructive sleep apnoea on the human carotid baroreceptor-vascular resistance reflex. J Physiol (2004) 0.90

SLEEP DISORDERED BREATHING AND METABOLIC EFFECTS: EVIDENCE FROM ANIMAL MODELS. Sleep Med Clin (2007) 0.90

Obstructive sleep apnea and coronary artery disease: from pathophysiology to clinical implications. Pulm Med (2013) 0.89

Firing patterns of muscle vasoconstrictor neurons in respiratory disease. Front Physiol (2012) 0.89

Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia. Front Physiol (2014) 0.88

P2Y1 receptors expressed by C1 neurons determine peripheral chemoreceptor modulation of breathing, sympathetic activity, and blood pressure. Hypertension (2013) 0.88

Respiratory modulation of muscle sympathetic nerve activity is not increased in essential hypertension or chronic obstructive pulmonary disease. J Physiol (2011) 0.88

Mechanisms of sleep-disordered breathing: causes and consequences. Pflugers Arch (2011) 0.88

Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea. J Thorac Dis (2015) 0.87

Urinary melatonin and risk of incident hypertension among young women. J Hypertens (2010) 0.87

Time course of intermittent hypoxia-induced impairments in resistance artery structure and function. Respir Physiol Neurobiol (2009) 0.87

Chemoreflexes, sleep apnea, and sympathetic dysregulation. Curr Hypertens Rep (2014) 0.86

Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea. Exp Physiol (2016) 0.86

The effect of aging and severity of sleep apnea on heart rate variability indices in obstructive sleep apnea syndrome. Psychiatry Investig (2012) 0.85

The effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia. Respir Physiol Neurobiol (2014) 0.85

Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease. Pulm Med (2013) 0.84

Peripheral chemoreception and arterial pressure responses to intermittent hypoxia. Compr Physiol (2015) 0.84

Functional and structural changes in the brain associated with the increase in muscle sympathetic nerve activity in obstructive sleep apnoea. Neuroimage Clin (2014) 0.84

Pulmonary hemodynamics in obstructive sleep apnea: frequency and causes of pulmonary hypertension. Lung (2003) 0.84

CrossTalk opposing view: Most cardiovascular diseases in sleep apnoea are not caused by sympathetic activation. J Physiol (2012) 0.83

Reversal of functional changes in the brain associated with obstructive sleep apnoea following 6 months of CPAP. Neuroimage Clin (2015) 0.83

Respiratory modulation of human autonomic function: long-term neuroplasticity in space. J Physiol (2016) 0.82

Angiotensin II type 1a receptors in subfornical organ contribute towards chronic intermittent hypoxia-associated sustained increase in mean arterial pressure. Am J Physiol Heart Circ Physiol (2014) 0.82

Snoring, inflammatory markers, adipokines and metabolic syndrome in apparently healthy Chinese. PLoS One (2011) 0.82

Knockdown of tyrosine hydroxylase in the nucleus of the solitary tract reduces elevated blood pressure during chronic intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol (2013) 0.82

Diagnostic and therapeutic approach to coexistent chronic obstructive pulmonary disease and obstructive sleep apnea. Int J Chron Obstruct Pulmon Dis (2008) 0.81

Prognosis and sleep disordered breathing in heart failure. Thorax (1998) 0.81

Sleep apnoea and snoring: potential links with vascular disease. Thorax (1998) 0.80

Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study. Int J Hypertens (2010) 0.80

Hypertension and obstructive sleep apnea. Nat Sci Sleep (2013) 0.80

Evolution and physiology of neural oxygen sensing. Front Physiol (2014) 0.80

Sleep apnoea in women. Thorax (1998) 0.80

Menstrual cycle and sex effects on sympathetic responses to acute chemoreflex stress. Am J Physiol Heart Circ Physiol (2014) 0.80

Influence of increased plasma osmolality on sympathetic outflow during apnea. Am J Physiol Regul Integr Comp Physiol (2010) 0.79

Sleep-related changes in autonomic control in obstructive sleep apnea: a model-based perspective. Respir Physiol Neurobiol (2013) 0.79

Functional Imaging of the Human Brainstem during Somatosensory Input and Autonomic Output. Front Hum Neurosci (2013) 0.78

Understanding the metabolic syndrome: a modeling perspective. IEEE Rev Biomed Eng (2012) 0.78

Development of autonomic dysfunction with intermittent hypoxia in a lean murine model. Respir Physiol Neurobiol (2013) 0.78

Carotid body potentiation during chronic intermittent hypoxia: implication for hypertension. Front Physiol (2014) 0.78

Hypoxia-induced vasodilation and effects of regional phentolamine in awake patients with sleep apnea. J Appl Physiol (1985) (2010) 0.78

Modeling of autonomic control in sleep-disordered breathing. Cardiovasc Eng (2008) 0.77

Obstructive sleep apnea - management update. Neuropsychiatr Dis Treat (2006) 0.77

Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome. J Mol Med (Berl) (2015) 0.77

Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla. Respir Physiol Neurobiol (2015) 0.76

Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia. Respir Physiol Neurobiol (2016) 0.76

Increased Carbonic Anhydrase Activity is Associated with Sleep Apnea Severity and Related Hypoxemia. Sleep (2015) 0.76

Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol (2016) 0.75

Effects of 12 Months Continuous Positive Airway Pressure on Sympathetic Activity Related Brainstem Function and Structure in Obstructive Sleep Apnea. Front Neurosci (2016) 0.75

Blood Pressure Increases in OSA due to Maintained Neurovascular Sympathetic Transduction: Impact of CPAP. Sleep (2015) 0.75

Saliva production and surface tension: influences on patency of the passive upper airway. J Physiol (2008) 0.75

The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma. J Investig Med High Impact Case Rep (2015) 0.75

Model-Derived Markers of Autonomic Cardiovascular Dysfunction in Sleep-Disordered Breathing. Sleep Med Clin (2016) 0.75

Obstructive sleep apnea and energy balance regulation: A systematic review. Sleep Med Rev (2016) 0.75

Ascorbic acid attenuates the pressor response to voluntary apnea in postmenopausal women. Physiol Rep (2015) 0.75

Inspiratory Muscle Training Improves Sleep and Mitigates Cardiovascular Dysfunction in Obstructive Sleep Apnea. Sleep (2016) 0.75

Parallel changes in resting muscle sympathetic nerve activity and blood pressure in a hypertensive OSAS patient demonstrate treatment efficacy. Clin Auton Res (2006) 0.75

Increased inspiratory resistance affects the dynamic relationship between blood pressure changes and subarachnoid space width oscillations. PLoS One (2017) 0.75

Polysomnography underestimates altered cardiac autonomic control in patients with obstructive sleep apnea. Herzschrittmacherther Elektrophysiol (2012) 0.75

Cardiovascular Consequences of Repetitive Arousals over the Entire Sleep Duration. Biomed Res Int (2017) 0.75

Articles by these authors

Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev (1979) 7.25

The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol (1977) 4.23

Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age. J Physiol (1978) 4.22

Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res (1985) 3.88

General characteristics of sympathetic activity in human muscle nerves. Acta Physiol Scand (1972) 3.12

Manoeuvres affecting sympathetic outflow in human muscle nerves. Acta Physiol Scand (1972) 3.07

Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci (2002) 3.02

General characteristics of sympathetic activity in human skin nerves. Acta Physiol Scand (1972) 2.96

The responses of human muscle spindle endings to vibration during isometric contraction. J Physiol (1976) 2.91

The responses of human muscle spindle endings to vibration of non-contracting muscles. J Physiol (1976) 2.89

Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves. J Physiol (1980) 2.72

Manoeuvres affecting sympathetic outflow in human skin nerves. Acta Physiol Scand (1972) 2.62

Two sites for modulation of human sympathetic activity by arterial baroreceptors? J Physiol (2001) 2.51

Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension (1987) 2.46

Sympathetic reflex latencies and conduction velocities in normal man. J Neurol Sci (1980) 2.35

Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation. J Physiol (2005) 2.27

Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure. Circulation (1986) 2.19

Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis. Lancet (1993) 2.00

The discharge behaviour of single vasoconstrictor motoneurones in human muscle nerves. J Physiol (1994) 1.97

Increased incidence of coronary artery disease in sleep apnoea: a long-term follow-up. Eur Respir J (2006) 1.93

Sympathetic outflow to muscles during vasovagal syncope. J Auton Nerv Syst (1982) 1.91

Comparison of sympathetic nerve activity in normotensive and hypertensive subjects. Circ Res (1973) 1.91

Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat. Pain (1992) 1.89

Regional similarities and differences in thermoregulatory vaso- and sudomotor tone. J Physiol (1980) 1.83

Snoring and sleep apnoea in men: association with central obesity and hypertension. Int J Obes Relat Metab Disord (1993) 1.82

Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans. J Physiol (2006) 1.79

An independent association between obstructive sleep apnoea and coronary artery disease. Eur Respir J (1999) 1.78

Long-term variability and reproducibility of resting human muscle nerve sympathetic activity at rest, as reassessed after a decade. Clin Auton Res (1993) 1.76

Respiratory disturbance index: an independent predictor of mortality in coronary artery disease. Am J Respir Crit Care Med (2000) 1.76

Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man. Acta Physiol Scand (1981) 1.72

The discharge behaviour of single sympathetic neurones supplying human sweat glands. J Auton Nerv Syst (1996) 1.67

Sympathetic transients caused by abrupt alterations of carotid baroreceptor activity in humans. Am J Physiol (1982) 1.63

The effect of carotid sinus nerve stimulation on muscle and skin nerve sympathetic activity in man. Pflugers Arch (1975) 1.63

Impairment of vascular endothelial function and left ventricular filling : association with the severity of apnea-induced hypoxemia during sleep. Chest (2001) 1.59

Human muscle nerve sympathetic activity in cardiac arrhythmias. Scand J Clin Lab Invest (1974) 1.59

The effects of propofol on cerebral blood flow velocity and cerebral oxygen extraction during cardiopulmonary bypass. Anesth Analg (1998) 1.57

Management of obstructive sleep apnea in Europe. Sleep Med (2010) 1.56

Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension? J Hypertens Suppl (1988) 1.55

Comparison of atenolol, amlodipine, enalapril, hydrochlorothiazide, and losartan for antihypertensive treatment in patients with obstructive sleep apnea. Am J Respir Crit Care Med (2000) 1.54

Effect of lower body negative pressure on human muscle nerve sympathetic activity. J Physiol (1978) 1.54

Muscle sympathetic activity and norepinephrine release during mental challenge in humans. Am J Physiol (1989) 1.50

Inhaled salmeterol and salbutamol in asthmatic patients. An evaluation of asthma symptoms and the possible development of tachyphylaxis. Am Rev Respir Dis (1990) 1.50

Sympathetic activity in man after spinal cord injury. Outflow to skin below the lesion. Brain (1984) 1.50

Night-time symptoms: a forgotten dimension of COPD. Eur Respir Rev (2011) 1.50

Spectral analysis of burst periods in EEG from healthy and post-asphyctic full-term neonates. Clin Neurophysiol (2004) 1.49

Respiratory modulation of muscle sympathetic and vagal cardiac outflow in man. J Physiol (1985) 1.49

Firing properties of single muscle vasoconstrictor neurons in the sympathoexcitation associated with congestive heart failure. Circulation (1999) 1.48

Quality of life after cardiac surgery complicated by multiple organ failure. Crit Care Med (1997) 1.47

High thoracic epidural anesthesia does not inhibit sympathetic nerve activity in the lower extremities. Anesthesiology (1999) 1.46

Energy expenditure in obstructive sleep apnea: effects of treatment with continuous positive airway pressure. Am J Physiol (1996) 1.45

Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activity. J Physiol (1999) 1.45

Sympathetic muscle nerve activity during sleep in man. Brain (1991) 1.44

High prevalence of hypertension in sleep apnea patients independent of obesity. Am J Respir Crit Care Med (1994) 1.43

The influence of the sympathetic impulse pattern on contractile responses of rat mesenteric arteries and veins. Acta Physiol Scand (1985) 1.43

Sympathetic outflow in man after anaesthesia of the glossopharyngeal and vagus nerves. Brain (1985) 1.40

Integrative mechanisms of blood pressure regulation in humans and rats: cross-species similarities. Am J Physiol Regul Integr Comp Physiol (2010) 1.38

Reduction in sympathetic activity after long-term CPAP treatment in sleep apnoea: cardiovascular implications. Eur Respir J (1995) 1.38

Sympathetic activity in man after spinal cord injury. Outflow to muscle below the lesion. Brain (1986) 1.34

Sympathetic nerve activity in arm and leg muscles during lower body negative pressure in humans. J Appl Physiol (1985) (1989) 1.34

Sympathetic nerve activity underlying electrodermal and cardiovascular reactions in man. Psychophysiology (1981) 1.33

Depressed baroreflex sensitivity in patients with obstructive sleep apnea. Am J Respir Crit Care Med (1996) 1.33

Dissociation of sympathetic nerve activity in arm and leg muscle during mental stress. Hypertension (1987) 1.32

Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea. Arch Otolaryngol Head Neck Surg (2001) 1.32

Clinical and humanistic outcomes of a lipid management program in the community pharmacy setting. J Am Pharm Assoc (Wash) (2000) 1.31

Increased cardiac adrenergic drive precedes generalized sympathetic activation in human heart failure. Circulation (1997) 1.29

Hypercapnia and hypoxia: chemoreceptor-mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves. Brain Res (1981) 1.28

Baroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans. Acta Physiol Scand (1988) 1.27

Respiratory and cardiac modulation of single sympathetic vasoconstrictor and sudomotor neurones to human skin. J Physiol (1999) 1.25

Syncope induced by glossopharyngeal neuralgia: sympathetic outflow to muscle. Neurology (1984) 1.23

Impact of obstructive sleep apnea and sleepiness on metabolic and cardiovascular risk factors in the Swedish Obese Subjects (SOS) Study. Int J Obes Relat Metab Disord (1995) 1.22

Adenosine mechanisms in the regulation of breathing in the rat. Eur J Pharmacol (1984) 1.20

Direct evidence of neurally mediated vasodilatation in hairy skin of the human foot. J Physiol (1987) 1.20

Regional sympathetic function in high spinal cord injury during mental stress and autonomic dysreflexia. Brain (1998) 1.19

A quantitative study of muscle nerve sympathetic activity in resting normotensive and hypertensive subjects. Hypertension (1981) 1.19

Intracellular ion concentrations in single crayfish axons. Acta Physiol Scand (1968) 1.18

Therapy with nCPAP: incomplete elimination of Sleep Related Breathing Disorder. Eur Respir J (2000) 1.18

Stent insertion or endoluminal brachytherapy as palliation of patients with advanced cancer of the esophagus and gastroesophageal junction. Results of a randomized, controlled clinical trial. Dis Esophagus (2005) 1.18

Sympathetic muscle nerve activity, peripheral blood flows, and baroreceptor reflexes in humans during propofol anesthesia and surgery. Anesthesiology (1994) 1.17

Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide. Eur J Pharmacol (1991) 1.16

The pH dependency of relative ion permeabilities in the crayfish giant axon. Biophys J (1969) 1.16

Postmenopausal estrogen administration suppresses muscle sympathetic nerve activity. J Clin Endocrinol Metab (2001) 1.16

Sympathetic outflow to muscles during treatment of hypertension with metoprolol. Hypertension (1984) 1.15

Relative ion permeabilities in the crayfish giant axon determined from rapid external ion changes. J Gen Physiol (1967) 1.13

EEG theta rhythm in infants and preschool children. Clin Neurophysiol (2006) 1.12

Appendico-cutaneous fistula. A case report. Acta Chir Scand (1978) 1.12

Sympathetic nerve traffic correlates with the release of nitric oxide in humans: implications for blood pressure control. J Physiol (1997) 1.12

Sympathetic skin nerve activity and skin temperature changes in man. Acta Physiol Scand (1974) 1.11

Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans. Am J Physiol Heart Circ Physiol (2006) 1.11

Sympathetic nerve activity after acupuncture in humans. Pain (1998) 1.11