PubRank

P Rorsman

Author PubWeight™ 132.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 1989 6.00
2 Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch 1986 3.51
3 Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions. J Physiol 1986 3.46
4 Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP. Pflugers Arch 1985 2.66
5 Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells. J Physiol 1993 2.47
6 Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells. Nature 1993 2.40
7 Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells. EMBO J 1995 2.39
8 Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells. Nature 1991 2.35
9 Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells. Nature 1989 2.07
10 Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol 1997 2.06
11 Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels. J Physiol 2000 2.05
12 Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets. J Physiol 1999 2.01
13 Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. Diabetes 2000 1.88
14 Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. Biophys J 2001 1.79
15 The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery. Proc Natl Acad Sci U S A 1999 1.78
16 Rapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells. J Physiol 1997 1.72
17 Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells. FEBS Lett 1990 1.68
18 Multivesicular exocytosis in rat pancreatic beta cells. Diabetologia 2011 1.63
19 Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels. J Gen Physiol 1997 1.62
20 Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells. J Gen Physiol 1999 1.59
21 Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells. Proc Natl Acad Sci U S A 1994 1.59
22 Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets. J Physiol 2000 1.49
23 Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells. J Biol Chem 1987 1.49
24 Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. Pflugers Arch 1998 1.46
25 Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia 2009 1.46
26 Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes 1998 1.45
27 Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic beta-cells. FEBS Lett 1984 1.42
28 Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization. J Physiol 1996 1.41
29 Stimulus-secretion coupling in pancreatic beta cells. J Cell Biochem 1994 1.38
30 Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification. J Cell Sci 2001 1.37
31 Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling. Diabetes 1998 1.33
32 Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells. Proc Biol Sci 1991 1.32
33 Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells. Pflugers Arch 1999 1.32
34 Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium. J Physiol 1996 1.28
35 Effects of external tetraethylammonium ions and quinine on delayed rectifying K+ channels in mouse pancreatic beta-cells. J Physiol 1990 1.26
36 PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. Science 1996 1.22
37 Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization. Diabetes 1995 1.22
38 Regulation of glucagon secretion by glucose: paracrine, intrinsic or both? Diabetes Obes Metab 2011 1.21
39 Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes. Science 1993 1.19
40 Block of ATP-regulated and Ca2(+)-activated K+ channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine. J Physiol 1990 1.17
41 Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells. J Gen Physiol 1990 1.16
42 Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors. Pflugers Arch 1997 1.14
43 Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells. J Physiol 1993 1.13
44 Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release. FEBS Lett 1995 1.12
45 ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion. Biochem Soc Trans 1990 1.11
46 CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells. J Physiol 1999 1.11
47 Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation. J Physiol 2002 1.11
48 Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+. Acta Physiol Scand 1985 1.09
49 Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin. Neuron 1996 1.09
50 Ca(2+)-induced Ca2+ release in insulin-secreting cells. FEBS Lett 1992 1.06
51 Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps. J Physiol 1996 1.06
52 Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. J Physiol 2001 1.04
53 Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells. Diabetes 1999 0.98
54 The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein. Proc Natl Acad Sci U S A 1999 0.97
55 Autocrine regulation of insulin secretion. Diabetes Obes Metab 2012 0.96
56 Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell. FEBS Lett 1992 0.96
57 Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration. J Biol Chem 1989 0.96
58 Voltage-activated Na+ currents and their suppression by phorbol ester in clonal insulin-producing RINm5F cells. Am J Physiol 1986 0.95
59 Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism. Diabetes 1997 0.95
60 Calcium and pancreatic beta-cell function. XI. Modification of 45Ca fluxes by Na+ removal. Biochem Med 1980 0.94
61 Inhibition of ATP-regulated K(+)-channels by a photoactivatable ATP-analogue in mouse pancreatic beta-cells. Biochim Biophys Acta 1991 0.94
62 Compound exocytosis in voltage-clamped mouse pancreatic beta-cells revealed by carbon fibre amperometry. Pflugers Arch 2000 0.93
63 Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells. J Physiol 2000 0.92
64 Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic beta-cells. Biosci Rep 1986 0.92
65 Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells. Pflugers Arch 1993 0.90
66 Direct measurements of increased free cytoplasmic Ca2+ in mouse pancreatic beta-cells following stimulation by hypoglycemic sulfonylureas. FEBS Lett 1985 0.90
67 New insights into the regulation of glucagon secretion by glucagon-like peptide-1. Horm Metab Res 2005 0.90
68 Glucose-induced increase in cytoplasmic pH in pancreatic beta-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C. J Biol Chem 1991 0.90
69 G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells. J Physiol 1997 0.89
70 Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool. Biochem J 1990 0.88
71 Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta. Diabetologia 2009 0.88
72 Galanin and the endocrine pancreas. FEBS Lett 1988 0.87
73 Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells. Biophys J 1999 0.85
74 Expression of voltage-gated K+ channels in insulin-producing cells. Analysis by polymerase chain reaction. FEBS Lett 1990 0.85
75 Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells. FEBS Lett 1991 0.85
76 Depolarization-independent net uptake of calcium into clonal insulin-releasing cells exposed to glucose. Biosci Rep 1983 0.85
77 Glucose stimulates the entry of Ca2+ into the insulin-producing beta cells but not into the glucagon-producing alpha 2 cells. Acta Physiol Scand 1987 0.85
78 Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials. Pflugers Arch 2001 0.85
79 Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration. J Biol Chem 1988 0.85
80 Demonstration of A-currents in pancreatic islet cells. Pflugers Arch 1989 0.84
81 Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms. Br J Pharmacol 1996 0.83
82 Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity. J Clin Invest 1993 0.83
83 The glucagon-producing alpha cell: an electrophysiologically exceptional cell. Diabetologia 2010 0.82
84 Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells. Pflugers Arch 2001 0.82
85 The dual action of glucose on the cytosolic Ca2+ activity in pancreatic beta-cells. Demonstration of an inhibitory effect of glucose on insulin release in the mouse and man. Biomed Biochim Acta 1985 0.82
86 Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion. Diabetologia 2011 0.81
87 Manganese accumulation in pancreatic beta-cells and its stimulation by glucose. Biochem J 1982 0.81
88 Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon. Diabetologia 2008 0.81
89 Glucose-responsive beta cells in islets isolated from a patient with long-standing type 1 diabetes mellitus. Diabetologia 2010 0.81
90 Does galanin inhibit insulin secretion by opening of the ATP-regulated K+ channel in the beta-cell? Peptides 1989 0.81
91 Defective regulation of the cytosolic Ca2+ activity in parathyroid cells from patients with hyperparathyroidism. Biosci Rep 1984 0.80
92 The interaction between manganese and calcium fluxes in pancreatic beta-cells. Biochem J 1983 0.79
93 Demonstration of voltage-dependent and TTX-sensitive Na(+)-channels in human melanocytes. Pigment Cell Res 1994 0.79
94 Cell biology. Glutamate primes the pump. Nature 1999 0.79
95 Reduction of the cytosolic calcium activity in clonal insulin-releasing cells exposed to glucose. Biosci Rep 1983 0.78
96 Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting beta TC3 cells. Acta Physiol Scand 1996 0.78
97 Single calcium channel activity in mouse pancreatic beta-cells. Ann N Y Acad Sci 1989 0.78
98 Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects. Diabetes Res 1994 0.78
99 Intracellular pH and the stimulus-secretion coupling in insulin-producing RINm5F cells. Biochem J 1992 0.78
100 Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion. Ups J Med Sci 1980 0.78
101 Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells. Pflugers Arch 1992 0.77
102 Glucose in glucagon release. Nature 1990 0.77
103 Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells. Biosci Rep 1991 0.77
104 Calcium currents in insulin-secreting beta-cells. Ann N Y Acad Sci 1989 0.76
105 Neuropeptides in the regulation of islet hormone secretion--localization, effects and mode of action. Adv Exp Med Biol 1991 0.76
106 Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15. FEBS Lett 1988 0.75
107 Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture. Br J Cancer 1988 0.75
108 Calcium and potassium currents recorded from pancreatic beta-cells under voltage clamp control. Adv Exp Med Biol 1986 0.75
109 Glucose promotes intracellular sequestration of manganese in pancreatic beta-cells. Acta Biol Med Ger 1982 0.75
110 Demonstration of respiratory pigments in clonal insulin-producing beta-cells. Biomed Biochim Acta 1985 0.75
111 Mechanisms of action of entero-insular hormones and neural input on the insulin secretory process. Biochem Soc Trans 1990 0.75
112 Intracellular pH, cytosolic calcium concentration and electrical activity in RINm5F insulinoma cells. Biochim Biophys Acta 1994 0.75
113 Dynamics of the cationic, bioelectrical and secretory responses to formycin A in pancreatic islet cells. Pflugers Arch 1996 0.75
114 The riddle of formycin A insulinotropic action. Biochem Mol Med 1996 0.75
115 Interaction with the inositol 1,4,5-trisphosphate receptor promotes Ca2+ sequestration in permeabilised insulin-secreting cells. FEBS Lett 1991 0.75