Published in J Biol Chem on January 15, 1993
Mechanisms of tau-induced neurodegeneration. Acta Neuropathol (2009) 2.27
Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. Mol Biol Cell (1995) 2.15
The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Mol Biol Cell (1998) 1.41
Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol Biol Cell (2007) 1.37
Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention. J Cell Mol Med (2007) 1.21
The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains. Mol Biol Cell (1999) 1.17
PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners. FEBS Lett (2006) 1.12
Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356. Biochem J (1996) 1.04
Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro. J Biol Chem (2009) 0.96
Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem (2010) 0.95
Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine. Biochim Biophys Acta (2011) 0.94
The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures. Biochem J (1995) 0.93
Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly. Biochem J (1997) 0.92
Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E. J Biol Chem (2010) 0.88
Developing pharmacological therapies for Alzheimer disease. Cell Mol Life Sci (2007) 0.87
Phosphorylated tau can promote tubulin assembly. Proc Natl Acad Sci U S A (1999) 0.86
Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP. Biochem J (1995) 0.86
Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PLoS One (2013) 0.83
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci (2012) 0.81
tau kinases in the rat heat shock model: possible implications for Alzheimer disease. Proc Natl Acad Sci U S A (2000) 0.80
Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro. J Proteome Res (2013) 0.77
Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies. Hum Mol Genet (2014) 0.77
Influence of phosphorylation on isoform composition and function of a microtubule-associated protein from developing Artemia. Biochem J (1995) 0.75
14-3-3ζ Mediates Tau Aggregation in Human Neuroblastoma M17 Cells. PLoS One (2016) 0.75
Tau Structures. Front Aging Neurosci (2016) 0.75
Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA (2001) 8.80
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science (1997) 6.10
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
A combined PET/CT scanner for clinical oncology. J Nucl Med (2000) 4.99
BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut (2004) 4.06
The regulation of AMP-activated protein kinase by phosphorylation. Biochem J (2000) 3.76
Babies sleeping with parents: case-control study of factors influencing the risk of the sudden infant death syndrome. CESDI SUDI research group. BMJ (1999) 3.76
Improving the repeat prescribing process in a busy general practice. A study using continuous quality improvement methodology. Qual Health Care (1999) 3.61
Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Gastroenterology (2001) 3.52
What do we know about how to do audit and feedback? Pitfalls in applying evidence from a systematic review. BMC Health Serv Res (2005) 3.51
The Uterine Mucosa in Menstruation and Pregnancy; the Action of the Chorionic Cells and the Function of the Decidua: Structure of the Uterine Mucosa and the Cause of the Opening-up of the Vessels during Menstruation. Proc R Soc Med (1911) 3.46
Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue. Histopathology (2000) 3.36
The AEtiology of Eclampsia and Albuminuria and their Relation to Accidental Haemorrhage: (An Anatomical and Experimental Investigation.). Proc R Soc Med (1914) 3.13
Morphology of sporadic colorectal cancer with DNA replication errors. Gut (1998) 3.11
Performance evaluation of the microPET P4: a PET system dedicated to animal imaging. Phys Med Biol (2001) 3.07
Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology. Proteomics (2001) 3.02
Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells. J Clin Invest (1981) 2.97
Incidence and consequences of falls due to stroke: a systematic inquiry. BMJ (1995) 2.94
Oligosaccharides on proteoglycans from the swarm rat chondrosarcoma. J Biol Chem (1980) 2.89
DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol (1999) 2.78
Prospective study of outcome in antenatally diagnosed renal pelvis dilatation. Arch Dis Child Fetal Neonatal Ed (1999) 2.73
Pharmacokinetic and pharmacodynamic studies with long-acting propranolol. Br J Clin Pharmacol (1978) 2.68
A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. N Engl J Med (1997) 2.66
Development of a questionnaire measure of adjustment to cancer: the MAC scale. Psychol Med (1988) 2.53
Dissociation, somatization, and affect dysregulation: the complexity of adaptation of trauma. Am J Psychiatry (1996) 2.43
Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet (1996) 2.19
Childhood origins of self-destructive behavior. Am J Psychiatry (1991) 2.18
HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nat Med (1997) 2.15
Hyperplastic polyposis: association with colorectal cancer. Am J Surg Pathol (2001) 2.10
Future directions for geriatric medicine. Geriatricians must move with their patients into the community. BMJ (2000) 2.10
Structure determination of a human lymphocyte derived neutrophil activating peptide (LYNAP). Biochem Biophys Res Commun (1988) 2.10
Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism. J Biol Chem (1994) 2.04
THE COMPLETE AMINO ACID SEQUENCE OF THE PROTEIN OF TOBACCO MOSAIC VIRUS. Proc Natl Acad Sci U S A (1960) 2.02
Decision-making in rectal surgery. Colorectal Dis (2014) 2.01
Absence of activating mutations in the GnRH receptor gene in human pituitary gonadotroph adenomas. Eur J Endocrinol (1998) 1.99
Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. J Biol Chem (1996) 1.98
Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways. J Clin Pathol (1999) 1.98
Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut (2000) 1.95
The sequence of chick alpha-actinin reveals homologies to spectrin and calmodulin. J Biol Chem (1987) 1.95
alpha-Actinins and the DMD protein contain spectrin-like repeats. Cell (1988) 1.94
Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev (2011) 1.93
Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Res (2001) 1.87
Diffusion of standards of care for cancer pain. CMAJ (1995) 1.86
Sequence-tagged connectors: a sequence approach to mapping and scanning the human genome. Proc Natl Acad Sci U S A (1999) 1.85
Effect of antibodies to recombinant and synthetic peptides on P. falciparum sporozoites in vitro. Science (1986) 1.81
Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer. Histopathology (2006) 1.78
A comparison of double-isotope derivative and radioimmunological estimation of plasma aldosterone concentration in man. Clin Sci Mol Med (1973) 1.76
Information provision for stroke patients and their caregivers. Cochrane Database Syst Rev (2008) 1.69
Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability. Eur J Cancer (2002) 1.66
Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. Fam Cancer (2004) 1.66
Vaccination against hydatidosis using a defined recombinant antigen. Parasite Immunol (1996) 1.63
High-level expression, activation, and subcellular localization of p38-MAP kinase in thyroid neoplasms. J Pathol (2006) 1.62
A discrete cis element in the human immunodeficiency virus long terminal repeat mediates synergistic trans activation by cytomegalovirus immediate-early proteins. J Virol (1991) 1.62
Evidence databases, the Internet, and general practitioners: the New Zealand story. N Z Med J (2001) 1.62
Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: a placebo-controlled trial. Hepatology (1997) 1.62
The genetic basis of tuberous sclerosis. Mol Med Today (1998) 1.60
Primary sequence and domain structure of chicken vinculin. Biochem J (1989) 1.59
DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. Gut (2000) 1.58
Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum. Histopathology (2000) 1.57
Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display. Oncogene (2006) 1.56
Hantavirus transmission in the United States. Emerg Infect Dis (1997) 1.55
Xp22.3 deletions in isolated familial Kallmann's syndrome. J Clin Endocrinol Metab (1993) 1.54
Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer. Gut (2004) 1.53
Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability. Cancer Res (2001) 1.52
Stroke rehabilitation: can we do better? BMJ (1992) 1.50
Identification of the genes encoding two capsid proteins of herpes simplex virus type 1 by direct amino acid sequencing. J Gen Virol (1990) 1.50
Psychiatric interview and psychometric predictors of cardiac transplant survival. Am J Psychiatry (1996) 1.49
Rehabilitation for older people. BMJ (1998) 1.47
Toxicity of pneumolysin to pulmonary alveolar epithelial cells. Infect Immun (1993) 1.45
Psychiatrist-patient sexual contact: results of a national survey, II: Psychiatrists' attitudes. Am J Psychiatry (1987) 1.45
Evidence-based guidelines for early stroke management. Hosp Med (1999) 1.45
The design and physical characteristics of a small animal positron emission tomograph. Phys Med Biol (1995) 1.44
The treatment of postprandial hypotension in autonomic failure with 3,4-DL-threo-dihydroxyphenylserine. Neurology (1996) 1.43
A transforming growth factor beta 1 receptor type II mutation in ulcerative colitis-associated neoplasms. Gastroenterology (1997) 1.42
Information provision for stroke patients and their caregivers. Cochrane Database Syst Rev (2001) 1.41
The postprandial state does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control. Diabetologia (2004) 1.40
A multidisciplinary falls consultation service in a nursing home. Gerontologist (1991) 1.39
Outcome, tolerability and compliance of compassionate use interferon and ribavirin for hepatitis C infection in a shared care hospital clinic. Intern Med J (2003) 1.39
Genomic analysis of orthologous mouse and human olfactory receptor loci. Proc Natl Acad Sci U S A (2001) 1.39
The effect of cycloheximide on synthesis of proteoglycans by cultured chondrocytes from the Swarm rat chondrosarcoma. J Biol Chem (1981) 1.39
Specialist nurse support for patients with stroke in the community: a randomised controlled trial. BMJ (1996) 1.38
Audit of support given to lay carers of the demented elderly by a primary care team. J R Coll Gen Pract (1988) 1.38
The filmless radiology reading room: a survey of established picture archiving and communication system sites. J Digit Imaging (2000) 1.38
Is a man's facial appearance predictive of how he will die? Int J Clin Pract (1999) 1.38
What are the information priorities for cancer patients involved in treatment decisions? An experienced surrogate study in Hodgkin's disease. Br J Cancer (1996) 1.37
Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes. Genes Immun (2006) 1.35
Elk restoration in Ontario, Canada: infectious disease management strategy, 1998-2001. Ann N Y Acad Sci (2002) 1.34
Analysis of genetic and phenotypic heterogeneity in juvenile polyposis. Gut (2000) 1.34
Community based cancer support groups: an undervalued resource? Clin Oncol (R Coll Radiol) (1992) 1.34
Specialist gynaecologists and survival outcome in ovarian cancer: a Scottish national study of 1866 patients. Br J Obstet Gynaecol (1999) 1.33
Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats. Endocrinology (1993) 1.32
Experimental evaluation of a new composite mesh with the selective property of incorporation to the abdominal wall without adhering to the intestines. J Biomed Mater Res (1994) 1.31
Structure of the complex between hyaluronic acid, the hyaluronic acid-binding region, and the link protein of proteoglycan aggregates from the swarm rat chondrosarcoma. J Biol Chem (1979) 1.29
Comparative efficacies of erythromycin-sulfisoxazole and cefaclor in acute otitis media: a double blind randomized trial. Pediatr Infect Dis J (1987) 1.29
Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus. Proc Natl Acad Sci U S A (1997) 1.29
The protein non-folding problem: amino acid determinants of intrinsic order and disorder. Pac Symp Biocomput (2001) 1.29
Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population. Hepatology (1997) 1.28
Neural correlates of dual task interference can be dissociated from those of divided attention: an fMRI study. Cereb Cortex (2001) 1.28
Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogene (2007) 1.28