Published in Biochemistry on March 08, 1977
The molecular electrostatic potential of the B-DNA helix. VI. The regions of the base pairs in poly (dG.dC) and poly (dA.dT). Nucleic Acids Res (1979) 1.57
Selective hydrolysis by exo- and endonucleases of phosphodiester bonds adjacent to an apurinic site. Nucleic Acids Res (1989) 1.23
Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling. Chem Res Toxicol (2005) 1.15
Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry. Chem Res Toxicol (2007) 1.10
Error-free excision of the cytotoxic,mutagenic N2-deoxyguanosine DNA adduct formed in human fibroblasts by (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Proc Natl Acad Sci U S A (1980) 1.09
Mechanism of phage phiX174 DNA inactivation by benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide. Proc Natl Acad Sci U S A (1977) 1.07
Covalent adducts of DNA and the nonprotein chromophore of neocarzinostatin contain a modified deoxyribose. Proc Natl Acad Sci U S A (1982) 1.02
In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adducts. Nucleic Acids Res (1995) 0.99
Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection. Chem Res Toxicol (2006) 0.97
Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer. J Org Chem (2009) 0.97
Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione. J Biol Chem (2009) 0.95
The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chem Res Toxicol (2008) 0.95
Chemistry and structural biology of DNA damage and biological consequences. Chem Biodivers (2011) 0.92
Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adduct. Chem Res Toxicol (2012) 0.91
The analysis of DNA adducts: the transition from (32)P-postlabeling to mass spectrometry. Cancer Lett (2012) 0.87
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons. Chem Res Toxicol (2014) 0.86
Quantitation of exposure to benzo[a]pyrene with monoclonal antibodies. Environ Health Perspect (1985) 0.81
The molecular electrostatic potential and steric accessibility of poly (dI.dC). Comparison with poly (dG.dC). Nucleic Acids Res (1981) 0.80
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol. Chem Res Toxicol (2011) 0.80
Synthesis of (13)C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene. Tetrahedron (2012) 0.78
The role of base excision repair genes OGG1, APN1 and APN2 in benzo[a]pyrene-7,8-dione induced p53 mutagenesis. Mutat Res (2012) 0.78
Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line. Toxicol Rep (2014) 0.77
Interactions of chrysotile and benzopyrene in a human cell culture systems. Environ Health Perspect (1983) 0.75
Cis-1,2-dihydroxy-1,2-dihydronaphthalene: a bacterial metabolite from naphthalene. Arch Biochem Biophys (1971) 3.31
Initial reactions in the oxidation of naphthalene by Pseudomonas putida. Biochemistry (1975) 3.25
Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors. Science (1978) 3.00
Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene (1993) 2.99
Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer. Oncogene (1989) 2.67
Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences. DNA (1988) 2.61
Tumour promotor induces plasminogen activator. Nature (1976) 2.60
Induction of the Z conformation in poly(dG-dC).poly(dG-dC) by binding of N-2-acetylaminofluorene to guanine residues. Proc Natl Acad Sci U S A (1981) 2.54
Analysis of type 5 adenovirus transformation with a cloned rat embryo cell line (CREF). Proc Natl Acad Sci U S A (1982) 2.36
Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. Science (1976) 2.34
Structure of the fluorescent Y base from yeast phenylalanine transfer ribonucleic acid. J Am Chem Soc (1970) 2.21
Structure of carbohydrate of hemoglobin AIc. J Biol Chem (1977) 2.21
Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology (1996) 2.16
Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture. Proc Natl Acad Sci U S A (1977) 2.09
Direct detection and amplification of Helicobacter pylori ribosomal 16S gene segments from gastric endoscopic biopsies. Diagn Microbiol Infect Dis (1991) 2.06
Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res (1992) 1.95
Multiple functions of p27(Kip1) and its alterations in tumor cells: a review. J Cell Physiol (2000) 1.94
Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells. Cancer Res (1997) 1.92
Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell (1988) 1.91
Oligonucleotide probe for detection and identification of Campylobacter pylori. J Clin Microbiol (1989) 1.90
Test for malignant transformation of rat liver cells in culture: cytology, growth in soft agar, and production of plasminogen activator. J Natl Cancer Inst (1977) 1.86
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci U S A (1993) 1.84
Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor. Proc Natl Acad Sci U S A (1979) 1.82
Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene. Science (1980) 1.78
A preparative method for obtaining enucleated mammalian cells. Biochem Biophys Res Commun (1975) 1.71
Epidermal growth factor, like phorbol esters, induces plasminogen activator in HeLa cells. Nature (1978) 1.70
Structures of benzo(a)pyrene--nucleic acid adducts formed in human and bovine bronchial explants. Nature (1977) 1.68
A pilot project in molecular cancer epidemiology: determination of benzo[a]pyrene--DNA adducts in animal and human tissues by immunoassays. Carcinogenesis (1982) 1.66
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay. Carcinogenesis (1998) 1.61
Rapid and sensitive nonradioactive detection of mutant K-ras genes via 'enriched' PCR amplification. Oncogene (1991) 1.59
Identification of receptors for phorbol ester tumor promoters in intact mammalian cells and of an inhibitor of receptor binding in biologic fluids. Proc Natl Acad Sci U S A (1981) 1.59
Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family. Proc Natl Acad Sci U S A (1987) 1.59
Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element. Mol Cell Biol (1999) 1.58
Cellular Moloney murine sarcoma (c-mos) sequences are hypermethylated and transcriptionally silent in normal and transformed rodent cells. Mol Cell Biol (1982) 1.58
Inhibition of protein kinase C by tamoxifen. Cancer Res (1985) 1.56
Letter: Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct. J Am Chem Soc (1976) 1.53
An approach to the development of new drugs for African trypanosomiasis. J Exp Med (1978) 1.51
The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene (1993) 1.50
Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation. J Chronic Dis (1982) 1.49
Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay. Cancer Res (1980) 1.49
Isolation and structure determination of the fluorescent base from bovine liver phenylalanine transfer ribonucleic acid. Biochemistry (1973) 1.48
Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin Cancer Res (2001) 1.47
Summary of a scientific conference on preventive nutrition: pediatrics to geriatrics. Circulation (1999) 1.46
Does smoking reduction result in reduction of biomarkers associated with harm? A pilot study using a nicotine inhaler. Nicotine Tob Res (2000) 1.46
Monooxygenase activity in Cunninghamella bainieri: evidence for a fungal system similar to liver microsomes. Arch Biochem Biophys (1973) 1.44
Fractionation of rat liver transfer ribonucleic acid. Isolation of tyrosine, valine, serine, and phenylalanine transfer ribonucleic acids and their coding properties. Biochemistry (1969) 1.43
Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins. Proc Natl Acad Sci U S A (1996) 1.41
Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. Cancer Res (1998) 1.40
X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA. Proc Natl Acad Sci U S A (1975) 1.39
Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells. Science (1978) 1.39
Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma. Biochem Biophys Res Commun (1993) 1.38
Rearranged c-mos locus in a MOPC 21 murine myeloma cell line and its persistence in hybridomas. Nature (1984) 1.38
Design of a retrovirus-derived vector for expression and transduction of exogenous genes in mammalian cells. Mol Cell Biol (1983) 1.37
Action of phorbol esters in cell culture: mimicry of transformation, altered differentiation, and effects on cell membranes. J Supramol Struct (1979) 1.36
Molecular epidemiology: recent advances and future directions. Carcinogenesis (2000) 1.36
Differential excision from DNA of the C-8 and N2 guanosine adducts of N-acetyl-2-aminofluorene by single strand-specific endonucleases. Cancer Res (1977) 1.35
Differences in the transfer RNA's of normal liver and Novikoff hepatoma. Proc Natl Acad Sci U S A (1969) 1.35
Metallointercalation reagents. 2-hydroxyethanethiolato(2,2',2'-terpyridine)-platinum(II) monocation binds strongly to DNA by intercalation. Proc Natl Acad Sci U S A (1974) 1.33
Studies on the effect of cortisone on rat liver transfer ribonucleic acid. Biochemistry (1969) 1.33
Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas. Arch Dermatol (1995) 1.33
Formation and persistence of arylamine DNA adducts in vivo. Environ Health Perspect (1985) 1.33
Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry (1998) 1.32
DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment. Chem Res Toxicol (1993) 1.31
The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation. Biochemistry (2001) 1.31
Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase. Chem Res Toxicol (1996) 1.30
Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promoters. Science (1984) 1.30
Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters. J Biol Chem (1992) 1.29
Protein synthesis in a subcellular system from Bacillus stearothermophilus. Biochim Biophys Acta (1966) 1.28
Modification of ribonucleic acid by chemical carcinogens. IV. Circular dichroism and proton magnetic resonance studies of oligonucleotides modified with N-2-acetylaminofluorene. J Mol Biol (1971) 1.28
Hint1 is a haplo-insufficient tumor suppressor in mice. Oncogene (2006) 1.27
Detection of carcinogen-DNA adducts by radiommunoassay. Nature (1977) 1.26
Membrane effects of tumor promoters: stimulation of sugar uptake in mammalian cell cultures. J Cell Physiol (1979) 1.25
Amplification of the EGF receptor and c-myc genes in human esophageal cancers. Int J Cancer (1988) 1.23
Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells. J Interferon Res (1985) 1.23
Modification of ribonucleic acid by chemical carcinogens. VI. Effect of N-2-acetylaminofluorene modification of guanosine on the codon function of adjacent nucleosides in oligonucleotides. J Mol Biol (1974) 1.21
Helicobacter pylori inhibits the G1 to S transition in AGS gastric epithelial cells. Cancer Res (1999) 1.21
Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene. Carcinogenesis (1980) 1.21
Current concepts and controversies in chemical carcinogenesis. J Supramol Struct Cell Biochem (1981) 1.20
Monoclonal antibodies to DNA modified by a benzo[a]pyrene diol epoxide. Carcinogenesis (1984) 1.20
Structure of hydrated oligonucleotides studied by in situ scanning tunneling microscopy. Proc Natl Acad Sci U S A (1993) 1.20
Measurement of benzo(a)pyrene-DNA adducts by enzyme immunoassays and radioimmunoassay. Cancer Res (1981) 1.20
Molecular cloning of TPAR1, a gene whose expression is repressed by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA). Exp Cell Res (1994) 1.20
Quantitative approaches for assessing dose-response relationships in genetic toxicology studies. Environ Mol Mutagen (2012) 1.19
Patterns of viral DNA integration in cells transformed by wild type or DNA-binding protein mutants of adenovirus type 5 and effect of chemical carcinogens on integration. J Virol (1980) 1.19
Reduction of the carcinogen 1-nitropyrene to 1-aminopyrene by rat intestinal bacteria. Carcinogenesis (1983) 1.19
Coding and conformational properties of oligonucleotides modified with the carcinogen N-2-acetylaminofluorene. Proc Natl Acad Sci U S A (1970) 1.19