Published in Crit Rev Oral Biol Med on January 01, 1993
Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol (2007) 10.17
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci U S A (1997) 4.82
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest (1997) 4.31
Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol (1994) 3.68
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13
Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc Natl Acad Sci U S A (1996) 2.93
Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development (1996) 2.88
Metalloproteinases and their inhibitors: regulators of wound healing. Int J Biochem Cell Biol (2007) 2.65
The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases. Protein Sci (1995) 2.63
Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med (2010) 2.51
Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc Natl Acad Sci U S A (1997) 2.35
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis (2000) 2.32
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol (1995) 2.30
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci (2002) 2.21
Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol (1996) 2.05
Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis. J Clin Invest (1998) 2.02
TIMP-2 is required for efficient activation of proMMP-2 in vivo. J Biol Chem (2000) 2.00
Taxonomy, biology, and periodontal aspects of Fusobacterium nucleatum. Clin Microbiol Rev (1996) 1.99
Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Mol Biol Cell (1995) 1.96
High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. J Cell Biol (1994) 1.96
Matrilysin expression and function in airway epithelium. J Clin Invest (1998) 1.94
Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Am J Pathol (2008) 1.93
Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc Natl Acad Sci U S A (1996) 1.92
The molecular pathogenesis of osteosarcoma: a review. Sarcoma (2011) 1.91
Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol (1999) 1.87
Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest (1994) 1.83
Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). J Clin Invest (2001) 1.78
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. J Cell Sci (2001) 1.76
Matrix-degrading metalloproteinases in photoaging. J Investig Dermatol Symp Proc (2009) 1.72
The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J (1994) 1.68
Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases. J Clin Invest (1997) 1.67
Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. J Clin Invest (1999) 1.67
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck. Am J Pathol (1997) 1.66
Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene. J Cell Biol (1996) 1.64
Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers. Gut (1999) 1.63
Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3. Br J Cancer (1999) 1.61
Effect of Mycobacterium tuberculosis and its components on macrophages and the release of matrix metalloproteinases. Thorax (1996) 1.61
The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse. Mol Biol Cell (1995) 1.60
Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. Crit Care (2009) 1.57
A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor. J Clin Invest (1996) 1.57
JunB is essential for mammalian placentation. EMBO J (1999) 1.57
Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter. Mol Cell Biol (1997) 1.57
Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix. Am J Pathol (1996) 1.55
Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients. Br J Cancer (2007) 1.52
The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system. Am J Pathol (2000) 1.51
Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme. Protein Sci (1995) 1.50
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Ann Rheum Dis (2002) 1.48
Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am J Pathol (1998) 1.48
Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut (2003) 1.47
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Proc Natl Acad Sci U S A (1999) 1.46
Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter. J Cell Biol (1999) 1.45
Wnt5 signaling in vertebrate pancreas development. BMC Biol (2005) 1.45
Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol (2009) 1.44
Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. J Clin Invest (1998) 1.44
Matrix metalloproteinase inhibitors. Invest New Drugs (1997) 1.43
VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis. J Clin Invest (1995) 1.43
TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Mol Biol Cell (2001) 1.42
Bacterial exposure induces and activates matrilysin in mucosal epithelial cells. J Cell Biol (2000) 1.41
TMJ disorders: future innovations in diagnostics and therapeutics. J Dent Educ (2008) 1.40
Selective regulation of MMP and TIMP mRNA levels in tree shrew sclera during minus lens compensation and recovery. Invest Ophthalmol Vis Sci (2005) 1.40
Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention. J Exp Clin Cancer Res (2014) 1.39
Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas. Br J Cancer (1999) 1.38
Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis. Am J Pathol (1998) 1.38
The time course of changes in mRNA levels in tree shrew sclera during induced myopia and recovery. Invest Ophthalmol Vis Sci (2002) 1.37
First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases. EMBO J (1993) 1.36
Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies. Ann Rheum Dis (1995) 1.35
Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo. Am J Pathol (2005) 1.35
Gelatinase A activity directly modulates melanoma cell adhesion and spreading. EMBO J (1995) 1.34
Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinases-1. J Exp Med (1996) 1.34
Disruption of the myocardial extracellular matrix leads to cardiac dysfunction. J Clin Invest (2000) 1.33
The dual role of p55 tumour necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction. Clin Exp Immunol (2007) 1.32
Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways. Thorax (2004) 1.29
Use of a specific MMP-inhibitor (galardin) for preservation of hybrid layer. Dent Mater (2010) 1.27
Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis. Am J Pathol (2008) 1.25
Quantitation of TIMP-1 in plasma of healthy blood donors and patients with advanced cancer. Br J Cancer (1999) 1.24
Structural organization and chromosomal localization of the mouse collagenase type I gene. Biochem J (1995) 1.22
Human shoulder tendon biopsy samples in organ culture produce procollagenase and tissue inhibitor of metalloproteinases. Ann Rheum Dis (1995) 1.22
The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis. J Clin Invest (1997) 1.21
Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am J Pathol (2006) 1.20
Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism. J Cell Biol (1997) 1.20
Proteolytic-antiproteolytic balance and its regulation in carcinogenesis. World J Gastroenterol (2005) 1.20
Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma. Br J Cancer (2006) 1.19
Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1). Biochem J (1998) 1.19
MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells. Clin Exp Metastasis (1997) 1.19
Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. J Invest Dermatol (2006) 1.18
Loss of TGF-beta signaling contributes to autoimmune pancreatitis. J Clin Invest (2000) 1.18
Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome. Am J Pathol (2000) 1.16
Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors. Am J Pathol (1998) 1.15
Requirement for matrix metalloproteinase stromelysin-3 in cell migration and apoptosis during tissue remodeling in Xenopus laevis. J Cell Biol (2000) 1.15
Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness. Gut (2000) 1.14
Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate. Biochem J (1995) 1.14
Matrix metalloproteases and lung disease. Thorax (1994) 1.13
MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line. Oncogene (2007) 1.12
Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring. Am J Pathol (2003) 1.11
Epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4: implication in tissue fibrosis. Am J Pathol (2010) 1.11
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. Am J Pathol (1999) 1.10
Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors or metalloproteinases-1, -2, and -3 in rabbit aortic smooth muscle cells. Biochem J (1996) 1.10
Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma. Br J Cancer (1997) 1.10
Increase of GKLF messenger RNA and protein expression during progression of breast cancer. Cancer Res (2000) 2.80
The nucleotide sequence and protein-coding capability of the transposable element IS5. Gene (1981) 2.60
Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation. Proc Natl Acad Sci U S A (1997) 2.59
The nucleotide sequence of the chicken thymidine kinase gene and the relationship of its predicted polypeptide to that of the vaccinia virus thymidine kinase. Nucleic Acids Res (1984) 1.96
Conserved sequences at the origin of adenovirus DNA replication. J Virol (1982) 1.83
Structural models of human apolipoprotein A-I: a critical analysis and review. Biochim Biophys Acta (2001) 1.80
Human papillomavirus DNA replication compartments in a transient DNA replication system. J Virol (1999) 1.76
Regulation of sulfur assimilation in higher plants: a sulfate transporter induced in sulfate-starved roots plays a central role in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1997) 1.67
The evolution of the adenoviral genome. Ann N Y Acad Sci (1980) 1.48
Addition of a short peptide ligand to the adenovirus fiber protein. Gene Ther (1995) 1.42
Unusual DNA structures in the adenovirus genome. J Biol Chem (1986) 1.38
Domains required for assembly of adenovirus type 2 fiber trimers. J Virol (1996) 1.35
Localization of human cytomegalovirus structural proteins to the nuclear matrix of infected human fibroblasts. J Virol (1998) 1.34
Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation. J Biol Chem (2000) 1.31
Monoclonal antibodies to human fibroblast procollagenase. Inhibition of enzymatic activity, affinity purification of the enzyme, and evidence for clustering of epitopes in the NH2-terminal end of the activated enzyme. Biochemistry (1988) 1.30
The structure of human lipoprotein A-I. Evidence for the "belt" model. J Biol Chem (1999) 1.28
Truncation of the amino terminus of human apolipoprotein A-I substantially alters only the lipid-free conformation. Biochemistry (1997) 1.25
Activation and novel processing of matrix metalloproteinases by a thiol-proteinase from the oral anaerobe Porphyromonas gingivalis. J Dent Res (1997) 1.24
Structural analysis of apolipoprotein A-I: effects of amino- and carboxy-terminal deletions on the lipid-free structure. Biochemistry (1998) 1.24
The lipid-free structure of apolipoprotein A-I: effects of amino-terminal deletions. Biochemistry (1998) 1.22
The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal. Virology (1991) 1.21
Adenovirus precursor to terminal protein interacts with the nuclear matrix in vivo and in vitro. J Virol (1993) 1.19
Mutations of the precursor to the terminal protein of adenovirus serotypes 2 and 5. J Virol (1989) 1.18
Characterization of the early region 3 and fiber genes of Ad7. Virology (1988) 1.18
Nucleotide sequence of the genes encoded in early region 2b of human adenovirus type 12. Gene (1986) 1.17
Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters. J Biol Chem (1993) 1.16
TGF-beta increases retinal endothelial cell permeability by increasing MMP-9: possible role of glial cells in endothelial barrier function. Invest Ophthalmol Vis Sci (2001) 1.16
Expression of enzymatically active adenovirus DNA polymerase from cloned DNA requires sequences upstream of the main open reading frame. Virology (1987) 1.13
Relative accessibility of N-acetylglucosamine in trimers of the adenovirus types 2 and 5 fiber proteins. J Virol (1990) 1.12
Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Am J Pathol (2001) 1.07
Comparative sequence specificities of human 72- and 92-kDa gelatinases (type IV collagenases) and PUMP (matrilysin). Biochemistry (1993) 1.04
Site-directed mutagenesis of the region around Cys-241 of complement component C2. Evidence for a C4b binding site. J Immunol (1991) 1.01
Receptor mediated uptake of peptides that bind the human transferrin receptor. Eur J Biochem (2001) 1.01
Linker insertion mutations in the adenovirus preterminal protein that affect DNA replication activity in vivo and in vitro. J Virol (1991) 1.01
Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts. Biochim Biophys Acta (2000) 1.00
Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis. Blood (2001) 0.99
The nucleotide sequence of the genes encoded in early region 2b of human adenovirus type 7. Gene (1983) 0.98
Association of the human papillomavirus type 11 E1 protein with histone H1. J Virol (1998) 0.98
Mutagenesis of conserved region I in the DNA polymerase from human adenovirus serotype 2. Virology (1991) 0.98
Characteristics of a 95-kDa matrix metalloproteinase produced by mammary carcinoma cells. Biochemistry (1991) 0.95
Amplification of recombinant adenoviral transgene products occurs by inhibition of histone deacetylase. Virology (1997) 0.94
The precise structure and coding capacity of mRNAs from early region 2B of human adenovirus serotype 2. Virology (1988) 0.94
Transcriptional suppression of matrix metalloproteinase-2 gene expression in human astroglioma cells by TNF-alpha and IFN-gamma. J Immunol (1998) 0.93
Tyrosine kinase-dependent release of an adenovirus preterminal protein complex from the nuclear matrix. J Virol (1996) 0.93
Mutational analysis of residues in and around the active site of human fibroblast-type collagenase. J Biol Chem (1994) 0.92
Intracellular localization of Porphyromonas gingivalis thiol proteinase in periodontal tissues of chronic periodontitis patients. Oral Dis (2004) 0.92
Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells. Cancer Res (2001) 0.92
An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase. Biochemistry (1991) 0.90
Induction of matrix metalloproteinases and a collagen-degrading phenotype in fibroblasts and epithelial cells by secreted Porphyromonas gingivalis proteinase. J Periodontal Res (1998) 0.90
Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix. J Virol (1998) 0.89
Remaining dentine thickness and human pulp responses. Int Endod J (2003) 0.88
Crystallization of truncated human apolipoprotein A-I in a novel conformation. Acta Crystallogr D Biol Crystallogr (1999) 0.88
Nicotine increases the collagen-degrading ability of human gingival fibroblasts. J Periodontal Res (2007) 0.87
Use of inhibitory (anti-catalytic) antibodies to study extracellular proteolysis. Immunol Invest (1989) 0.87
Proteolytic activities of human fibroblast collagenase: hydrolysis of a broad range of substrates at a single active site. Biochemistry (1990) 0.86
Functional domains of human TIMP-1 (tissue inhibitor of metalloproteinases). J Biol Chem (1994) 0.86
Cloning, characterization, and expression analysis of mouse enamelysin. J Dent Res (2000) 0.86
Adenovirus preterminal protein synthesized in COS cells from cloned DNA is active in DNA replication in vitro. J Virol (1988) 0.86
APMA (4-aminophenylmercuric acetate) activation of stromelysin-1 involves protein interactions in addition to those with cysteine-75 in the propeptide. Biochemistry (1996) 0.86
Activation of human progelatinase A by collagenase and matrilysin: activation of procollagenase by matrilysin. J Protein Chem (1996) 0.85
Replacement of conserved cysteines in human tissue inhibitor of metalloproteinases-1. J Biol Chem (1997) 0.85
Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1. Protein Eng (2000) 0.84
Mutations in two cysteine-histidine-rich clusters in adenovirus type 2 DNA polymerase affect DNA binding. J Virol (1992) 0.84
Functional aspects of the human salivary cystatins in the oral environment. Oral Dis (1999) 0.84
Sequences of human adenovirus Ad3 and Ad7 DNAs encoding the promoter and first leader segment of late RNAs. Gene (1981) 0.83
Heterogeneity in the collagen-degrading ability of Porphyromonas gingivalis-stimulated human gingival fibroblasts. J Periodontal Res (2007) 0.83
Restriction endonuclease BamHI cleaves bacteriophage Mu DNA within cistrons E and F. Gene (1980) 0.81
Comparison of pulp responses to resin composites. Oper Dent (2003) 0.80
Design, expression, and crystallization of recombinant lectin from the garden pea (Pisum sativum). J Biol Chem (1989) 0.80
The nucleotide sequence of the polypeptide IX gene of human adenovirus type 3. Gene (1981) 0.80
Human apolipoprotein A-I: structure determination and analysis of unusual diffraction characteristics. Acta Crystallogr D Biol Crystallogr (1999) 0.79
Analysis of the TIMP-1/FIB-CL complex. Ann N Y Acad Sci (1994) 0.79
The mechanism of inhibition of collagenase by TIMP-1. J Biol Chem (1996) 0.79
Glycosylation and NH2-terminal domain mutants of the tissue inhibitor of metalloproteinases-1 (TIMP-1). Biochim Biophys Acta (1998) 0.79
92K-GL (MMP-9) and 72K-GL (MMP-2) are produced in vivo by human oral squamous cell carcinomas and can enhance FIB-CL (MMP-1) activity in vitro. J Dent Res (1999) 0.79
Degradation of collagen fibrils by live cells: role of expression and activation of procollagenase. Matrix Suppl (1992) 0.79