MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.

PubWeight™: 9.70‹?› | Rank: Top 0.1%

🔗 View Article (PMC 2839071)

Published in Cell on May 01, 1998

Authors

T H Vu1, J M Shipley, G Bergers, J E Berger, J A Helms, D Hanahan, S D Shapiro, R M Senior, Z Werb

Author Affiliations

1: Department of Anatomy, University of California, San Francisco 94143, USA.

Associated clinical trials:

Association of SNPs in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population. | NCT04463290

Articles citing this

(truncated to the top 100)

How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol (2001) 14.05

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol (2000) 13.29

Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol (2007) 10.17

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 9.36

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev (2000) 8.24

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell (2000) 8.00

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev (1999) 6.10

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest (2000) 4.90

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest (2000) 4.79

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev (2001) 4.45

Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol (2000) 4.33

Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A (2000) 4.22

An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest (2004) 4.03

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med (2002) 4.00

Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell (2003) 3.68

Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys (2008) 3.61

Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3. J Cell Biol (2000) 3.53

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (2004) 3.45

Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol (2003) 3.45

Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev (2001) 3.43

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest (2003) 3.41

Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. J Clin Invest (1999) 3.35

Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev (1999) 3.32

Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A (2004) 3.27

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res (2000) 3.24

Where tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical load. J Anat (2006) 3.01

Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. J Cell Biol (2001) 2.95

Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol (2000) 2.87

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A (2001) 2.82

Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem (2004) 2.70

Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol Biol Cell (2002) 2.62

Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61

Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest (2002) 2.59

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest (2002) 2.52

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model. Proc Natl Acad Sci U S A (2000) 2.47

DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. J Bone Miner Res (2005) 2.46

Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest (2004) 2.45

Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res (2008) 2.45

Altered fracture repair in the absence of MMP9. Development (2003) 2.41

The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. J Clin Invest (2008) 2.24

Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci (2006) 2.23

Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci (2002) 2.21

Matrix metalloproteinases in lung biology. Respir Res (2000) 2.18

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol (2005) 2.18

Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev (2007) 2.14

Stromelysin-1 regulates adipogenesis during mammary gland involution. J Cell Biol (2001) 2.03

Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Proc Natl Acad Sci U S A (2000) 1.98

Matrix remodeling during endochondral ossification. Trends Cell Biol (2004) 1.97

Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid. J Exp Med (1998) 1.96

Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol (2005) 1.96

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol (2007) 1.95

Matrilysin expression and function in airway epithelium. J Clin Invest (1998) 1.94

Development of the endochondral skeleton. Cold Spring Harb Perspect Biol (2013) 1.89

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev (2004) 1.88

Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol (1999) 1.87

Matricellular proteins as modulators of cell-matrix interactions: adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2. Mol Biol Cell (2000) 1.85

Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res (2010) 1.83

Physiology and pathophysiology of matrix metalloproteases. Amino Acids (2010) 1.83

MMPs as therapeutic targets--still a viable option? Semin Cell Dev Biol (2007) 1.78

The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter. Oncogene (2000) 1.77

The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep (2001) 1.76

Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest (2006) 1.75

Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J (2007) 1.74

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest (2004) 1.72

Osteopenia and decreased bone formation in osteonectin-deficient mice. J Clin Invest (2000) 1.70

Experimental metastasis is suppressed in MMP-9-deficient mice. Clin Exp Metastasis (1999) 1.70

Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis (2008) 1.69

Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J (2004) 1.64

Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions. J Clin Invest (1999) 1.64

Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. J Bone Miner Res (2013) 1.64

A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing. Blood (2011) 1.61

Important role of matrix metalloproteinase 9 in epileptogenesis. J Cell Biol (2008) 1.61

Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res (2010) 1.60

Matrix metalloproteinases: old dogs with new tricks. Genome Biol (2003) 1.59

Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin. Am J Pathol (2000) 1.59

Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. J Cell Biol (2011) 1.58

Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet (2007) 1.56

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med (2006) 1.54

Genetic disorders of the skeleton: a developmental approach. Am J Hum Genet (2003) 1.52

Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res (2006) 1.50

Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover. J Cell Sci (2008) 1.49

Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders. Arthritis Res Ther (2010) 1.48

Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus. J Clin Invest (2002) 1.47

Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Proc Natl Acad Sci U S A (1999) 1.46

Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions. Biochim Biophys Acta (2009) 1.46

Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol (2004) 1.45

Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation. Am J Pathol (2002) 1.45

Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity. J Exp Med (2001) 1.43

Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis. Mol Cell Biol (2007) 1.43

Macrophage elastase kills bacteria within murine macrophages. Nature (2009) 1.42

Elastase-induced intracranial aneurysms in hypertensive mice. Hypertension (2009) 1.42

The matricellular protein CCN1 is essential for cardiac development. Circ Res (2006) 1.41

Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling. PLoS Pathog (2012) 1.41

Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9. J Leukoc Biol (2009) 1.41

Fibronectin matrix turnover occurs through a caveolin-1-dependent process. Mol Biol Cell (2004) 1.40

MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing. Am J Pathol (2009) 1.40

Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis. Matrix Biol (2009) 1.40

ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genet (2017) 1.39

Articles cited by this

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell (1997) 16.78

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell (1997) 13.53

Matrix metalloproteinases: a review. Crit Rev Oral Biol Med (1993) 9.03

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature (1990) 8.94

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science (1996) 8.14

Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell (1996) 7.70

PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science (1996) 6.33

ECM and cell surface proteolysis: regulating cellular ecology. Cell (1997) 6.00

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science (1994) 5.97

Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J Biol Chem (1997) 3.09

Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science (1996) 3.01

The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases. J Biol Chem (1996) 2.88

How does extracellular matrix control capillary morphogenesis? Cell (1989) 2.84

Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell (1997) 2.68

Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths. Development (1992) 2.19

Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J Biol Chem (1995) 2.06

Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro. J Cell Physiol (1993) 2.01

High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. J Cell Biol (1994) 1.96

Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J Cell Physiol (1993) 1.88

Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation. Development (1996) 1.78

Interstitial collagenase is required for angiogenesis in vitro. Dev Biol (1994) 1.55

Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide gene deletion. Endocrinology (1996) 1.46

Fine structural aspects of vascular invasion of the tibial epiphyseal plate of growing rats. Acta Anat (Basel) (1968) 1.33

The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern. Biochem J (1993) 1.28

Chondroclasts and endothelial cells collaborate in the process of cartilage resorption. Anat Rec (1992) 1.28

End labeling studies of fragmented DNA in the avian growth plate: evidence of apoptosis in terminally differentiated chondrocytes. J Bone Miner Res (1995) 1.28

Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis. Mech Dev (1997) 1.25

Invasion and resorption in enchondral ossification. An electron microscopic study. J Bone Joint Surg Am (1966) 1.23

Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development. FEBS Lett (1996) 1.18

A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation. Dev Biol (1996) 1.13

Cellular turnover at the chondro-osseous junction of growth plate cartilage: analysis by serial sections at the light microscopical level. J Orthop Res (1989) 1.12

Immunolocalization of metalloproteinases and their inhibitor in the rabbit growth plate. J Bone Joint Surg Am (1989) 1.11

Transferrin promotes endothelial cell migration and invasion: implication in cartilage neovascularization. J Cell Biol (1997) 1.11

Bone development. Ciba Found Symp (1988) 1.09

Transforming growth factor-beta 1 and fibroblast growth factors in rat growth plate. J Orthop Res (1995) 1.09

Microvascular pattern in the metaphysis during bone growth. Anat Rec (1995) 1.08

Matrix metalloproteinases in blood vessel development in human fetal skin and in cutaneous tumors. J Invest Dermatol (1995) 1.05

Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. Eur J Cell Biol (1995) 1.05

Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B. J Clin Invest (1995) 1.04

A metalloproteinase inhibitor as an inhibitor of neovascularization. J Cell Biochem (1991) 1.00

Lysosomal cysteine and aspartic proteinases, acid phosphatase, and an endogenous cysteine proteinase inhibitor, cystatin-beta, in rat osteoclasts. J Histochem Cytochem (1993) 0.99

Epiphyseal growth plate cartilage and chondrocytes in mineralising cultures produce a low molecular mass angiogenic procollagenase activator. Bone Miner (1987) 0.95

Articles by these authors

Studies on transformation of Escherichia coli with plasmids. J Mol Biol (1983) 116.81

Plasmid screening at high colony density. Gene (1980) 16.47

How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol (2001) 14.05

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol (2000) 13.29

Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants. Proc Natl Acad Sci U S A (1990) 10.46

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature (1985) 9.78

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med (1999) 9.18

Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science (1997) 8.19

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell (2000) 8.00

Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (1989) 7.30

Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Science (1988) 6.77

Genetic and physical linkage of exogenous sequences in transformed cells. Cell (1980) 6.67

Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science (1995) 6.35

Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J (2003) 6.23

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev (1999) 6.10

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell (1999) 6.08

McrA and McrB restriction phenotypes of some E. coli strains and implications for gene cloning. Nucleic Acids Res (1988) 5.76

Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev (2000) 5.33

Plasmid screening at high colony density. Methods Enzymol (1983) 5.24

Plasmid transformation of Escherichia coli and other bacteria. Methods Enzymol (1991) 5.21

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Nat Genet (2001) 4.96

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science (1999) 4.91

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest (2000) 4.90

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med (1999) 4.85

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest (2000) 4.79

Implantation and the placenta: key pieces of the development puzzle. Science (1994) 4.75

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71

Elastase secretion by stimulated macrophages. Characterization and regulation. J Exp Med (1975) 4.60

Secretion of a specific collagenase by stimulated macrophages. J Exp Med (1975) 4.56

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature (1995) 4.56

Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts. Proc Natl Acad Sci U S A (1982) 4.54

Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature (1980) 4.37

Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J Cell Biol (1997) 4.22

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc Natl Acad Sci U S A (1988) 4.19

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest (2000) 4.16

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med (1998) 4.04

Endogenous activiation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. N Engl J Med (1977) 3.81

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J Clin Invest (1982) 3.77

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol (1994) 3.68

Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell (1980) 3.66

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum (2009) 3.61

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates. J Biol Chem (1985) 3.51

Chemotactic activity of elastin-derived peptides. J Clin Invest (1980) 3.33

Novel method for studying mRNA phenotypes in single or small numbers of cells. J Cell Biochem (1989) 3.30

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. J Cell Biol (1992) 3.29

Construction and characterization of a 2.5-kilobase procollagen clone. Proc Natl Acad Sci U S A (1978) 3.26

Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest (2000) 3.26

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. J Biol Chem (1986) 3.24

The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol (2001) 3.22

Plasma membrane synthesis in the macrophage following phagocytosis of polystyrene latex particles. J Biol Chem (1972) 3.10

Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development (1991) 3.09

The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development (2001) 3.04

Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci U S A (1981) 3.03

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med (1997) 3.03

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell (1988) 2.99

Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science (1998) 2.95

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc Natl Acad Sci U S A (1996) 2.93

Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr Opin Cell Biol (1992) 2.91

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature (1987) 2.90

Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am J Respir Cell Mol Biol (2000) 2.90

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development (1996) 2.88

Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol (2000) 2.87

Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science (1983) 2.80

Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proc Natl Acad Sci U S A (1999) 2.80

BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity (2000) 2.79

92-kD type IV collagenase mediates invasion of human cytotrophoblasts. J Cell Biol (1991) 2.79

K-ras activation generates an inflammatory response in lung tumors. Oncogene (2006) 2.78

Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol (1994) 2.73

Human 92- and 72-kilodalton type IV collagenases are elastases. J Biol Chem (1991) 2.71

Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos. Science (1988) 2.70

Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardium. Circ Res (2000) 2.66

Matrix metalloproteinases and the development of cancer. Chem Biol (1996) 2.63

Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development. J Clin Invest (1990) 2.56

Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J Cell Biol (1989) 2.54

A specific collagenase from rabbit fibroblasts in monolayer culture. Biochem J (1974) 2.53

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell (1991) 2.52

Cellular transformation and malignancy induced by ras require c-jun. Mol Cell Biol (1996) 2.51

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature (1994) 2.51

The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell (2000) 2.49

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest (1999) 2.48

Craniofacial tissue engineering by stem cells. J Dent Res (2006) 2.48

Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. J Exp Med (1997) 2.47

Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev (1999) 2.46

Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol (1995) 2.45

Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J Clin Invest (1998) 2.43

Inflammatory cells and cancer: think different! J Exp Med (2001) 2.42

The cellular and molecular origins of beak morphology. Science (2003) 2.41

Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development (1993) 2.41