Published in Acta Neuropathol on January 01, 1993
The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J Neural Transm (Vienna) (2006) 1.50
Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. Am J Pathol (2005) 1.02
Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling. Front Physiol (2012) 0.97
Acetylcholine receptors in dementia and mild cognitive impairment. Eur J Nucl Med Mol Imaging (2008) 0.96
Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease. J Neuropathol Exp Neurol (2012) 0.95
Blocking the apolipoprotein E/amyloid-β interaction reduces fibrillar vascular amyloid deposition and cerebral microhemorrhages in TgSwDI mice. J Alzheimers Dis (2011) 0.94
The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology. J Biol Chem (2009) 0.94
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease. Mol Neurodegener (2010) 0.89
Cholinesterase inhibitors for the treatment of Alzheimer's disease:: getting on and staying on. Curr Ther Res Clin Exp (2003) 0.85
Supplementation of Convolvulus pluricaulis attenuates scopolamine-induced increased tau and amyloid precursor protein (AβPP) expression in rat brain. Indian J Pharmacol (2012) 0.84
Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. Cell Mol Neurobiol (2007) 0.81
Cholinesterases colocalize with sites of neurofibrillary degeneration in aged and Alzheimer's brains. Acta Neuropathol (1994) 0.80
Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex. Curr Alzheimer Res (2012) 0.78
Amyloidosis in Alzheimer's Disease: The Toxicity of Amyloid Beta (A β ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy. Evid Based Complement Alternat Med (2013) 0.77
Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology (2015) 0.75
Diagnosis of Alzheimer's disease. Arch Neurol (1985) 12.77
A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES. J Histochem Cytochem (1964) 10.70
The molecular pathology of Alzheimer's disease. Neuron (1991) 8.21
Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest (1987) 4.98
A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining. Acta Neuropathol (1988) 4.10
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell (1988) 3.11
The molecular forms of cholinesterase and acetylcholinesterase in vertebrates. Annu Rev Neurosci (1982) 3.07
Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals. Neurosci Lett (1988) 2.26
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol (1989) 1.95
Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease. Acta Neuropathol (1989) 1.93
Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study. Acta Neuropathol (1982) 1.93
Technical considerations on the use of horseradish peroxidase as a neuronal marker. Neuroscience (1977) 1.92
Comparison of butyrylcholinesterase and acetylcholinesterase. Biochem J (1989) 1.77
Immune system response in Alzheimer's disease. Can J Neurol Sci (1989) 1.75
Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. Lab Invest (1988) 1.70
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc Natl Acad Sci U S A (1990) 1.66
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. Am J Pathol (1988) 1.65
A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol (1989) 1.62
Alzheimer's disease: a cell biological perspective. Science (1992) 1.55
Alzheimer patients and Down patients: cerebral preamyloid deposits differ ultrastructurally and histochemically from the amyloid of senile plaques. Neurosci Lett (1989) 1.35
Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease. J Neurosci (1991) 1.27
Acetylcholinesterase hydrolyzes substance P. Neuroscience (1980) 1.20
Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques. Acta Neuropathol (1984) 1.19
Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin. Neurobiol Aging (1990) 1.19
Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome. Am J Pathol (1990) 1.17
Anchorage of collagen-tailed acetylcholinesterase to the extracellular matrix is mediated by heparan sulfate proteoglycans. J Cell Biol (1985) 1.13
Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease. Ann Neurol (1987) 1.13
Evidence for cholinergic neurites in senile plaques. Science (1984) 1.08
Interactions of asymmetric forms of acetylcholinesterase with basement membrane components. J Biol Chem (1983) 1.07
Immunodetection of the amyloid P component in Alzheimer's disease. Acta Neuropathol (1989) 1.06
Anatomy of cholinesterase inhibition in Alzheimer's disease: effect of physostigmine and tetrahydroaminoacridine on plaques and tangles. Ann Neurol (1987) 1.06
Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: selective loss of the intermediate (10S) form. Neurosci Lett (1983) 1.05
Cholinergic innervation in neuritic plaques. Science (1982) 1.02
Protein kinase C alteration is an early biochemical marker in Alzheimer's disease. J Neurosci (1991) 1.01
Molecular forms of acetylcholinesterase and butyrylcholinesterase in the aged human central nervous system. J Neurochem (1986) 1.00
Widespread serum amyloid P immunoreactivity in cortical amyloid deposits and the neurofibrillary pathology of Alzheimer's disease and other degenerative disorders. Neuropathol Appl Neurobiol (1991) 0.99
Acetylcholinesterase fibers and the development of senile plaques. Brain Res (1987) 0.99
Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience (1989) 0.97
Spatiotemporal relationship of embryonic cholinesterases with cell proliferation in chicken brain and eye. Proc Natl Acad Sci U S A (1987) 0.97
The enkephalins are amongst the peptides hydrolyzed by purified acetylcholinesterase. Neuroscience (1983) 0.94
Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease. J Histochem Cytochem (1992) 0.93
Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease. Ann Neurol (1986) 0.91
Acetylcholinesterase exhibits trypsin-like and metalloexopeptidase-like activity in cleaving a model peptide. Neuroscience (1987) 0.90
Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue. Brain Res (1991) 0.89
Chromogranin A-like immunoreactive neurites are major constituents of senile plaques. Lab Invest (1991) 0.88
Distribution pattern and functional state of alpha 1-antichymotrypsin in plaques and vascular amyloid in Alzheimer's disease. A immunohistochemical study with monoclonal antibodies against native and inactivated alpha 1-antichymotrypsin. Acta Neuropathol (1991) 0.87
Senile plaques: staining for acetylcholinesterase and A4 protein: a comparative study in the hippocampus and entorhinal cortex. Acta Neuropathol (1990) 0.87
A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease. Biochemistry (1991) 0.87
Substance P hydrolysis by human serum cholinesterase. J Neurochem (1982) 0.86
Cranial nerve growth in birds is preceded by cholinesterase expression during neural crest cell migration and the formation of an HNK-1 scaffold. Cell Tissue Res (1991) 0.85
Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease. Acta Neuropathol (1989) 0.85
The distribution of neuritic plaques and acetylcholinesterase staining in the amygdala in Alzheimer's disease. Neurology (1988) 0.84
Cholinesterase histochemistry in the human brain: effect of various fixation and storage conditions. J Neurosci Methods (1992) 0.83
Molecular forms of acetylcholinesterases in Alzheimer's disease. Fed Proc (1986) 0.83
Cortical metabolism, acetylcholinesterase staining and pathological changes in Alzheimer's disease. Can J Neurol Sci (1986) 0.81
Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain. Biol Psychiatry (1990) 0.80
Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain. Brain Res (1992) 0.78
Acetylcholinesterase undergoes autolysis to generate trypsin-like activity. Neurosci Lett (1988) 0.76
Acetylcholinesterase converts Met5-enkephalin-containing peptides to Met5-enkephalin. Neurosci Lett (1988) 0.76
Development of transient acetylcholinesterase staining in cells and permanent staining in fibers in cortex of rat brain. Brain Res Bull (1991) 0.76
Identification of the trypsin-like activity in commercial preparations of eel acetylcholinesterase. Biochem Biophys Res Commun (1991) 0.76
Insula of the old world monkey. III: Efferent cortical output and comments on function. J Comp Neurol (1982) 4.23
Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med (1995) 3.64
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology (2007) 3.26
Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience (1983) 3.26
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J (2001) 3.22
Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J Comp Neurol (1983) 3.19
Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain. J Comp Neurol (1982) 2.57
Insula of the old world monkey. II: Afferent cortical input and comments on the claustrum. J Comp Neurol (1982) 2.54
Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann Neurol (2001) 2.51
Some observations on the course and composition of the cingulum bundle in the rhesus monkey. J Comp Neurol (1984) 1.79
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann Neurol (1999) 1.75
A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res (1992) 1.69
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains. J Neurosci Res (1990) 1.60
Immunocytochemical localization of the dopamine transporter in human brain. J Comp Neurol (1999) 1.55
Cortical projections arising from the basal forebrain: a study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase. Neuroscience (1984) 1.52
Neural inputs into the temporopolar cortex of the rhesus monkey. J Comp Neurol (1987) 1.49
The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp Neurol (1989) 1.45
[Diagnosis of Alzheimer's disease. Evaluation of senile plaques of the diffuse type]. Med Clin (Barc) (1992) 1.40
Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys. J Comp Neurol (1998) 1.39
Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Neuroscience (1984) 1.38
Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration. Proc Natl Acad Sci U S A (2009) 1.37
Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Proc Natl Acad Sci U S A (1996) 1.37
Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease. Proc Natl Acad Sci U S A (2001) 1.33
Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease. J Neurosci Res (1992) 1.30
TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin. J Comp Neurol (1994) 1.26
Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease. J Comp Neurol (1999) 1.25
Insular interconnections with the amygdala in the rhesus monkey. Neuroscience (1981) 1.25
FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Mol Cell Neurosci (2001) 1.22
Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies. J Comp Neurol (1996) 1.21
Neural inputs into the nucleus basalis of the substantia innominata (Ch4) in the rhesus monkey. Brain (1984) 1.21
Thalamic connections of the insula in the rhesus monkey and comments on the paralimbic connectivity of the medial pulvinar nucleus. J Comp Neurol (1984) 1.20
Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A (2000) 1.17
Tau-66: evidence for a novel tau conformation in Alzheimer's disease. J Neurochem (2001) 1.11
Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment. J Histochem Cytochem (2000) 1.09
Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J Neurosci (1995) 1.08
The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Natl Acad Sci U S A (1994) 1.04
Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease. Mov Disord (1998) 1.03
Tau in situ hybridization in normal and Alzheimer brain: localization in the somatodendritic compartment. Ann Neurol (1989) 1.02
Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease. Neurology (2011) 1.00
Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum. Neuroscience (1983) 0.98
NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease. Exp Neurol (1989) 0.98
Human orbitofrontal cortex: cytoarchitecture and quantitative immunohistochemical parcellation. J Comp Neurol (1995) 0.98
Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain. Neuroscience (1997) 0.97
Distribution of galaninergic immunoreactivity in the brain of the mouse. J Comp Neurol (2001) 0.96
Cholinergic and non-cholinergic septohippocampal pathways. Neurosci Lett (1985) 0.96
Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway. Exp Neurol (2001) 0.96
Additional factors influencing sensitivity in the tetramethyl benzidine method for horseradish peroxidase neurohistochemistry. J Histochem Cytochem (1980) 0.96
Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. J Comp Neurol (1999) 0.95
Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis. Neurology (2007) 0.95
Amyloid load and neural elements in Alzheimer's disease and nondemented individuals with high amyloid plaque density. Exp Neurol (1996) 0.95
Galanin in Alzheimer's disease: neuroinhibitory or neuroprotective? Cell Mol Life Sci (2008) 0.92
Retrograde transport of brain-derived neurotrophic factor (BDNF) following infusion in neo- and limbic cortex in rat: relationship to BDNF mRNA expressing neurons. J Comp Neurol (1996) 0.91
Systematic regional differences in the cholinergic innervation of the primate cerebral cortex: distribution of enzyme activities and some behavioral implications. Ann Neurol (1986) 0.90
Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra. J Comp Neurol (2000) 0.90
MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD. Neurobiol Aging (2009) 0.90
Ectopic galanin expression and normal galanin receptor 2 and galanin receptor 3 mRNA levels in the forebrain of galanin transgenic mice. Neuroscience (2005) 0.90
Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons. Neuroscience (1984) 0.89
A confocal microscopic analysis of galaninergic hyperinnervation of cholinergic basal forebrain neurons in Alzheimer's disease. Brain Pathol (1997) 0.88
Reduction in TrkA-immunoreactive neurons is not associated with an overexpression of galaninergic fibers within the nucleus basalis in Down's syndrome. J Neurochem (2000) 0.88
Presenilin-1 protein expression in familial and sporadic Alzheimer's disease. Ann Neurol (1997) 0.88
Ascending cholinergic pathways: functional organization and implications for disease models. Prog Brain Res (1993) 0.88
Ultrastructural localization of fructose-1,6-bisphosphatase in mouse brain. Microsc Res Tech (2011) 0.87
Evidence that transmitter-containing dystrophic neurites precede paired helical filament and Alz-50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease. J Comp Neurol (1993) 0.87
Age-related shrinkage of cortically projecting cholinergic neurons: a selective effect. Ann Neurol (1987) 0.87
trk-immunoreactivity in the monkey central nervous system: forebrain. J Comp Neurol (1994) 0.86
Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients. Brain Res Mol Brain Res (1994) 0.86
Connections of the hippocampal formation in humans: II. The endfolial fiber pathway. J Comp Neurol (1997) 0.86
Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease. J Comp Neurol (2001) 0.86
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients. Neurobiol Aging (1989) 0.85
Regional variations in cortical cholinergic innervation: chemoarchitectonics of acetylcholinesterase-containing fibers in the macaque brain. Brain Res (1984) 0.84
Alz-50 immunoreactive neuropil differentiates hippocampal complex subfields in Alzheimer's disease. J Comp Neurol (1991) 0.84
Cholinesterase histochemistry in the human brain: effect of various fixation and storage conditions. J Neurosci Methods (1992) 0.83
Galanin-like immunoreactivity within the primate basal forebrain: differential staining patterns between humans and monkeys. J Comp Neurol (1990) 0.83
Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: trophic and tropic effects in a rodent model of Huntington's disease. J Comp Neurol (1997) 0.83
Fetal brain transplant: reduction of cognitive deficits in rats with frontal cortex lesions. Science (1983) 0.82
Cholinergic innervation in the human hippocampal formation including the entorhinal cortex. J Comp Neurol (1994) 0.82
Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer's disease. CNS Drug Rev (2001) 0.81
Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors. J Comp Neurol (1997) 0.81
Epidermal growth factor receptor expression in demented elderly: localization to vascular endothelial cells of brain, pituitary and skin. Brain Res (1993) 0.81
Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase. Neurochem Int (1984) 0.80
Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate. Brain Res (1996) 0.80
Delivery of trophic factors to the primate brain. Exp Neurol (1993) 0.80
NGF receptor (p75)-immunoreactivity in the developing primate basal ganglia. J Comp Neurol (1993) 0.80
Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins. Exp Neurol (1994) 0.80
Ubiquitinated granular structures and initial neurofibrillary changes in the human brain. J Neurol Sci (2001) 0.80
Degeneration in the spinal cord of old rats. Exp Neurol (1980) 0.80
Galanin immunoreactivity within the primate basal forebrain: evolutionary change between monkeys and apes. J Comp Neurol (1993) 0.80
Cholinesterases colocalize with sites of neurofibrillary degeneration in aged and Alzheimer's brains. Acta Neuropathol (1994) 0.80
Demonstrating immune-related antigens in Alzheimer's disease brain tissue. Neurobiol Aging (1990) 0.79
Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to Tau and PHF in Alzheimer's disease. Exp Neurol (1995) 0.79
The rapid anterograde transport of horseradish peroxidase. Neuroscience (1980) 0.79
Galanin immunoreactivity in the primate central nervous system. J Comp Neurol (1992) 0.79
Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain. Brain Res (1992) 0.78