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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997 11.35
2 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995 9.09
3 Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996 3.49
4 Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 1999 3.37
5 Fatal septicaemia after fibroid embolisation. Lancet 1999 2.48
6 Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 1997 2.32
7 Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science 1993 2.25
8 The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. EMBO J 1992 2.16
9 Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science 1993 2.10
10 Melanocortin receptors in leptin effects. Nature 1997 2.01
11 Purification and characterization of recombinant human p50csk protein-tyrosine kinase from an Escherichia coli expression system overproducing the bacterial chaperones GroES and GroEL. Proc Natl Acad Sci U S A 1995 1.78
12 Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. J Biol Chem 1999 1.61
13 The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks. Horm Metab Res 1996 1.57
14 Regulation of src family tyrosine kinases in lymphocytes. Trends Biochem Sci 1993 1.49
15 Amphitropic proteins: a new class of membrane proteins. Trends Biochem Sci 1988 1.40
16 Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase. Eur J Immunol 1992 1.32
17 Identification and functional analysis of novel human melanocortin-4 receptor variants. Diabetes 1999 1.30
18 Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats. Am J Physiol 1997 1.30
19 Diacylglycerol in large alpha-actinin/actin complexes and in the cytoskeleton of activated platelets. Nature 1985 1.29
20 The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J Biol Chem 1996 1.28
21 Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Mol Cell Biol 1994 1.27
22 Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase. Mol Cell Biol 1994 1.26
23 Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J Histochem Cytochem 1999 1.26
24 Catalytic domains of the LAR and CD45 protein tyrosine phosphatases from Escherichia coli expression systems: purification and characterization for specificity and mechanism. Biochemistry 1992 1.23
25 Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res 1996 1.23
26 Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion. Am J Physiol 1998 1.20
27 A prospective single centre study comparing computed tomography pneumocolon against colonoscopy in the detection of colorectal neoplasms. Gut 2000 1.18
28 Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein. Mol Cell Biol 1994 1.12
29 The mahogany protein is a receptor involved in suppression of obesity. Nature 1999 1.12
30 Role of the CNS melanocortin system in the response to overfeeding. J Neurosci 1999 1.12
31 Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck. Proc Natl Acad Sci U S A 1992 1.11
32 Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an Escherichia coli expression system. Biochemistry 1991 1.10
33 Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am J Physiol 1996 1.08
34 Evaluation of the catalytic mechanism of recombinant human Csk (C-terminal Src kinase) using nucleotide analogs and viscosity effects. J Biol Chem 1994 1.06
35 Protein tyrosine kinase p59fyn is associated with the T cell receptor-CD3 complex in functional human lymphocytes. Eur J Immunol 1992 1.06
36 Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase. Eur J Immunol 1995 1.04
37 Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation. Mol Cell Biol 1994 1.04
38 The cytoskeletal protein vinculin contains transformation-sensitive, covalently bound lipid. Science 1987 1.03
39 Hsp90-mediated folding of the lymphoid cell kinase p56lck. Biochemistry 1996 1.03
40 The role of the catalytic base in the protein tyrosine kinase Csk. J Biol Chem 1995 0.99
41 Strategies and potential molecular targets for obesity treatment. Science 1998 0.98
42 Overproduction of bacterial chaperones improves the solubility of recombinant protein tyrosine kinases in Escherichia coli. Cell Mol Biol (Noisy-le-grand) 1994 0.97
43 Anti-CD3 and phorbol ester induce distinct phosphorylated sites in the SH2 domain of p56lck. J Biol Chem 1993 0.95
44 TCR/CD3-triggering causes increased activity of the p50csk tyrosine kinase and engagement of its SH2 domain. Oncogene 1994 0.93
45 Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase. J Biol Chem 1998 0.92
46 The PMA-induced specific association of LFA-1 and talin in intact cloned T helper cells. J Mol Cell Immunol 1990 0.92
47 Activation of phosphatidylinositol-3-kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase. Eur J Immunol 1994 0.92
48 Central leptin stimulates corticosterone secretion at the onset of the dark phase. Diabetes 1997 0.90
49 Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. J Biol Chem 1997 0.90
50 OB protein binds specifically to the choroid plexus of mice and rats. Proc Natl Acad Sci U S A 1996 0.89
51 Isolation of in situ crosslinked ligand-receptor complexes using an anticrosslinker specific antibody. Anal Biochem 1982 0.86
52 Identification of a signaling complex involving CD2, zeta chain and p59fyn in T lymphocytes. Eur J Immunol 1994 0.85
53 Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization. Protein Expr Purif 1998 0.84
54 Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am J Physiol 1999 0.83
55 Melanocortin and leptin signaling systems: central regulation of catabolic energy balance. J Recept Signal Transduct Res 1999 0.83
56 Differential and multiple binding of signal transducing molecules to the ITAMs of the TCR-zeta chain. J Cell Biochem 1996 0.83
57 Splice variants of the OB receptor gene are differentially expressed in brain and peripheral tissues of mice. J Recept Signal Transduct Res 1999 0.82
58 CD45 phosphotyrosine phosphatase and p56lck protein tyrosine kinase: a functional complex crucial in T cell signal transduction. Int Immunol 1992 0.81
59 Towards unraveling the complexity of T cell signal transduction. Bioessays 1995 0.81
60 Melanocortin-4 receptor: a novel signalling pathway involved in body weight regulation. Int J Obes Relat Metab Disord 1999 0.81
61 The Src homology 2 domain of the protein-tyrosine kinase p56lck mediates both intermolecular and intramolecular interactions. Proc Natl Acad Sci U S A 1993 0.80
62 Purification and characterization of an activated form of the protein tyrosine kinase Lck from an Escherichia coli expression system. J Cell Biochem 1994 0.79
63 Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanisms. Eur J Immunol 1997 0.78
64 Mapping of the p56lck-mediated phosphorylation of GAP and analysis of its influence on p21ras-GTPase activity in vitro. Biochim Biophys Acta 1994 0.78
65 Csk-mediated phosphorylation of substrates is regulated by substrate tyrosine phosphorylation. Farmaco 1998 0.76
66 Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine. J Med Chem 1982 0.76
67 [OB protein and its receptor: signal transduction between adipose tissue and central nervous system]. Journ Annu Diabetol Hotel Dieu 1997 0.76
68 CD4:p56lck association studied in vivo using antibody-induced capping and double indirect immunofluorescence microscopy. J Recept Res 1993 0.76
69 Feeding inhibition by neuropeptide Y. Nature 1996 0.75
70 OB protein: A peripheral signal linking adiposity and central neural networks. Appetite 1996 0.75
71 Brain administration of OB protein (leptin) inhibits neuropeptide-Y-induced feeding in ob/ob mice. Regul Pept 1998 0.75
72 Re: the value of hyoscine butylbromide in pelvic MRI. Clin Radiol 2008 0.75
73 alpha 2-Adrenoceptor agonist properties of exo- and endo-isomers of 2-amino-6,7,dihydroxybenzonorbornene designed as rigid catecholamines. J Pharm Pharmacol 1983 0.75
74 Obesity genes: molecular genetic approaches to drug target identification. Farmaco 1998 0.75
75 Antinociceptive and sympathomimetic activities of exo-andendo-2-aminobenzonorbornene and their N-methylated derivatives [proceedings]. J Pharm Pharmacol 1976 0.75
76 Sympathomimetic effects of exo- and endo-isomers of 2-aminobenzonorbornene in vitro and in vivo. J Pharm Pharmacol 1980 0.75
77 Changes in metabolic parameters and body shape after replacement of protease inhibitor With efavirenz in virologically controlled HIV-1-positive persons: single-arm observational cohort. J Acquir Immune Defic Syndr 2001 0.75
78 Synthesis and antinociceptive properties of a series of exo- and endo-6-hydroxy-2-aminobenzonorbornenes. J Pharm Sci 1986 0.75
79 Mouse monoclonal antibodies that specifically recognize an amino-terminal epitope of p56lck protein tyrosine kinase. FEBS Lett 1993 0.75