PubRank

A Altman

Author PubWeight™ 164.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2. J Exp Med 1981 3.27
2 Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 1992 3.24
3 T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 1990 3.23
4 Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc Natl Acad Sci U S A 1989 2.70
5 Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon. J Immunol 1983 2.61
6 Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation. Nat Immunol 2001 2.18
7 Neoadjuvant hormonal ablative therapy before radical prostatectomy: a review. Is it indicated? J Urol 2000 2.16
8 NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta. Proc Natl Acad Sci U S A 2000 2.13
9 Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science 1993 2.10
10 Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J Biol Chem 1993 1.98
11 Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity 1996 1.95
12 Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes. Mol Cell Biol 1996 1.86
13 Identification of a T cell hybridoma that produces large quantities of macrophage-activating factor. J Exp Med 1982 1.81
14 Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma. Proc Natl Acad Sci U S A 1983 1.73
15 Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J Cell Biol 2001 1.70
16 A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation. Immunity 2000 1.65
17 Chlorophyll catabolism in senescing plant tissues: In vivo breakdown intermediates suggest different degradative pathways for Citrus fruit and parsley leaves. Proc Natl Acad Sci U S A 1987 1.61
18 Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence. J Biol Chem 1998 1.60
19 T-lymphocyte activation: the role of protein kinase C and the bifurcating inositol phospholipid signal transduction pathway. Immunol Rev 1987 1.60
20 Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines. Exp Cell Res 1983 1.53
21 Dual Mechanisms in Polyamine-mediated Control of Ribonuclease Activity in Oat Leaf Protoplasts. Plant Physiol 1978 1.48
22 Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes. Proc Natl Acad Sci U S A 1992 1.48
23 Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45). Oncogene 1990 1.44
24 Suppression of T lymphocyte function by measles virus is due to cell cycle arrest in G1. J Immunol 1988 1.38
25 Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem Biophys Res Commun 1993 1.37
26 Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. J Biol Chem 2000 1.37
27 Human T lymphocyte activation by tumor promoters: role of protein kinase C. J Immunol 1987 1.35
28 Presence and identification of polyamines in xylem and Phloem exudates of plants. Plant Physiol 1986 1.32
29 Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest 1998 1.31
30 Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. Proc Natl Acad Sci U S A 1995 1.31
31 Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Mol Cell Biol 1994 1.27
32 Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. J Biol Chem 1999 1.26
33 Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity 1998 1.25
34 Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death. J Immunol 1999 1.24
35 Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock 1997 1.24
36 Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif. J Biol Chem 1997 1.22
37 Cell-free media of mixed lymphocyte cultures augmenting sensitization in vitro of mouse T lymphocytes against allogeneic fibroblasts. Eur J Immunol 1976 1.22
38 Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. Mol Cell Biol 1996 1.20
39 p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation. Proc Natl Acad Sci U S A 1994 1.19
40 Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation. J Biol Chem 2000 1.17
41 Differential effects of sucrose, abscisic Acid, and benzyladenine on shoot growth and callus formation in the abscission zone of excised citrus buds. Plant Physiol 1977 1.15
42 Views on Vav. Immunol Today 1997 1.15
43 Role of Ethylene in Abscisic Acid-induced Callus Formation in Citrus Bud Cultures. Plant Physiol 1979 1.14
44 Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. Proc Natl Acad Sci U S A 1994 1.14
45 A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost 2006 1.13
46 Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein. Mol Cell Biol 1994 1.12
47 Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. J Biol Chem 1998 1.12
48 Polyamines and root formation in mung bean hypocotyl cuttings : I. Effects of exogenous compounds and changes in endogenous polyamine content. Plant Physiol 1982 1.11
49 Construction of T cell hybridomas secreting allogeneic effect factor. J Exp Med 1980 1.11
50 T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. Proc Natl Acad Sci U S A 2000 1.10
51 Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells. Eur J Immunol 1999 1.09
52 Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses. J Immunol 1997 1.06
53 Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes. J Immunol 1985 1.06
54 Activation-modulated association of 14-3-3 proteins with Cbl in T cells. J Biol Chem 1996 1.05
55 Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester. J Biol Chem 1990 1.05
56 Expression and biochemical characterization of human protein kinase C-theta. Eur J Biochem 1994 1.04
57 Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase. Eur J Immunol 1995 1.04
58 Molecular analysis of the beta-thalassemia phenotype associated with inheritance of hemoglobin E (alpha 2 beta2(26)Glu leads to Lys). J Clin Invest 1981 1.04
59 Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation. Mol Cell Biol 1994 1.04
60 Vav modulation of the Ras/MEK/ERK signaling pathway plays a role in NFAT activation and CD69 up-regulation. Eur J Immunol 2000 1.03
61 Do CD4 and CD8 control T-cell activation via a specific tyrosine protein kinase? Immunol Today 1989 1.03
62 Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene 1999 1.02
63 Cbl: complex formation and functional implications. Cell Signal 1998 1.01
64 Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter. Mol Cell Biol 2001 1.01
65 Improved specificity of RT-PCR amplifications using nested cDNA primers. Nucleic Acids Res 1993 1.00
66 Specific high-affinity binding and biologic action of retinoic acid in human neuroblastoma cell lines. Proc Natl Acad Sci U S A 1983 0.99
67 Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C. J Immunol 1993 0.99
68 Production and isolation of helper and suppressor factors. J Immunol Methods 1980 0.98
69 TCR antagonist peptides induce formation of APC-T cell conjugates and activate a Rac signaling pathway. Eur J Immunol 2000 0.98
70 Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2. Proc Natl Acad Sci U S A 1984 0.98
71 Constitutive and mitogen-induced production of T cell growth factor by stable T cell hybridoma lines. J Immunol 1982 0.97
72 Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. J Immunol 2001 0.95
73 Lpr T cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis. J Biol Chem 1988 0.94
74 Hypertonic saline activates protein tyrosine kinases and mitogen-activated protein kinase p38 in T-cells. J Trauma 1997 0.94
75 The biology of monoclonal lymphokines secreted by T cell lines and hybridomas. Adv Immunol 1982 0.93
76 Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH. Genomics 1995 0.93
77 Integrin-dependent tyrosine phosphorylation and growth regulation by Vav. Cell Adhes Commun 1999 0.92
78 Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol 1994 0.92
79 Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells. J Immunol 1994 0.92
80 American Academy of Pediatrics Report of the Subcommittee on the Management of Pain Associated with Procedures in Children with Cancer. Pediatrics 1990 0.91
81 A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells. Curr Biol 1999 0.90
82 The tumor promoter teleocidin induces IL 2 receptor expression and IL 2-independent proliferation of human peripheral blood T cells. J Immunol 1985 0.90
83 Membrane lipid microdomains and the role of PKCtheta in T cell activation. Semin Immunol 2001 0.90
84 PICOT-HD: a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules. Trends Biochem Sci 2000 0.90
85 New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C. Stem Cells 1998 0.89
86 Teleocidin and phorbol ester tumor promoters exert similar mitogenic effects on human lymphocytes. Biochem Biophys Res Commun 1985 0.89
87 Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells. J Biol Chem 1997 0.89
88 Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2. Eur J Biochem 1996 0.89
89 Superior vena cava syndrome - changing etiology in the third millennium. Lupus 2011 0.88
90 Production of interleukin 2 (IL 2) by salivary gland lymphocytes in Sjögren's syndrome. Detection of reactive cells by using antibody directed to synthetic peptides of IL 2. J Immunol 1985 0.88
91 Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro. J Virol 1995 0.88
92 Interleukin 2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro. Proc Natl Acad Sci U S A 1986 0.88
93 Transcriptional activity of isolated maize chloroplasts. Arch Biochem Biophys 1984 0.88
94 Spatial dependence of the phase in localized bioelectrical impedance analysis. Phys Med Biol 2001 0.87
95 Polyamines and Root Formation in Mung Bean Hypocotyl Cuttings : II. Incorporation of Precursors into Polyamines. Plant Physiol 1985 0.86
96 Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk. Eur J Biochem 1997 0.86
97 Direct cloning of human neuroblastoma cells in soft agar culture. Cancer Res 1980 0.86
98 Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins. J Immunol 1999 0.85
99 Existence of T cells manifesting self-reactivity indistinguishable from alloreactivity. J Immunol 1980 0.84
100 Stimulation of tumor-specific cytotoxic T-lymphocyte responses in vitro by hapten-reactive helper T lymphocytes and the allogeneic effect. Clin Immunol Immunopathol 1980 0.84
101 Jun kinase phosphorylates and regulates the DNA binding activity of an octamer binding protein, T-cell factor beta1. Mol Cell Biol 1999 0.84
102 Normal T-cell receptors for alloantigens. Cell Immunol 1973 0.84
103 Treatment of fractures of the middle third of the root. ASDC J Dent Child 1971 0.84
104 An efficient expression, purification and immunodetection system for recombinant gene products. Biotechniques 1994 0.84
105 Tyrosine phosphorylation in T-cell activation. Scand J Immunol 1991 0.84
106 Autoreactive rat T-cell lines: establishment and cellular characteristics. Cell Immunol 1984 0.83
107 Characterization of BspA, a major boiling-stable, water-stress-responsive protein in aspen (Populus tremula). Tree Physiol 1995 0.83
108 Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. J Biol Chem 2001 0.83
109 Immunological and structural homology between human T-cell leukemia virus type I envelope glycoprotein and a region of human interleukin-2 implicated in binding the beta receptor. J Virol 1988 0.83
110 Replication of tomato yellow leaf curl virus (TYLCV) DNA in agroinoculated leaf discs from selected tomato genotypes. Plant Mol Biol 1993 0.83
111 Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck. J Biol Chem 1996 0.82
112 The frequency split method for helical cone-beam reconstruction. Med Phys 2004 0.82
113 Benign skin changes associated with chronic sunlight exposure. Cutis 1984 0.82
114 Functional and molecular characterization of a monoclonal antibody against human interleukin 2. Immunobiology 1986 0.82
115 The induction of autoreactive T lymphocytes by allogeneic effect factor (AEF): relevance to normal pathways of lymphocyte differentiation. Immunol Rev 1980 0.82
116 Protein kinase C-activating phorbol esters augment expression of T cell receptor genes. Eur J Immunol 1987 0.81
117 Human T cell hybridomas specific for Epstein Barr virus-infected B lymphocytes. J Immunol 1983 0.81
118 The nonspecific helper effect of mixed lymphocyte reactions on the induction of T cell-mediated immunity in vitro. Eur J Immunol 1974 0.81
119 Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents. Cell Signal 1989 0.81
120 Genotypic variation in drought tolerance of poplar in relation to abscisic acid. Tree Physiol 1997 0.80
121 Heterogeneity in the development of cytotoxic T lymphocytes in vitro revealed by sensitivity to hydrocortisone. J Exp Med 1975 0.80
122 Mechanism of T-cell lymphomagenesis: transformation of growth-factor-dependent T-lymphoblastoma cells to growth-factor-independent T-lymphoma cells. Proc Natl Acad Sci U S A 1984 0.80
123 Natural cell-mediated cytotoxicity in guinea pigs: properties and specificity of natural killer cells. J Immunol 1978 0.80
124 Mitogen-induced human T cell proliferation is associated with increased expression of selected PKC genes. Mol Immunol 1992 0.80
125 Simultaneous performance on verbal, nonverbal and motor tasks by right-handed adults. Cortex 1978 0.80
126 Informal caregiving to older cancer patients: preliminary research outcomes and implications. Ann Oncol 2013 0.80
127 Helper factor production in murine secondary syngeneic mixed leukocyte reactions. J Immunol 1982 0.79
128 Highly efficient transformation and regeneration of aspen plants through shoot-bud formation in root culture. Plant Cell Rep 1996 0.79
129 Manipulation of cytotoxic T lymphocyte responses to syngeneic tumors. I. Hapten-reactive helper T lymphocytes augment tumor-specific CTL responses in vitro. J Immunol 1979 0.79
130 Production of antigen-nonspecific immunoregulatory lymphokines by T cell hybridomas. Curr Top Microbiol Immunol 1982 0.79
131 The biologic effects of allogeneic effect factor on T lymphocytes. I. The mitogenic activity and the autonomous induction of cytotoxic T lymphocytes by AEF. J Immunol 1980 0.78
132 Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z. J Biol Chem 1999 0.78
133 The biological effects of allogeneic effect factor (AEF) on T lymphocytes. III.--Interferon does not contribute to the biological activities displayed by AEF on both T and B lymphocytes. Ann Immunol (Paris) 1980 0.78
134 The role of p56lck in CD4-mediated suppression of CD3-induced early signaling events in T lymphocytes. Life Sci 1995 0.78
135 The biologic effects of allogeneic factor on T lymphocytes. II. The specificity of AEF-induced cytotoxic T lymphocytes. J Immunol 1980 0.78
136 Radiation port dermatophytosis. J Am Acad Dermatol 1988 0.78
137 Construction and characterization of lck- and fyn-specific tRNA: ribozyme chimeras. Mol Immunol 1994 0.78
138 Human interleukin 2. Quantitation by a sensitive radioimmunoassay. J Immunol Methods 1986 0.78
139 Agrobacterium rhizogenes-mediated DNA transfer inPinus halepensis Mill. Plant Cell Rep 1996 0.78
140 Signal transduction and intracellular events in T-lymphocyte activation. Immunol Today 1986 0.77
141 Biological effects of allogeneic effect factor on T lymphocytes: in vitro induction of cytotoxic T lymphocytes manifesting preferential lytic activity against H-2-identical tumor cells. Proc Natl Acad Sci U S A 1979 0.77
142 Differentiation of murine bone marrow stem cells in vitro: long-term growth promoted by a lymphocyte-derived mediator. Science 1981 0.77
143 Effect of protein kinase C activating tumor promoters on metastases formation by fibrosarcoma cells. Invasion Metastasis 1991 0.77
144 Inhibition of PMA-induced human T cell proliferation by bryostatin is associated with enhanced degradation of conventional protein kinase C (cPKC): Ca2+ signals restore mitogenic activity without abrogating enhanced cPKC degradation. Cell Immunol 1994 0.77
145 Vav: function and regulation in hematopoietic cell signaling. Stem Cells 1996 0.77
146 Radiation leukemia virus and X-irradiation induce in C57BL/6 mice two distinct T-cell neoplasms: a growth factor-dependent lymphoma and a growth factor-independent lymphoma. Leuk Res 1987 0.77
147 Combined anti-fungal therapy and surgical resection as treatment of disseminated aspergillosis of the lung and brain following BMT. Bone Marrow Transplant 1993 0.76
148 Cytotoxic activity of guinea-pig lymph node cells stimulated in vitro. Int J Cancer 1978 0.76
149 A phage display system for detection of T cell receptor-antigen interactions. Mol Immunol 1995 0.76
150 Staining and fluorescence-activated cell sorter analysis of human lymphocytes using antibodies to a short, chemically synthesized human IL-2 peptide. Cell Immunol 1985 0.76
151 Stimulation of PIP2 hydrolysis by aluminum fluoride in resting T cell subsets of normal and autoimmune-prone lpr mice. J Immunol 1989 0.76
152 Adenosine deaminase positive, E receptor negative lymphoma. Am J Pediatr Hematol Oncol 1982 0.75
153 Lego therapy. J Psychosoc Nurs Ment Health Serv 1995 0.75
154 Evaluation of hemostasis with gold foil. Am J Surg 1968 0.75
155 Interleukin-2 blocks oligodendrocyte progenitor proliferation. Ann N Y Acad Sci 1988 0.75
156 Use of terminal deoxynucleotidyl transferase in the diagnosis of leukemia. Ann Clin Lab Sci 1983 0.75
157 Identification of a T cell hybridoma which produces extraordinary quantities of macrophage activating factor. Adv Exp Med Biol 1982 0.75
158 Differentiation of cytotoxic T lymphocytes enhanced by T cell factors produced during mixed lymphocyte interactions. Adv Exp Med Biol 1976 0.75
159 Nonpenetrating abdominal trauma as cause of renal vascular hypertension. JAMA 1966 0.75
160 Proceedings: The helper effect of mixed lymphocyte culture supernatants on an in vitro T cell-mediated mouse transplantation reaction. Isr J Med Sci 1975 0.75
161 Human figure drawings in a prospective study of six disorders: hypertension, coronary heart disease, malignant tumor, suicide, mental illness, and emotional disturbance. J Nerv Ment Dis 1975 0.75
162 Changes in the integrity of large unilamellar vesicles due to their interaction with tobacco cell suspensions. Plant Cell Rep 1988 0.75
163 [Recurrent multiple pulmonary emboli]. Harefuah 2009 0.75
164 Augmentation of cell mediated lysis (CML) by THF. Adv Exp Med Biol 1976 0.75
165 Crohn's ileocolitis, cutaneous gangrene and cryoglobulinema. Mt Sinai J Med 1979 0.75
166 Legionella-induced sudden hearing loss: a rare complication. Infection 2009 0.75
167 B-cell specific immunoregulatory lymphokines. Immunol Today 2007 0.75
168 B cell-specific immunoregulatory factors: development of bioassays for growth and differentiation-promoting activities. Lymphokine Res 1982 0.75
169 Effect of cyclosporine A on early stages of T cell activation. Transplant Proc 1987 0.75
170 Abortion funding: legal and moral questions. Hastings Cent Rep 1978 0.75
171 Promotion of hematopoietic stem cell differentiation in vitro by a soluble mediator, allogeneic effect factor. J Supramol Struct 1980 0.75
172 The use of leukocyte acid phosphatase in the diagnosis of malignant disease. Case report and review of literature. Ann Clin Lab Sci 1980 0.75
173 Existence of T lymphocytes manifesting self-reactivity indistinguishable from alloreactivity: implications for self-recognition and MHC polymorphism. Transplant Proc 1981 0.75
174 Association of immunophenotype with cerebrospinal fluid involvement in childhood B-lineage acute lymphoblastic leukemia. Am J Clin Pathol 1997 0.75
175 Distinct functions of Vav1 in JNK1 activation in Jurkat T cells versus non-haematopoietic cells. Scand J Immunol 2004 0.75
176 Use of computer tomography in subperiosteal implant therapy. J Prosthet Dent 1988 0.75
177 Liposome-mediated introduction of the chloramphenicol acetyl transferase (CAT) gene and its expression in tobacco protoplasts. Plant Mol Biol 1988 0.75