CD22, a B cell-specific receptor, mediates adhesion and signal transduction.

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med (1994) 2.23

Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus. Arthritis Res Ther (2006) 1.82

Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol (2007) 1.63

Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes. Proc Natl Acad Sci U S A (1998) 1.57

CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies. Clin Cancer Res (2009) 1.10

Toxin-based therapeutic approaches. Toxins (Basel) (2010) 1.00

Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human "naive" and "memory" CD4+ T cells. J Exp Med (1994) 1.00

Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. J Exp Med (1995) 0.95

Soluble CD22 as a tumor marker for hairy cell leukemia. Blood (2008) 0.88

Epitope mapping and key amino acid identification of anti-CD22 immunotoxin CAT-8015 using hybrid β-lactamase display. Protein Eng Des Sel (2010) 0.84

Differential expression of CD22 (Lyb8) on murine B cells. Int Immunol (1996) 0.83

CD22 is required for protection against West Nile virus Infection. J Virol (2013) 0.83

Characterization of CD22 expression in acute lymphoblastic leukemia. Pediatr Blood Cancer (2015) 0.79

Pharmacokinetics and tolerability of human mouse chimeric anti-CD22 monoclonal antibody in Chinese patients with CD22-positive non-Hodgkin lymphoma. MAbs (2012) 0.79

CD22 is required for formation of memory B cell precursors within germinal centers. PLoS One (2017) 0.76

Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling. Arthritis Res Ther (2017) 0.75

Class A β-lactamases as versatile scaffolds to create hybrid enzymes: applications from basic research to medicine. Biomed Res Int (2013) 0.75