Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma.

PubWeight™: 1.41‹?› | Rank: Top 5%

🔗 View Article (PMID 8504412)

Published in Cancer Res on June 15, 1993

Authors

B H Ye1, P H Rao, R S Chaganti, R Dalla-Favera

Author Affiliations

1: Department of Pathology, College of Physicians and Surgeons, Columbia University, New York 10032.

Articles citing this

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci U S A (1996) 3.10

The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol (1999) 3.02

BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev (2000) 2.83

Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma. Proc Natl Acad Sci U S A (1996) 2.15

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A (1995) 2.13

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J (1995) 1.94

Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol (1999) 1.91

Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. Blood (2009) 1.64

CtBP is an essential corepressor for BCL6 autoregulation. Mol Cell Biol (2008) 1.41

DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med (2010) 1.39

BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells. J Exp Med (2003) 1.36

Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis. Trends Mol Med (2014) 1.18

MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma. Nat Immunol (2013) 1.17

Pathogenesis of AIDS-related lymphomas: molecular and histogenetic heterogeneity. Am J Pathol (1998) 1.15

Molecular pathogenesis of diffuse large B-cell lymphoma. Semin Diagn Pathol (2011) 1.11

A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells. Am J Pathol (1995) 1.07

Cytogenetic alterations affecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-cell component. Am J Pathol (2004) 0.96

BCL-6 protein expression in AIDS-related non-Hodgkin's lymphomas: inverse relationship with Epstein-Barr virus-encoded latent membrane protein-1 expression. Am J Pathol (1997) 0.95

PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells. Mol Cell Biol (2009) 0.94

The IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma. Proc Natl Acad Sci U S A (2000) 0.93

Chromosomal translocation t(11;18)(q21;q21) in gastrointestinal mucosa associated lymphoid tissue lymphoma. J Clin Pathol (2003) 0.88

STAT3 inhibitors: finding a home in lymphoma and leukemia. Oncologist (2014) 0.88

The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche. Dev Biol (2012) 0.87

Molecular pathology of lymphoma. Eye (Lond) (2012) 0.86

EBNA2 interferes with the germinal center phenotype by downregulating BCL6 and TCL1 in non-Hodgkin's lymphoma cells. J Virol (2006) 0.81

Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata. Hum Mol Genet (2013) 0.81

Regulation of hematopoietic development by ZBTB transcription factors. Int J Hematol (2016) 0.75

Kruppel-like Factor 6 Promotes Macrophage-mediated Inflammation by Suppressing B Cell Leukemia/Lymphoma 6 Expression. J Biol Chem (2016) 0.75

BCL-6 and other genomic alterations in non-Hodgkin's lymphoma (NHL). Br J Cancer (1997) 0.75

Point mutation of 5' noncoding region of BCL-6 gene in primary gastric lymphomas. World J Gastroenterol (2005) 0.75

The role of aberrant proteolysis in lymphomagenesis. Curr Opin Hematol (2015) 0.75

An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation. PLoS Pathog (2017) 0.75

Articles by these authors

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (1982) 11.15

In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood (1995) 6.91

Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient. Nature (1982) 6.78

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature (2001) 6.70

A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc Natl Acad Sci U S A (1974) 6.51

Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 5.80

Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med (2001) 5.66

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet (1997) 5.55

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A (1997) 5.43

Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29). Proc Natl Acad Sci U S A (1982) 4.70

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet (1996) 4.59

A common molecular basis for rearrangement disorders on chromosome 22q11. Hum Mol Genet (1999) 4.14

Direct activation of TERT transcription by c-MYC. Nat Genet (1999) 3.98

Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol (2002) 3.91

Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science (1993) 3.89

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. Cell (1991) 3.84

Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science (1983) 3.82

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (1991) 3.69

Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene (2001) 3.32

BCL-6 protein is expressed in germinal-center B cells. Blood (1995) 3.18

A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood (2000) 3.13

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci U S A (1996) 3.10

Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product. Proc Natl Acad Sci U S A (1983) 3.03

Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sci U S A (1982) 3.02

In situ localization of human fibronectin (FN) genes to chromosome regions 2p14----p16, 2q34----q36, and 11q12.1----q13.5 in germ line cells, but to chromosome 2 sites only in somatic cells. Cytogenet Cell Genet (1986) 2.83

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci U S A (1998) 2.76

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood (2001) 2.73

BCL-6 regulates chemokine gene transcription in macrophages. Nat Immunol (2000) 2.58

Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. Proc Natl Acad Sci U S A (1986) 2.47

Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. J Urol (1998) 2.44

Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood (1994) 2.38

Pathogenesis of Burkitt lymphoma: expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts. Cell (1987) 2.27

Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science (1982) 2.27

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev (1998) 2.23

Isochromosome of the short arm of chromosome 12: clinically useful markers for male germ cell tumors. J Natl Cancer Inst (1989) 2.19

Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science (1999) 2.17

Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer. Blood (1996) 2.17

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A (1995) 2.13

T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms. Proc Natl Acad Sci U S A (1985) 2.10

Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc Natl Acad Sci U S A (1986) 2.09

Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes. Proc Natl Acad Sci U S A (1982) 2.06

Analysis of RAS oncogene mutations in human lymphoid malignancies. Proc Natl Acad Sci U S A (1988) 2.01

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene (1990) 1.95

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J (1995) 1.94

A human onc gene homologous to the transforming gene (v-sis) of simian sarcoma virus. Nature (1981) 1.94

Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma. Nat Genet (1997) 1.94

Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol (1999) 1.91

Gene amplification in gastric and esophageal adenocarcinomas. Cancer Res (1990) 1.90

Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridization. Blood (1998) 1.85

Binding and suppression of the Myc transcriptional activation domain by p107. Science (1994) 1.84

Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma. Science (1987) 1.80

Genetically determined sex-reversal in 46,XY humans. Science (1978) 1.76

Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma. Blood (1991) 1.73

Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem (1998) 1.71

Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Proc Natl Acad Sci U S A (1993) 1.70

Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS). The New York University Medical Center experience with 105 patients (1981-1986). Ann Intern Med (1988) 1.69

Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus. Blood (1989) 1.69

Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res (1998) 1.68

Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia. Genomics (1997) 1.68

Bloom's syndrome. IV. Sister-chromatid exchanges in lymphocytes. Am J Hum Genet (1977) 1.67

Establishment of AIDS-related lymphoma cell lines from lymphomatous effusions. Leukemia (1996) 1.63

Molecular cytogenetic characterization of head and neck squamous cell carcinoma and refinement of 3q amplification. Cancer Res (2001) 1.62

t(3;22)(q27;q11): a novel translocation associated with diffuse non-Hodgkin's lymphoma. Blood (1989) 1.62

Chromosomal aberrations in soft tissue tumors. Relevance to diagnosis, classification, and molecular mechanisms. Am J Pathol (1994) 1.60

Chromosomal and gene amplification in diffuse large B-cell lymphoma. Blood (1998) 1.60

Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis. J Exp Med (1986) 1.60

Histopathological, cytogenetic, and molecular characterization of renal cortical tumors. Cancer Res (1991) 1.59

IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Immunity (2001) 1.56

Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia. Science (1984) 1.56

Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. J Natl Cancer Inst (1991) 1.55

Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas. Blood (2001) 1.52

The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice. Proc Natl Acad Sci U S A (1995) 1.52

Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells. Proc Natl Acad Sci U S A (1989) 1.51

Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma. Blood (1992) 1.51

Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin mu locus in a Burkitt lymphoma. Nature (1984) 1.49

Localization of c-ras oncogene family on human germ-line chromosomes. Proc Natl Acad Sci U S A (1983) 1.46

Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma. Proc Natl Acad Sci U S A (1988) 1.43

p53 mutations are associated with histologic transformation of follicular lymphoma. Blood (1993) 1.40

Allelotype analysis of cervical carcinoma. Cancer Res (1994) 1.38

REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma. Blood (1996) 1.35

A recurring translocation, t(11;22)(p13;q11.2), characterizes intra-abdominal desmoplastic small round-cell tumors. Cancer Genet Cytogenet (1993) 1.35