alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMC 2120674)

Published in J Cell Biol on December 01, 1995

Authors

M Conese1, A Nykjaer, C M Petersen, O Cremona, R Pardi, P A Andreasen, J Gliemann, E I Christensen, F Blasi

Author Affiliations

1: Dipartimento di Ricerca Biologica e Tecnologica, H.S. Raffaele Scientific Institute, Università di Milano, Italy.

Articles citing this

Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer (2009) 5.02

Regulation of cell signalling by uPAR. Nat Rev Mol Cell Biol (2010) 3.77

Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J Cell Biol (1999) 2.35

Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. Proc Natl Acad Sci U S A (1996) 2.20

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J (1997) 1.64

Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity. Mol Biol Cell (2001) 1.45

Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. J Cell Biol (2002) 1.35

Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood (2008) 1.25

Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery. Mol Biol Cell (2006) 1.21

Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth. J Cell Biol (2001) 1.12

Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction. J Cell Biol (1998) 1.09

Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR. PLoS One (2008) 1.06

Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1. Cancer Res (2010) 1.05

LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities. Mol Cell Biol (2008) 1.04

uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies. Breast Cancer Res (2014) 1.02

Role of urokinase receptor in tumor progression and development. Theranostics (2013) 1.00

Binding of urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex to the endocytosis receptors alpha2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor. Biochem J (1998) 0.99

Urokinase-type plasminogen activator receptor is internalized by different mechanisms in polarized and nonpolarized Madin-Darby canine kidney epithelial cells. Mol Biol Cell (1999) 0.94

Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2007) 0.93

The inhibitory effect of HKa in endothelial cell tube formation is mediated by disrupting the uPA-uPAR complex and inhibiting its signaling and internalization. Am J Physiol Cell Physiol (2008) 0.93

Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein. Biochem J (2001) 0.90

Fluorescence correlation spectroscopy and photon counting histogram on membrane proteins: functional dynamics of the glycosylphosphatidylinositol-anchored urokinase plasminogen activator receptor. J Biomed Opt (2008) 0.89

beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter. Mol Cell Biol (2001) 0.88

The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand. Biochem J (2004) 0.88

Number and brightness image analysis reveals ATF-induced dimerization kinetics of uPAR in the cell membrane. FASEB J (2011) 0.88

Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy. Mol Cancer Ther (2013) 0.86

Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor. J Biol Chem (2011) 0.85

Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells. Am J Respir Cell Mol Biol (2012) 0.84

LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. J Proteome Res (2010) 0.84

A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance. J Biol Chem (2010) 0.81

Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to β-catenin in different cancers. BMC Cancer (2010) 0.79

LRP1 regulates remodeling of the extracellular matrix by fibroblasts. Matrix Biol (2009) 0.79

Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase. J Biol Chem (2011) 0.79

Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. Mol Pharmacol (2015) 0.77

Transforming growth factor-Beta and urokinase-type plasminogen activator: dangerous partners in tumorigenesis-implications in skin cancer. ISRN Dermatol (2013) 0.77

Maspin increases extracellular plasminogen activator activity associated with corneal fibroblasts and myofibroblasts. Exp Eye Res (2011) 0.75

Plasminogen Activator System and Breast Cancer: Potential Role in Therapy Decision Making and Precision Medicine. Biomark Insights (2016) 0.75

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

On the preparation of cryosections for immunocytochemistry. J Ultrastruct Res (1984) 5.12

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase. J Cell Biol (1985) 3.62

A study of positive staining of ultrathin frozen sections. J Ultrastruct Res (1978) 3.58

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J (1990) 3.27

In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella. J Cell Biol (1994) 3.19

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. Biochemistry (1989) 3.18

LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell (1992) 3.12

The serpin superfamily of proteinase inhibitors: structure, function, and regulation. J Biol Chem (1994) 3.07

Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem (1994) 2.92

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J Biol Chem (1987) 2.73

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes. Proc Natl Acad Sci U S A (1985) 2.72

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J Biol Chem (1991) 2.68

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem (1990) 2.42

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem (1992) 2.40

Autocrine saturation of pro-urokinase receptors on human A431 cells. Cell (1986) 2.38

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol (1990) 2.36

Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A (1991) 2.32

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J Biol Chem (1992) 2.27

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem (1992) 2.09

Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes. J Biol Chem (1989) 2.05

In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase. J Cell Biol (1988) 1.90

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes. J Exp Med (1995) 1.89

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J (1990) 1.87

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis. Cancer Res (1993) 1.86

The urokinase receptor is required for human monocyte chemotaxis in vitro. J Clin Invest (1994) 1.82

Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci U S A (1993) 1.82

Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. J Biol Chem (1991) 1.74

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells. Cancer Res (1988) 1.70

Plasminogen activator dependent pathways in the dissemination of human tumor cells in the chick embryo. Cell (1988) 1.63

Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes. J Biol Chem (1993) 1.50

Binding of single-chain prourokinase to the urokinase receptor of human U937 cells. J Biol Chem (1986) 1.49

Inhibition of tumor-cell-mediated extracellular matrix destruction by a fibroblast proteinase inhibitor, protease nexin I. Proc Natl Acad Sci U S A (1986) 1.47

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Proc Natl Acad Sci U S A (1992) 1.45

Analysis of ligand recognition by the purified alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein). Evidence that high affinity of alpha 2-macroglobulin-proteinase complex is achieved by binding to adjacent receptors. J Biol Chem (1991) 1.43

The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants. J Biol Chem (1990) 1.43

Regulation of urokinase receptors in monocytelike U937 cells by phorbol ester phorbol myristate acetate. J Cell Biol (1989) 1.41

The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin. J Cell Biol (1990) 1.40

In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion. J Cell Biol (1991) 1.33

Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor. FEBS Lett (1991) 1.32

Purification of urokinase by affinity chromatography. Biochim Biophys Acta (1976) 1.32

Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor. Proc Natl Acad Sci U S A (1989) 1.29

Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor. J Biol Chem (1992) 1.29

Interaction of plasminogen activator inhibitor (PAI-1) with vitronectin. J Biol Chem (1989) 1.20

Functional characteristics of receptor-bound urokinase on human monocytes: catalytic efficiency and susceptibility to inactivation by plasminogen activator inhibitors. Blood (1989) 1.15

Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy? Trends Pharmacol Sci (1994) 1.15

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor. J Biol Chem (1994) 1.10

The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy. EMBO J (1994) 1.09

The human alpha 2-macroglobulin receptor contains high affinity calcium binding sites important for receptor conformation and ligand recognition. J Biol Chem (1990) 1.08

Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells. Cell Regul (1990) 1.06

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase. J Biol Chem (1993) 1.05

Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center. J Biol Chem (1992) 1.05

Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation. Cell Regul (1991) 1.03

N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand. J Biol Chem (1993) 1.00

Protease nexin-1-urokinase complexes are internalized and degraded through a mechanism that requires both urokinase receptor and alpha 2-macroglobulin receptor. J Biol Chem (1994) 0.97

Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats. J Biol Chem (1993) 0.96

Urokinase receptors in human monocytes. Biochim Biophys Acta (1990) 0.96

Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within growth factor-like domain of urokinase in the experimental and spontaneous metastasis model. Int J Cancer (1994) 0.95

Purification of the human placental alpha 2-macroglobulin receptor. FEBS Lett (1989) 0.93

A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells. J Biol Chem (1994) 0.88

Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor. J Biol Chem (1994) 0.86

Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activator. Eur J Biochem (1992) 0.79

PMA-induced down-regulation of the receptor for alpha 2-macroglobulin in human U937 cells. FEBS Lett (1995) 0.77

Articles by these authors

Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res (1985) 8.64

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci U S A (1995) 4.35

Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proc Natl Acad Sci U S A (1993) 3.82

125 years after Robert Koch's discovery of the tubercle bacillus: the new XDR-TB threat. Is "science" enough to tackle the epidemic? Eur Respir J (2007) 3.67

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell (1999) 3.54

Guidelines for the management of adult lower respiratory tract infections. Eur Respir J (2005) 3.51

CHIP28 water channels are localized in constitutively water-permeable segments of the nephron. J Cell Biol (1993) 3.50

Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc Natl Acad Sci U S A (1993) 3.46

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J (1990) 3.27

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J (2001) 3.13

Guidelines for the management of adult lower respiratory tract infections--full version. Clin Microbiol Infect (2011) 2.99

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol Cell Biol (2001) 2.80

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J Biol Chem (1987) 2.73

Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Proc Natl Acad Sci U S A (1994) 2.72

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes. Proc Natl Acad Sci U S A (1985) 2.72

Nucleotide sequence of the attenuator region of the histidine operon of Escherichia coli K-12. Proc Natl Acad Sci U S A (1978) 2.71

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem (1997) 2.69

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J Biol Chem (1991) 2.68

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J (1992) 2.65

Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors. J Cell Biol (1987) 2.63

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem (1999) 2.55

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta. J Cell Biol (1986) 2.44

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas. Am J Pathol (1991) 2.38

Autocrine saturation of pro-urokinase receptors on human A431 cells. Cell (1986) 2.38

A procedure for measurement of distribution spaces in isolated fat cells. Biochim Biophys Acta (1972) 2.22

Receptor-binding region of insulin. Nature (1976) 2.14

The human urokinase-plasminogen activator gene and its promoter. Nucleic Acids Res (1985) 2.14

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. Proc Natl Acad Sci U S A (2002) 2.14

Binding and degradation of 125I-labelled insulin by isolated rat fat cells. Biochim Biophys Acta (1973) 2.14

Antibiotic prescribing for adults with acute cough/lower respiratory tract infection: congruence with guidelines. Eur Respir J (2011) 2.13

A simple free fat cell bioassay for insulin. Horm Metab Res (1974) 2.10

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem (1992) 2.09

Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle. J Cell Biol (1997) 2.04

Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol (1999) 2.03

Renal albumin absorption in physiology and pathology. Kidney Int (2006) 1.99

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts. EMBO J (1987) 1.98

Application of a computerised method to measure static pressure volume curve in acute respiratory distress syndrome. Intensive Care Med (2000) 1.95

Prep1, a novel functional partner of Pbx proteins. EMBO J (1998) 1.94

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3). Proc Natl Acad Sci U S A (2001) 1.94

The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev (1999) 1.93

The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J (1998) 1.93

Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res (1992) 1.90

Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J Biol Chem (1996) 1.90

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J (1990) 1.87

cDNA cloning of human plasminogen activator-inhibitor from endothelial cells. J Clin Invest (1986) 1.84

A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. EMBO J (1992) 1.81

Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA. Proc Natl Acad Sci U S A (1984) 1.80

Trial of roxithromycin in subjects with asthma and serological evidence of infection with Chlamydia pneumoniae. Am J Respir Crit Care Med (2001) 1.79

Exchange of 3-O-methylglucose in isolated fat cells. Concentration dependence and effect of insulin. J Biol Chem (1976) 1.79

Kinetic parameters of transport of 3-O-methylglucose and glucose in adipocytes. J Biol Chem (1979) 1.76

Analysis of IMGSAC autism susceptibility loci: evidence for sex limited and parent of origin specific effects. J Med Genet (2005) 1.74

European union standards for tuberculosis care. Eur Respir J (2012) 1.73

Chlamydia pneumoniae: crossing the barriers? Eur Respir J (2004) 1.70

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells. Cancer Res (1988) 1.70

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J Clin Invest (1995) 1.70

Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J (1996) 1.70

Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Development (2000) 1.69

Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants. J Bacteriol (1977) 1.69

Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection. Blood (2000) 1.69

Plasminogen activator inhibitor type-1: reactive center and amino-terminal heterogeneity determined by protein and cDNA sequencing. FEBS Lett (1986) 1.68

The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus. J Cell Biol (2001) 1.67

Structure and function of epidermal growth factor-like regions in proteins. FEBS Lett (1988) 1.66

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest (2000) 1.66

The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene (1995) 1.66

Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature (2000) 1.65

Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor. FEBS Lett (1990) 1.65

Interaction between histidyl transfer ribonucleic acid and the first enzyme for histidine biosynthesis of Salmonella typhimurium. J Bacteriol (1970) 1.64

Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct. Am J Physiol (1995) 1.64

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J (1997) 1.64

Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla. J Clin Invest (1995) 1.63

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Proc Natl Acad Sci U S A (2001) 1.61

Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. EMBO J (1999) 1.61

Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma: a comparison with clinically used tumor markers. Clin Cancer Res (2000) 1.60

Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney. Am J Physiol (1995) 1.59

The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med (1999) 1.59

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem (1999) 1.57

Effects of iodinated x-ray contrast media on renal epithelial cells in culture. Invest Radiol (1994) 1.52

The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator. J Biol Chem (1991) 1.52

Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme. J Biol Chem (1986) 1.51

Isolation of transducing bacteriophages for the histidine and isoleucine-valine operons in Escherichia coli K-12. J Bacteriol (1972) 1.50

Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes. J Biol Chem (1993) 1.50

Binding of single-chain prourokinase to the urokinase receptor of human U937 cells. J Biol Chem (1986) 1.49