Published in Nature on August 15, 1970
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
High resolution two-dimensional electrophoresis of proteins. J Biol Chem (1975) 133.45
Efficient isolation of genes by using antibody probes. Proc Natl Acad Sci U S A (1983) 34.00
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A (1980) 30.08
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. J Virol (1974) 26.25
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels. J Bacteriol (1983) 25.26
TnphoA: a transposon probe for protein export signals. Proc Natl Acad Sci U S A (1985) 21.06
Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J (1985) 20.39
Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci U S A (1978) 18.32
Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect Immun (1981) 18.13
"Panning" for lymphocytes: a method for cell selection. Proc Natl Acad Sci U S A (1978) 17.69
Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion. J Virol (1972) 17.28
Efficient translation of tobacco mosaic virus RNA and rabbit globin 9S RNA in a cell-free system from commercial wheat germ. Proc Natl Acad Sci U S A (1973) 16.94
Proteins specified by herpes simplex virus. XII. The virion polypeptides of type 1 strains. J Virol (1974) 16.33
Pathogenesis of group A streptococcal infections. Clin Microbiol Rev (2000) 15.35
A protein factor essential for microtubule assembly. Proc Natl Acad Sci U S A (1975) 15.35
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Res (1984) 14.92
Affinity purification of sequence-specific DNA binding proteins. Proc Natl Acad Sci U S A (1986) 14.92
Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme. Proc Natl Acad Sci U S A (1977) 14.75
Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J Bacteriol (1984) 14.64
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A (1979) 14.61
Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces. J Cell Biol (1984) 14.58
A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J Virol (1988) 13.93
Characterization of plasmids and plasmid-associated determinants of Yersinia enterocolitica pathogenesis. Infect Immun (1981) 13.80
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell (1985) 13.73
Simian virus 40 tandem repeated sequences as an element of the early promoter. Proc Natl Acad Sci U S A (1981) 13.67
Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res (1997) 13.15
Role of hemolysin for the intracellular growth of Listeria monocytogenes. J Exp Med (1988) 12.95
Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A (1982) 12.84
Processing of adenovirus 2-induced proteins. J Virol (1973) 12.52
In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. J Virol (1988) 12.52
Proteins specified by herpes simplex virus. XI. Identification and relative molar rates of synthesis of structural and nonstructural herpes virus polypeptides in the infected cell. J Virol (1973) 12.48
Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1982) 12.30
Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci U S A (1996) 12.25
Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc Natl Acad Sci U S A (1987) 12.15
Proteins specified by herpes simplex virus. 8. Characterization and composition of multiple capsid forms of subtypes 1 and 2. J Virol (1972) 11.71
Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J (1993) 11.30
Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells. Proc Natl Acad Sci U S A (1989) 10.84
T cell growth factor receptors. Quantitation, specificity, and biological relevance. J Exp Med (1981) 10.66
Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol (1993) 10.65
How ribosomes select initiator regions in mRNA: base pair formation between the 3' terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli. Proc Natl Acad Sci U S A (1975) 10.60
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med (1989) 10.60
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci U S A (1993) 10.36
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13
Purification and mapping of specific mRNAs by hybridization-selection and cell-free translation. Proc Natl Acad Sci U S A (1979) 9.94
Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci U S A (1995) 9.93
Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol (1991) 9.89
Light limitation of photosynthesis and activation of ribulose bisphosphate carboxylase in wheat seedlings. Proc Natl Acad Sci U S A (1981) 9.71
Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrob Agents Chemother (1982) 9.58
The 65-kilodalton antigen of Mycobacterium tuberculosis. J Bacteriol (1987) 9.50
Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175. J Virol (1980) 9.30
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 9.23
Easy identification of cDNA clones. EMBO J (1983) 9.18
Internal ribosome entry site within hepatitis C virus RNA. J Virol (1992) 9.14
beta-Glucuronidase from Escherichia coli as a gene-fusion marker. Proc Natl Acad Sci U S A (1986) 9.05
A Tn3 lacZ transposon for the random generation of beta-galactosidase gene fusions: application to the analysis of gene expression in Agrobacterium. EMBO J (1985) 9.03
Type I Escherichia coli pili: characterization of binding to monkey kidney cells. J Exp Med (1977) 8.96
Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family. J Virol (1982) 8.88
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci U S A (1984) 8.84
rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. Proc Natl Acad Sci U S A (1989) 8.76
Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J Bacteriol (1993) 8.75
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol (1986) 8.74
Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas. J Cell Biol (1986) 8.65
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A (1987) 8.53
Nucleotide sequence of an Escherichia coli chromosomal hemolysin. J Bacteriol (1985) 8.53
Tn5-induced mutations affecting virulence factors of Bordetella pertussis. Infect Immun (1983) 8.49
Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol (1993) 8.47
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A (1992) 8.46
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol (1993) 8.36
Six widespread bacterial clones among Escherichia coli K1 isolates. Infect Immun (1983) 8.35
hy8, a new class of arabidopsis long hypocotyl mutants deficient in functional phytochrome A. Plant Cell (1993) 8.28
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med (1992) 8.27
Identification of group A rotavirus gene 4 types by polymerase chain reaction. J Clin Microbiol (1992) 8.25
Myristoylation-dependent replication and assembly of human immunodeficiency virus 1. Proc Natl Acad Sci U S A (1990) 8.23
Post-translational transport into intact chloroplasts of a precursor to the small subunit of ribulose-1,5-bisphosphate carboxylase. Proc Natl Acad Sci U S A (1978) 8.17
Different Roles for Phytochrome in Etiolated and Green Plants Deduced from Characterization of Arabidopsis thaliana Mutants. Plant Cell (1989) 8.16
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J Cell Biol (1992) 7.97
Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus. J Virol (1990) 7.90
A safe packaging line for gene transfer: separating viral genes on two different plasmids. J Virol (1988) 7.87
The detection of DNA-binding proteins by protein blotting. Nucleic Acids Res (1980) 7.84
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol (1998) 7.78
Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc Natl Acad Sci U S A (1986) 7.78
Expression of methicillin resistance in heterogeneous strains of Staphylococcus aureus. Antimicrob Agents Chemother (1986) 7.71
Hemagglutination by purified type I Escherichia coli pili. J Exp Med (1977) 7.61
Arabidopsis Mutants Selected for Resistance to the Phytotoxin Coronatine Are Male Sterile, Insensitive to Methyl Jasmonate, and Resistant to a Bacterial Pathogen. Plant Cell (1994) 7.59
The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J Exp Med (1983) 7.55
Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol (1983) 7.55
Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose. Proc Natl Acad Sci U S A (1987) 7.53
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol (1994) 7.53
Phytochrome A null mutants of Arabidopsis display a wild-type phenotype in white light. Plant Cell (1993) 7.51
Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens. J Virol (1980) 7.51
A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor. Mol Cell Biol (1986) 7.49
The distribution of tau in the mammalian central nervous system. J Cell Biol (1985) 7.47
Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation. Proc Natl Acad Sci U S A (1977) 7.46
Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1. Mol Cell Biol (1995) 7.36
An octamer of histones in chromatin and free in solution. Proc Natl Acad Sci U S A (1975) 7.35
Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J Biol Chem (1977) 72.51
Maturation of the head of bacteriophage T4. I. DNA packaging events. J Mol Biol (1973) 33.51
Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold. Cell (1984) 8.31
The detection of DNA-binding proteins by protein blotting. Nucleic Acids Res (1980) 7.84
Polypeptides of the tail fibres of bacteriophage T4. J Mol Biol (1971) 6.97
The structure of histone-depleted metaphase chromosomes. Cell (1977) 6.78
Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster. Cell (1986) 4.15
Metaphase chromosome structure. Involvement of topoisomerase II. J Mol Biol (1986) 4.14
Higher order metaphase chromosome structure: evidence for metalloprotein interactions. Cell (1982) 3.89
Visualization of chromosomal domains with boundary element-associated factor BEAF-32. Cell (1995) 3.87
Chromosome assembly in vitro: topoisomerase II is required for condensation. Cell (1991) 3.24
Metaphase chromosome structure: evidence for a radial loop model. Cell (1979) 3.16
Role of nonhistone proteins in metaphase chromosome structure. Cell (1977) 3.00
The metaphase scaffold is helically folded: sister chromatids have predominantly opposite helical handedness. Cell (1988) 2.88
A factor preventing the major head protein of bacteriophage T4 from random aggregation. J Mol Biol (1970) 2.70
Architecture of metaphase chromosomes and chromosome scaffolds. J Cell Biol (1983) 2.61
Metaphase chromosome structure: bands arise from a differential folding path of the highly AT-rich scaffold. Cell (1994) 2.60
Form-determining function of the genes required for the assembly of the head of bacteriophage T4. J Mol Biol (1970) 2.43
Isolation of a protein scaffold from mitotic HeLa cell chromosomes. Proc Natl Acad Sci U S A (1977) 2.41
Non-histone proteins and long-range organization of HeLa interphase DNA. J Mol Biol (1982) 2.33
Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions. EMBO J (1989) 2.33
The organisation of chromatin loops: characterization of a scaffold attachment site. EMBO J (1986) 2.28
SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin. EMBO J (1993) 2.27
Metaphase chromosome structure: the role of nonhistone proteins. Cold Spring Harb Symp Quant Biol (1978) 2.10
Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element. Mol Cell Biol (1991) 2.02
In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics. EMBO J (1992) 1.91
Characterization of DNA condensates induced by poly(ethylene oxide) and polylysine. Proc Natl Acad Sci U S A (1975) 1.89
Identification of nuclear pre-replication centers poised for DNA synthesis in Xenopus egg extracts: immunolocalization study of replication protein A. J Cell Biol (1992) 1.72
Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome. J Mol Biol (1986) 1.72
Evidence for two levels of DNA folding in histone-depleted HeLa interphase nuclei. J Mol Biol (1982) 1.69
Interaction of DNA with nuclear scaffolds in vitro. J Mol Biol (1988) 1.63
Specific inhibition of DNA binding to nuclear scaffolds and histone H1 by distamycin. The role of oligo(dA).oligo(dT) tracts. J Mol Biol (1989) 1.55
Bacteriophage T4 tail assembly: structural proteins and their genetic identification. J Mol Biol (1973) 1.55
SARs are cis DNA elements of chromosome dynamics: synthesis of a SAR repressor protein. Cell (1995) 1.54
Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts. EMBO J (1994) 1.53
Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster. Mol Cell (2000) 1.52
The scs' boundary element: characterization of boundary element-associated factors. Mol Cell Biol (1997) 1.49
Scaffold attachment of DNA loops in metaphase chromosomes. J Mol Biol (1988) 1.48
Highly preferential nucleation of histone H1 assembly on scaffold-associated regions. J Mol Biol (1989) 1.44
Facilitation of chromatin dynamics by SARs. Curr Opin Genet Dev (1998) 1.35
Maturation of the head of bacteriophage T4. IV. The proteins of the core of the tubular polyheads and in vitro cleavage of the head proteins. Virology (1974) 1.34
Chromatin opening of DNA satellites by targeted sequence-specific drugs. Mol Cell (2000) 1.33
Identification of a class of chromatin boundary elements. Mol Cell Biol (1998) 1.33
Maturation of the head of bacteriophage T4. V. A possible DNA packaging mechanism: in vitro cleavage of the head proteins and the structure of the core of the polyhead. J Supramol Struct (1974) 1.32
Evidence for an antagonistic relationship between the boundary element-associated factor BEAF and the transcription factor DREF. Chromosoma (1999) 1.26
In vivo analysis of scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation. EMBO J (1998) 1.23
Maturation of the head of bacteriophage T4. III. DNA packaging into preformed heads. J Mol Biol (1974) 1.14
SARs stimulate but do not confer position independent gene expression. Nucleic Acids Res (1994) 1.13
From the chromosomal loops and the scaffold to the classic bands of metaphase chromosomes. Cold Spring Harb Symp Quant Biol (1993) 1.09
Improved methods for the isolation of individual and clustered mitotic chromosomes. Exp Cell Res (1987) 1.07
Correlation between structural transformation and cleavage of the major head protein of T4 bacteriophage. Cell (1976) 1.07
A model for chromatin opening: stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin. EMBO J (1993) 1.07
Studies on the morphopoiesis of the head of phage T-even. V. The formation of polyheads. Mol Gen Genet (1968) 1.07
Morphogenetic core of the bacteriophage T4 head. Structure of the core in polyheads. J Mol Biol (1977) 1.06
Head length determination in bacteriophage T4: the role of the core protein P22. J Mol Biol (1976) 1.06
Interphase nuclear matrix and metaphase scaffolding structures. J Cell Sci Suppl (1984) 1.05
A simple method to renature DNA-binding proteins separated by SDS-polyacrylamide gel electrophoresis. Nucleic Acids Res (1993) 1.04
Relation of chromosome structure and gene expression. Philos Trans R Soc Lond B Biol Sci (1987) 1.04
Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides. EMBO J (2001) 1.04
Maturation of the head of bacteriophage T4. II. Head-related, aberrant tau-particles. J Mol Biol (1973) 1.01
Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha. EMBO J (1999) 0.99
Mapping nucleolar proteins with monoclonal antibodies. J Cell Biol (1984) 0.96
Silver staining the chromosome scaffold. Chromosoma (1984) 0.93
Cell cycle changes in Physarum polycephalum histone H1 phosphate: relationship to deoxyribonucleic acid binding and chromosome condensation. Biochemistry (1980) 0.87
Immunization in vitro and production of monoclonal antibodies specific to insoluble and weakly immunogenic proteins. Proc Natl Acad Sci U S A (1984) 0.79
Studies on the maturation of the head of bacteriophage T4. Philos Trans R Soc Lond B Biol Sci (1976) 0.78
Maturation of the head of bacteriophage T4: 9-aminoacridine blocks a late step in DNA packaging. Virology (1979) 0.76
Levels of organization of the DNA in eucaryotic chromosomes. Pharmacol Rev (1978) 0.75