Association of the viral oncoprotein STP-C488 with cellular ras.

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Published in Mol Cell Biol on December 01, 1995

Authors

J U Jung1, R C Desrosiers

Author Affiliations

1: New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA.

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HIV-1 origins. A finger on the missing link. Nature (1990) 1.26

High-titer immune responses elicited by recombinant vaccinia virus priming and particle boosting are ineffective in preventing virulent SIV infection. AIDS Res Hum Retroviruses (1994) 1.26

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Characterization of monoclonal antibodies that distinguish simian immunodeficiency virus isolates from each other and from human immunodeficiency virus types 1 and 2. J Gen Virol (1990) 1.22

Induction of lymphocyte proliferation and severe gastrointestinal disease in macaques by a nef gene variant SIVmac239. Am J Pathol (1996) 1.22