Published in Biochem J on January 01, 1996
Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med (2010) 7.31
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol (2004) 5.29
Reactive oxygen species in cancer. Free Radic Res (2010) 3.20
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest (2008) 3.17
Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc Natl Acad Sci U S A (1997) 2.74
DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer (2012) 2.70
Peto's Paradox: evolution's prescription for cancer prevention. Trends Ecol Evol (2011) 2.48
Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ (2014) 2.00
Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res (2001) 1.97
Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int (2013) 1.97
Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair. J Nucleic Acids (2010) 1.91
Heat-induced formation of reactive oxygen species and 8-oxoguanine, a biomarker of damage to DNA. Nucleic Acids Res (2002) 1.82
Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression. Am J Pathol (2003) 1.75
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. J Neurooncol (2011) 1.67
Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol (2009) 1.64
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res (2007) 1.62
Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens. Mol Cell Proteomics (2011) 1.53
The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta (2009) 1.50
A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression. J Pathol (2015) 1.45
Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells. Cell Commun Signal (2010) 1.36
NF-kappaB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages. Mol Biol Cell (1999) 1.33
Autophagy and cancer. Cold Spring Harb Perspect Biol (2012) 1.30
Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid Med Cell Longev (2010) 1.30
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. Am J Pathol (2006) 1.28
Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. Biochem J (1999) 1.26
Fingerprinting of polysaccharides attacked by hydroxyl radicals in vitro and in the cell walls of ripening pear fruit. Biochem J (2001) 1.22
Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Mol Cell Biol (2007) 1.22
Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity. Nucleic Acids Res (2008) 1.21
Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. J Biomed Biotechnol (2012) 1.20
Reactive oxygen species: their relation to pneumoconiosis and carcinogenesis. Environ Health Perspect (1998) 1.19
Multitargeted therapy of cancer by lycopene. Cancer Lett (2008) 1.19
Single-walled carbon nanotubes induces oxidative stress in rat lung epithelial cells. J Nanosci Nanotechnol (2007) 1.19
Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. Free Radic Biol Med (2009) 1.17
Exposure to traffic exhausts and oxidative DNA damage. Occup Environ Med (2005) 1.16
Cystathionine γ-lyase protects against renal ischemia/reperfusion by modulating oxidative stress. J Am Soc Nephrol (2013) 1.16
Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan. Environ Health Perspect (2001) 1.15
Fabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapy. Proc Natl Acad Sci U S A (2008) 1.15
Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines. Evid Based Complement Alternat Med (2013) 1.15
Lipid peroxidation and antioxidant status in colorectal cancer. World J Gastroenterol (2005) 1.15
Retracted Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway. J Biol Chem (2010) 1.14
Roles of reactive oxygen species and antioxidants in ovarian toxicity. Biol Reprod (2012) 1.14
Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin. Neuroscience (2009) 1.08
The Escherichia coli methyl-directed mismatch repair system repairs base pairs containing oxidative lesions. J Bacteriol (2003) 1.07
Abnormalities in nitric oxide and its derivatives in lung cancer. Am J Respir Crit Care Med (2005) 1.07
Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells. Br J Cancer (2015) 1.07
Regulation of cancer metastasis by stress pathways. Clin Exp Metastasis (2003) 1.07
Towards understanding vacuolar antioxidant mechanisms: a role for fructans? J Exp Bot (2013) 1.06
Protein biomarkers of ovarian cancer: the forest and the trees. Future Oncol (2012) 1.05
Activated ras. Yet another player in melanoma? Am J Pathol (1996) 1.05
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? Redox Biol (2015) 1.02
Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort. Carcinogenesis (2008) 1.01
Hyperbaric oxygen therapy for malignancy: a review. World J Surg (2006) 1.01
Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis. Immunology (2004) 1.00
Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages. Clin Exp Immunol (2001) 0.99
Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat. Gut (2001) 0.99
HBx sensitizes cells to oxidative stress-induced apoptosis by accelerating the loss of Mcl-1 protein via caspase-3 cascade. Mol Cancer (2011) 0.98
Therapeutic targeting of cancer cell cycle using proteasome inhibitors. Cell Div (2012) 0.98
Total Phenolic Content and Antioxidant Activity of Some Malvaceae Family Species. Antioxidants (Basel) (2012) 0.98
Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy. Immunology (1998) 0.98
Oxidative DNA damage preventive activity and antioxidant potential of plants used in Unani system of medicine. BMC Complement Altern Med (2010) 0.97
Nuclear targeted silver nanospheres perturb the cancer cell cycle differently than those of nanogold. Bioconjug Chem (2011) 0.97
An emissive C analog distinguishes between G, 8-oxoG, and T. Org Lett (2009) 0.97
Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study. Occup Environ Med (2010) 0.97
Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity. World J Gastroenterol (2009) 0.96
The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. Front Pharmacol (2012) 0.96
Soft X-ray and low energy electron-induced damage to DNA under N2 and O2 atmospheres. J Phys Chem B (2011) 0.96
DNA repair is indispensable for survival after acute inflammation. J Clin Invest (2012) 0.96
Genomic alterations in breast cancer patients in betel quid and non betel quid chewers. PLoS One (2012) 0.94
Tolerance of spermatogonia to oxidative stress is due to high levels of Zn and Cu/Zn superoxide dismutase. PLoS One (2011) 0.94
In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis. Clin Exp Immunol (2007) 0.93
Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. World J Gastroenterol (2005) 0.93
Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis. Parasitol Res (2010) 0.93
Plasma and esophageal mucosal levels of vitamin C: role in the pathogenesis and neoplastic progression of Barrett's esophagus. Dig Dis Sci (2004) 0.93
Repair of DNA double-strand breaks following UV damage in three Sulfolobus solfataricus strains. J Bacteriol (2010) 0.93
Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell. PLoS One (2011) 0.92
Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model. Am J Pathol (2000) 0.92
Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery. Int J Nanomedicine (2011) 0.92
Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Invest New Drugs (2008) 0.92
Repair of oxidative DNA damage in Drosophila melanogaster: identification and characterization of dOgg1, a second DNA glycosylase activity for 8-hydroxyguanine and formamidopyrimidines. Nucleic Acids Res (2000) 0.92
Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket. Nucleic Acids Res (2004) 0.91
Dispersal evolution in neoplasms: the role of disregulated metabolism in the evolution of cell motility. Cancer Prev Res (Phila) (2011) 0.91
The Role of p21 in Apoptosis, Proliferation, Cell Cycle Arrest, and Antioxidant Activity in UVB-Irradiated Human HaCaT Keratinocytes. Med Sci Monit Basic Res (2015) 0.91
Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis. Circ Res (2013) 0.91
Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA. J Biol Chem (2011) 0.90
8-hydroxy-2'-deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution. Environ Health Perspect (1999) 0.90
Role of nitric oxide and its metabolites as potential markers in lung cancer. Ann Thorac Med (2010) 0.90
Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols. Coord Chem Rev (2012) 0.90
Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways. Toxicol Appl Pharmacol (2014) 0.90
A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts. PLoS One (2014) 0.89
Positive ALDH1A3 and negative GPX3 expressions are biomarkers for poor prognosis of gallbladder cancer. Dis Markers (2013) 0.89
Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. Cytokine (2009) 0.89
Induction of cell death through alteration of oxidants and antioxidants in lung epithelial cells exposed to high energy protons. J Biol Chem (2010) 0.88
Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochem J (1999) 0.88
In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters. Sci Rep (2013) 0.88
Quantitative proteomics profiling of murine mammary gland cells unravels impact of annexin-1 on DNA damage response, cell adhesion, and migration. Mol Cell Proteomics (2012) 0.88
Dual effect of oxidative stress on leukemia cancer induction and treatment. J Exp Clin Cancer Res (2014) 0.88
Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death. Mutagenesis (2009) 0.88
Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters. Proc Natl Acad Sci U S A (2015) 0.87
p16 mutation spectrum in the premalignant condition Barrett's esophagus. PLoS One (2008) 0.87
Food-derived bioactive peptides on inflammation and oxidative stress. Biomed Res Int (2014) 0.87
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature (1993) 10.95
Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83
Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem (1994) 7.80
Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A (1994) 6.84
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A (1991) 6.42
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer (1992) 6.12
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature (1991) 6.04
The reaction of no with superoxide. Free Radic Res Commun (1993) 5.65
Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun (1992) 4.45
Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet (1992) 4.11
Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci (1993) 3.80
Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med (1995) 3.75
Role of superoxide dismutase in cancer: a review. Cancer Res (1979) 3.34
DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett (1991) 3.33
Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions. Annu Rev Biochem (1993) 3.33
Oxidative chemistry of peroxynitrite. Methods Enzymol (1994) 3.03
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev (1994) 2.96
Endogenous oxidative DNA damage, aging, and cancer. Free Radic Res Commun (1989) 2.79
Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res (1994) 2.78
Programmed cell death and Bcl-2 protection in very low oxygen. Nature (1995) 2.76
Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood (1990) 2.72
Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation. Free Radic Res Commun (1986) 2.71
The antioxidants of human extracellular fluids. Arch Biochem Biophys (1990) 2.62
Body iron stores and the risk of cancer. N Engl J Med (1988) 2.61
Diet and health: what should we eat? Science (1994) 2.58
Nucleotide repeats. Slippery DNA and diseases. Nature (1993) 2.56
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J Biol Chem (1993) 2.52
Reactive oxygen species in tumorigenesis. Cancer Res (1994) 2.47
Spontaneous cancer and its possible relationship to oxygen metabolism. Proc Natl Acad Sci U S A (1980) 2.43
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol (1994) 2.43
The relation of infection with the hepatitis B agent to primary hepatic carcinoma. Am J Pathol (1975) 2.39
Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. J Biol Chem (1993) 2.38
Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett (1994) 2.38
Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res (1994) 2.31
Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis (1992) 2.31
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet (1993) 2.20
A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. N Engl J Med (1993) 2.15
Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci U S A (1993) 2.08
Cytotoxicity and genotoxicity of lipid-oxidation products. Am J Clin Nutr (1993) 2.06
Free radical theory of aging. Mutat Res (1992) 2.05
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool. Proc Natl Acad Sci U S A (1992) 2.04
Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Lett (1986) 1.97
Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat Res (1992) 1.97
Inflammatory breast cancer: a review. J Clin Oncol (1992) 1.93
Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis (1993) 1.92
Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease. Gastroenterology (1992) 1.92
Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals. Biochemistry (1993) 1.91
Oxidants and free radicals in inflammatory bowel disease. Lancet (1994) 1.90
Oxy-radicals and cancer. Lancet (1994) 1.80
Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci U S A (1994) 1.79
Free radicals and antioxidants: a personal view. Nutr Rev (1994) 1.76
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A (1991) 1.74
Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Ann N Y Acad Sci (1992) 1.70
Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers. Annu Rev Nutr (1992) 1.68
The etiology of breast cancer. Characteristic alteration in hydroxyl radical-induced DNA base lesions during oncogenesis with potential for evaluating incidence risk. Cancer (1993) 1.63
How to characterize a biological antioxidant. Free Radic Res Commun (1990) 1.62
DNA oxidative damage and life expectancy in houseflies. Proc Natl Acad Sci U S A (1994) 1.62
Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents. Chem Res Toxicol (1992) 1.58
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem (1995) 1.56
Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol Ther (1992) 1.54
Inflammation, chromosomal instability, and cancer: the schistosomiasis model. Cancer Res (1994) 1.54
Peroxynitrite-induced rat colitis--a new model of colonic inflammation. Gastroenterology (1993) 1.53
NAD(+)-dependent repair of damaged DNA by human cell extracts. J Biol Chem (1993) 1.50
The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects? Biochem Pharmacol (1987) 1.47
Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis. Cancer Res (1994) 1.47
DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions. Proc Natl Acad Sci U S A (1993) 1.46
Oxygen radicals, nitric oxide and human inflammatory joint disease. Ann Rheum Dis (1995) 1.46
Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases. Ann Rheum Dis (1993) 1.45
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies. Proc Natl Acad Sci U S A (1989) 1.44
Thymine ring saturation and fragmentation products: lesion bypass, misinsertion and implications for mutagenesis. Mutat Res (1993) 1.44
Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro. Nucleic Acids Res (1994) 1.44
Activated neutrophils induce prolonged DNA damage in neighboring cells. Carcinogenesis (1988) 1.41
Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status. Ann Rheum Dis (1989) 1.40
Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase. Mol Carcinog (1992) 1.38
Free radical adducts induce alterations in DNA cytosine methylation. Proc Natl Acad Sci U S A (1994) 1.38
Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA. Chem Res Toxicol (1995) 1.38
Major alterations in the nucleotide structure of DNA in cancer of the female breast. Cancer Res (1991) 1.37
Endogenous DNA adducts: potential and paradox. Chem Res Toxicol (1994) 1.37
Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro. Carcinogenesis (1995) 1.34
DNA base modifications in chromatin of human cancerous tissues. FEBS Lett (1992) 1.32
Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions. Arch Biochem Biophys (1991) 1.31
The data support a role for antioxidants in reducing cancer risk. Nutr Rev (1992) 1.31
Antioxidants and disease prevention. Mol Aspects Med (1994) 1.29
Role of reactive oxygen in bile salt stimulation of colonic epithelial proliferation. J Clin Invest (1986) 1.29
Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res (1992) 1.27
Cigarette smoking induces formation of 8-hydroxydeoxyguanosine, one of the oxidative DNA damages in human peripheral leukocytes. Free Radic Res Commun (1990) 1.24
beta-Carotene and alpha-tocopherol are synergistic antioxidants. Arch Biochem Biophys (1992) 1.24
Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease. FEBS Lett (1994) 1.23
The reaction of nitric oxide with organic peroxyl radicals. Biochem Biophys Res Commun (1993) 1.21
Analysis of methylated and oxidized purines in urine by capillary gas chromatography-mass spectrometry. Chem Res Toxicol (1992) 1.21
Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion. Biochem J (1994) 1.20
Macrophage-mediated induction of drug-resistant variants in a mouse mammary tumor cell line. Cancer Res (1986) 1.20
Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization. Cancer Res (1991) 1.20
Recognition of oxidized abasic sites by repair endonucleases. Nucleic Acids Res (1994) 1.19
8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus. FEBS Lett (1994) 1.19
Neutrophil-mediated nitrosamine formation: role of nitric oxide in rats. Gastroenterology (1992) 1.18
Is apoptosis mediated by reactive oxygen species? Free Radic Res (1994) 1.18
Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J (1984) 13.20
Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol (1990) 11.00
The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med (1989) 5.10
Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys (1986) 4.67
Oxygen radicals and human disease. Ann Intern Med (1987) 4.57
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature (1998) 4.34
Formation of thiobarbituric-acid-reactive substance from deoxyribose in the presence of iron salts: the role of superoxide and hydroxyl radicals. FEBS Lett (1981) 3.92
Glutathione and ascorbic acid in spinach (Spinacia oleracea) chloroplasts. The effect of hydrogen peroxide and of Paraquat. Biochem J (1983) 3.82
The presence of glutathione and glutathione reductase in chloroplasts: A proposed role in ascorbic acid metabolism. Planta (1976) 3.52
Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates: is it a mechanism for hydroxyl radical production in biochemical systems? FEBS Lett (1978) 3.14
The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci (1990) 2.86
Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine. Biochem J (1979) 2.82
The importance of free radicals and catalytic metal ions in human diseases. Mol Aspects Med (1985) 2.79
Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem J (1981) 2.68
Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. Lancet (1984) 2.53
Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicity. J Biol Chem (1997) 2.48
Free radicals and antioxidants in the year 2000. A historical look to the future. Ann N Y Acad Sci (2000) 2.47
The importance of iron in rheumatoid disease. Lancet (1981) 2.44
Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett (1994) 2.38
Intramitochondrial localisation of glycine decarboxylase in spinach leaves. Biochem Biophys Res Commun (1977) 2.34
Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem (1997) 2.10
Subcellular localisation and identification of superoxide dismutase in the leaves of higher plants. Eur J Biochem (1978) 2.09
Failure of the ubiquitin-proteasome system in Parkinson's disease. Nat Rev Neurosci (2001) 2.04
Antioxidant protection against hypochlorous acid in human plasma. J Lab Clin Med (1993) 1.95
Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol (1994) 1.95
Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Its role in degradation of hyaluronic acid by a superoxide-generating system. FEBS Lett (1978) 1.91
Inhibition of lipid peroxidation by the iron-binding protein lactoferrin. Biochem J (1981) 1.85
The chloroplast at work. A review of modern developments in our understanding of chloroplast metabolism. Prog Biophys Mol Biol (1978) 1.84
A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J Neurochem (1997) 1.83
Superoxide-dependent formation of hydroxyl radicals: detection of hydroxyl radicals by the hydroxylation of aromatic compounds. Anal Biochem (1981) 1.82
Formation of nitrating and chlorinating species by reaction of nitrite with hypochlorous acid. A novel mechanism for nitric oxide-mediated protein modification. J Biol Chem (1996) 1.78
The measurement of free radical reactions in humans. Some thoughts for future experimentation. FEBS Lett (1987) 1.77
Iron ion-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine/xanthine oxidase. J Biol Chem (1989) 1.77
Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of 'catalytic' iron and anti-oxidant activity in extracellular fluids. Biochem J (1982) 1.72
Nitric oxide and oxygen radicals: a question of balance. FEBS Lett (1995) 1.70
Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: the key role of superoxide dismutase. Cell Biol Int Rep (1978) 1.68
Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem J (1991) 1.68
Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation? Biochem J (1987) 1.67
Oxidation of formate by peroxisomes and mitochondria from spinach leaves. Biochem J (1974) 1.62
Lipid peroxidation in rheumatoid arthritis: thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients. Clin Sci (Lond) (1984) 1.61
Oxidation of biologic molecules by ozone: the effect of pH. J Lab Clin Med (1993) 1.58
The role of superoxide and hydroxyl radicals in the degradation of hyaluronic acid induced by metal ions and by ascorbic acid. J Inorg Biochem (1981) 1.58
Production of superoxide, hydrogen peroxide and hydroxyl radicals by phagocytic cells: a cause of chronic inflammatory disease? Cell Biol Int Rep (1982) 1.57
Aldehyde-induced protein modifications in human plasma: protection by glutathione and dihydrolipoic acid. J Lab Clin Med (1994) 1.56
Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy. J Biol Chem (1989) 1.54
Oxidants, antioxidants, and respiratory tract lining fluids. Environ Health Perspect (1994) 1.53
Effect of a specific iron chelating agent on animal models of inflammation. Ann Rheum Dis (1983) 1.52
Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem Biophys Res Commun (2000) 1.51
Methods for the measurement of hydroxyl radicals in biomedical systems: deoxyribose degradation and aromatic hydroxylation. Methods Biochem Anal (1988) 1.50
Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids. Biochem J (1986) 1.50
Properties of freshly purified and thiol-treated spinach chloroplast fructose bisphosphatase. Biochem J (1980) 1.49
Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent? Biochem J (1988) 1.49
Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radic Biol Med (2001) 1.48
Protection against superoxide and hydrogen peroxide in synovial fluid from rheumatoid patients. Clin Sci (Lond) (1981) 1.48
Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts. Biochem J (2000) 1.48
The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects? Biochem Pharmacol (1987) 1.47
Micronutrients: oxidant/antioxidant status. Br J Nutr (2001) 1.47
Tyrosine modification by reactive nitrogen species: a closer look. Arch Biochem Biophys (1995) 1.45
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid. Xenobiotica (1992) 1.44
Action of calcium ions on spinach (Spinacia oleracea) chloroplast fructose bisphosphatase and other enzymes of the Calvin cycle. Biochem J (1980) 1.41
Ascorbic acid, metal ions and the superoxide radical. Biochem J (1976) 1.40
Effect of hydrogen peroxide on spinach (Spinacia oleracea) chloroplast fructose bisphosphatase. Biochem J (1980) 1.39
The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide. Antioxid Redox Signal (2001) 1.39
Oxidative decarboxylation of glycollate and glyoxylate by leaf peroxisomes. Biochem J (1974) 1.39
Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction. Am J Clin Nutr (1995) 1.39
Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo? Biochem J (1987) 1.39
Antioxidant activity of vitamin C in iron-overloaded human plasma. J Biol Chem (1997) 1.38
Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts. Biochim Biophys Acta (1985) 1.37
An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J Neurochem (1997) 1.36
Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates. J Biol Chem (1989) 1.35
Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm Res (1996) 1.35
Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Lett (1987) 1.34
The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of alpha 1-antiproteinase against inactivation by hypochlorous acid. Biochem J (1987) 1.32
Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids. Am J Physiol (1999) 1.32
An aromatic hydroxylation assay for hydroxyl radicals utilizing high-performance liquid chromatography (HPLC). Use to investigate the effect of EDTA on the Fenton reaction. Free Radic Res Commun (1986) 1.31
Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions. Arch Biochem Biophys (1991) 1.31
The definition and measurement of antioxidants in biological systems. Free Radic Biol Med (1995) 1.31
Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation. Biochem J (1992) 1.31
Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability. Biochem Pharmacol (1991) 1.30
The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem J (1988) 1.29
Metal ions and oxygen radical reactions in human inflammatory joint disease. Philos Trans R Soc Lond B Biol Sci (1985) 1.28
Superoxide-dependent formation of hydroxyl radicals in the presence of thiol compounds. FEBS Lett (1982) 1.27
Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis. Clin Sci (Lond) (1985) 1.27
An attempt to demonstrate a reaction between superoxide and hydrogen peroxide. FEBS Lett (1976) 1.27
A reassessment of the peroxynitrite scavenging activity of uric acid. Ann N Y Acad Sci (2002) 1.26
Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants. Free Radic Res (1996) 1.25
Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species. J Neurochem (1998) 1.24
Free radicals and hearing. Cause, consequence, and criteria. Ann N Y Acad Sci (1999) 1.23
Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease. FEBS Lett (1994) 1.23
Antioxidant protection: a function of tracheobronchial and gastrointestinal mucus. Lancet (1984) 1.23
Cobalt(II) ion as a promoter of hydroxyl radical and possible 'crypto-hydroxyl' radical formation under physiological conditions. Differential effects of hydroxyl radical scavengers. Biochim Biophys Acta (1985) 1.22
Effect of ferritin-containing fractions with different iron loading on lipid peroxidation. Biochem J (1983) 1.22
Cerebral and ocular toxicity induced by desferrioxamine. Q J Med (1985) 1.21
Formation of hydroxyl radicals from the paraquat radical cation, demonstrated by a highly specific gas chromatographic technique. the role of superoxide radical anion, hydrogen peroxide, and glutathione reductase. J Inorg Biochem (1982) 1.21
Formation of hydroxyl radicals in the presence of ferritin and haemosiderin. Is haemosiderin formation a biological protective mechanism? Biochem J (1986) 1.20
Reactions of ferrioxamine and desferrioxamine with the hydroxyl radical. Chem Biol Interact (1982) 1.20
Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion. Biochem J (1994) 1.20
The superoxide dismutase activity of iron complexes. FEBS Lett (1975) 1.20
Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions. Biochem J (1992) 1.19