Functional substitution identifies a cell survival promoting domain common to adenovirus E1B 19 kDa and Bcl-2 proteins.

PubWeight™: 0.92‹?›

🔗 View Article (PMID 8570192)

Published in Oncogene on December 07, 1995

Authors

T Subramanian1, J M Boyd, G Chinnadurai

Author Affiliations

1: Institute for Molecular Virology, St. Louis University Medical Center, Missouri 63110, USA.

Articles by these authors

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell (1994) 3.86

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J (1995) 3.70

Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc Natl Acad Sci U S A (1995) 3.28

Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis. Nucleic Acids Res (1989) 2.72

A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J (1993) 2.58

Physical mapping of a large-plaque mutation of adenovirus type 2. J Virol (1979) 2.50

Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein. Proc Natl Acad Sci U S A (1991) 2.17

BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13

Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology (1996) 2.12

Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. J Biol Chem (1998) 2.06

Adenovirus 2 Ip+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation. Cell (1983) 2.01

Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence. J Biol Chem (1998) 1.81

Distinct cis-acting regions in U3 regulate trans-activation of the human spumaretrovirus long terminal repeat by the viral bel1 gene product. Nucleic Acids Res (1991) 1.63

Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J Biol Chem (1999) 1.57

Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex. Mol Cell Biol (2007) 1.49

Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype. Virology (1990) 1.48

19-kDa tumor antigen coded by early region E1b of adenovirus 2 is required for efficient synthesis and for protection of viral DNA. J Biol Chem (1984) 1.47

A unique pattern of integrated viral genes in hamster cells transformed by highly oncogenic human adenovirus 12. Cell (1976) 1.45

Epstein-Barr virus BHRF1 protein protects against cell death induced by DNA-damaging agents and heterologous viral infection. Virology (1994) 1.42

An N-terminal region of adenovirus E1a essential for cell transformation and induction of an epithelial cell growth factor. Oncogene (1988) 1.41

Enhanced infectivity of adenovirus type 2 DNA and a DNA-protein complex. J Virol (1978) 1.40

Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein. Oncogene (1989) 1.40

Nicotinamide adenine dinucleotide stimulates oligomerization, interaction with adenovirus E1A and an intrinsic dehydrogenase activity of CtBP. FEBS Lett (2003) 1.38

The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation. Nucleic Acids Res (1996) 1.33

Adenovirus transforming 19-kD T antigen has an enhancer-dependent trans-activation function and relieves enhancer repression mediated by viral and cellular genes. Genes Dev (1987) 1.30

Evidence that a second tumor antigen coded by adenovirus early gene region E1a is required for efficient cell transformation. Proc Natl Acad Sci U S A (1985) 1.27

Synergistic activation of the human immunodeficiency virus type 1 promoter by the viral Tat protein and cellular transcription factor Sp1. J Virol (1992) 1.25

Relationship between the transforming and transcriptional regulatory functions of adenovirus 2 E1a oncogene. Virology (1987) 1.24

Heterologous basic domain substitutions in the HIV-1 Tat protein reveal an arginine-rich motif required for transactivation. EMBO J (1991) 1.24

Functional dissection of the human spumaretrovirus transactivator identifies distinct classes of dominant-negative mutants. J Virol (1993) 1.24

p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins. Cell Growth Differ (1995) 1.23

BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells. Oncogene (2007) 1.22

Pre-early polypeptides of bacteriophages T5 and BF23. J Virol (1977) 1.21

Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities. Oncogene (1998) 1.17

Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2. J Biol Chem (2005) 1.17

Structural determinants present in the C-terminal binding protein binding site of adenovirus early region 1A proteins. J Biol Chem (1998) 1.17

Association of class I histone deacetylases with transcriptional corepressor CtBP. FEBS Lett (2003) 1.16

Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells. Cancer Res (2002) 1.16

Functional substitution of the basic domain of the HIV-1 trans-activator, Tat, with the basic domain of the functionally heterologous Rev. Virology (1990) 1.15

Genetic identification of adenovirus type 5 genes that influence viral spread. J Virol (2006) 1.14

Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization. Virology (1990) 1.13

Modulation of mitochondrial Ca(2+) homeostasis by Bcl-2. J Biol Chem (1999) 1.12

bfl-1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity. Cancer Res (1996) 1.11

mRNA from the transforming segment of the adenovirus 2 genome in productively infected and transformed cells. J Virol (1976) 1.11

Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1. Oncogene (1996) 1.10

BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. Cancer Res (1999) 1.09

Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis. J Biol Chem (2000) 1.08

Requirement of a phage-induced 5'-exonuclease for the expression of late genes of bacteriophage T5. Proc Natl Acad Sci U S A (1973) 1.08

Contribution of the type III secretion system (TTSS) to virulence of Aeromonas salmonicida subsp. salmonicida. Microbiology (2006) 1.07

Membrane-associated quinoprotein formaldehyde dehydrogenase from Methylococcus capsulatus Bath. J Bacteriol (2001) 1.04

Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells. J Immunol (2001) 1.03

The pro-apoptotic protein, Bik, exhibits potent antitumor activity that is dependent on its BH3 domain. Mol Cancer Ther (2001) 1.01

Adenovirus cyt+ locus, which controls cell transformation and tumorigenicity, is an allele of lp+ locus, which codes for a 19-kilodalton tumor antigen. J Virol (1984) 1.01

Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation. Cancer Res (1996) 0.99

Dual role of gene D5 in the development of bacteriophage T5. Nature (1974) 0.98

Functional dissection of the pro-apoptotic protein Bik. Heterodimerization with anti-apoptosis proteins is insufficient for induction of cell death. J Biol Chem (1997) 0.97

The carboxy-terminal transcription enhancement region of the human spumaretrovirus transactivator contains discrete determinants of the activator function. J Virol (1993) 0.97

Activation of the adenovirus 2 protein IX promoter by DNA replication in a transient expression assay. Nucleic Acids Res (1987) 0.97

Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors. J Virol (2010) 0.97

Hinf family: a novel repeated DNA family of the human genome. Nature (1983) 0.96

Transforming genes among three different oncogenic subgroups of human adenoviruses have similar replicative functions. J Virol (1981) 0.95

Silencing of human immunodeficiency virus long terminal repeat expression by an adenovirus E1a mutant. Proc Natl Acad Sci U S A (1990) 0.95

Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells. Oncogene (2006) 0.95

Use of the radial forearm fasciocutaneous free flap and montgomery salivary bypass tube for pharyngoesophageal reconstruction. Head Neck (2000) 0.95

Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog. Oncogene (1998) 0.94

Regulation of expression of late genes of bacteriophage T5. J Virol (1974) 0.94

Topological analysis and role of the transmembrane domain in polar targeting of PilS, a Pseudomonas aeruginosa sensor kinase. Mol Microbiol (2000) 0.94

Changes in C-terminal binding protein 2 (CtBP2) corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2. J Biol Chem (2006) 0.94

Immortalization of rat embryo fibroblasts by an adenovirus 2 mutant expressing a single functional E1a protein. J Virol (1985) 0.94

Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences. Gene (2000) 0.93

Evidence for involvement of BH3-only proapoptotic members in adenovirus-induced apoptosis. J Virol (2007) 0.93

Mutational analysis of the transforming and apoptosis suppression activities of the adenovirus E1B 175R protein. Gene (1993) 0.92

Functional comparison of the basic domains of the Tat proteins of human immunodeficiency virus types 1 and 2 in trans activation. J Virol (1992) 0.92

A potent cell death activity associated with transient high level expression of BCL-2. J Biol Chem (1998) 0.90

Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector. Proc Natl Acad Sci U S A (1990) 0.90

Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K. Oncogene (2005) 0.90

PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions. Oncogene (2007) 0.90

Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2. BMC Mol Biol (2009) 0.89

Antepartum detection of macrosomic fetus: clinical versus sonographic, including soft-tissue measurements. Obstet Gynecol (2000) 0.89

Requirement of BAX for efficient adenovirus-induced apoptosis. J Virol (2002) 0.88

A nonessential glycoprotein is coded by early region E3 of adenovirus type 7. Virology (1981) 0.87

Method for introducing site-specific mutations into adenovirus 2 genome: construction of a small deletion mutant in VA-RNAI gene. Proc Natl Acad Sci U S A (1981) 0.87

Differential gene expression by Pseudomonas aeruginosa during interaction with respiratory mucus. Am J Respir Crit Care Med (1996) 0.86

Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1b. Oncogene (1991) 0.85

Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK. J Cell Biochem (2003) 0.85

Separation of immortalization and T24-ras oncogene cooperative functions of adenovirus E1a. Oncogene (1988) 0.85

Identification of early proteins induced by highly oncogenic human adenovirus 12 during lytic infection and in hamster tumors. Biochem Biophys Res Commun (1977) 0.85

BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition? Mol Cancer Res (2009) 0.83

Adenovirus L-E1A activates transcription through mediator complex-dependent recruitment of the super elongation complex. J Virol (2013) 0.83

Separation of the functions controlled by adenovirus 2 lp+ locus. Virology (1986) 0.83

Functional similarity between adenovirus e1b 19k gene and bcl2 oncogene - mutant complementation and suppression of cell-death induced by DNA-damaging agents. Int J Oncol (1993) 0.82

Activation of a heterologous promoter by human immunodeficiency virus type 1 Tat requires Sp1 and is distinct from the mode of activation by acidic transcriptional activators. J Virol (1993) 0.81

A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein. J Virol (2003) 0.81

Cell type dependent transformation by adenovirus 5 E1a proteins. Oncogene (1988) 0.81

Functional identification of the apoptosis effector BH3 domain in cellular protein BNIP1. Oncogene (2000) 0.80